NL2033681A

NL2033681A - Traditional chinese medicine composition for treating respiratory tract infection and preparation method and application thereof

Info

Publication number: NL2033681A
Application number: NL2033681A
Authority: NL
Inventors: Jia Lei; Hu Faguang
Original assignee: Beijing Zhongbao Jiayi International Biotechnology Res Co Ltd
Priority date: 2021-12-21
Filing date: 2022-12-07
Publication date: 2023-06-29
Also published as: CN114053355A

Abstract

A traditional Chinese medicine composition for treating respiratory tract infection, a preparation. method, and an application thereof are provided. The traditional Chinese medicine composition is prepared from the following parts by weight of raw materials: 150—300 parts of Lonicera japonica, 150—300 parts of green tea, 150—300 parts of lemon, 150—300 parts of Siraitia grosvenorii, 100—150 parts of Flos Sophorae, 100—150 parts of almond, 50—100 parts of Agastache rugosa and 50—100 parts of Mentha canadensis. The traditional Chinese medicine composition of the present invention can rapidly decompose sputum, free lung and relieve asthma, sterilizing, dredge body fluid and eliminate stagnation, dilate trachea, remove chest distress. Meanwhile, the traditional Chinese medicine composition of the present invention can supply oxygen to cardiac artery via lung while supplying oxygen to cells to relieve pain.

Description

P1637 /NL

TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING RESPIRATORY

TRACT INFECTION AND PREPARATION METHOD AND APPLICATION THEREOF

TECHNICAL FIELD

The present invention relates to the technical field of com- position, and in particular to a traditional Chinese medicine com- position for treating respiratory tract infections and a prepara- tion method and an application thereof.

BACKGROUND ART

Respiratory tract infection includes upper respiratory tract infection, lower respiratory tract infection, bacterial pneumonia or mixed bacterial infection. Respiratory tract infection is the most common infectious disease. At present, the respiratory tract infection is mainly treated by the medicines such as, quinolone antibiotics and cephalosporin antibiotics at home and abroad. To control the state of disease, such antibiotics are used in large amounts, resulting in enhanced bacterial resistance. Moreover, an- tibiotics cause certain side effects to the body. Therefore, anti- biotics have been unable to meet the demand for the medicaments for preventing and treating respiratory tract infection.

Therefore, there is an urgent need to develop a safe medica- ment capable of preventing and treating respiratory tract infec- tion.

SUMMARY

The objective of the present invention is to provide a tradi- tional Chinese medicine composition for treating respiratory tract infection, and a preparation method and an application thereof.

The traditional Chinese medicine composition has excellent anti- bacterial and antiviral ability and has significant therapeutic effects on respiratory tract infection.

To achieve the above objective of the present invention, the following technical solutions are particularly applied: a first aspect of the present invention provides a tradition-

al Chinese medicine composition for treating respiratory tract in- fection, and the Chinese medicine composition is prepared from the following parts by weight of raw materials: 150-300 parts of Lonicera japonica, 150-300 parts of green tea, 150-300 parts of lemon, 150-300 parts of Siraitia grosveno- rii, 100-150 parts of Flos Sophorae, 100-150 parts of almond, 50- 100 parts of Agastache rugosa and 50-100 parts of Mentha canaden- sis.

Preferably, the traditional Chinese medicine composition for treating respiratory tract infection is prepared from the follow- ing parts by weight of raw materials: 200-250 parts of Lonicera japonica, 200-250 parts of green tea, 200-250 parts of lemon, 200-250 parts of Siraitia grosveno- rii, 120-130 parts of Flos Sophorae, 120-130 parts of almond, 60- 80 parts of Agastache rugosa and 60-80 parts of Mentha canadensis.

Preferably, the traditional Chinese medicine composition for treating respiratory tract infection is prepared from the follow- ing parts by weight of raw materials: 220 parts of Lonicera japonica, 230 parts of green tea, 220 parts of lemon, 240 parts of Siraitia grosvenorii, 120 parts of

Flos Sophorae, 130 parts of almond, 70 parts of Agastache rugosa and 70 parts of Mentha canadensis.

A second aspect of the present invention provides a method for preparing the above traditional Chinese medicine composition for treating respiratory tract infection, and the preparation method includes the following steps of: (a) weighing each raw material in parts by weight; (b) soaking each raw material into ethanol respectively and distilling to obtain an extract of each raw material; {c) mixing the extract of each raw material to obtain the traditional Chinese medicine composition for treating respiratory tract infection.

Preferably, a mass-to-volume ratio of each raw material to ethanol is 1:{(3-10).

Preferably, the soaking temperature is room temperature and the soaking time is 5-10 h.

Preferably, the step (a) further includes a step of pulveriz-

ing each raw material to a particle size not greater than 2 mm re- spectively.

A third aspect of the present invention provides a pharmaceu- tical granule for treating upper respiratory tract infection, in- cluding the above traditional Chinese medicine composition.

Preferably, the pharmaceutical granule for treating upper respiratory tract infection is prepared by mixing and granulating the above traditional Chinese medicine composition with a bio- enzyme; the bio-enzyme in the pharmaceutical granule has a mass con- tent of 4%-9%. The bio-enzyme may be commercially available.

Preferably, the pharmaceutical granule for treating upper respiratory tract infection has a weight of 0.2-0.3 g per granule.

Compared with the prior art, the present invention at least includes the following beneficial effects:

The traditional Chinese medicine composition of the present invention can rapidly decompose sputum, free lung and relieve asthma, sterilizing, dredge body fluid and eliminate stagnation, dilate trachea, remove chest distress. Meanwhile, the traditional

Chinese medicine composition of the present invention can supply oxygen to cardiac artery via lung while supplying oxygen to cells to relieve pain. Moreover, dark substances of the biological medi- cine thereof will rapidly enter into blood circulation to be brought into cells and tissues of various organs for oxygen sup- ply, thus activating glands to enhance immunity. Therefore, the traditional Chinese medicine composition of the present invention can achieve the purposes of “treating diseases via body fluid con- ditioning” and preventing and treating respiratory tract infection by sterilizing with heat, clearing away phlegm-damp and removing dirt.

The pharmaceutical granule of the present invention has the efficacy of rapidly slowing down or eliminating common upper res- piratory tract infections, bacterial/viral infections, in particu- lar to nasal, pharyngeal, laryngeal or oral inflammatory swelling, fever and cough with excessive sputum in trachea and lung, asthma and chest distress or acute and chronic infectious diseases accom- panied by insufficient oxygen supply to the heart and brain via aerosol administration.

The raw material components of the present invention are se- lected from extracts of medicinal and edible traditional Chinese medicine. Therefore, the present invention has no side effects, and is safe and effective in clinical use.

DETAILED DESCRIPTION OF THE EMBODIMENTS

Embodiments of the present invention will be described in de- tail with reference to the examples hereinafter. The following ex- amples only serve to specify the technical solutions of the pre- sent invention more clearly, and are only used as examples, but not construed as limiting the protection scope of the present in- vention.

It should be noted that the technical or scientific terms used herein have the ordinary meanings as understood by a person skilled in the art, unless otherwise indicated.

Example 1

I. Traditional Chinese medicine composition for treating res- piratory tract infection

The above traditional Chinese medicine composition was pre- pared by the following parts by weight of raw materials: 300 parts of Lonicera japonica, 150 parts of green tea, 150 parts of lemon, 300 parts of Siraitia grosvenorii, 150 parts of

Flos Sophorae, 100 parts of almond, 100 parts of Agastache rugosa and 50 parts of Mentha canadensis.

II. Preparation method

A method for preparing the above traditional Chinese medicine composition for treating respiratory tract infection included the following steps: (a) each raw material was weighed in part by weight and re- spectively pulverized to a particle size not greater than 2 mm; (b) each raw material was soaked into ethanol at room temper- ature for 7 h according to a mass-volume ratio of 1:8, and dis- tilled to obtain an extract of each raw material; (c) the extract of each raw material was mixed to obtain the above traditional Chinese medicine composition for treating res- piratory tract infection.

Example 2

The above traditional Chinese medicine composition was pre- 5 pared by the following parts by weight of raw materials: 150 parts of Lonicera japonica, 300 parts of green tea, 300 parts of lemon, 150 parts of Siraitia grosvenorii, 100 parts of

Flos Sophorae, 150 parts of almond, 50 parts of Agastache rugosa and 100 parts of Mentha canadensis.

II. Preparation method

A method for preparing the above traditional Chinese medicine composition for treating respiratory tract infection included the following steps: (a) each raw material was weighed in part by weight and re- spectively pulverized to a particle size not greater than 2 mm; (b) each raw material was soaked into ethanol at room temper- ature for 7 h according to a mass-volume ratio of 1:5, and dis- tilled to obtain an extract of each raw material; (c) the extract of each raw material was mixed to obtain the above traditional Chinese medicine composition for treating res- piratory tract infection.

Example 3

The above traditional Chinese medicine composition was pre- pared by the following parts by weight of raw materials: 250 parts of Lonicera japonica, 200 parts of green tea, 250 parts of lemon, 250 parts of Siraitia grosvenorii, 120 parts of

Flos Sophorae, 120 parts of almond, 80 parts of Agastache rugosa and 60 parts of Mentha canadensis.

II. Preparation method

A method for preparing the above traditional Chinese medicine composition for treating respiratory tract infection included the following steps: (a) each raw material was weighed in part by weight and re- spectively pulverized to a particle size not greater than 2 mm; {(b) each raw material was soaked into ethanol at room temper-

ature for 10 h according to a mass-volume ratio of 1:3, and dis- tilled to obtain an extract of each raw material; {(c) the extract of each raw material was mixed to obtain the above traditional Chinese medicine composition for treating res- piratory tract infection.

Example 4

The above traditional Chinese medicine composition was pre- pared by the following parts by weight of raw materials: 200 parts of Lonicera japonica, 250 parts of green tea, 200 parts of lemon, 200 parts of Siraitia grosvenorii, 130 parts of

Flos Sophorae, 130 parts of almond, 60 parts of Agastache rugosa and 80 parts of Mentha canadensis.

II. Preparation method

A method for preparing the above traditional Chinese medicine composition for treating respiratory tract infection included the following steps: (a) each raw material was weighed in part by weight and re- spectively pulverized to a particle size not greater than 2 mm; (b) each raw material was soaked into ethanol at room temper- ature for 5 h according to a mass-volume ratio of 1:10, and dis- tilled to obtain an extract of each raw material; (c) the extract of each raw material was mixed to obtain the above traditional Chinese medicine composition for treating res- piratory tract infection.

Example 5

The above traditional Chinese medicine composition was pre- pared by the following parts by weight of raw materials: 220 parts of Lonicera japonica, 230 parts of green tea, 220 parts of lemon, 240 parts of Siraitia grosvenorii, 120 parts of

II. Preparation method

A method for preparing the above traditional Chinese medicine composition for treating respiratory tract infection included the following steps: (a) each raw material was weighed in part by weight and re- spectively pulverized to a particle size not greater than 2 mm; {(b) each raw material was soaked into ethanol at room temper- ature for 8 h according to a mass-volume ratio of 1:6, and dis- tilled to obtain an extract of each raw material; (c) the extract of each raw material was mixed to obtain the above traditional Chinese medicine composition for treating res- piratory tract infection.

Example 6

This example is a pharmaceutical granule for treating upper respiratory tract infection; the pharmaceutical granule includes the traditional Chinese medicine composition of Example 1 and a bio-enzyme; the bio-enzyme in the pharmaceutical granule has a mass content of is 5%; the above pharmaceutical granule was prepared by mixing and granulating the above traditional Chinese medicine composition of

Example 1 with a bio-enzyme, each granule had a weigh of 0.25 g.

Example 7

This example is a pharmaceutical granule for treating upper respiratory tract infection; the pharmaceutical granule includes the traditional Chinese medicine composition of Example 3 and a bio-enzyme; the bio-enzyme in the pharmaceutical granule has a mass content of is 4%; the above pharmaceutical granule was prepared by mixing and granulating the above traditional Chinese medicine composition of

Example 3 with a bio-enzyme, each granule had a weigh of 0.3g.

Example 8

This example is a pharmaceutical granule for treating upper respiratory tract infection; the pharmaceutical granule includes the traditional Chinese medicine composition of Example 4 and a bio-enzyme; the bio-enzyme in the pharmaceutical granule has a mass content of is 9%; the above pharmaceutical granule was prepared by mixing and granulating the above traditional Chinese medicine composition of

Example 4 with a bio-enzyme, each granule had a weigh of 0.2g.

Example 9

This example is a pharmaceutical granule for treating upper respiratory tract infection; the pharmaceutical granule includes the traditional Chinese medicine composition of Example 5 and a bio-enzyme; the bio-enzyme in the pharmaceutical granule has a mass content of is 7%; the above pharmaceutical granule was prepared by mixing and granulating the above traditional Chinese medicine composition of

Example 5 with a bic-enzyme, each granule had a weigh of 0.25 g.

The administration method (inhalation method) and action mechanism of the pharmaceutical granule of the present invention are as follows:

The pharmaceutical granule of the present invention is heated by a heating rod. A user directly inhales the medicament volati- lized by heating into oral cavity and lung. The relatively high hot gas is utilized to directly contact mucosal tissues, thus gen- erating heat flow to accelerate the impact on the lesion such that the relatively low-temperature phlegm-damp fluid and the inflow hot air are subjected to hot-cold air convection collision to cre- ate resonance. In such a way, the sputum may be rapidly decomposed and each component may rapidly exert self-pharmacological func- tions, thus achieving the purpose of preventing and treating res- piratory tract infections.

Typical cases are as follows:

Case 1

Patient Li, male, 30 years old, suffered throat swelling and pain, tonsil inflammation and swelling, nasal congestion and runny nose, paroxysmal expectoration with thick and yellow sputum due to cold fever on March 20, 2021 and thus, only took liquid food. The patient was diagnosed as laryngopharyngeal tonsillitis recurrence and upper respiratory tract infection in the hospital, and was given conventional antibiotics, antivirus and other traditional

Chinese and Western medicines. One week later after administra- tion, only fever was relieved and the symptoms were slightly re- lieved; the patient had stomachache and felt sick, loss of appe- tite and anxiety, and then withdrew the medicament soon. In March 30, the patient began to take the pharmaceutical granule prepared in Example 9 of the present invention by a heating inhalation method, with 3 times a day and 2 g each time. The patient stopped cough on the same evening, and the pain in oral cavity was greatly reduced. 3 days later after continuous inhalation, the symptoms were completely eliminated.

Case 2

Patient Feng, female, 42 years old, had suffered from refrac- tory chronic pharyngolaryngitis for a long time since childhood based on her own statement. The patient was also prone to cold to cause recurrence with sore threat and hoarseness, itchy throat and dry cough, difficulty in sleeping at night, and thus was weak and thin. The patient had been diagnosed as chronic pharyngolaryngitis with lymphoid follicular tissue hyperplasia by multiple large hos- pitals. The patient had no sign of healing by traditional Chinese medicine and Western medicine, but took medicines to decrease the frequency of catching a cold only. Since the end of 2020, the pa- tient had taken the pharmaceutical granule prepared in Example 9 of the present invention, and stopped administering all the other medicaments. In October 2021, the patient specifically went to the hospital for laryngoscopy, the lymphatic follicular tissues in the throat were normal, and the original symptoms disappeared; moreo- ver, the patient also gained weight by 5 kg.

Case 3

Patient Sun, female, 68 years old, resident of Zhumadian City of Henan province, had suffered from chronic bronchitis since childhood. The patient suffered from chronic bronchitis more se- verely and frequently in autumn and winter, with cough and exces- sive sputum at night and difficulty in sleeping, and thus need take ephedrine and aminophylline for a long time. Since November 2018, the patient had begun to take the pharmaceutical granule prepared in Example 9 of the present invention, and stopped taking all the medicaments for dilating trachea and resolving phlegm in the winter of that year; then the patient had reduced cough and almost no phlegm, and all went well until this year, and had no attack of the disease in the winter, and didn’t take medicines at ordinary times.

Case 4

Patient Zhang, male, 46 years old, resident of Suzhou of An- hui province, suffered from rhinitis and pulmonary bulla, and had chest distress and shortness of breath for many years, weakness of limbs and asthma, difficult breathing, accompanied by cough and excessive sputum after catching a cold. After the patient took the pharmaceutical granule prepared in Example 9 of the present inven- tion for consecutive 20 days, the symptoms disappeared. Currently, the patient has been taking the medicine all the time without re- currence.

Finally, it should be noted that: the above examples are merely illustrative of the technical solutions of the present in- vention, but not construed as liming the same. Although the pre- sent invention has been described in detail with reference to the foregoing examples, it should be understood that a person skilled in the art can still amend the technical solutions disclosed in the foregoing examples, or make equivalent replacements on the some or all of the technical features therein. Moreover, these amendments and replacements will not enable the essence of the corresponding technical solution to depart from the scope of the examples of the present invention, but shall fall within the scope of the claims and the description of the present invention.

Claims

CONCLUSIONS

1. Traditional Chinese medicine composition for the treatment of respiratory infections prepared from the following parts by weight of raw materials: 150 to 300 parts Lonicera japonica, 150 to 300 parts green tea, 150 to 300 parts lemon, 150 to 300 parts Siraitia grosvenorii, 100 to 150 parts Flos Sophorae, 100 to 150 parts almond, 50 to 100 parts Agastache rugosa and 50 to 100 parts Mentha canadensis.

A traditional Chinese medicine composition for the treatment of respiratory infections according to claim 1, prepared from the following parts by weight of raw materials: 200 to 250 parts of Lonicera japonica, 200 to 250 parts of green tea, 200 to 250 parts of lemon, 200 to 250 parts of Siraitia grosvenorii, 120 to 130 parts Flos Sophorae, 120 to 130 parts almond, 60 to 80 parts Agastache rugosa and 60 to 80 parts Mentha canadensis.

A traditional Chinese medicine composition for the treatment of respiratory infections according to claim 1, prepared from the following parts by weight of raw materials: 220 parts Lonicera japonica, 230 parts green tea, 220 parts lemon, 240 parts Siraitia grosvenorii, 120 parts Flos Sophorae, 130 parts almond , 70 parts Agastache rugosa and 70 parts Mentha canadensis.

A method for preparing the traditional Chinese medicine composition for treating respiratory infection according to any one of claims 1 to 3, comprising the steps of: a) weighing each raw material in parts by weight; (b) respectively soaking each raw material in ethanol and distilling to obtain an extract of each raw material; (c) mixing the extract of each raw material to form the traditional Chinese medicine composition for treating airborne

road infections.

The production method according to claim 4, wherein a mass to volume ratio of each raw material to ethanol is 1: {3 to 10).

The preparation method according to claim 4, wherein the soaking temperature is room temperature and the soaking time is 5 to 10 hours.

The preparation method according to claim 4, wherein step (a) further comprises a step of pulverizing each raw material to a particle size of not more than 2 mm, respectively.

A pharmaceutical granule for treating upper respiratory tract infection comprising the traditional Chinese medicine composition according to any one of claims 1 to 7.

The pharmaceutical granules for treating upper respiratory tract infection according to claim 8, wherein the pharmaceutical granules for treating upper respiratory tract infections are prepared by mixing and granulating the traditional Chinese medicine composition according to any one of claims 1 to 7 with a bioenzyme; wherein the bioenzyme in the pharmaceutical granulate has a mass content of 4% to 9%.

The pharmaceutical granules for the treatment of upper respiratory tract infection according to claim 8, wherein the pharmaceutical granules for the treatment of upper respiratory tract infection have a weight of 0.2 to 0.3 g per granule.