NL7704004A - Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities - Google Patents
Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activitiesInfo
- Publication number
- NL7704004A NL7704004A NL7704004A NL7704004A NL7704004A NL 7704004 A NL7704004 A NL 7704004A NL 7704004 A NL7704004 A NL 7704004A NL 7704004 A NL7704004 A NL 7704004A NL 7704004 A NL7704004 A NL 7704004A
- Authority
- NL
- Netherlands
- Prior art keywords
- naphthyridine
- oxo
- indolo
- methyl
- antianoxia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Naphthyridine derivs. of formula (I), as racemates or optical isomers, and their suitable salts with acids are new. In (I) R1=H, 1-4C alkyl, 2-oxopropyl, 2-hydroxypropyl, 3-oxobutyl, 3-hydroxybutyl, cyclopropyl methyl, benzyl (opt. halogenated esp. by F or Cl), acetyl, cyclopropylcarbonyl, benzoyl or (CH2)nR1. R2=H, halo, CH3 or CH3O. R6=H or COR7. R3=CH3 or C2H5, and R4=OH or H and R5=H, or R3+R4=oxo and R5=H, or R3=CH3 or C2H5 and R4+R5=an additional C-C bond. n=1 or 2. R1=(m)ethoxycarbonyl or CN. R7=OH, 1-4C alkoxy, NH2(opt. substd. by 1 or 2 CH3 or by one cyclopropyl). The following cpds. are excluded: R3+R4=oxo; (a) R1=H=R6 and R2=10-CH3O and (b) R1=R2=R6=H; but when R6=alkoxycarbonyl stereoisomers are included. Dose is 10-100 mg/day. In an example methyl 1,2,3,3a,4,5,-hexahydro-3-methyl-6-oxo-6H-indolo 3,2,1-de 1,5 naphthyridine-4-carboxylate was prepd. fron Nb-methyltryptamine and diethyl alpha-formyl succinate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7610773A FR2358146A1 (en) | 1976-04-13 | 1976-04-13 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
| FR7616445A FR2353550A2 (en) | 1976-06-01 | 1976-06-01 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
| FR7632319A FR2368955A2 (en) | 1976-10-27 | 1976-10-27 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7704004A true NL7704004A (en) | 1977-10-17 |
Family
ID=27250614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7704004A NL7704004A (en) | 1976-04-13 | 1977-04-13 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL7704004A (en) |
-
1977
- 1977-04-13 NL NL7704004A patent/NL7704004A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | A search report has been drawn up | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BV | The patent application has lapsed | ||
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |