BE868796A - Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes - Google Patents
Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composesInfo
- Publication number
- BE868796A BE868796A BE189121A BE189121A BE868796A BE 868796 A BE868796 A BE 868796A BE 189121 A BE189121 A BE 189121A BE 189121 A BE189121 A BE 189121A BE 868796 A BE868796 A BE 868796A
- Authority
- BE
- Belgium
- Prior art keywords
- aziridine
- acyl
- cyano
- compounds
- preparation
- Prior art date
Links
- PGZUFTROELAOMP-UHFFFAOYSA-N aziridine-2-carbonitrile Chemical compound N#CC1CN1 PGZUFTROELAOMP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C07D203/24—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F42—AMMUNITION; BLASTING
- F42B—EXPLOSIVE CHARGES, e.g. FOR BLASTING, FIREWORKS, AMMUNITION
- F42B3/00—Blasting cartridges, i.e. case and explosive
- F42B3/087—Flexible or deformable blasting cartridges, e.g. bags or hoses for slurries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772731264 DE2731264A1 (de) | 1977-07-11 | 1977-07-11 | Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
BE868796A true BE868796A (fr) | 1979-01-08 |
Family
ID=6013651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE189121A BE868796A (fr) | 1977-07-11 | 1978-07-06 | Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes |
Country Status (26)
Country | Link |
---|---|
US (1) | US4267174A (fr) |
JP (1) | JPS5436254A (fr) |
AT (1) | AT356663B (fr) |
AU (2) | AU3782678A (fr) |
BE (1) | BE868796A (fr) |
CA (1) | CA1086309A (fr) |
CS (1) | CS208656B2 (fr) |
DD (1) | DD137710A5 (fr) |
DE (1) | DE2731264A1 (fr) |
DK (1) | DK306978A (fr) |
ES (1) | ES471512A1 (fr) |
FI (1) | FI782157A (fr) |
FR (1) | FR2397403A1 (fr) |
GB (1) | GB1594079A (fr) |
HU (1) | HU179428B (fr) |
IL (1) | IL55109A (fr) |
IT (1) | IT1096910B (fr) |
LU (1) | LU79937A1 (fr) |
NL (1) | NL7807276A (fr) |
NO (1) | NO782399L (fr) |
NZ (1) | NZ187794A (fr) |
PL (1) | PL126639B1 (fr) |
PT (1) | PT68263A (fr) |
SE (1) | SE7807642L (fr) |
SU (1) | SU1077565A3 (fr) |
ZA (1) | ZA783829B (fr) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7470699B2 (en) | 2003-07-11 | 2008-12-30 | Arena Pharmaceuticals, Inc. | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US7812159B2 (en) | 2005-01-10 | 2010-10-12 | Arena Pharamaceuticals, Inc. | Processes for preparing aromatic ethers |
US8293751B2 (en) | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
US8362248B2 (en) | 2005-01-10 | 2013-01-29 | Arena Pharmaceuticals, Inc. | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
US10894787B2 (en) | 2010-09-22 | 2021-01-19 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
US11884626B2 (en) | 2015-06-22 | 2024-01-30 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound1) for use in S1P1 receptor-associated disorders |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2906603A1 (de) * | 1979-02-21 | 1980-09-04 | Boehringer Mannheim Gmbh | N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel |
US4393000A (en) * | 1979-12-12 | 1983-07-12 | Mitsui Toatsu Chemicals, Inc. | Cyclization process for producing aziridine-2-carboxylic acid or its salts |
US4925835A (en) * | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
US6982263B2 (en) * | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
DK1606282T3 (da) * | 2003-02-24 | 2009-03-16 | Arena Pharm Inc | Phenyl- og pyridylpipereidinye-derivater som modulatorer af glucosemetabolisme |
PE20060530A1 (es) * | 2004-06-04 | 2006-06-28 | Arena Pharm Inc | Aril y heteroaril derivados sustituidos como moduladores del metabolismo de la glucosa |
NI200800078A (es) * | 2005-09-16 | 2009-03-03 | Moduladores del metabolismo y tratamiento de los trastornos metabólicos | |
TW200811140A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
TW200811147A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
EP4148045A1 (fr) | 2010-01-27 | 2023-03-15 | Arena Pharmaceuticals, Inc. | Composés intermédiaires pour la préparation de l'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclopenta[b]indol-3-yl) acétique et de ses sels |
LV15518A (lv) * | 2019-02-18 | 2020-08-20 | Latvijas Organiskās Sintēzes Institūts | Aziridīn-2-karboksamīda atvasinājumi kā tioredoksīnreduktāzes inhibitori ar pretvēža un pretmetastatisku iedarbību un to sintēze |
WO2021141507A1 (fr) * | 2020-01-10 | 2021-07-15 | Uniwersytet Jagielloński | Dérivés de sulfonamides aromatiques inhibant pdi a3, leur synthèse et leur utilisation |
WO2021141506A1 (fr) * | 2020-01-10 | 2021-07-15 | Uniwersytet Jagielloński | Dérivés de sulfonamides aromatiques inhibant pdi a1, leur synthèse et leur utilisation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD110492A1 (fr) * | 1974-03-21 | 1974-12-20 | ||
JPS5932772B2 (ja) * | 1974-09-21 | 1984-08-10 | 旭光学工業 (株) | 照射光走査装置 |
DE2528460A1 (de) * | 1975-06-26 | 1977-01-13 | Boehringer Mannheim Gmbh | Verwendung von l-carboxamido-2- cyan-aziridin als immunstimulans |
-
1977
- 1977-07-11 DE DE19772731264 patent/DE2731264A1/de not_active Withdrawn
-
1978
- 1978-05-17 GB GB20099/78A patent/GB1594079A/en not_active Expired
- 1978-06-16 US US05/916,389 patent/US4267174A/en not_active Expired - Lifetime
- 1978-07-04 SU SU782631500A patent/SU1077565A3/ru active
- 1978-07-04 CA CA306,740A patent/CA1086309A/fr not_active Expired
- 1978-07-04 FI FI782157A patent/FI782157A/fi not_active Application Discontinuation
- 1978-07-04 ZA ZA783829A patent/ZA783829B/xx unknown
- 1978-07-05 NL NL7807276A patent/NL7807276A/xx not_active Application Discontinuation
- 1978-07-05 PL PL1978208195A patent/PL126639B1/pl unknown
- 1978-07-06 ES ES471512A patent/ES471512A1/es not_active Expired
- 1978-07-06 BE BE189121A patent/BE868796A/fr unknown
- 1978-07-06 DD DD78206567A patent/DD137710A5/xx unknown
- 1978-07-06 AU AU37826/78A patent/AU3782678A/en active Granted
- 1978-07-06 AU AU37826/78A patent/AU519219B2/en not_active Expired
- 1978-07-07 NZ NZ187794A patent/NZ187794A/xx unknown
- 1978-07-07 SE SE7807642A patent/SE7807642L/xx unknown
- 1978-07-07 IT IT25474/78A patent/IT1096910B/it active
- 1978-07-07 PT PT68263A patent/PT68263A/pt unknown
- 1978-07-07 LU LU79937A patent/LU79937A1/de unknown
- 1978-07-07 DK DK783069A patent/DK306978A/da not_active Application Discontinuation
- 1978-07-07 CS CS784544A patent/CS208656B2/cs unknown
- 1978-07-09 IL IL55109A patent/IL55109A/xx unknown
- 1978-07-10 HU HU78BO1723A patent/HU179428B/hu unknown
- 1978-07-10 AT AT496478A patent/AT356663B/de not_active IP Right Cessation
- 1978-07-10 FR FR7820468A patent/FR2397403A1/fr not_active Withdrawn
- 1978-07-10 NO NO782399A patent/NO782399L/no unknown
- 1978-07-11 JP JP8364578A patent/JPS5436254A/ja active Pending
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8293751B2 (en) | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
US8933083B2 (en) | 2003-01-14 | 2015-01-13 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
US7470699B2 (en) | 2003-07-11 | 2008-12-30 | Arena Pharmaceuticals, Inc. | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US7838525B2 (en) | 2003-07-11 | 2010-11-23 | Arena Pharmaceuticals, Inc. | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US8546429B2 (en) | 2003-07-11 | 2013-10-01 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US7812159B2 (en) | 2005-01-10 | 2010-10-12 | Arena Pharamaceuticals, Inc. | Processes for preparing aromatic ethers |
US8362248B2 (en) | 2005-01-10 | 2013-01-29 | Arena Pharmaceuticals, Inc. | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
US10894787B2 (en) | 2010-09-22 | 2021-01-19 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
US11884626B2 (en) | 2015-06-22 | 2024-01-30 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound1) for use in S1P1 receptor-associated disorders |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
Also Published As
Publication number | Publication date |
---|---|
AT356663B (de) | 1980-05-12 |
HU179428B (en) | 1982-10-28 |
CS208656B2 (en) | 1981-09-15 |
FI782157A (fi) | 1979-01-12 |
SE7807642L (sv) | 1979-03-14 |
ATA496478A (de) | 1979-10-15 |
NZ187794A (en) | 1980-05-08 |
PT68263A (de) | 1978-08-01 |
DD137710A5 (de) | 1979-09-19 |
JPS5436254A (en) | 1979-03-16 |
IT7825474A0 (it) | 1978-07-07 |
IL55109A0 (en) | 1978-09-29 |
ES471512A1 (es) | 1979-10-01 |
IL55109A (en) | 1982-07-30 |
ZA783829B (en) | 1980-03-26 |
IT1096910B (it) | 1985-08-26 |
AU3782578A (en) | 1980-01-10 |
NL7807276A (nl) | 1979-01-15 |
AU519219B2 (en) | 1981-11-19 |
AU3782678A (en) | 1980-01-10 |
FR2397403A1 (fr) | 1979-02-09 |
GB1594079A (en) | 1981-07-30 |
CA1086309A (fr) | 1980-09-23 |
DK306978A (da) | 1979-01-12 |
PL126639B1 (en) | 1983-08-31 |
NO782399L (no) | 1979-01-12 |
LU79937A1 (de) | 1980-02-14 |
SU1077565A3 (ru) | 1984-02-29 |
US4267174A (en) | 1981-05-12 |
DE2731264A1 (de) | 1979-02-01 |
PL208195A1 (fr) | 1980-03-24 |
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