NL7412301A - 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid - Google Patents
2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acidInfo
- Publication number
- NL7412301A NL7412301A NL7412301A NL7412301A NL7412301A NL 7412301 A NL7412301 A NL 7412301A NL 7412301 A NL7412301 A NL 7412301A NL 7412301 A NL7412301 A NL 7412301A NL 7412301 A NL7412301 A NL 7412301A
- Authority
- NL
- Netherlands
- Prior art keywords
- acid
- dibromo
- cyclohexyl
- amino
- methyl
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A therapeutically active dihaloaminobenzylamine of formula (I) (where Y is H) and its acid addn. salt, more partic. hydrochloride is prepd. by reacting 2,4-dibromo-6- (N-cyclohexyl-N-methyl) aminomethyl benzoic acid of formula (I) (where Y is COOH). with hydrazoic acid (HN3) in an inert organic solvent, e.g. chloroform, which contains conc. sulphuric acid, polyphosphoric acid or another strong acid, at a temp. of 35-100 degrees C with the hydrazoic acid reacting in the nascent state by adding to the named soln. a salt of hydrazoic acid, e.g. sodium azide, whereupon, if desired, the formed 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine is by a usual method, converted into an acid addn. salt.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7412301A NL7412301A (en) | 1974-09-17 | 1974-09-17 | 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7412301A NL7412301A (en) | 1974-09-17 | 1974-09-17 | 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7412301A true NL7412301A (en) | 1976-03-19 |
Family
ID=19822115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7412301A NL7412301A (en) | 1974-09-17 | 1974-09-17 | 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid |
Country Status (1)
Country | Link |
---|---|
NL (1) | NL7412301A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102531922A (en) * | 2011-12-31 | 2012-07-04 | 陈学峰 | Novel preparation method for bromhexine hydrochloride |
CN104086445A (en) * | 2014-07-15 | 2014-10-08 | 浙江万邦药业股份有限公司 | Method for detecting related substances in bromhexine hydrochloride and preparations of bromhexine hydrochloride |
-
1974
- 1974-09-17 NL NL7412301A patent/NL7412301A/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102531922A (en) * | 2011-12-31 | 2012-07-04 | 陈学峰 | Novel preparation method for bromhexine hydrochloride |
CN104086445A (en) * | 2014-07-15 | 2014-10-08 | 浙江万邦药业股份有限公司 | Method for detecting related substances in bromhexine hydrochloride and preparations of bromhexine hydrochloride |
CN104086445B (en) * | 2014-07-15 | 2016-06-08 | 万邦德制药集团股份有限公司 | A kind of bromhexine hydrochloride and preparation have the detection method of related substance |
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Legal Events
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BC | A request for examination has been filed | ||
BV | The patent application has lapsed |