NL7510606A - Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexine - Google Patents

Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexine

Info

Publication number
NL7510606A
NL7510606A NL7510606A NL7510606A NL7510606A NL 7510606 A NL7510606 A NL 7510606A NL 7510606 A NL7510606 A NL 7510606A NL 7510606 A NL7510606 A NL 7510606A NL 7510606 A NL7510606 A NL 7510606A
Authority
NL
Netherlands
Prior art keywords
activity
cephem
carboxylic acid
cephalexine
tissue distribution
Prior art date
Application number
NL7510606A
Other languages
Dutch (nl)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NL7510606A publication Critical patent/NL7510606A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

7-(3-Alkanesulphonamidophenyl-D-glycinamido)-3-methyl-3-cephem-4-- carboxylic acid of formula (I) or its salts, is prepd. by reacting 7-amino-3-methyl-3-cephem-4-carboxylic acid (II) or its salt with 3-alkanesulphonamidophenyl-glycine (III) or its carboxy deriv. in the presence of a liquid culture or its worked-up material of a micro-organism which is able to N-acylate (II) with (III). (where R = alkyl (1-6C, pref. 1-4C) (I) is an antimicrobial agent for oral use with a high activity against pathogenous micro-organisms esp. Klebsiella pneumonia and Proteus mirabilis. The activity, blood levels, tissue distribution bile-secretion and protecting activity on experimental infected mice of (I) are better than those of known cephalexine.
NL7510606A 1974-09-09 1975-09-09 Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexine NL7510606A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49104243A JPS5132792A (en) 1974-09-09 1974-09-09 77 * 33 arukansuruhoniruaminofueniru dd gurishinamido * 33 mechiru 33 sefuemu 44 karubonsanrui no seizoho

Publications (1)

Publication Number Publication Date
NL7510606A true NL7510606A (en) 1976-03-11

Family

ID=14375498

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7510606A NL7510606A (en) 1974-09-09 1975-09-09 Antimicrobial substd.-3-cephem-4-carboxylic acid - with better activity, tissue distribution, bile secretion and protecting activity than known cephalexine

Country Status (7)

Country Link
JP (1) JPS5132792A (en)
AT (1) AT340049B (en)
CA (1) CA1055415A (en)
DK (1) DK401275A (en)
HU (1) HU169999B (en)
NL (1) NL7510606A (en)
SE (1) SE7509984L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6222328A (en) * 1985-07-19 1987-01-30 株式会社マキタ Selector switch

Also Published As

Publication number Publication date
HU169999B (en) 1977-03-28
DK401275A (en) 1976-03-10
JPS5132792A (en) 1976-03-19
JPS5733036B2 (en) 1982-07-14
ATA691675A (en) 1977-03-15
SE7509984L (en) 1976-03-10
CA1055415A (en) 1979-05-29
AT340049B (en) 1977-11-25

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Legal Events

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