IT1096815B - Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities - Google Patents
Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activitiesInfo
- Publication number
- IT1096815B IT1096815B IT2486978A IT2486978A IT1096815B IT 1096815 B IT1096815 B IT 1096815B IT 2486978 A IT2486978 A IT 2486978A IT 2486978 A IT2486978 A IT 2486978A IT 1096815 B IT1096815 B IT 1096815B
- Authority
- IT
- Italy
- Prior art keywords
- naphthyridine
- oxo
- indolo
- methyl
- antianoxia
- Prior art date
Links
- BARGRPPQVLTBDS-UHFFFAOYSA-N 7h-indolo[2,3-c][1,5]naphthyridine Chemical compound C1=CC=NC2=C3C4=CC=CC=C4NC3=CN=C21 BARGRPPQVLTBDS-UHFFFAOYSA-N 0.000 title 1
- 230000000506 psychotropic effect Effects 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- -1 2-hydroxypropyl Chemical group 0.000 abstract 3
- HQMKWWYYKCFZJF-UHFFFAOYSA-N 1,5-naphthyridine-4-carboxylic acid Chemical compound C1=CN=C2C(C(=O)O)=CC=NC2=C1 HQMKWWYYKCFZJF-UHFFFAOYSA-N 0.000 abstract 1
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 abstract 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Naphthyridine derivs. of formula (I), as racemates or optical isomers, and their suitable salts with acids are new. In (I) R1=H, 1-4C alkyl, 2-oxopropyl, 2-hydroxypropyl, 3-oxobutyl, 3-hydroxybutyl, cyclopropyl methyl, benzyl (opt. halogenated esp. by F or Cl), acetyl, cyclopropylcarbonyl, benzoyl or (CH2)nR1. R2=H, halo, CH3 or CH3O. R6=H or COR7. R3=CH3 or C2H5, and R4=OH or H and R5=H, or R3+R4=oxo and R5=H, or R3=CH3 or C2H5 and R4+R5=an additional C-C bond. n=1 or 2. R1=(m)ethoxycarbonyl or CN. R7=OH, 1-4C alkoxy, NH2(opt. substd. by 1 or 2 CH3 or by one cyclopropyl). The following cpds. are excluded: R3+R4=oxo; (a) R1=H=R6 and R2=10-CH3O and (b) R1=R2=R6=H; but when R6=alkoxycarbonyl stereoisomers are included. Dose is 10-100 mg/day. In an example methyl 1,2,3,3a,4,5,-hexahydro-3-methyl-6-oxo-6H-indolo 3,2,1-de 1,5 naphthyridine-4-carboxylate was prepd. fron Nb-methyltryptamine and diethyl alpha-formyl succinate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2486978A IT1096815B (en) | 1978-06-22 | 1978-06-22 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2486978A IT1096815B (en) | 1978-06-22 | 1978-06-22 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7824869A0 IT7824869A0 (en) | 1978-06-22 |
| IT1096815B true IT1096815B (en) | 1985-08-26 |
Family
ID=11214989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2486978A IT1096815B (en) | 1978-06-22 | 1978-06-22 | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1096815B (en) |
-
1978
- 1978-06-22 IT IT2486978A patent/IT1096815B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7824869A0 (en) | 1978-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL114690A (en) | Antimigraine oxazolidinone substituted indole derivatives | |
| ES356976A1 (en) | 1h - imidazo(4,5-b)pyrazin - 2 - one and processes for their preparation | |
| FR2358146A1 (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| FR2374905A2 (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| FR2383181A2 (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| FR2383182A2 (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| IT1096815B (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| FR2368955A2 (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| FR2353550A2 (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| NL7704004A (en) | Indolo-(1,5)-naphthyridine derivs. - having antianoxia and psychotropic activities | |
| ES2100397T3 (en) | ESPIRO (5.5) UNDECANS 3,9-DISUBSTITUTED ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THE SAME. | |
| GB1098835A (en) | Spiro-oxazolidinones, spiro-oxazines, their process of preparation and therapeutic compositions containing said derivatives | |
| GR73647B (en) | ||
| NZ224956A (en) | Benzo-thieno-thiazine derivatives, pharmaceuticals and intermediates | |
| FR2068402A1 (en) | Medicaments contg 2-phenyl-benzimidazoles | |
| FR2254549A1 (en) | 3-(Substd. phenyl)-2-chloropropionic acid derivs - hypolipidaemics and hypoglycaemics | |
| FR2161051A2 (en) | Tricyclic dihydroquinazolinone derivs - with bronchodilating or hypotensive activity | |
| CA2189731A1 (en) | New 1,4-oxazine tetracyclic compounds, process for preparing the same and pharmceutical compositions containing them | |
| FR2042309A1 (en) | New heterocyclic antiphlogistic compounds | |
| NL7004461A (en) | New heterocyclic antiphlogistic compounds | |
| GB1218590A (en) | N-substituted piperidine spiro compounds | |
| PT69549A (en) | Nitrogen bridgehead compounds and process for the preparation thereof | |
| BE748560A (en) | New heterocyclic antiphlogistic compounds | |
| FR2381041A1 (en) | Antiulcer hydroxy-substd. di:carboxylic acid derivs. - prepd. e.g. by redn. of hydroxy-iso-canadenoic acid (BE 16.8.78) | |
| FR2208659A1 (en) | 13-Alkyl, alkoxy or allyl berberrubin derivatives - anticancer agents, prepd by demethylation of a 13-subst berberine salt |