BE771752A - Dihydroquinidine polyannuronate - antiarrhythmic - with reduced side-effects - Google Patents

Dihydroquinidine polyannuronate - antiarrhythmic - with reduced side-effects

Info

Publication number
BE771752A
BE771752A BE771752A BE771752A BE771752A BE 771752 A BE771752 A BE 771752A BE 771752 A BE771752 A BE 771752A BE 771752 A BE771752 A BE 771752A BE 771752 A BE771752 A BE 771752A
Authority
BE
Belgium
Prior art keywords
dihydroquinidine
antiarrhythmic
effects
reduced side
acid
Prior art date
Application number
BE771752A
Other languages
French (fr)
Original Assignee
Berenguer Beneyto Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berenguer Beneyto Lab filed Critical Berenguer Beneyto Lab
Priority to BE771752A priority Critical patent/BE771752A/en
Publication of BE771752A publication Critical patent/BE771752A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dihydroquinidine polymannuronate - antiarrhythmic, with reduced side-effects. Title cpd. which has the empirical formula: (C26H34O8N2)X (where x is the no. of monomeric mannuronic acid units in the poly-acid), possesses the antiarrhythmic activity of dihydroquinidine, but does not cause local irritation of the digestive tract and gives stable and long-lasting blood dihydroquinidine levels. It may be prepd. by reacting stoichiometric amounts of dihydroquinidine and polymannuronic acid, either in free form or as organic or inorganic salts, at 70-75 degrees C in the presence of a solvent until the pH of the soln. is practically 7, then isolating the salt formed.
BE771752A 1971-08-25 1971-08-25 Dihydroquinidine polyannuronate - antiarrhythmic - with reduced side-effects BE771752A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BE771752A BE771752A (en) 1971-08-25 1971-08-25 Dihydroquinidine polyannuronate - antiarrhythmic - with reduced side-effects

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE771752A BE771752A (en) 1971-08-25 1971-08-25 Dihydroquinidine polyannuronate - antiarrhythmic - with reduced side-effects

Publications (1)

Publication Number Publication Date
BE771752A true BE771752A (en) 1971-12-31

Family

ID=3858560

Family Applications (1)

Application Number Title Priority Date Filing Date
BE771752A BE771752A (en) 1971-08-25 1971-08-25 Dihydroquinidine polyannuronate - antiarrhythmic - with reduced side-effects

Country Status (1)

Country Link
BE (1) BE771752A (en)

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