NL7702027A - Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamase - Google Patents
Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamaseInfo
- Publication number
- NL7702027A NL7702027A NL7702027A NL7702027A NL7702027A NL 7702027 A NL7702027 A NL 7702027A NL 7702027 A NL7702027 A NL 7702027A NL 7702027 A NL7702027 A NL 7702027A NL 7702027 A NL7702027 A NL 7702027A
- Authority
- NL
- Netherlands
- Prior art keywords
- antibiotics
- beta
- lactamase
- useful
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Clavulanic acid derivs. of formula (I) and their salts when R1 is COOH are new. (R = residue of an S- contg. nuleophite. R1 = opt. esterified car oxyl). They are prepd. e.g. by reacting corresp cpds. having R replaced by halo with the appropriate nucleophile. (I) are antibiotics, but are esp. useful as beta-lactamase inhibitors, i.e. potentiators for other penicillin and cephalosponin antibiotics (II) against beta-lactamase producing strains of e.g. Staphylococcus aureus, E. coli. Enterobacter cloacae etc. They can be used in human or veterinary medicine. The wt. ratio (I):(II) is 1:10-10:1, best 1:2-2:1 and the total dose of antibiotic is 0.1-1g/day. In an example (3R, 5R, z)-2-(2-acetylthioethylidene)-clavam-3-carboxylic acid 4-nitrobenzyl ester was prepd. by reacting thioacetic acid with the corresp. 2-chloroethylidene cpd.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7897/76A GB1579531A (en) | 1976-02-27 | 1976-02-27 | Oxazolo-azetidinine antibiotic derivatives |
GB2659476 | 1976-06-25 | ||
GB5261276 | 1976-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7702027A true NL7702027A (en) | 1977-08-30 |
Family
ID=27255084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7702027A NL7702027A (en) | 1976-02-27 | 1977-02-25 | Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamase |
Country Status (1)
Country | Link |
---|---|
NL (1) | NL7702027A (en) |
-
1977
- 1977-02-25 NL NL7702027A patent/NL7702027A/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BV | The patent application has lapsed |