NO118145B - - Google Patents
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- Publication number
- NO118145B NO118145B NO148703A NO14870363A NO118145B NO 118145 B NO118145 B NO 118145B NO 148703 A NO148703 A NO 148703A NO 14870363 A NO14870363 A NO 14870363A NO 118145 B NO118145 B NO 118145B
- Authority
- NO
- Norway
- Prior art keywords
- streptomyces
- antibiotic
- liters
- activity
- concentrated
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 241000220254 Streptomyces coeruleorubidus Species 0.000 claims description 16
- 238000009826 distribution Methods 0.000 claims description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000003242 anti bacterial agent Substances 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- 229910052500 inorganic mineral Chemical class 0.000 claims description 4
- 239000011707 mineral Chemical class 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 4
- -1 designated 9865 RP Substances 0.000 claims description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 42
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 36
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 36
- 239000000203 mixture Substances 0.000 description 33
- 239000000243 solution Substances 0.000 description 33
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- 241000187747 Streptomyces Species 0.000 description 27
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- 230000000694 effects Effects 0.000 description 23
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
- 238000000855 fermentation Methods 0.000 description 18
- 230000004151 fermentation Effects 0.000 description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 15
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 15
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- 239000000047 product Substances 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 8
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- DPEYHNFHDIXMNV-UHFFFAOYSA-N (9-amino-3-bicyclo[3.3.1]nonanyl)-(4-benzyl-5-methyl-1,4-diazepan-1-yl)methanone dihydrochloride Chemical compound Cl.Cl.CC1CCN(CCN1Cc1ccccc1)C(=O)C1CC2CCCC(C1)C2N DPEYHNFHDIXMNV-UHFFFAOYSA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B28—WORKING CEMENT, CLAY, OR STONE
- B28C—PREPARING CLAY; PRODUCING MIXTURES CONTAINING CLAY OR CEMENTITIOUS MATERIAL, e.g. PLASTER
- B28C7/00—Controlling the operation of apparatus for producing mixtures of clay or cement with other substances; Supplying or proportioning the ingredients for mixing clay or cement with other substances; Discharging the mixture
- B28C7/04—Supplying or proportioning the ingredients
- B28C7/06—Supplying the solid ingredients, e.g. by means of endless conveyors or jigging conveyors
- B28C7/08—Supplying the solid ingredients, e.g. by means of endless conveyors or jigging conveyors by means of scrapers or skips
- B28C7/0835—Supplying the solid ingredients, e.g. by means of endless conveyors or jigging conveyors by means of scrapers or skips using skips to be hoisted along guides or to be tilted, to charge working-site concrete mixers
- B28C7/0847—Supplying the solid ingredients, e.g. by means of endless conveyors or jigging conveyors by means of scrapers or skips using skips to be hoisted along guides or to be tilted, to charge working-site concrete mixers the skips being hoisted along vertical or inclined guides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR898076A FR1533151A (fr) | 1962-05-18 | 1962-05-18 | Nouvel antibiotique et sa préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO118145B true NO118145B (fr) | 1969-11-17 |
Family
ID=8779290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO148703A NO118145B (fr) | 1962-05-18 | 1963-05-16 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3997662A (fr) |
| AT (1) | AT243434B (fr) |
| BR (1) | BR6349165D0 (fr) |
| CH (1) | CH436569A (fr) |
| DK (1) | DK106726C (fr) |
| ES (1) | ES288106A1 (fr) |
| FI (1) | FI43060B (fr) |
| FR (1) | FR1533151A (fr) |
| GB (1) | GB985598A (fr) |
| NO (1) | NO118145B (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989598A (en) * | 1962-05-18 | 1976-11-02 | Rhone-Poulenc S.A. | Antibiotic daunorubicin and its preparation |
| FR1551195A (fr) * | 1967-11-15 | 1968-12-27 | ||
| FR1593235A (fr) * | 1968-11-18 | 1970-05-25 | ||
| US3852425A (en) * | 1968-11-27 | 1974-12-03 | Pfizer | Mitocromin and process for preparing same |
| GB1550359A (en) * | 1975-08-07 | 1979-08-15 | Beecham Group Ltd | Antibiotic compositions for oral administration |
| US4039736A (en) * | 1976-04-15 | 1977-08-02 | Bristol-Myers Company | Antibiotic compounds marcellomycin and musettamycin |
| JPS52148064A (en) | 1976-05-31 | 1977-12-08 | Microbial Chem Res Found | Antitumors |
| US4192915A (en) | 1976-08-16 | 1980-03-11 | Bristol-Myers Company | Anthracycline glycosides from streptomyces |
| NL176004C (nl) | 1976-10-05 | 1985-02-01 | Microbial Chem Res Found | Werkwijze ter bereiding van geneesmiddelen met antitumorwerking op basis van anthracycline glycosiden en werkwijze ter bereiding van daartoe dienende anthracycline glycosiden. |
| US4209588A (en) | 1976-10-05 | 1980-06-24 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Process for producing new antitumor anthracycline antibiotics |
| US4248970A (en) | 1978-05-30 | 1981-02-03 | Bristol-Myers Company | Antibiotic complex producing bacterial culture |
| JPS5750994A (en) * | 1980-09-12 | 1982-03-25 | Microbial Chem Res Found | Novel antibiotic mf266 substance and its preparation |
| IT1155446B (it) * | 1982-12-23 | 1987-01-28 | Erba Farmitalia | Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine |
| US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5220001A (en) * | 1989-10-25 | 1993-06-15 | Zaidan Hojim Biseibutsu Dong-A Pharm Co. | Anthracycline glycoside derivatives |
| GB0112868D0 (en) * | 2001-05-25 | 2001-07-18 | Secr Defence | Detection system |
| GB0223563D0 (en) * | 2002-10-10 | 2002-11-20 | Secr Defence | Detection system |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| WO2010075549A2 (fr) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Phosphoramidates de nucléosides |
| CN102325783A (zh) | 2008-12-23 | 2012-01-18 | 法莫赛特股份有限公司 | 嘌呤核苷的合成 |
| US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
| SI3290428T1 (sl) | 2010-03-31 | 2022-01-31 | Gilead Pharmasset Llc | Tableta, ki obsega kristalinični (S)-izopropil 2-(((S)-(((2R,3R,4R,5R) -5-(2,4-diokso-3,4-dihidropirimidin-1(2H)-il)-4-fluoro-3-hidroksi-4- metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat |
-
1962
- 1962-05-18 FR FR898076A patent/FR1533151A/fr not_active Expired
-
1963
- 1963-05-15 BR BR149165/63A patent/BR6349165D0/pt unknown
- 1963-05-16 NO NO148703A patent/NO118145B/no unknown
- 1963-05-16 GB GB19567/63A patent/GB985598A/en not_active Expired
- 1963-05-16 US US04/280,816 patent/US3997662A/en not_active Expired - Lifetime
- 1963-05-17 AT AT401663A patent/AT243434B/de active
- 1963-05-17 ES ES288106A patent/ES288106A1/es not_active Expired
- 1963-05-17 DK DK236663AA patent/DK106726C/da active
- 1963-05-17 CH CH623663A patent/CH436569A/fr unknown
- 1963-05-17 FI FI1017/63A patent/FI43060B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| AT243434B (de) | 1965-11-10 |
| BR6349165D0 (pt) | 1973-08-02 |
| FR1533151A (fr) | 1968-07-19 |
| ES288106A1 (es) | 1963-11-16 |
| FI43060B (fr) | 1970-10-01 |
| DK106726C (da) | 1967-03-13 |
| CH436569A (fr) | 1967-05-31 |
| GB985598A (en) | 1965-03-10 |
| US3997662A (en) | 1976-12-14 |
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