NL7702027A - Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamase - Google Patents

Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamase

Info

Publication number
NL7702027A
NL7702027A NL7702027A NL7702027A NL7702027A NL 7702027 A NL7702027 A NL 7702027A NL 7702027 A NL7702027 A NL 7702027A NL 7702027 A NL7702027 A NL 7702027A NL 7702027 A NL7702027 A NL 7702027A
Authority
NL
Netherlands
Prior art keywords
antibiotics
beta
lactamase
useful
inhibitors
Prior art date
Application number
NL7702027A
Other languages
Dutch (nl)
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7897/76A external-priority patent/GB1579531A/en
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of NL7702027A publication Critical patent/NL7702027A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Clavulanic acid derivs. of formula (I) and their salts when R1 is COOH are new. (R = residue of an S- contg. nuleophite. R1 = opt. esterified car oxyl). They are prepd. e.g. by reacting corresp cpds. having R replaced by halo with the appropriate nucleophile. (I) are antibiotics, but are esp. useful as beta-lactamase inhibitors, i.e. potentiators for other penicillin and cephalosponin antibiotics (II) against beta-lactamase producing strains of e.g. Staphylococcus aureus, E. coli. Enterobacter cloacae etc. They can be used in human or veterinary medicine. The wt. ratio (I):(II) is 1:10-10:1, best 1:2-2:1 and the total dose of antibiotic is 0.1-1g/day. In an example (3R, 5R, z)-2-(2-acetylthioethylidene)-clavam-3-carboxylic acid 4-nitrobenzyl ester was prepd. by reacting thioacetic acid with the corresp. 2-chloroethylidene cpd.
NL7702027A 1976-02-27 1977-02-25 Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamase NL7702027A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB7897/76A GB1579531A (en) 1976-02-27 1976-02-27 Oxazolo-azetidinine antibiotic derivatives
GB2659476 1976-06-25
GB5261276 1976-12-16

Publications (1)

Publication Number Publication Date
NL7702027A true NL7702027A (en) 1977-08-30

Family

ID=27255084

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7702027A NL7702027A (en) 1976-02-27 1977-02-25 Clavulanic acid derivs. substd. by sulphur nucleophiles - useful as antibiotics and inhibitors of beta:lactamase

Country Status (1)

Country Link
NL (1) NL7702027A (en)

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Legal Events

Date Code Title Description
BV The patent application has lapsed