NL2020386B1 - Device for collecting a sample of blood. - Google Patents

Device for collecting a sample of blood. Download PDF

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Publication number
NL2020386B1
NL2020386B1 NL2020386A NL2020386A NL2020386B1 NL 2020386 B1 NL2020386 B1 NL 2020386B1 NL 2020386 A NL2020386 A NL 2020386A NL 2020386 A NL2020386 A NL 2020386A NL 2020386 B1 NL2020386 B1 NL 2020386B1
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Netherlands
Prior art keywords
lateral flow
strip
flow paper
blood
frame part
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NL2020386A
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Dutch (nl)
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Cornelis Wilhelmus Poland Dennis
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Labonovum B V
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Priority to NL2020386A priority Critical patent/NL2020386B1/en
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Publication of NL2020386B1 publication Critical patent/NL2020386B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

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  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Blood serum is used for many types of analyses and may provide useful insights into a state of health of a person of whom the blood serum belongs. Blood serum needs to be separated from blood, which in turn has to be collected from a person. A device is provided in which a strip of lateral flow paper may be placed. When a sample of blood is provided on a receiving section of the strip of lateral flow paper, due to capillary action, the blood is transported through the lateral flow paper. While being transported, the lateral flow paper acts a sieve in which amongst others red blood cells are trapped. Blood serum, and many constituents it holds, is not sieved and is therefor separated from the blood. The blood serum on the lateral flow paper may be used for analysis when dissolved in an extraction liquid.

Description

Title: Device for collecting a sample of blood.
TECHNICAL FIELD
The present invention relates to a device for collecting blood samples.
BACKGROUND
Examples of conventional ways of collecting a sample of blood are inserting a needle into a vein, and finger puncture or heel puncture sampling, wherein the skin is pierced with a lancet, and a small sample of blood may be collected in a capillary tube or on a piece of paper.
When collecting blood by inserting a needle into a vein, an unnecessarily large sample of blood is collected into a tube, which has to be stored under precise conditions and eventually has to be disposed of properly. A sample collected from a finger prick or heel prick sampling on paper allows for a smaller amount of analysis options, as the blood dries after collection.
From a collected blood sample, obtained by venepuncture, blood serum may be separated by allowing blood to clot and subsequently separated from the serum by centrifuging the blood. The blood serum then needs to be stored under specific conditions in order to prevent deterioration.
SUMMARY
It is preferred to provide a device for collecting small blood samples. Furthermore, it is preferred to provide a method for separating blood cells from serum, and for preserving the blood serum to be used lateron for analysis without the need for precisely conditioned storage.
A first aspect provides a device for collecting a blood sample, comprising an elongated frame, arranged to hold a strip of lateral flow paper. The device comprises: a first frame part, comprising an opening arranged to expose a receiving section of the strip of lateral flow paper such that the sample of blood can be provided directly to the receiving section through the opening; a second frame part, arranged to be connected to the first frame part to support the strip of lateral flow paper in the device between the first frame part and the second frame part. At least one of the first frame part and the second frame part comprises one or more support protrusions arranged to support the strip of lateral flow paper; and the first frame part and the second frame part are releasably connected, such that the strip of lateral flow paper may be removed from the device.
Lateral flow paper is paper comprising fibres oriented in a particular direction, parallel to one another. Such paper may comprise cellulose fibres constituting the paper and oriented glass fibres which glass fibres are provided parallel to one another. Such paper is used in pregnancy tests to allow liquid matter to flow towards markers that react with certain constituents resolved in the liquid.
In an embodiment of the device for collecting a blood sample, the second frame part is hingedly connected to the first frame part. The first frame part may comprise a scraping protrusion adjacent to the opening, arranged to increase the ease with which the sample of blood may be collected from a finger in which a small hole has been punctured.
A second aspect provides a method for separating blood serum from a sample of blood comprising providing the sample of blood to a receiving section a strip of lateral flow paper, wherein the lateral flow paper is arranged to transport the sample of blood from the receiving section through a separation section, wherein in the separation section blood cells are separated from the blood serum.
Lateral flow paper may be fragile and it’s effectiveness in separating blood serum from a sample of blood may be at least partially comprised when handled incorrectly. The device for collecting a blood sample is arranged to protect the lateral flow paper from incorrect handling, and to increase easy with which the sample of blood may be collected, by substantially enclosing the lateral flow paper. Incorrect handling may be applying to much pressure to the lateral flow paper, touching the paper with dirty or greasy fingers, accidentally tearing the paper, or any other form of handling which may comprise the working of the lateral flow paper.
The receiving section of the lateral flow paper may be provided with a larger thickness than the separating section to allow a larger sample of blood to be collected. The larger thickness may be achieved by folding part of the strip of lateral flow paper double at the receiving section.
BRIEF DESCRIPTION OF THE FIGURES
The various aspects and embodiments thereof will now be discussed in further detail. In the figures,
Fig. 1A shows a device for collecting a sample of blood.
Fig. IB shows the device in a closed position.
Fig. 2A shows a piano of another embodiment of the device.
Fig. 2B shows the device in an open position.
Fig. 2C shows the device in a closed position.
Fig. 2D shows the device with a strip of lateral flow paper on which a sample of blood has been provided.
DETAILED DESCRIPTION OF THE EMBODIMENTS
Fig. 1A shows an embodiment of a device 100 for collecting a sample of blood, comprising an elongated frame arranged to hold a strip of lateral flow paper. The elongated frame comprises a first frame part 110 and a second frame part 120. The first frame part 110 comprises a receiving opening 111, arranged to expose a receiving section of the strip of lateral flow paper. The receiving section is arranged to receive the sample of blood.
Blood serum provided in the sample of blood is transported through the lateral flow paper, during which the blood serum is separated from the sample of blood in a separation section of the strip of lateral flow paper as red blood cells are left behind during transportation. The separation section is provided adjacent to the receiving section of the strip of lateral flow paper, and both the receiving section and the separation section may be comprised by a one and the same strip of lateral flow paper.
The second frame part 120 is arranged to be connected to the first frame part 110 to support the strip of lateral flow paper in the device 100. The first frame part 110 and the second frame 120 may be releasably connected, such that the strip of lateral flow paper may be removed from the device 100, for example after the blood serum is separated from the sample of blood.
In the embodiment as shown in Fig. 1A, the first frame part 110 comprises laterally elongated protrusions at the receiving opening 111 as a first set of support protrusions 131. The second frame part 120 comprises laterally elongated protrusions as a second set of support protrusion 132. The first set of support protrusions 131 and the second set of support protrusions 132 are arranged to support at least a substantial part of the receiving section of the strip of lateral flow paper.
In the embodiment of the device 100 as shown in Fig. 1A, the first frame part 110 further comprises pins protruding from the first frame part 110 as a third set of support protrusions 133. The second frame part 120 further comprises pins protruding from the second frame part 120 as a fourth set of support protrusions 134. The pins comprised by the third set of support protrusions 133 and the fourth set of support protrusions 134 are arranged to support the strip of lateral flow paper with a minimal or at least very small contact area to optimize flow of the sample of blood through the lateral flow paper. The pins may therefor be arranged with a rounded of end, or as at least partially tapered pins, tapered away from the frame part from which the pins protrude, as to minimize the contact area between protrusions and the strip of lateral flow paper. A minimal contact area is to be understood as a contact area that is as small as possible to manufacture with, for example, an injection moulding system or, alternatively or additionally, is of such size that it has no or a negligible effect on a flow of blood serum through the strip of lateral flow paper.
In an embodiment of the device 100, at least part of the support protrusions comprised by the first frame part 110 and at least part of the support protrusions comprised by the second frame part 120 are aligned. The alignment is such that the strip of lateral flow paper is at both sides of the paper supported at the same area, which minimises a negative impact contact between the lateral flow paper and the support protrusions may have on the flow of blood serum through the strip of lateral flow paper.
The first set of support protrusions 131, second set of support protrusions 132, third set of support protrusions 133, and the fourth set of support protrusions 134 may comprises any number of protrusions, including only one protrusion, and the protrusions may have any shape. The protrusions may all have the same shape or different shapes. In a closed position of the device 100, the pins of the third set of support protrusions 133 are preferably provided substantially opposite to the pins of the fourth set of support protrusions 134.
Embodiments of the device 100 are envisioned comprising none, one or more of the first set of support protrusions 131, second set of support protrusions 132, third set of support protrusions 133, and the fourth set of support protrusions 134, in any combination thereof.
The first frame 110 in the embodiment of the device 100 as shown in Fig. 1A comprises the receiving opening 111, arranged to expose the receiving section of the strip of lateral flow paper such that the receiving section may receive the sample of blood. The receiving opening 111 is provided parallel to the lateral flow paper.
In a further embodiment of the device 100, the second frame part 120 comprises one or more through holes 121, arranged to expose one or more sections of the strip of lateral flow paper. The exposure is arranged to provide a fluid connection between the strip of lateral flow paper and ambient air, which allows the sample of blood and the separated blood serum to dry more quickly.
In the embodiment of the device 100 as shown in Fig. 1A, the first frame part 110 and the second frame part 120 are arranged to be hingedly connected. In the embodiment, a hinge line 101 is provided at the same side of the device 100 as the receiving opening 111. In an alternative embodiment of the device 100, the hinge line 101 is provided at a side opposite to the side at which the receiving opening 111 is provided. In an embodiment of the device 100 where the first frame part 110 and the second frame part 120 are hingedly connected, a first of the first frame part 110 and the second frame part 120 comprises one or more hinge protrusions. The hinge protrusions are arranged to engage with one or more hinge indentations provided by a second of the first frame part 110 and the second frame part 120. The hinge line 101 as a rotation axis over which the hinging movement may be performed is then parallel to a direction of protrusion of the one or more hinge protrusions.
To releasably connect the first frame part 110 and the second frame part 120, a first of the first frame part 110 and the second frame part 120 may be provided with one or more connection protrusions 141, arranged to mate with one or more connection indentations 142 provided by a second of the first frame part 110 and the second frame part 120. The fit between the connection protrusions 141 and the connection indentations 142 may be chosen such that the connection may be released. A separate tool may be provided with the device 100 arranged to help release the connection between the first frame part 110 and the second frame part 120.
An embodiment of the device 100 comprises the strip of lateral flow paper, a thickness of the receiving section of the strip of lateral flow paper has a larger thickness than the separation section of the strip of lateral flow paper. A larger thickness of the receiving section of the strip of lateral flow paper allows a larger sample of blood to be collected by the device 100. Only a certain amount of blood can be absorbed by the strip of lateral flow paper with a certain thickness before the blood leaks through the paper. Increasing the thickness increases the amount of blood that may be provided before the bloods leaks through the paper, and allows more blood serum to be extracted since more blood comprises more blood serum.
To accommodate the different thicknesses of the strip of lateral flow paper, the first set of support protrusions 131 and the second set of support protrusions 132 may be arranged with a smaller protruding length than the third set of support protrusions 133 and the fourth set of support protrusions 134.
Fig. IB shows the device 100 from Fig. 1A in a closed position, in which the device 100 is arranged to constrain the strip of lateral flow paper between the first frame part 110 and the second frame part 120.
In the device 100 as shown in Fig. IB, the first frame part 110 further comprises a scraping protrusion 114, protruding outwards away from the first frame part 110. The scraping protrusion 114 is provided adjacent to the receiving opening 111, and is arranged to collect at least part of the blood sample. The scraping protrusion 114 is arranged to scrape blood towards the receiving opening 111, such that the scraped blood may be provided to the receiving section of the strip of lateral flow paper. When the blood is to be collected from a finger, the scraping protrusion 114 may be provided in a shape substantially corresponding to at least part of a shape of a tip of the finger.
In an embodiment of the device 100, the first frame part 110 further comprises an optional viewing opening 112, arranged to expose a pre-determined part of the strip of lateral flow paper. The exposure allows the pre-determined part of the strip of lateral flow paper to be viewable by a user of the device 100. As a certain pre-determined volume of blood is received by the receiving section of the lateral flow paper, the predetermined part of the strip of lateral flow paper will be coloured by virtue of red blood cells present in the received blood. The colouring of the predetermined part of the strip of lateral flow paper may indicate to the user that a sufficient amount of blood has been received by the device 100.
Fig. 2A shows a piano 200 for an embodiment of the device 100 for collecting a blood sample. Dashed lines indicate folding lines over which the piano 200 may be folded to form the device 100 as shown in Fig. 2B. Dashdotted lines indicate weakened lines over which the device 100 may be torn. The piano 200 comprises a first section 211 and a second section 212, which are arranged to be folded into the first frame part 110 as shown in Fig. 2B. The piano 200 further comprises a third section 213, a fourth section 214 and a fifth section 215, which are arranged to be folded into the second frame part 120 as shown in Fig. 2B.
The piano 200 is preferably one and the same piece of material, in which the material may be paper, cardboard, any other material, or any combination thereof. The folding lines, shown as dashed line in Fig. 2A, may be provided as weakened sections to increase ease of folding. After folding the piano 200 into the shape as shown in Fig. 2B, the first section 211 and the second section 212 may be connected. Similarly, any combination of the third section 213, the fourth section 214 and the fifth section 215 may be connected in order to maintain the shape of the device 100 as shown in Fig. 2B after folding. The connection may be applied using for example glue, tape, a clamping device such as a paper clip, any other connection method or any combination thereof.
The first section 211 and the section 212 comprise the receiving opening 111 and the viewing opening 112. The third section 213 comprises the fourth set of protrusions 134, which may be provided by embossing areas of the third section 213 adjacent to the protrusions of the fourth set of protrusions 134. The fourth section 214 comprises the second set of protrusions 132. The protrusions may be formed by removing a layer of the material of the piano 200 or by depressing areas adjacent to the intended locations of the protrusions. In Figure 2 B, the rectangles adjacent to the protrusions of the fourth set of protrusions 134 indicate depressed or compressed areas of material.
The device 100 as shown in Fig. 2B comprises the first frame part 110 and the second frame part 120, which are arranged to be folded towards each other over hinge line 101. The device 100 as shown in Fig. 2B is shown in an open position, arranged to be provided with the strip of lateral flow paper. To constrain the strip of lateral flow paper, the first frame part 110 and the second frame part 120 may be hinged into a closed position over the hinge line 101. In the closed position the strip of lateral flow paper is supported between the first frame part 110 and the second frame part 120. To connect the first frame part 110 and the second frame part 120 in the closed position, glue, tape, a clamping device such as a paperclip, any other connection method or a combination thereof may be used.
Fig. 2C shows an embodiment of the device 100 based on the piano 200 of Fig. 2A in the closed position, in which the strip of lateral flow paper may be substantially enclosed by the device 100. At least part of the receiving section of the strip of lateral flow paper is exposed via the receiving opening 111.
The enclosed strip of lateral flow paper is provided on the second set of protrusions 132 and fourth set of protrusions 134 comprised by the second frame part 120, provided underneath the first frame part 110 in Fig. 2C. The receiving opening 111 exposes at least part of the receiving section of the strip of lateral flow paper, and the viewing opening 112 exposes a predetermined part of the strip of lateral flow paper.
Fig. 2D shows the device 100 provided with a strip of lateral flow paper 300, on which on a receiving section 301 a sample of blood is provided. As the blood serum is transported through the strip of lateral flow paper 300, in Fig. 2D from left to right, red blood cells, in Fig. 2D shown as a shaded section, are left behind. Part of the separation section 302 of the strip of lateral flow paper is visible through the viewing opening 112, making also the progress of the separation process visible.
Part of the device 100 may be removed from the rest over the device by breaking off the device at the weakened section 150. This allows the strip of lateral flow paper 300 to be removed from the device 100 for further processing.
In the embodiments of the device 100 as shown in Figs. 2A, 2B, 2C and 2D, the viewing opening 112 is arranged to expose a pre-determined part of the strip of lateral flow paper, such that at least part of the predetermined part of the strip of lateral flow paper may be viewable by the user of the device 100. The viewability of the pre-determined part of the strip of lateral flow paper may provide an indication to the user of the volume of the sample of blood that has been provided to the receiving section of the strip of lateral flow paper.
The first frame part 110 may be provided with one or more markings to further indicate the volume of blood which has been provided to the receiving section. The markings may indicate a specific volume, whether a sufficient amount of blood has been provided, or a combination thereof. The exposure of the pre-determined part of the strip of lateral flow paper further decreases the contact area between the device 100 and the strip of lateral flow paper, which may increase the flow of blood through the strip of lateral flow paper.
In an alternative embodiment of the device 100, the receiving opening 111 is provided substantially perpendicular to the strip of lateral flow paper, such that at least part of the receiving section of the strip of lateral flow paper may protrude from the device 100. In yet another embodiment of the device 100, the device comprises a lid arranged to substantially seal off or at least substantially close the receiving opening
111.
The larger thickness of the receiving section of the strip of lateral flow paper may be provided in the production process of the strip of lateral flow paper. Alternatively, a strip of substantially uniform thickness may be provided in the device 100, of which part of the strip is provided over the hinge line between the first frame part 110 and the second frame part 120 when the first frame part 110 and the second frame part 120 are in the open position. When hinging the first frame part 110 relative to the second frame part 120, the part of the strip which is provided over the hinge line will be folded double, and herewith provided the increased thickness of the strip of lateral flow paper. Alternatively, the strip of lateral flow paper may be folded before being placed in the device 100.
In the embodiment of Figure 2 B, a first set of support protrusions is omitted compared to the embodiment shown by Figure 1 A. When the strip of lateral flow paper is to be folded double, the second set of support protrusions 132 may be arranged to clamp the strip to the first frame part 110 and in particular the part of the first frame part 110 surrounding the receiving opening 111 such that a substantial part of the folded part is pressed onto the strip to provided a fluid connection between the folded part and the strip of lateral flow paper. In another embodiment similar to that of Figure 2 B, the first set of support protrusions may be provided, in any way.
At least a part of at least one of the first frame part 110 and the second frame part 120 may be provided at least partially transparent, such that a pre-determined part of the strip of lateral flow paper provided in the device 100 may be viewable by the user of the device. In such an embodiment, the user may view the progression of the separation of the blood serum from the sample of blood, view the amount of blood provided to the strip of lateral flow paper, or a combination thereof.
An embodiment of the device is also envisioned wherein the device is arranged to hold a different shape of lateral flow paper, such as a square, rectangle, circle, or any other shape.
In an embodiment of the strip of lateral flow paper, the receiving section and the separation section are comprised by two individual strips of lateral flow paper which when provided in the device are arranged in a fluid connection such that at least part of the sample of blood may flow from the receiving section to the separation section.
In summary, blood serum is used for many types of analyses and may provide useful insights into a state of health of a person of whom the blood serum belongs. Blood serum needs to be separated from blood, which in turn has to be collected from a person. A device is provided in which a strip of lateral flow paper may be placed. When a sample of blood is provided on a receiving section of the strip of lateral flow paper, due to capillary action, the blood is transported through the lateral flow paper. While being transported, the lateral flow paper acts a sieve in which amongst others red blood cells are trapped. Blood serum, and many constituents it holds, is not sieved and is therefor separated from the blood. The blood serum on the lateral flow paper may be used for analysis when dissolved in an extraction liquid.
As such, the application may be further summarised, in a nonlimitative way, by means of the following numbered embodiments:
1. Device for collecting a sample of blood, comprising: An elongated frame, arranged to hold a strip of lateral flow paper, comprising:
A first frame part, comprising a receiving opening arranged to expose a receiving section of the strip of lateral flow paper such that the sample of blood can be provided directly to the receiving section through the receiving opening;
A second frame part, arranged to be connected to the first frame part to support the strip of lateral flow paper in the device between the first frame part and the second frame part;
wherein
At least one of the first frame part and the second frame part comprises one or more support protrusions arranged to support the strip of lateral flow paper; and
The first frame part and the second frame part are connected such that the strip of lateral flow paper may be removed from the device.
2. Device according to embodiment 1, wherein at least part of the support protrusions are arranged as laterally elongated protrusions provided at the receiving opening by the second frame part.
3. Device according to any of the previous embodiments, wherein at least part of the support protrusions is provided by the first frame part adjacent to the opening, wherein these support protrusions are arranged as laterally elongated protrusions.
4. Device according to any of the previous embodiments, wherein the second frame part is hingedly connected to the first frame part.
5. Device according to any of the previous embodiments, wherein at least part of the support protrusions are provided perpendicular to the lateral direction of the strip of lateral flow paper.
6. Device according to any of the previous embodiments, wherein at least part of the support protrusions are provided as pins, arranged to support the strip of lateral flow paper with a minimal contact area.
7. Device according to any of the previous embodiments, wherein the first frame part comprises a scraping protrusion adjacent to the opening.
8. Device according to any of the previous embodiments, wherein the first frame part comprises a viewing opening, arranged to expose a pre-determined part of the strip of lateral flow paper.
9. Device according to any of the previous embodiments, wherein the second frame part comprises one or more through holes, arranged to expose one or more parts of the strip of lateral flow paper.
10. Device according to any of the previous embodiments, wherein the frame comprises a weakened section, arranged to be removed from the frame, wherein with this removal, the strip may be removed from the device.
11. Device according to any of the previous embodiments, comprising the strip of lateral flow paper.
12. Device according to embodiment 11, wherein the receiving section of the strip of lateral flow paper has a larger thickness than a separation section of the strip of lateral flow paper.
13. Device according to embodiment 12, wherein the larger thickness of the strip of lateral flow paper at the receiving section is arranged by a section of the strip of lateral flow paper which is folded double.
14. Method of separating blood serum from a sample of blood comprising providing the sample of blood to a receiving section a strip of lateral flow paper, wherein the lateral flow paper is arranged to transport the sample of blood from the receiving section through a separation section, wherein in the separation section red blood cells are separated from the blood serum.
In the description above, it will be understood that when an element such as layer, region or substrate is referred to as being “on” or “onto” another element, the element is either directly on the other element, or intervening elements may also be present. Also, it will be understood that the values given in the description above, are given by way of example and that other values may be possible and/or may be strived for.
Furthermore, the invention may also be embodied with less components than provided in the embodiments described here, wherein one component carries out multiple functions. Just as well may the invention be embodied using more elements than depicted in the Figures, wherein functions carried out by one component in the embodiment provided are distributed over multiple components.
It is to be noted that the figures are only schematic representations of embodiments of the invention that are given by way of non-limiting examples. For the purpose of clarity and a concise description, features are described herein as part of the same or separate embodiments, however, it will be appreciated that the scope of the invention may include embodiments having combinations of all or some of the features described. The word ‘comprising’ does not exclude the presence of other features or steps than those listed in a claim. Furthermore, the words 'a' and 'an' shall not be construed as limited to 'only one', but instead are used to mean 'at least one', and do not exclude a plurality.
A person skilled in the art will readily appreciate that various parameters and values thereof disclosed in the description may be modified and that various embodiments disclosed and/or claimed may be combined without departing from the scope of the invention.
It is stipulated that the reference signs in the claims do not limit the scope of the claims, but are merely inserted to enhance the legibility of the claims.

Claims (12)

ConclusiesConclusions 1. 1. Apparaat voor het verzamelen van een bloedmonster, omvattende: een langgerekt frame, ingericht om een strip lateraalstroompapier vast te houden, omvattende: een eerste framedeel, omvattende een ontvangstopening ingericht om een ontvangstsectie van de strip lateraalstroompapier bloot te stellen zodat het bloedmonster kan direct kan worden voorzien op de ontvangstsectie door de ontvangstopening; een tweede framedeel, ingericht om verbonden te worden aan het eerste framedeel om de strip lateraalstroompapier te ondersteunen in het apparaat tussen het eerste framedeel en het tweede framedeel; Apparatus for collecting a blood sample, comprising: an elongated frame adapted to hold a strip of lateral flow paper, comprising: a first frame portion, comprising a receiving opening adapted to expose a receiving section of the lateral flow paper strip so that the blood sample can be directly provided on the receiving section through the receiving opening; a second frame portion adapted to be connected to the first frame portion to support the lateral flow paper strip in the apparatus between the first frame portion and the second frame portion; Waarin In which ten minste een van het eerste framedeel en het tweede framedeel een of meerdere ondersteuningsuitsteeksels omvat ingericht om de strip lateraalstroompapier te ondersteunen; en het eerste framedeel en het tweede framedeel losneembaar verbonden zijn, zodanig dat de strip lateraalstroompapier verwijderd kan worden van het apparaat. at least one of the first frame member and the second frame member comprises one or more support protrusions adapted to support the lateral flow paper strip; and the first frame part and the second frame part are releasably connected, such that the lateral flow paper strip can be removed from the device. 2. 2. Apparaat volgens conclusie 1, waarin ten minste een deel van de ondersteuningsuitsteeksels zijn ingericht als lateraal uitgerekte uitsteeksel voorzien bij de ontvangstopening door het tweede framedeel. Apparatus as claimed in claim 1, wherein at least a portion of the support protrusions are arranged as laterally elongated protrusions provided at the receiving opening through the second frame portion. 3. 3. Apparaat volgens een van de voorgaande conclusies, waarin ten minste deel van de ondersteuningsuitsteeksels voorzien zijn door het eerste framedeel nabij de ontvangstopening, waarin deze Apparatus as claimed in any of the foregoing claims, wherein at least part of the support protrusions are provided by the first frame part near the receiving opening, in which these
ondersteuningsuitsteeksels zijn ingericht als lateraal uitgerekte uitsteeksels.support protrusions are arranged as laterally elongated protrusions. 4. Apparaat volgens een van de voorgaande conclusies, waarin het tweede framedeel scharnierbaar bevestigd is aan het eerste framedeel.Apparatus as claimed in any of the foregoing claims, wherein the second frame part is hinged to the first frame part. 5. Apparaat volgens een van de voorgaande conclusies, waarin ten minste deel van de ondersteuningsuitsteeksels loodrecht voorzien zijn op de laterale richting van de strip lateraalstroompapier.Apparatus according to any of the preceding claims, wherein at least part of the support protrusions are provided perpendicular to the lateral direction of the strip of lateral flow paper. 6. Apparaat volgens een van de voorgaande conclusies, waarin ten minste deel van de ondersteuningsuitsteeksels voorzien zijn als pennen, ingericht om de strip lateraalstroompapier te ondersteunen met een minimaal contactoppervlakte.Apparatus as claimed in any one of the preceding claims, wherein at least part of the support protrusions are provided as pins adapted to support the strip of lateral flow paper with a minimum contact surface. 7. Apparaat volgens een van de voorgaande conclusies, waarin het eerste framedeel een schraapuitsteeksel omvat nabij de ont van gstop enin g.Apparatus as claimed in any one of the preceding claims, wherein the first frame part comprises a scraper protrusion near the receiving plug and socket. 8. Apparaat volgens een van de voorgaande conclusies, waarin het eerste framedeel een kijkopening omvat, ingericht om een vooraf bepaald deel van de strip lateraalstroompapier bloot te stellen.An apparatus according to any preceding claim, wherein the first frame portion comprises a viewing opening adapted to expose a predetermined portion of the lateral flow paper strip. 9. Apparaat volgens een van de voorgaande conclusies, waarin het tweede framedeel een of meerdere gaten omvat, ingericht om een of meerdere delen van de strip lateraalstroompapier bloot te stellen.An apparatus according to any one of the preceding claims, wherein the second frame portion comprises one or more holes adapted to expose one or more portions of the lateral flow paper strip. 10. Apparaat volgens een van de voorgaande conclusies, waarin het langgerekte frame een verzwakte sectie omvat, ingericht om verwijderd te worden van het langgerekte frame, waarin met dit verwijderen, de strip lateraalstroompapier van het apparaat verwijderd kan worden.Apparatus according to any of the preceding claims, wherein the elongated frame comprises a weakened section adapted to be removed from the elongated frame, wherein with this removal, the strip of lateral flow paper can be removed from the apparatus. 11. Apparaat volgens een van de voorgaande conclusies, omvattende de strip lateraalstroompapier.Device according to any of the preceding claims, comprising the strip of lateral flow paper. 12. Apparaat volgens conclusie 11, waarin de ontvangstsectie van de strip lateraalstroompapier een grotere dikte heeft dan een scheidingssectie van de strip lateraalstroompapier.The apparatus of claim 11, wherein the receiving section of the lateral flow paper strip has a greater thickness than a separation section of the lateral flow paper strip. 13. Apparaat volgens conclusie 12, waarin de grotere dikte van de strip lateraalstroompapier bij de ontvangstsectie is voorzien door een dubbelgevouwen deel van de strip lateraalstroompapier.The apparatus of claim 12, wherein the greater thickness of the lateral flow paper strip at the receiving section is provided by a folded portion of the lateral flow paper strip. 14. Werkwijze voor het scheiden van bloedserum van een bloedmonster omvattende voorzien van het bloedmonster aan een ontvangstsectie van een strip lateraalstroompapier, waarin het lateraalstroompapier is ingericht om het bloedmonster van de ontvangstsectie door een scheidingssectie te transporteren, waarin in de scheidingssectie rode bloedcellen worden gescheiden van het bloedserum.A method for separating blood serum from a blood sample comprising providing the blood sample on a receiving section of a strip of lateral flow paper, wherein the lateral flow paper is adapted to transport the blood sample from the receiving section through a separation section, wherein in the separation section red blood cells are separated from the blood serum.
NL2020386A 2018-02-06 2018-02-06 Device for collecting a sample of blood. NL2020386B1 (en)

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NL2025535B1 (en) 2020-05-08 2021-11-23 Labonovum B V Processing of dried blood samples on lateral flow paper
NL2025534B1 (en) 2020-05-08 2021-11-23 Labonovum B V Collecting of blood and processing of dried blood samples

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WO2021225446A1 (en) 2020-05-08 2021-11-11 Labonovum B.V. Processing of dried blood samples on lateral flow paper
NL2025535B1 (en) 2020-05-08 2021-11-23 Labonovum B V Processing of dried blood samples on lateral flow paper
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