NL7510606A - Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexine - Google Patents
Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexineInfo
- Publication number
- NL7510606A NL7510606A NL7510606A NL7510606A NL7510606A NL 7510606 A NL7510606 A NL 7510606A NL 7510606 A NL7510606 A NL 7510606A NL 7510606 A NL7510606 A NL 7510606A NL 7510606 A NL7510606 A NL 7510606A
- Authority
- NL
- Netherlands
- Prior art keywords
- activity
- cephem
- carboxylic acid
- cephalexine
- tissue distribution
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 title abstract 2
- 230000002633 protecting effect Effects 0.000 title abstract 2
- 230000000845 anti-microbial effect Effects 0.000 title 1
- 210000000941 bile Anatomy 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- NVIAYEIXYQCDAN-HWZXHQHMSA-N (6r)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)C(N)[C@@H]12 NVIAYEIXYQCDAN-HWZXHQHMSA-N 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 abstract 1
- 241000588747 Klebsiella pneumoniae Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 abstract 1
- 241000588770 Proteus mirabilis Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000009630 liquid culture Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49104243A JPS5132792A (en) | 1974-09-09 | 1974-09-09 | 77 * 33 arukansuruhoniruaminofueniru dd gurishinamido * 33 mechiru 33 sefuemu 44 karubonsanrui no seizoho |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7510606A true NL7510606A (en) | 1976-03-11 |
Family
ID=14375498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7510606A NL7510606A (en) | 1974-09-09 | 1975-09-09 | Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexine |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5132792A (enExample) |
| AT (1) | AT340049B (enExample) |
| CA (1) | CA1055415A (enExample) |
| DK (1) | DK401275A (enExample) |
| HU (1) | HU169999B (enExample) |
| NL (1) | NL7510606A (enExample) |
| SE (1) | SE7509984L (enExample) |
-
1974
- 1974-09-09 JP JP49104243A patent/JPS5132792A/ja active Granted
-
1975
- 1975-09-05 CA CA235,029A patent/CA1055415A/en not_active Expired
- 1975-09-08 AT AT691675A patent/AT340049B/de not_active IP Right Cessation
- 1975-09-08 DK DK401275A patent/DK401275A/da unknown
- 1975-09-08 SE SE7509984A patent/SE7509984L/ not_active Application Discontinuation
- 1975-09-09 NL NL7510606A patent/NL7510606A/xx not_active Application Discontinuation
- 1975-09-09 HU HUFU340A patent/HU169999B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU169999B (enExample) | 1977-03-28 |
| JPS5132792A (en) | 1976-03-19 |
| ATA691675A (de) | 1977-03-15 |
| DK401275A (da) | 1976-03-10 |
| SE7509984L (sv) | 1976-03-10 |
| JPS5733036B2 (enExample) | 1982-07-14 |
| CA1055415A (en) | 1979-05-29 |
| AT340049B (de) | 1977-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |