NL7117845A - Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularins - Google Patents
Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularinsInfo
- Publication number
- NL7117845A NL7117845A NL7117845A NL7117845A NL7117845A NL 7117845 A NL7117845 A NL 7117845A NL 7117845 A NL7117845 A NL 7117845A NL 7117845 A NL7117845 A NL 7117845A NL 7117845 A NL7117845 A NL 7117845A
- Authority
- NL
- Netherlands
- Prior art keywords
- substd
- reaction
- nebularins
- disubstd
- vasodilatory
- Prior art date
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 title 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 title 1
- 208000001953 Hypotension Diseases 0.000 title 1
- 229960005305 adenosine Drugs 0.000 title 1
- 229910021529 ammonia Inorganic materials 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 title 1
- 230000000304 vasodilatating effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000824 D-ribofuranosyl group Chemical group [H]OC([H])([H])[C@@]1([H])OC([H])(*)[C@]([H])(O[H])[C@]1([H])O[H] 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12407770A JPS5034039B1 (cs) | 1970-12-28 | 1970-12-28 | |
| DK461771AA DK126043B (da) | 1970-09-25 | 1971-09-22 | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
| DK621371A DK135130B (da) | 1970-12-28 | 1971-12-20 | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7117845A true NL7117845A (en) | 1972-06-30 |
Family
ID=27222004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7117845A NL7117845A (en) | 1970-12-28 | 1971-12-24 | Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularins |
Country Status (5)
| Country | Link |
|---|---|
| CA (1) | CA965411A (cs) |
| DK (1) | DK135130B (cs) |
| HU (1) | HU164526B (cs) |
| NL (1) | NL7117845A (cs) |
| SE (1) | SE391337B (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1194441B1 (en) * | 1999-06-22 | 2003-10-22 | Cv Therapeutics, Inc. | A2a receptor agonists |
| US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
| USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
| US6214807B1 (en) | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
| US6180615B1 (en) | 1999-06-22 | 2001-01-30 | Cv Therapeutics, Inc. | Propargyl phenyl ether A2A receptor agonists |
| CA2439222C (en) | 2000-02-23 | 2009-07-14 | Cv Therapeutics, Inc. | Identification of partial agonists of the a2a adenosine receptor |
| US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
| US20050020915A1 (en) | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
| AU2003259264A1 (en) | 2002-07-29 | 2004-02-16 | Cv Therapeutics, Inc. | Myocardial perfusion imaging using a2a receptor agonists |
| AU2005295437B2 (en) | 2004-10-20 | 2011-05-19 | Gilead Palo Alto, Inc. | Use of A2A adenosine receptor agonists |
| PT1989214T (pt) | 2006-02-03 | 2016-09-22 | Gilead Sciences Inc | Processo para preparar um agonista de recetor de adenosina a2a e polimorfos do mesmo |
-
1971
- 1971-12-20 DK DK621371A patent/DK135130B/da unknown
- 1971-12-21 CA CA130,670A patent/CA965411A/en not_active Expired
- 1971-12-23 HU HUTA001164 patent/HU164526B/hu unknown
- 1971-12-24 NL NL7117845A patent/NL7117845A/xx unknown
- 1971-12-27 SE SE1669271A patent/SE391337B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA965411A (en) | 1975-04-01 |
| DK135130B (da) | 1977-03-07 |
| SE391337B (sv) | 1977-02-14 |
| DK135130C (cs) | 1977-08-01 |
| HU164526B (cs) | 1974-02-28 |
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