NO153508B - QUICK METHOD FOR DETERMINING THE REDUCTION IN VENE BLOOD. - Google Patents
QUICK METHOD FOR DETERMINING THE REDUCTION IN VENE BLOOD. Download PDFInfo
- Publication number
- NO153508B NO153508B NO840179A NO840179A NO153508B NO 153508 B NO153508 B NO 153508B NO 840179 A NO840179 A NO 840179A NO 840179 A NO840179 A NO 840179A NO 153508 B NO153508 B NO 153508B
- Authority
- NO
- Norway
- Prior art keywords
- blood
- determination
- lowering
- tube
- vene
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 22
- 210000004369 blood Anatomy 0.000 title claims description 15
- 239000008280 blood Substances 0.000 title claims description 15
- 238000007792 addition Methods 0.000 claims description 2
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
Fremgangsmåte for hurtig bestemmelse av blodsenkningen Procedure for rapid determination of the blood drop
i veneblod. in venous blood.
En av de mest benyttede laboratorieprøver i den generelle legepraksis er bestemmelse av senkningen i veneblod. One of the most commonly used laboratory tests in general medical practice is the determination of the drop in venous blood.
Den tradisjonelle metode etter Westergren er forbundet The traditional method according to Westergren is connected
med den praktiske ulempe at det tar 1 time før resultatet foreligger, meget ofte vil konsultasjonen da allerede være avsluttet. with the practical disadvantage that it takes 1 hour before the result is available, very often the consultation will then have already ended.
Det har vært gjort mange forsøk på å modifisere denne Many attempts have been made to modify this
metode for å oppnå en senkningsbestemmelse på kortere tid. Imidlertid har metoder med oppvarmning av senkningsblodet eller kjemiske tilsetninger ikke vært vellykket. method to achieve a lowering determination in a shorter time. However, methods of heating the immersion blood or chemical additives have not been successful.
Imidlertid har man oppdaget at en skråstilling av senknings-bestemmelsesrøret ga en betydelig øket hastighet og dette har gitt opphav til flere forsøk på såkalte hurtigmetoder. However, it has been discovered that an inclined position of the lowering-determining tube gave a significantly increased speed and this has given rise to several attempts at so-called quick methods.
Grunnen til den økede hastighet er at rørets skråstilling bevirker en raskere "pengerulldannelse" og aggregering av The reason for the increased speed is that the inclined position of the tube causes a faster "money roll formation" and aggregation of
erytrocyttene mot glassveggen i pipetten, det oppadstigende plasma yter mindre motstand og sedimenteringshastigheten øker. the erythrocytes against the glass wall in the pipette, the rising plasma offers less resistance and the sedimentation rate increases.
Den mest anvendte hurtigmetode medfører at senkningsrøret vippes 60° fra vertikalplanet og det har vært angitt at en avlesning av senkningen etter 7 henholdsvis 10 minutter skulle gi et pålitelig uttrykk for vanlig vertikal senkning avlest etter 1 henholdsvis 2 timer. The most used rapid method means that the lowering pipe is tilted 60° from the vertical plane and it has been stated that a reading of the lowering after 7 or 10 minutes should give a reliable expression of normal vertical lowering read after 1 or 2 hours.
Det er videre gjort forsøk med andre hellingsvinkler. Experiments have also been carried out with other inclination angles.
Det har vært foretatt nærmere undersøkelser når det gjelder disse metoders pålitelighet og det skal her henvises til en artikkel av Steinar Westin og Astrid Helland, "Senknings-måling i almenpraksis", samt en artikkel av Jon Block og Martin Holte, "Hurtigsenkning", begge deler i "Tidsskrift for den norske Legeforening", nr.29, 1976, sidene 1551-1553 med henholdsvis 1553-1555. More research has been carried out regarding the reliability of these methods and reference should be made here to an article by Steinar Westin and Astrid Helland, "Sink measurement in general practice", as well as an article by Jon Block and Martin Holte, "Rapid sinking", both parts in "Journal of the Norwegian Medical Association", no. 29, 1976, pages 1551-1553 with 1553-1555 respectively.
I begge artikler konkluderes det med at den såkalte skrå-metode kun bør benyttes i unntakstilfelle (Westin og Helland) samt at konsekvent bruk av bare hurtigsenkning ikke er å anbefale (Block og Holte). In both articles, it is concluded that the so-called oblique method should only be used in exceptional cases (Westin and Helland) and that consistent use of only rapid lowering is not recommended (Block and Holte).
I tillegg til de observasjoner og anmerkninger man finner In addition to the observations and comments you find
i disse to artikler har søkeren funnet ut at Westergrens 60 minutters metode heller ikke viste den gode og sikre reproduserbarhet som var ønskelig. in these two articles, the applicant has found that Westergren's 60 minute method also did not show the good and reliable reproducibility that was desirable.
Årsaken til dette kan være en blandingseffekt i det blodet som suges opp i pipetten, hvor hurtig eller langsomt blodet suges opp og volumnøyaktigheten av blod i pipetten. The reason for this may be a mixing effect in the blood that is sucked up into the pipette, how quickly or slowly the blood is sucked up and the accuracy of the volume of blood in the pipette.
Noen av de problemer som ifølge artikkelforfatterne oppstår Some of the problems that, according to the article's authors, arise
og som kan være årsaken til at de tidligere hurtigsenknings-metoder ikke helt er å anbefale er det "haleheng" av røde blodlegemer som etter hvert dannes når senkningsrøret står i skråstilling. and which may be the reason why the previous rapid lowering methods are not entirely recommended is the "tail hanging" of red blood cells that eventually forms when the lowering tube is in an inclined position.
Foreliggende oppfinnelse har til hensikt å avhjelpe manglene ved den kjente teknikk og således å tilveiebringe en hurtig, pålitelig og reproduserbar metode for måling av blodsenkningen i veneblod. The present invention aims to remedy the shortcomings of the known technique and thus to provide a fast, reliable and reproducible method for measuring the blood lowering in venous blood.
Dette oppnås ved en fremgangsmåte der blodet etter de nød-vendige tilsetninger hensettes i et dertil egnet rør for senkningsbestemmelse og der bestemmelsesrøret ved bestemmelsens begynnelse anbringes i en vinkel mot vertikallinjen, og denne fremgangsmåte karakteriseres ved at røret, eventuelt etter en passiv skråstilling, deretter samtidig gis en såvel om sin egen akse roterende, som lengdeaksen opprettende bevegelse, hvoretter senkningen avleses umiddelbart etter at rør-et har nådd vertikal posisjon eller etter en periode i passiv vertikal stilling. This is achieved by a method where, after the necessary additions, the blood is placed in a suitable tube for determination of lowering and where the determination tube is placed at an angle to the vertical line at the beginning of the determination, and this method is characterized by the tube, possibly after a passive tilt, then simultaneously is given a movement both rotating about its own axis and erecting the longitudinal axis, after which the lowering is read immediately after the pipe has reached a vertical position or after a period in a passive vertical position.
Foretatte undersøkelser tyder på at denne metode Conducted investigations indicate that this method
gir mere konsistente og reproduserbare resultater. gives more consistent and reproducible results.
Oppfinnelsen skal forklares nærmere under henvisning til The invention shall be explained in more detail with reference to
de ledsagende tegninger, der the accompanying drawings, there
Figur 1 viser en klassisk skråstillingssituasjon, Figure 1 shows a classic tilt situation,
Figur 2 viser en utvikling av denne teknikk, og Figure 2 shows a development of this technique, and
Figurene 3 og 4 er illustrerende for oppfinnelsen. Figures 3 and 4 are illustrative of the invention.
I figurene er de samme elementer eller elementer som opp-fyller samme funksjon, gitt de samme henvisningstall. In the figures, the same elements or elements that fulfill the same function are given the same reference numbers.
Figur 1 viser en klassisk skråstillingsmetode etter at bestemmelsen har pågått en tid. Figure 1 shows a classic tilting method after the determination has been ongoing for some time.
Citratblodet som var fyllt i bestemmelsesrøret 6 har begynt å skille seg i en fraksjon 4 med øket erytrocyttkonsentra-sjon og et derover liggende plasma 3. Med 5 er angitt den meniskus som dannes i bestemmelsesrøret. The citrated blood that was filled in the determination tube 6 has begun to separate into a fraction 4 with an increased erythrocyte concentration and an overlying plasma 3. 5 indicates the meniscus that forms in the determination tube.
Man ser at det ved erytrocyttavsetningen dannes et haleheng 2' som i en viss grad vil forstyrre bestemmelsen. It can be seen that a tail hanging 2' is formed during the erythrocyte deposition which will interfere with the determination to a certain extent.
Bestemmelsesrøret 6 er i bunnen utstyrt med en gummipropp 7 og hviler i et egnet stativ 8. The determination tube 6 is equipped at the bottom with a rubber stopper 7 and rests in a suitable stand 8.
I figur 2 vises en videreutvikling av den såkalte "passive" skråstillingsmetode der bestemmelsesrøret hviler i stativet 8, men i tillegg er utstyrt med et roterende element 9, forbundet med røret 6 via en forbindelse 9', idet rotasjons-elementet dreier seg om et dertil egnet stativ. Figure 2 shows a further development of the so-called "passive" tilting method where the determination tube rests in the stand 8, but is additionally equipped with a rotating element 9, connected to the tube 6 via a connection 9', the rotating element revolves around a suitable stand.
Ved denne i og for seg kjente dreining av bestemmelsesrøret oppnår man å unngå det haleheng som er vist i figur 1 ved 2'. Søkeren har imidlertid funnet at heller ikke dette gir den ønskede grad av reproduserbarhet og nøyaktighet og er kommet frem til en metode som angitt ovenfor. With this known in and of itself rotation of the determination tube, it is possible to avoid the tail hanging which is shown in Figure 1 at 2'. However, the applicant has found that this also does not provide the desired degree of reproducibility and accuracy and has arrived at a method as stated above.
Denne metode skal beskrives under henvisning til figurene This method shall be described with reference to the figures
3 og 4 . 3 and 4.
I figur 4 hviler røret i et leie som dannes av to hull i In Figure 4, the pipe rests in a bed formed by two holes in
ører 8' som igjen er festet til en aksel som står i forbindelse med f.eks. et tidsur. Røret er utstyrt med en ring 8" for ikke å gli. ears 8' which are again attached to an axle which is in connection with e.g. a time clock. The tube is equipped with a ring 8" to prevent slipping.
Bestemmelsen gjennomføres på den måte at røret først hensettes i en skråstilling og så, evnt. etter en periode i passiv skråstilling, gis en samtidig akseopprettende bevegelse rundt dreieaksen 8 og samtidig en om sin egen akse roterende bevegelse ved hjelp av et dertil egnet hjul 10, som bringes til rotasjon ved kontakt med et egnet anlegg 11. The determination is carried out in such a way that the pipe is first placed in an inclined position and then, possibly after a period in a passive inclined position, a simultaneous axis-correcting movement around the axis of rotation 8 and at the same time a rotating movement about its own axis is given by means of a suitable wheel 10, which is brought into rotation by contact with a suitable plant 11.
Den teori som ligger til grunn for foreliggende oppfinnelse er at det haleheng som oppstår som antydet i figur 1 skyldes en for hurtig sedimentering. Denne noe for hurtige sedimentering kan avhjelpes å dreie røret som antydet i forbindelse med figur 2 men de beste resultater oppnås når røret i tillegg til dreiebevegelsen gis en samtidig bevegelse fra skråstilling til vertikalstilling. The theory underlying the present invention is that the tail hanging that occurs as indicated in Figure 1 is due to too rapid sedimentation. This somewhat too rapid sedimentation can be remedied by turning the pipe as indicated in connection with Figure 2, but the best results are obtained when the pipe is given a simultaneous movement from an inclined position to a vertical position in addition to the turning movement.
Det er klart at oppfinnelsens mål kan nås ved hjelp av andre midler enn de som er vist i figurene 3 og 4 og disse skal derfor ikke ansees som begrensende for oppfinnelsens omfang, men kun som eksempler på en foretrukket utførelsesform. It is clear that the objectives of the invention can be achieved by means other than those shown in Figures 3 and 4 and these should therefore not be considered as limiting the scope of the invention, but only as examples of a preferred embodiment.
Videre er det klart at også opprettingstid og omdreinings-hastighet kan varieres innen vide grenser, disse verdier kan bestemmes ved rutineforsøk av den enkelte lege alt etter den apparatur han benytter. Furthermore, it is clear that the recovery time and rotation speed can also be varied within wide limits, these values can be determined by routine testing by the individual doctor depending on the equipment he uses.
Claims (1)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO840179A NO153508C (en) | 1984-01-18 | 1984-01-18 | QUICK METHOD FOR DETERMINING THE REDUCTION IN VENE BLOOD. |
DE19853500565 DE3500565A1 (en) | 1984-01-18 | 1985-01-10 | METHOD FOR QUICK DETERMINATION OF THE SEDIMENTATION OF VENOESE BLOOD |
GB08500749A GB2153072B (en) | 1984-01-18 | 1985-01-11 | Test method for determining the sedimentation of venous blood |
SE8500199A SE8500199L (en) | 1984-01-18 | 1985-01-16 | PROCEDURE FOR QUICK DETERMINATION OF BLOOD SINK IN FRIENDLY BLOOD |
FI850185A FI78179C (en) | 1984-01-18 | 1985-01-16 | Quick method for determining the lowering of vein blood |
IT09310/85A IT1201210B (en) | 1984-01-18 | 1985-01-17 | QUICK TEST METHOD TO DETERMINE THE SEDIMENTATION OF VENOUS BLOOD |
DK021685A DK159406C (en) | 1984-01-18 | 1985-01-17 | PROCEDURE FOR QUICK DETERMINATION OF THE BLOOD LOWER IN VENE BLOOD |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO840179A NO153508C (en) | 1984-01-18 | 1984-01-18 | QUICK METHOD FOR DETERMINING THE REDUCTION IN VENE BLOOD. |
Publications (3)
Publication Number | Publication Date |
---|---|
NO840179L NO840179L (en) | 1985-07-19 |
NO153508B true NO153508B (en) | 1985-12-23 |
NO153508C NO153508C (en) | 1986-04-02 |
Family
ID=19887442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO840179A NO153508C (en) | 1984-01-18 | 1984-01-18 | QUICK METHOD FOR DETERMINING THE REDUCTION IN VENE BLOOD. |
Country Status (7)
Country | Link |
---|---|
DE (1) | DE3500565A1 (en) |
DK (1) | DK159406C (en) |
FI (1) | FI78179C (en) |
GB (1) | GB2153072B (en) |
IT (1) | IT1201210B (en) |
NO (1) | NO153508C (en) |
SE (1) | SE8500199L (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE467508B (en) * | 1990-11-29 | 1992-07-27 | Hemocue Ab | DEVICE FOR QUICK PERFORMANCE OF BLOOD RECONCILIATION REACTION |
EP0754945B1 (en) * | 1995-07-21 | 2000-09-13 | Becton, Dickinson and Company | A method and apparatus for determining the erythrocyte sedimentation rate |
EP0755654B1 (en) * | 1995-07-21 | 2000-03-22 | Becton, Dickinson and Company | A test tube for determining the erythrocyte sedimentation rate and a surfactant for use therein |
US5914272A (en) * | 1996-06-19 | 1999-06-22 | Becton Dickinson And Company | Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein |
US6974701B2 (en) | 2003-03-21 | 2005-12-13 | Hemovations, Llc | Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE7724794U1 (en) * | 1979-02-08 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | Device for determining the rate of sedimentation | |
DE894925C (en) * | 1949-11-01 | 1955-03-07 | Walter Stein Dr Med | Apparatus for measuring the rate of sedimentation |
-
1984
- 1984-01-18 NO NO840179A patent/NO153508C/en unknown
-
1985
- 1985-01-10 DE DE19853500565 patent/DE3500565A1/en active Granted
- 1985-01-11 GB GB08500749A patent/GB2153072B/en not_active Expired
- 1985-01-16 FI FI850185A patent/FI78179C/en not_active IP Right Cessation
- 1985-01-16 SE SE8500199A patent/SE8500199L/en unknown
- 1985-01-17 DK DK021685A patent/DK159406C/en not_active IP Right Cessation
- 1985-01-17 IT IT09310/85A patent/IT1201210B/en active
Also Published As
Publication number | Publication date |
---|---|
GB8500749D0 (en) | 1985-02-13 |
DK159406C (en) | 1991-03-04 |
SE8500199D0 (en) | 1985-01-16 |
FI78179C (en) | 1989-06-12 |
FI850185L (en) | 1985-07-19 |
IT1201210B (en) | 1989-01-27 |
IT8509310A0 (en) | 1985-01-17 |
FI850185A0 (en) | 1985-01-16 |
DK21685A (en) | 1985-07-19 |
NO840179L (en) | 1985-07-19 |
DE3500565A1 (en) | 1985-07-25 |
GB2153072B (en) | 1987-08-05 |
DE3500565C2 (en) | 1988-03-24 |
NO153508C (en) | 1986-04-02 |
DK159406B (en) | 1990-10-08 |
SE8500199L (en) | 1985-07-19 |
DK21685D0 (en) | 1985-01-17 |
GB2153072A (en) | 1985-08-14 |
FI78179B (en) | 1989-02-28 |
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