NL7807276A - Nieuwe 1-acyl-2-cyaanaziridinen, en werkwijzen voor hun bereiding en toepassing. - Google Patents
Nieuwe 1-acyl-2-cyaanaziridinen, en werkwijzen voor hun bereiding en toepassing.Info
- Publication number
- NL7807276A NL7807276A NL7807276A NL7807276A NL7807276A NL 7807276 A NL7807276 A NL 7807276A NL 7807276 A NL7807276 A NL 7807276A NL 7807276 A NL7807276 A NL 7807276A NL 7807276 A NL7807276 A NL 7807276A
- Authority
- NL
- Netherlands
- Prior art keywords
- cyanaziridines
- acyl
- preparation
- new
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C07D203/24—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F42—AMMUNITION; BLASTING
- F42B—EXPLOSIVE CHARGES, e.g. FOR BLASTING, FIREWORKS, AMMUNITION
- F42B3/00—Blasting cartridges, i.e. case and explosive
- F42B3/087—Flexible or deformable blasting cartridges, e.g. bags or hoses for slurries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772731264 DE2731264A1 (de) | 1977-07-11 | 1977-07-11 | Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7807276A true NL7807276A (nl) | 1979-01-15 |
Family
ID=6013651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7807276A NL7807276A (nl) | 1977-07-11 | 1978-07-05 | Nieuwe 1-acyl-2-cyaanaziridinen, en werkwijzen voor hun bereiding en toepassing. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4267174A (it) |
| JP (1) | JPS5436254A (it) |
| AT (1) | AT356663B (it) |
| AU (2) | AU519219B2 (it) |
| BE (1) | BE868796A (it) |
| CA (1) | CA1086309A (it) |
| CS (1) | CS208656B2 (it) |
| DD (1) | DD137710A5 (it) |
| DE (1) | DE2731264A1 (it) |
| DK (1) | DK306978A (it) |
| ES (1) | ES471512A1 (it) |
| FI (1) | FI782157A (it) |
| FR (1) | FR2397403A1 (it) |
| GB (1) | GB1594079A (it) |
| HU (1) | HU179428B (it) |
| IL (1) | IL55109A (it) |
| IT (1) | IT1096910B (it) |
| LU (1) | LU79937A1 (it) |
| NL (1) | NL7807276A (it) |
| NO (1) | NO782399L (it) |
| NZ (1) | NZ187794A (it) |
| PL (1) | PL126639B1 (it) |
| PT (1) | PT68263A (it) |
| SE (1) | SE7807642L (it) |
| SU (1) | SU1077565A3 (it) |
| ZA (1) | ZA783829B (it) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2906603A1 (de) * | 1979-02-21 | 1980-09-04 | Boehringer Mannheim Gmbh | N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel |
| US4393000A (en) * | 1979-12-12 | 1983-07-12 | Mitsui Toatsu Chemicals, Inc. | Cyclization process for producing aziridine-2-carboxylic acid or its salts |
| US4925835A (en) * | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
| US6982263B2 (en) * | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| ATE374766T1 (de) | 2003-01-14 | 2007-10-15 | Arena Pharm Inc | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
| EP1606282B1 (en) * | 2003-02-24 | 2008-11-12 | Arena Pharmaceuticals, Inc. | Phenyl- and pyridylpipereidinye-derivatives as modulators of glucose metabolism |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| PT1756084E (pt) * | 2004-06-04 | 2009-02-17 | Arena Pharm Inc | Composto seleccionado de compostos de fórmula (i) e seus sais, solvatos, hidratos e n-óxidos farmaceuticamente aceitáveis |
| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
| MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| CA2619093A1 (en) * | 2005-09-16 | 2007-03-29 | Arena Pharmaceuticals, Inc. | Modulators of metabolism and the treatment of disorders related thereto |
| TW200811140A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
| TW200811147A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス |
| CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
| CA3002551A1 (en) | 2015-06-22 | 2016-12-29 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| LV15518A (lv) * | 2019-02-18 | 2020-08-20 | Latvijas Organiskās Sintēzes Institūts | Aziridīn-2-karboksamīda atvasinājumi kā tioredoksīnreduktāzes inhibitori ar pretvēža un pretmetastatisku iedarbību un to sintēze |
| US20230069886A1 (en) * | 2020-01-10 | 2023-03-09 | Uniwersytet Jagiellonski | Aromatic sulphonamides derivatives that inhibits pdi a3, their synthesis and use |
| EP4087651A1 (en) * | 2020-01-10 | 2022-11-16 | Uniwersytet Jagiellonski | Aromatic sulphonamides derivatives that inhibits pdi a1, their synthesis and use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD110492A1 (it) * | 1974-03-21 | 1974-12-20 | ||
| JPS5932772B2 (ja) * | 1974-09-21 | 1984-08-10 | 旭光学工業 （株） | 照射光走査装置 |
| DE2528460A1 (de) * | 1975-06-26 | 1977-01-13 | Boehringer Mannheim Gmbh | Verwendung von l-carboxamido-2- cyan-aziridin als immunstimulans |
-
1977
- 1977-07-11 DE DE19772731264 patent/DE2731264A1/de not_active Withdrawn
-
1978
- 1978-05-17 GB GB20099/78A patent/GB1594079A/en not_active Expired
- 1978-06-16 US US05/916,389 patent/US4267174A/en not_active Expired - Lifetime
- 1978-07-04 SU SU782631500A patent/SU1077565A3/ru active
- 1978-07-04 FI FI782157A patent/FI782157A/fi not_active Application Discontinuation
- 1978-07-04 ZA ZA783829A patent/ZA783829B/xx unknown
- 1978-07-04 CA CA306,740A patent/CA1086309A/en not_active Expired
- 1978-07-05 PL PL1978208195A patent/PL126639B1/pl unknown
- 1978-07-05 NL NL7807276A patent/NL7807276A/xx not_active Application Discontinuation
- 1978-07-06 BE BE189121A patent/BE868796A/xx unknown
- 1978-07-06 ES ES471512A patent/ES471512A1/es not_active Expired
- 1978-07-06 AU AU37826/78A patent/AU519219B2/en not_active Expired
- 1978-07-06 AU AU37826/78A patent/AU3782678A/en active Granted
- 1978-07-06 DD DD78206567A patent/DD137710A5/xx unknown
- 1978-07-07 CS CS784544A patent/CS208656B2/cs unknown
- 1978-07-07 IT IT25474/78A patent/IT1096910B/it active
- 1978-07-07 SE SE7807642A patent/SE7807642L/xx unknown
- 1978-07-07 LU LU79937A patent/LU79937A1/de unknown
- 1978-07-07 NZ NZ187794A patent/NZ187794A/xx unknown
- 1978-07-07 PT PT68263A patent/PT68263A/pt unknown
- 1978-07-07 DK DK783069A patent/DK306978A/da not_active Application Discontinuation
- 1978-07-09 IL IL55109A patent/IL55109A/xx unknown
- 1978-07-10 FR FR7820468A patent/FR2397403A1/fr not_active Withdrawn
- 1978-07-10 HU HU78BO1723A patent/HU179428B/hu unknown
- 1978-07-10 NO NO782399A patent/NO782399L/no unknown
- 1978-07-10 AT AT496478A patent/AT356663B/de not_active IP Right Cessation
- 1978-07-11 JP JP8364578A patent/JPS5436254A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ187794A (en) | 1980-05-08 |
| DE2731264A1 (de) | 1979-02-01 |
| FR2397403A1 (fr) | 1979-02-09 |
| AT356663B (de) | 1980-05-12 |
| LU79937A1 (de) | 1980-02-14 |
| IT1096910B (it) | 1985-08-26 |
| PT68263A (de) | 1978-08-01 |
| PL208195A1 (it) | 1980-03-24 |
| AU3782578A (en) | 1980-01-10 |
| AU519219B2 (en) | 1981-11-19 |
| BE868796A (fr) | 1979-01-08 |
| US4267174A (en) | 1981-05-12 |
| JPS5436254A (en) | 1979-03-16 |
| HU179428B (en) | 1982-10-28 |
| FI782157A (fi) | 1979-01-12 |
| IL55109A (en) | 1982-07-30 |
| CA1086309A (en) | 1980-09-23 |
| ATA496478A (de) | 1979-10-15 |
| SU1077565A3 (ru) | 1984-02-29 |
| DK306978A (da) | 1979-01-12 |
| ZA783829B (en) | 1980-03-26 |
| IT7825474A0 (it) | 1978-07-07 |
| CS208656B2 (en) | 1981-09-15 |
| AU3782678A (en) | 1980-01-10 |
| SE7807642L (sv) | 1979-03-14 |
| IL55109A0 (en) | 1978-09-29 |
| GB1594079A (en) | 1981-07-30 |
| NO782399L (no) | 1979-01-12 |
| ES471512A1 (es) | 1979-10-01 |
| PL126639B1 (en) | 1983-08-31 |
| DD137710A5 (de) | 1979-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BT | A notification was added to the application dossier and made available to the public | ||
| BT | A notification was added to the application dossier and made available to the public | ||
| BV | The patent application has lapsed |