CN104383104A - Application of bastard speedwell injection for preparing rectal administration preparation and aerosol inhalation preparation - Google Patents
Application of bastard speedwell injection for preparing rectal administration preparation and aerosol inhalation preparation Download PDFInfo
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Abstract
The invention belongs to the field of pharmaceutic preparations and particularly relates to a novel application of bastard speedwell injection for preparing rectal administration preparation and aerosol inhalation preparation. Being adopted for preparing the rectal administration preparation and the aerosol inhalation preparation, the bastard speedwell injection has the following characteristics: the absorption is fast, the first-pass effect is avoided, the operation is convenient, pain and trauma are prevented, children patients can easily accept, diseased tissues of some diseases can be directly acted, quick effect is realized, and the bioavailability of medicine is increased; in addition, the bastard speedwell injection has an outstanding curative effect on infectious diseases.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, be specifically related to brightly cause the purposes of Lemahui Injection for the preparation of rectally preparation and Neulized inhalation preparation.
Background technology
Rein in the horse back, formal name used at school Veronica linariifolia, first appeared in herbal for Relief of Famines, bitter in the mouth, is slightly cold; " Chinese medicine voluminous dictionary ", " Chinese Pharmacopoeia " version in 1977 one, all records.In order to treat bronchitis, lung abscess, acute nephritis, urinary tract infection, furuncle and phyma etc.; Hemorrhoid are controlled in external, skin eczema, and rubella is scratched where it itches, at the title having " Chinese medicine antibiotic " among the people.
At present, various clinical preparation has been derived with the medicine that rein in the horse back (Veronica linariifolia) is raw material, the dosage forms such as such as intramuscular dose, oral tablet, granule, health tea.
Pharmacodynamics test shows, and preparation of reining in the horse back all has inhibitory action to streptococcus pneumoniae, staphylococcus aureus, Bacillus typhi, shigella flexneri and shigella.In vitro coagulant blood and Free-radical scavenging activity and protect the liver, antitumor, there is certain pharmacological action the aspects such as the control of cardiovascular disease, therefore may be used for pneumonia, bronchitis, acute/chronic pharyngitis, pulmonary tuberculosis, urinary system infection, the treatment of prostatitis etc.Use without antagonism with Antibiotic combination.
Because injection can avoid first pass effect, improve the bioavailability of medicine, become Clinical practice mode the most frequently.Lemahui Injection is widely used in that carbuncle sore tumefacting virus, lung abscess, cough and asthma, chronic cough are more than, the treatment of the puckery pain of pyretic stranguria and dysuria etc.
But existing injection still also exists the consuming time and inconvenient problem for the treatment of in clinical treatment, especially for child patient, more there is the not adaptive for the treatment of.
Summary of the invention
For this reason, it is that preparation of reining in the horse back in prior art is not particularly suitable for the problem of child patient that the present invention will solve, and then provides a kind of novelty teabag utilizing Lemahui Injection to prepare rectally preparation and Neulized inhalation preparation.
For solving the problems of the technologies described above, the present invention is achieved by the following technical solutions:
A kind of Lemahui Injection of the present invention is for the preparation of the purposes of rectally preparation, described Lemahui Injection is prepared as follows: water intaking turnip 400-600 weight portion, decoct with water three times, first time 1-3 hour, second time 0.5-1.5 hour, third time 0.3-0.8 hour, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 0.5-1.5 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 50-70%, second time reaches 70-90%, leave standstill 22-26 hour, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 5.0-7.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 12-18 parts by volume, stir evenly, inject water to 800-1200 parts by volume, filter, embedding, sterilizing, obtain,
The pass of described weight portion and parts by volume is the relation of g/mL.
Such use of the present invention, described Lemahui Injection is prepared as follows: water intaking turnip 500 weight portion, decoct with water three times, 2 hours first times, second time 1 hour, 0.5 hour third time, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 1 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 60%, second time reaches 80%, leave standstill 24 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 6.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 15 parts by volume, stir evenly, inject water to 1000 parts by volume, filter, embedding, sterilizing, obtain.
Such use of the present invention, the day application dosage of described rectally preparation is 4-12mL.
A kind of Lemahui Injection of the present invention is for the preparation of the purposes of Neulized inhalation preparation, described Veronica linariifolia injection is prepared as follows: get 400-600 weight portion of reining in the horse back, decoct with water three times, first time 1-3 hour, second time 0.5-1.5 hour, third time 0.3-0.8 hour, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 0.5-1.5 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 50-70%, second time reaches 70-90%, leave standstill 22-26 hour, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 5.0-7.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 12-18 parts by volume, stir evenly, inject water to 800-1200 parts by volume, filter, embedding, sterilizing, obtain,
The pass of described weight portion and parts by volume is the relation of g/mL.
Such use of the present invention, described Lemahui Injection is prepared as follows: water intaking turnip 500 weight portion, decoct with water three times, 2 hours first times, second time 1 hour, 0.5 hour third time, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 1 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 60%, second time reaches 80%, leave standstill 24 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 6.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 15 parts by volume, stir evenly, inject water to 1000 parts by volume, filter, embedding, sterilizing, obtain.
Such use of the present invention, the day application dosage of described Neulized inhalation preparation is 4-10mL.
Rectally refers to sends medicine into intestinal tube by anus, systemic circulation is entered by rectal mucosal rapid absorption, play drug effect to treat the medication of whole body or local disease, be mainly used in the treatment of acute and chronic respiratory system disease, digestive system disease, diseases of urinary system and andropathy, gynaecopathia class, and there is good effect.
Fog inhalation therapy utilizes high-speed air-flow directly to be rushed by medicine atomisation to bronchia, eventually last bronchus and alveolar, medicine is made directly to touch lesion, thus raising local drug concentration, play expansion bronchus, antiinflammation, and can keep that air flue is moistening, desaturation sputum is in order to expectoration.Therefore, fog inhalation therapy for pharyngitis, laryngitis, pneumonia, tracheitis, bronchitis, pulmonary carcinoma, metastatic lung cancer, be accompanied with respiratory tract, clinical meaning that patients with pulmonary infection has it important.
The method of the invention is prepared rectally preparation or Neulized inhalation preparation with existing injection, carry out clinical administration, utilize and the diverse route of administration of prior art indication, compared with the scheme of existing intravenous injection or intramuscular injection, have absorb fast, avoid first pass effect, easy to operate, no pain, hurtless measure, be easy to accept, directly act on pathological tissues for part disease for child patient especially, the features such as effective fast, the bioavailability that increases medicine, and to infectious disease, there is outstanding therapeutic effect.
Experimental example
The rectally preparation prepared containing Lemahui Injection of the present invention by following clinical comparison experimental verification and the effect of Neulized inhalation preparation.Wherein, each medicine in following control experiment is commercially available product.
1, symptom: heating, pharyngalgia; Positive sign: throat wall is dispersed in herpes
Experimental group is treated: with the rectally preparation 4mL prepared by the embodiment of the present invention 1, acyclovir 0.25mg, antondin 2mL, dexamethasone 2mg, rectally, 1 day 2 times; Be aided with the 2mL that reins in the horse back, ribavirin 1mL carries out atomization inspiration treatment, 1 day 2 times; Oral children's's antivirus oral liquid 10mL, 1 day 2 times.Administration is after 2 days, and pharyngalgia is alleviated, body temperature 36.8 DEG C; After consolidating 1 day, change and take oral medicine, infant is fully recovered.
Treatment of control group: with the injection 4mL prepared by the embodiment of the present invention 1, antondin 2mL, dexamethasone 2mg, intramuscular injection, 1 day 2 times, acyclovir 0.25mg, dilutes quiet, 1 day 1 time; Be aided with the 2mL that reins in the horse back, ribavirin 1mL carries out atomization inspiration treatment 1 day 2 times; Oral children's's antivirus oral liquid 10mL, 1 day 2 times.Administration is after 2 days, and pharyngalgia is alleviated not obvious, uses rectally instead.
2, hemorrhoid
50 routine patient diagnosis are hemorrhoid, and 38 routine patients have crissum pain, redness, and having blood in stool appears in 20 examples, and 16 examples have mucus secretions.Be divided into experimental group and matched group at random, each 25 examples.
Experimental group is treated: with the rectally preparation 4mL+ Herba Houttuyniae and Herba Houttuyniae and Flos Lonicerae injection 4mL prepared by the embodiment of the present invention 1, carry out rectally, one day twice with injection tube; Coordinate oral some tongue ball, 12 ball, 2 times on the 1st, ZHICHUANG GAO external, gets before sleeping in right amount and is coated on crissum simultaneously, and mixed type is treated.After administration, one week patients symptomatic obviously improves, and continues use and then effects a radical cure for 1 month.
Treatment of control group: with the injection rectally preparation 4mL+ Herba Houttuyniae and Herba Houttuyniae and Flos Lonicerae injection 4mL prepared by the embodiment of the present invention 1, carry out intramuscular injection, one day twice; Simultaneously points of engagement tongue ball, ZHICHUANG GAO external, mixed type treatment 2 weeks, patients symptomatic improves not obvious, hemorrhagely alleviates, but pain and swelling is without obvious alleviation, after use the rectal then healing in 3 weeks of experimental group setting instead.
3, infantile common cold cough
There is cough after suffering from cold in 18 routine infants, the frequent dry cough of 11 routine infant, 4 examples cough up white slimy expectorant, and 3 routine infants cough up clear yellow viscous expectorant, and low grade fever appears in 5 routine infants.
Carry out rectally with the rectally preparation (4mL) prepared by the embodiment of the present invention 1, add the 2mL+ Ambroxol 15mg that reins in the horse back, rectally, 1 day 2 times simultaneously; Be aided with Herba Houttuyniae and Herba Houttuyniae and Flos Lonicerae injection 2mL according to the administration of Neulized inhalation mode, 1 day 2 times.Administration, after three days, is fully recovered.
4, hemorrhoid (mixed hemorrhoid)
40 routine patient diagnosis are hemorrhoid, and patient all has crissum pain, redness, pendant to rise, and it is outstanding that patient has anus to organize outward, and part can not Hui Na, and having blood in stool appears in 28 examples, and 38 examples have mucus or purulent secretion.All patients are divided into experimental group and each 20 examples of matched group at random.
Experimental group is treated: grind powder with 6, rectally preparation 4mL+ point tongue ball prepared by the embodiment of the present invention 1, rectally, once a day.Administration took effect the same day, 3-6 days transference cures.
Treatment of control group: with the rectally preparation 4mL intramuscular injection prepared by the embodiment of the present invention 1,6, oral some tongue ball, once a day.After administration 3 days, patients symptomatic improved not obvious, all used rectally recovery from illness instead afterwards.
5, cervical erosion I degree, II degree
10 routine patient diagnosis are cervical erosion, I degree 4 example, II degree 6 example, and 2 routine patients have lumbosacral region to fall the pain that rises, and leucorrhoea grow in quantity appears in 4 routine patients, 1 routine pudendal pruritus, and 4 routine patients are asymptomatic.Be divided into experimental group and matched group at random.
Experimental group is treated: the rectally preparation 4mL prepared by the embodiment of the present invention 1 is directly put in lesion with cotton balls.Administration is after ten days, and symptom disappears completely, colposcopy: I degree erosion patients all fully recover, and II degree erosion patients be clearly better, rear continual cure 10 days, and all patients is fully recovered.
Treatment of control group: by the rectally preparation 4mL intramuscular injection prepared by the embodiment of the present invention 1.After administration 10 days, patients symptomatic without being clearly better, colposcopy: I degree erosion patients has part to take a turn for the better, erosion patients is unchanged for II degree, after use rectally instead.
6, viral pneumonia
20 routine infants are diagnosed as viral pneumonia; 18 infant coughs, a little sticky expectorant, heating, weak, poor appetite; 13 routine infant hemogram increase.Be divided into experimental group and matched group at random.
Experimental group is treated: by the Neulized inhalation preparation 2mL+ Ambroxol 15mg prepared by the embodiment of the present invention 4, carry out nebulizer administration, 1 day 2 times with atomizer, and support of suiting the medicine to the illness.Administration is after 3 days, and 6 routine infant recoveries from illness, all the other continual cures, all cure for 5 days afterwards.
Treatment of control group: by the Neulized inhalation preparation 2mL intramuscular injection prepared by the embodiment of the present invention 4, Ambroxol 15mg Neulized inhalation, and support of suiting the medicine to the illness.After administration 3 days, 8 routine infant symptoms took a turn for the better, but because of pain continual cure difficulty, all used atomization inspiration treatment recovery from illness instead afterwards.
7, suppurative tonsillitis
18 routine infants are diagnosed as suppurative tonsillitis.Infant all has heating, red swelling of the pharynx pain, swallows pain obviously, takes food poor.Infant, with antiadoncus II--III degree, tonsil has purulent secretion, T:37.8 DEG C-39.2 DEG C.
By the Neulized inhalation preparation 2mL+ dexamethasone 1mL prepared by the embodiment of the present invention 4, nebulizer administration, 1 day 2 times, the oral Merrill Lynch 4-8mL of body temperature more than 38.5 DEG C persons, 1 day 1 time.After administration 3 is large, 15 routine infant recoveries from illness, 3 routine infant continual cures, fully recovered after 2 days.
8, infantile pneumonia
15 routine infants are diagnosed as pneumonia; Age 2-8 year, infant cough, dry cough or sticky expectorant, heating, weak, 3 routine infant chest pains; 5 routine infant hemogram increase.
By the Neulized inhalation preparation 2mL+ Ambroxol 15mg prepared by the embodiment of the present invention 4, nebulizer administration, 1 day 2 times, and support of suiting the medicine to the illness.After administration 3 days, infant symptom was clearly better, rear continual cure 2 days, and whole infant is cured.
9, the little small pox on skin
There is facial area erythema or pustule in 3 routine patients, medicinal external emulsifiable paste is invalid.
By the Neulized inhalation preparation 4mL prepared by the embodiment of the present invention 4, use atomizer to be atomized variola position, 1 day 3 times, each 10 minutes, after atomization, give a tongue ball coating.Administration is after 3 days, transference cure.
10, cat fever
There is heating in infant, body temperature 38.5 DEG C, with watery nasal discharge, cough, weak, takes food poor.
By the rectally preparation 2mL+ injection of Radix Bupleuri 2mL prepared by the embodiment of the present invention 4, rectally, 1 day 2 times, and oral infusion grain for cough and asthma of children.Administration one day after patient's heat is moved back, and symptom takes a turn for the better, and continues use recovery from illness in 2 days.
11, prostatitis
Male patient's frequent micturition, urgent micturition, to urinate not smooth 5 days, take QIANLIEKANG poor effect.
With 2, the rectally preparation prepared by the embodiment of the present invention 1, carry out rectally, one day 2 times, grind powder with tongue ball 2 ball, clear water is applied to perineal position, 1 day 1 time outside being in harmonious proportion.After administration, the same day, symptom alleviated, 3 days transference cures.
Visible, of the present inventionly be prepared with LEMAHUI ZHUSHEYE the scheme that rectally preparation and Neulized inhalation preparation carry out administration, compared to prior art Lemahui Injection, to infectious disease, there is more outstanding therapeutic effect, and it is more extensive to be suitable for patients.
Detailed description of the invention
Embodiment 1
The rectally preparation of reining in the horse back described in the present embodiment with treatment infectious disease is made up of following methods: water intaking turnip 500g, decoct with water three times, 2 hours first times, second time 1 hour, 0.5 hour third time, collecting decoction, filter, filtrate is concentrated into every 1mL containing crude drug 1g, let cool, add alcohol settling secondary, first time makes alcohol content reach 60%, second time reaches 80%, leave standstill 24 hours respectively, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 6.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 15mL, stir evenly, inject water to 1000mL, filter, embedding, sterilizing, obtain.
Embodiment 2
The rectally preparation of reining in the horse back described in the present embodiment with treatment infectious disease is made up of following methods: water intaking turnip 400g, decoct with water three times, 3 hours first times, second time 0.5 hour, 0.8 hour third time, collecting decoction, filter, filtrate is concentrated into every 1mL containing crude drug 0.5g, let cool, add alcohol settling secondary, first time makes alcohol content reach 70%, second time reaches 70%, leave standstill 26 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 5.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 18mL, stir evenly, inject water to 800mL, filter, embedding, sterilizing, obtain.
Embodiment 3
The rectally preparation of reining in the horse back described in the present embodiment with treatment infectious disease is made up of following methods: water intaking turnip 600g, decoct with water three times, 1 hour first time, second time 1.5 hours, 0.3 hour third time, collecting decoction, filter, filtrate is concentrated into every 1mL containing crude drug 1.5g, let cool, add alcohol settling secondary, first time makes alcohol content reach 50%, second time reaches 90%, leave standstill 22 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 7.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 12mL, stir evenly, inject water to 1200mL, filter, embedding, sterilizing, obtain.
Embodiment 4
The Neulized inhalation preparation of reining in the horse back described in the present embodiment with treatment infectious disease is made up of following methods: water intaking turnip 500g, decoct with water three times, 2 hours first times, second time 1 hour, 0.5 hour third time, collecting decoction, filter, filtrate is concentrated into every 1mL containing crude drug 1g, let cool, add alcohol settling secondary, first time makes alcohol content reach 60%, second time reaches 80%, leave standstill 24 hours respectively, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 6.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 15mL, stir evenly, inject water to 1000mL, filter, embedding, sterilizing, obtain.
Embodiment 5
The Neulized inhalation preparation of reining in the horse back described in the present embodiment with treatment infectious disease is made up of following methods: water intaking turnip 400g, decoct with water three times, 3 hours first times, second time 0.5 hour, 0.8 hour third time, collecting decoction, filter, filtrate is concentrated into every 1mL containing crude drug 0.5g, let cool, add alcohol settling secondary, first time makes alcohol content reach 70%, second time reaches 70%, leave standstill 26 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 5.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 18mL, stir evenly, inject water to 800mL, filter, embedding, sterilizing, obtain.
Embodiment 6
The Neulized inhalation preparation of reining in the horse back described in the present embodiment with treatment infectious disease is made up of following methods: water intaking turnip 600g, decoct with water three times, 1 hour first time, second time 1.5 hours, 0.3 hour third time, collecting decoction, filter, filtrate is concentrated into every 1mL containing crude drug 1.5g, let cool, add alcohol settling secondary, first time makes alcohol content reach 50%, second time reaches 90%, leave standstill 22 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 7.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 12mL, stir evenly, inject water to 1200mL, filter, embedding, sterilizing, obtain.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (6)
1. a Lemahui Injection is for the preparation of the purposes of rectally preparation, it is characterized in that, described Lemahui Injection is prepared as follows: water intaking turnip 400-600 weight portion, decoct with water three times, first time 1-3 hour, second time 0.5-1.5 hour, third time 0.3-0.8 hour, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 0.5-1.5 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 50-70%, second time reaches 70-90%, leave standstill 22-26 hour, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 5.0-7.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 12-18 parts by volume, stir evenly, inject water to 800-1200 parts by volume, filter, embedding, sterilizing, obtain,
The pass of described weight portion and parts by volume is the relation of g/mL.
2. purposes according to claim 1, it is characterized in that, described Lemahui Injection is prepared as follows: water intaking turnip 500 weight portion, decoct with water three times, 2 hours first times, second time 1 hour, 0.5 hour third time, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 1 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 60%, second time reaches 80%, leave standstill 24 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 6.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 15 parts by volume, stir evenly, inject water to 1000 parts by volume, filter, embedding, sterilizing, obtain.
3. purposes according to claim 1 and 2, is characterized in that, the day application dosage of described rectally preparation is 4-12mL.
4. a Lemahui Injection is for the preparation of the purposes of Neulized inhalation preparation, it is characterized in that, described Lemahui Injection is prepared as follows: water intaking turnip 400-600 weight portion, decoct with water three times, first time 1-3 hour, second time 0.5-1.5 hour, third time 0.3-0.8 hour, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 0.5-1.5 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 50-70%, second time reaches 70-90%, leave standstill 22-26 hour, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 5.0-7.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 12-18 parts by volume, stir evenly, inject water to 800-1200 parts by volume, filter, embedding, sterilizing, obtain,
The pass of described weight portion and parts by volume is the relation of g/mL.
5. purposes according to claim 4, it is characterized in that, described Lemahui Injection is prepared as follows: water intaking turnip 500 weight portion, decoct with water three times, 2 hours first times, second time 1 hour, 0.5 hour third time, collecting decoction, filter, filtrate is concentrated into every 1 parts by volume containing crude drug 1 weight portion, let cool, add alcohol settling secondary, first time makes alcohol content reach 60%, second time reaches 80%, leave standstill 24 hours, discard precipitation, filter, filtrate recycling ethanol, with sodium hydroxide saturated aqueous solution adjust pH to 6.0, cold preservation, filter, filtrate continuation is heated to without alcohol taste, add benzyl alcohol 15 parts by volume, stir evenly, inject water to 1000 parts by volume, filter, embedding, sterilizing, obtain.
6. the purposes according to claim 4 or 5, is characterized in that, the day application dosage of described Neulized inhalation preparation is 4-10mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410567978.6A CN104383104A (en) | 2014-10-23 | 2014-10-23 | Application of bastard speedwell injection for preparing rectal administration preparation and aerosol inhalation preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410567978.6A CN104383104A (en) | 2014-10-23 | 2014-10-23 | Application of bastard speedwell injection for preparing rectal administration preparation and aerosol inhalation preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619975A (en) * | 2016-10-18 | 2017-05-10 | 王景 | Medicine injected at Zusanli acupoint for treating diabetic foot and preparation method of medicine |
| CN109157583A (en) * | 2018-11-02 | 2019-01-08 | 朗致集团万荣药业有限公司 | It reins in the horse back pharmaceutical preparation and preparation method thereof |
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| CN1634413A (en) * | 2004-10-29 | 2005-07-06 | 张平 | Bastard speedwell injection and preparation method thereof |
| CN1698785A (en) * | 2005-05-26 | 2005-11-23 | 北京正大绿洲医药科技有限公司 | Dripping pills of abastard speedwell and its preparation process |
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| CN1634413A (en) * | 2004-10-29 | 2005-07-06 | 张平 | Bastard speedwell injection and preparation method thereof |
| CN1698785A (en) * | 2005-05-26 | 2005-11-23 | 北京正大绿洲医药科技有限公司 | Dripping pills of abastard speedwell and its preparation process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619975A (en) * | 2016-10-18 | 2017-05-10 | 王景 | Medicine injected at Zusanli acupoint for treating diabetic foot and preparation method of medicine |
| CN109157583A (en) * | 2018-11-02 | 2019-01-08 | 朗致集团万荣药业有限公司 | It reins in the horse back pharmaceutical preparation and preparation method thereof |
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