NL2025730B1 - Compounds for treatment of sepsis - Google Patents
Compounds for treatment of sepsis Download PDFInfo
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- NL2025730B1 NL2025730B1 NL2025730A NL2025730A NL2025730B1 NL 2025730 B1 NL2025730 B1 NL 2025730B1 NL 2025730 A NL2025730 A NL 2025730A NL 2025730 A NL2025730 A NL 2025730A NL 2025730 B1 NL2025730 B1 NL 2025730B1
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- sepsis
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- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2025730A NL2025730B1 (en) | 2020-06-02 | 2020-06-02 | Compounds for treatment of sepsis |
| CA3185054A CA3185054A1 (en) | 2020-06-02 | 2021-06-02 | Chromanol, quinone or hydroquinone compounds for treatment of sepsis |
| US17/928,645 US20230202997A1 (en) | 2020-06-02 | 2021-06-02 | Chromanol, quinone or hydroquinone compounds for treatment of sepsis |
| AU2021284148A AU2021284148A1 (en) | 2020-06-02 | 2021-06-02 | Chromanol, quinone or hydroquinone compounds for treatment of sepsis |
| PCT/NL2021/050351 WO2021246868A1 (en) | 2020-06-02 | 2021-06-02 | Chromanol, quinone or hydroquinone compounds for treatment of sepsis |
| EP21730995.4A EP4157261A1 (en) | 2020-06-02 | 2021-06-02 | Chromanol, quinone or hydroquinone compounds for treatment of sepsis |
| JP2022574167A JP2023529612A (ja) | 2020-06-02 | 2021-06-02 | 敗血症の治療のためのクロマノール、キノン又はヒドロキノン化合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2025730A NL2025730B1 (en) | 2020-06-02 | 2020-06-02 | Compounds for treatment of sepsis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL2025730B1 true NL2025730B1 (en) | 2022-01-20 |
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| NL2025730A NL2025730B1 (en) | 2020-06-02 | 2020-06-02 | Compounds for treatment of sepsis |
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| EP (1) | EP4157261A1 (https=) |
| JP (1) | JP2023529612A (https=) |
| AU (1) | AU2021284148A1 (https=) |
| CA (1) | CA3185054A1 (https=) |
| NL (1) | NL2025730B1 (https=) |
| WO (1) | WO2021246868A1 (https=) |
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| NL2010010C2 (en) * | 2012-12-19 | 2014-06-23 | Sulfateq B V | Compounds for protection of cells. |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6231894B1 (en) * | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| WO2014011047A1 (en) | 2012-07-12 | 2014-01-16 | Khondrion B.V. | Chromanyl derivatives for treating mitochondrial disease |
| WO2014098586A1 (en) | 2012-12-19 | 2014-06-26 | Sulfateq B.V. | Compounds for protection of cells |
| WO2017060432A1 (en) | 2015-10-08 | 2017-04-13 | Khondrion Ip B.V. | Novel compounds for treating mitochondrial disease |
| WO2017220810A1 (en) | 2016-06-24 | 2017-12-28 | Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañón | Cilastatin for use in the treatment of sepsis |
| WO2019172766A1 (en) | 2018-03-08 | 2019-09-12 | Am-Pharma B.V. | Recombinant alkaline phosphatase for use in treating sepsis-associated acute kidney injury |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004045534A2 (en) * | 2002-11-15 | 2004-06-03 | Galileo Pharmaceuticals, Inc. | Chroman derivatives for the reduction of inflammation symptoms |
| MX388654B (es) * | 2015-05-22 | 2025-03-20 | Sulfateq Bv | Derivados de cromano y uso de los mismos en el tratamiento de daño en un órgano diabético, tal como un riñón. |
| SG11202003743SA (en) * | 2017-11-22 | 2020-06-29 | Khondrion Ip B V | Compounds as mpges-1 inhibitors |
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2020
- 2020-06-02 NL NL2025730A patent/NL2025730B1/en active
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2021
- 2021-06-02 EP EP21730995.4A patent/EP4157261A1/en active Pending
- 2021-06-02 US US17/928,645 patent/US20230202997A1/en active Pending
- 2021-06-02 WO PCT/NL2021/050351 patent/WO2021246868A1/en not_active Ceased
- 2021-06-02 AU AU2021284148A patent/AU2021284148A1/en active Pending
- 2021-06-02 CA CA3185054A patent/CA3185054A1/en active Pending
- 2021-06-02 JP JP2022574167A patent/JP2023529612A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6231894B1 (en) * | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| WO2014011047A1 (en) | 2012-07-12 | 2014-01-16 | Khondrion B.V. | Chromanyl derivatives for treating mitochondrial disease |
| WO2014098586A1 (en) | 2012-12-19 | 2014-06-26 | Sulfateq B.V. | Compounds for protection of cells |
| WO2017060432A1 (en) | 2015-10-08 | 2017-04-13 | Khondrion Ip B.V. | Novel compounds for treating mitochondrial disease |
| WO2017220810A1 (en) | 2016-06-24 | 2017-12-28 | Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañón | Cilastatin for use in the treatment of sepsis |
| WO2019172766A1 (en) | 2018-03-08 | 2019-09-12 | Am-Pharma B.V. | Recombinant alkaline phosphatase for use in treating sepsis-associated acute kidney injury |
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| FLEISCHMANN-STRUZEK ET AL., INTENSIVE CARE MED., 2018, Retrieved from the Internet <URL:https://doi.org/10.1007/s00134-018-5377-4> |
| GOTTSMATTHEY, BMJ, vol. 353, 2016, pages i1585 |
| RUDD ET AL., LANCET, vol. 395, 2020, pages 200 - 211 |
| SEYMOUR ET AL., N. ENGL. J. MED., vol. 376, 2017, pages 2235 - 2244 |
Also Published As
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| EP4157261A1 (en) | 2023-04-05 |
| US20230202997A1 (en) | 2023-06-29 |
| WO2021246868A1 (en) | 2021-12-09 |
| CA3185054A1 (en) | 2021-12-09 |
| JP2023529612A (ja) | 2023-07-11 |
| AU2021284148A1 (en) | 2022-12-08 |
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| Date | Code | Title | Description |
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| PD | Change of ownership |
Owner name: SULFATEQ B.V.; NL Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), ASSIGNMENT; FORMER OWNER NAME: SULFATEQ B.V. Effective date: 20221125 |