NL7412301A - 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid - Google Patents

2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid

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Publication number
NL7412301A
NL7412301A NL7412301A NL7412301A NL7412301A NL 7412301 A NL7412301 A NL 7412301A NL 7412301 A NL7412301 A NL 7412301A NL 7412301 A NL7412301 A NL 7412301A NL 7412301 A NL7412301 A NL 7412301A
Authority
NL
Netherlands
Prior art keywords
acid
dibromo
cyclohexyl
amino
methyl
Prior art date
Application number
NL7412301A
Other languages
Dutch (nl)
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to NL7412301A priority Critical patent/NL7412301A/en
Publication of NL7412301A publication Critical patent/NL7412301A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A therapeutically active dihaloaminobenzylamine of formula (I) (where Y is H) and its acid addn. salt, more partic. hydrochloride is prepd. by reacting 2,4-dibromo-6- (N-cyclohexyl-N-methyl) aminomethyl benzoic acid of formula (I) (where Y is COOH). with hydrazoic acid (HN3) in an inert organic solvent, e.g. chloroform, which contains conc. sulphuric acid, polyphosphoric acid or another strong acid, at a temp. of 35-100 degrees C with the hydrazoic acid reacting in the nascent state by adding to the named soln. a salt of hydrazoic acid, e.g. sodium azide, whereupon, if desired, the formed 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine is by a usual method, converted into an acid addn. salt.
NL7412301A 1974-09-17 1974-09-17 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid NL7412301A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7412301A NL7412301A (en) 1974-09-17 1974-09-17 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7412301A NL7412301A (en) 1974-09-17 1974-09-17 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid

Publications (1)

Publication Number Publication Date
NL7412301A true NL7412301A (en) 1976-03-19

Family

ID=19822115

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7412301A NL7412301A (en) 1974-09-17 1974-09-17 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzylamine prepn - from the corresp 2-carboxy cpd. with nascent hydrazoic acid

Country Status (1)

Country Link
NL (1) NL7412301A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102531922A (en) * 2011-12-31 2012-07-04 陈学峰 Novel preparation method for bromhexine hydrochloride
CN104086445A (en) * 2014-07-15 2014-10-08 浙江万邦药业股份有限公司 Method for detecting related substances in bromhexine hydrochloride and preparations of bromhexine hydrochloride

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102531922A (en) * 2011-12-31 2012-07-04 陈学峰 Novel preparation method for bromhexine hydrochloride
CN104086445A (en) * 2014-07-15 2014-10-08 浙江万邦药业股份有限公司 Method for detecting related substances in bromhexine hydrochloride and preparations of bromhexine hydrochloride
CN104086445B (en) * 2014-07-15 2016-06-08 万邦德制药集团股份有限公司 A kind of bromhexine hydrochloride and preparation have the detection method of related substance

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