NO140858C - ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVES - Google Patents

ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVES

Info

Publication number
NO140858C
NO140858C NO743271A NO743271A NO140858C NO 140858 C NO140858 C NO 140858C NO 743271 A NO743271 A NO 743271A NO 743271 A NO743271 A NO 743271A NO 140858 C NO140858 C NO 140858C
Authority
NO
Norway
Prior art keywords
analogical
diamino
benzyl
procedures
preparation
Prior art date
Application number
NO743271A
Other languages
Norwegian (no)
Other versions
NO743271L (en
NO140858B (en
Inventor
Ivan Kompis
Gerald Rey-Bellet
Guido Zanetti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO743271L publication Critical patent/NO743271L/no
Publication of NO140858B publication Critical patent/NO140858B/en
Publication of NO140858C publication Critical patent/NO140858C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
NO743271A 1973-09-12 1974-09-11 ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVES NO140858C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1305773A CH591456A5 (en) 1973-09-12 1973-09-12

Publications (3)

Publication Number Publication Date
NO743271L NO743271L (en) 1975-04-07
NO140858B NO140858B (en) 1979-08-20
NO140858C true NO140858C (en) 1979-11-28

Family

ID=4388903

Family Applications (1)

Application Number Title Priority Date Filing Date
NO743271A NO140858C (en) 1973-09-12 1974-09-11 ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVES

Country Status (28)

Country Link
JP (1) JPS6042238B2 (en)
AR (2) AR207764A1 (en)
AT (1) AT338797B (en)
BE (1) BE819773A (en)
BR (1) BR7407614D0 (en)
CA (1) CA1037476A (en)
CH (1) CH591456A5 (en)
CU (1) CU34115A (en)
DD (2) DD122785A5 (en)
DE (1) DE2443682C2 (en)
DK (1) DK135683B (en)
ES (7) ES429949A1 (en)
FI (1) FI58638C (en)
FR (1) FR2242984B1 (en)
GB (3) GB1484481A (en)
HK (1) HK181A (en)
HU (1) HU170427B (en)
IE (1) IE40523B1 (en)
IL (1) IL45510A (en)
LU (1) LU70878A1 (en)
NL (1) NL155827B (en)
NO (1) NO140858C (en)
PH (1) PH10643A (en)
PL (2) PL97757B1 (en)
SE (1) SE419443B (en)
SU (3) SU577987A3 (en)
YU (3) YU217874A (en)
ZA (1) ZA745317B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
JPS5481278A (en) * 1977-10-18 1979-06-28 Wellcome Found Manufacture of triiseccaminomethane
CH639273A5 (en) 1978-09-12 1983-11-15 Hoffmann La Roche DIURETIC MEANS.
CH658246A5 (en) * 1981-11-09 1986-10-31 Wellcome Found METHOD FOR PRODUCING SUBSTITUTED 2,4-DIAMINO-5-BENZYLPYRIMIDINES.
DE3250132C2 (en) * 1981-11-09 1997-01-16 Mallinckrodt Veterinary Inc 2,4-Di:amino-5-benzyl-pyrimidine derivs. prepn.
GB2180836A (en) * 1985-09-27 1987-04-08 William James Stephen Barker Sunscreen
JPH0431685Y2 (en) * 1987-06-01 1992-07-30
CA1300166C (en) * 1987-12-03 1992-05-05 Alfredo Guerrato Process for the preparation of a benzoic acid ester
US4900859A (en) * 1987-12-03 1990-02-13 Hoffman-La Roche Inc. Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1103931B (en) * 1957-02-21 1961-04-06 Wellcome Found Process for the preparation of 2,4-diamino-5-benzylpyrimidine derivatives
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes

Also Published As

Publication number Publication date
ZA745317B (en) 1975-11-26
PH10643A (en) 1977-07-22
YU37154B (en) 1984-08-31
DE2443682C2 (en) 1983-11-10
BR7407614D0 (en) 1975-07-08
DD116824A5 (en) 1975-12-12
ES429949A1 (en) 1976-10-01
CU21022L (en) 1981-09-09
ES437013A1 (en) 1977-04-01
CA1037476A (en) 1978-08-29
IL45510A (en) 1978-08-31
DE2443682A1 (en) 1975-03-20
ES437008A1 (en) 1977-04-01
NL7411685A (en) 1975-03-14
DK135683C (en) 1977-11-14
FR2242984A1 (en) 1975-04-04
DK135683B (en) 1977-06-06
NO743271L (en) 1975-04-07
LU70878A1 (en) 1976-08-19
FI256174A (en) 1975-03-13
AR211387Q (en) 1977-12-15
FI58638B (en) 1980-11-28
GB1484482A (en) 1977-09-01
SE419443B (en) 1981-08-03
PL97757B1 (en) 1978-03-30
CU34115A (en) 1983-10-04
GB1484481A (en) 1977-09-01
DK468374A (en) 1975-05-12
GB1484483A (en) 1977-09-01
SE7411382L (en) 1975-03-13
YU301680A (en) 1983-04-27
HK181A (en) 1981-01-16
AU7263174A (en) 1976-02-26
JPS6042238B2 (en) 1985-09-20
SU577987A3 (en) 1977-10-25
HU170427B (en) 1977-06-28
YU217874A (en) 1982-06-18
CH591456A5 (en) 1977-09-15
ES437007A1 (en) 1977-04-01
SU571189A3 (en) 1977-08-30
AR207764A1 (en) 1976-10-29
FI58638C (en) 1981-03-10
BE819773A (en) 1975-03-11
JPS5053385A (en) 1975-05-12
ES437009A1 (en) 1977-04-01
NO140858B (en) 1979-08-20
ES437011A1 (en) 1977-04-01
YU37153B (en) 1984-08-31
ES437012A1 (en) 1977-04-01
IE40523B1 (en) 1979-06-20
IL45510A0 (en) 1974-11-29
YU301580A (en) 1983-04-27
FR2242984B1 (en) 1977-11-04
AT338797B (en) 1977-09-12
SU609465A3 (en) 1978-05-30
NL155827B (en) 1978-02-15
ATA735174A (en) 1977-01-15
IE40523L (en) 1975-03-12
PL99159B1 (en) 1978-06-30
DD122785A5 (en) 1976-11-05

Similar Documents

Publication Publication Date Title
NO140589C (en) ANALOGICAL PROCEDURE FOR PREPARING NEW THERAPEUTICALLY ACTIVE 3,4-DIHYDROCARBOSTYRIL DERIVATIVES
NO142304C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2-ACYL-4-OXO-HEXAHYDRO-4H-PYRAZINO- (2,1-A) -ISOKINOLINE DERIVATIVES
NO138565C (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PIPERAZINYL-PROPYL-1,2,4-TRIAZOLINON DERIVATIVES
NO138566C (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2,1,3-BENZOTIADIAZOLE DERIVATIVES
NO149281C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE 7ALFA METHOXYPHALOSPORINE DERIVATIVES
NO143846C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE 1,4-DIHYDROPYRIDINE DERIVATIVES
NO140058C (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE SUBSTITUTED PIPERIDINOALCANOL-OXIM DERIVATIVES
NO140597C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTIC ACTIVE 8-AZAPURIN-6-ON DERIVATIVES
NO138599C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTICALLY EFFECTIVE TIENOPYRIMIDIN DERIVATIVES
NO140821C (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PYRIDO-PYRIMIDINE DERIVATIVES
NO140858C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVES
NO140012C (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE DERIVATIVES OF NAFTYRIDINE
NO140670C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PYRAZOLODIAZEPIN DERIVATIVES
NO740405L (en) Analogous process for the preparation of therapeutically active thienotriazolodiazepine derivatives.
NO740411L (en) Analogous process for the preparation of new therapeutically active derivatives of isoindolin-1-one.
NO144110C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5: 6-BENZO-4-PYRON DERIVATIVES
NO740614L (en) Analogous process for the preparation of therapeutically active 2-phenylaminoimidazoline (2) compounds.
NO143499C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE INHANDER DERIVATIVES
NO138660C (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW 3- (PIPERAZINALKYL) -2,4-CHINAZOLINE INDIATIONS
NO741939A (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE 3,4,5,6-TETRAHYDRO (1,3) THIAZOLO (3,4-A) ISOKINOLINE DERIVATIVES.
NO139961C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE BENZOPYRANOPYRIDINE DERIVATIVES
NO138850C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE DERIVATIVES OF DITIINO (1,4) (2,3-C) PYRROL
NO137692C (en) ANALOGICAL PROCEDURES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE BENZODIAZEPIN DERIVATIVES
FI55836C (en) PROCEDURE FOR FRAMSTATING OF THERAPEUTIC VERKSAMMA 4-AMINO-3-BENZYLIDENHYDRAZINO-1,2,4-TRIAZOLER
NO741651L (en) Analogous process for the preparation of therapeutically active 4-benzazonine derivatives.