NL7204228A - 1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one - diaminoacetate esters - cns depressants - Google Patents

1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one - diaminoacetate esters - cns depressants

Info

Publication number
NL7204228A
NL7204228A NL7204228A NL7204228A NL7204228A NL 7204228 A NL7204228 A NL 7204228A NL 7204228 A NL7204228 A NL 7204228A NL 7204228 A NL7204228 A NL 7204228A NL 7204228 A NL7204228 A NL 7204228A
Authority
NL
Netherlands
Prior art keywords
alkyl
aryl
diaminoacetate
benzodiazepine
dihydro
Prior art date
Application number
NL7204228A
Other versions
NL172060C (en
NL172060B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NL7204228A publication Critical patent/NL7204228A/en
Publication of NL172060B publication Critical patent/NL172060B/en
Application granted granted Critical
Publication of NL172060C publication Critical patent/NL172060C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. are of formula (I): (where R1 is 1-6C alkyl opt. substd. by 6-10C aryl; R2 is ANR6R7 where A is 1-6C alkylene and R6 and R7 are 1-6C alkyl opt. substd. by 6-10C aryl, or NR1R2 = R4 is 1-6C alkyl opt. substd. by 1-6C O-alkyl, OH or 6-10C aryl, or 6-10C aryl, R5 is 1-6C NH alkyl or piperidino; n is 3-5; m is 1 or 2; r is 2 or 3; s is 0-6; t is 0-6; s+t = 3-6; R3 is H, 1-6C alkyl opt. substd. by 1-6C Oalkyl or 6-10C aryl; X is hal, CN, CF3, NO2 or 1-6C S-alkyl; and Y is H, hal, CF3, NO2, or 1-6C S-alkyl) and salts of (I). (I) are prepd. by reacting a 3-haloacetate ester with 2-3 moles of an amine HNR1R2.
NLAANVRAGE7204228,A 1971-03-30 1972-03-29 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ACTION ON THE CENTRAL NERVOUS SYSTEM BASED ON 5-ARYL-3-ACYLOXY-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINONE-2 AND METHOD FOR PREPARING THESE COMPOUNDS NL172060C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12963871A 1971-03-30 1971-03-30

Publications (3)

Publication Number Publication Date
NL7204228A true NL7204228A (en) 1972-10-03
NL172060B NL172060B (en) 1983-02-01
NL172060C NL172060C (en) 1983-07-01

Family

ID=22440914

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7204228,A NL172060C (en) 1971-03-30 1972-03-29 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ACTION ON THE CENTRAL NERVOUS SYSTEM BASED ON 5-ARYL-3-ACYLOXY-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINONE-2 AND METHOD FOR PREPARING THESE COMPOUNDS

Country Status (5)

Country Link
BE (1) BE781437A (en)
CA (1) CA964655A (en)
NL (1) NL172060C (en)
PH (1) PH11369A (en)
ZA (1) ZA721056B (en)

Also Published As

Publication number Publication date
BE781437A (en) 1972-09-29
PH11369A (en) 1977-11-08
NL172060C (en) 1983-07-01
CA964655A (en) 1975-03-18
ZA721056B (en) 1973-10-31
NL172060B (en) 1983-02-01

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