NL181552C - Werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten met prostaglandine-achtige eigenschappen, aldus bereid of vervaardigd gevormd preparaat alsmede werkwijze voor de bereiding van hiervoor geschikte hepteenzuurderivaten. - Google Patents

Werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten met prostaglandine-achtige eigenschappen, aldus bereid of vervaardigd gevormd preparaat alsmede werkwijze voor de bereiding van hiervoor geschikte hepteenzuurderivaten.

Info

Publication number
NL181552C
NL181552C NLAANVRAGE7410487,A NL7410487A NL181552C NL 181552 C NL181552 C NL 181552C NL 7410487 A NL7410487 A NL 7410487A NL 181552 C NL181552 C NL 181552C
Authority
NL
Netherlands
Prior art keywords
preparation
prepared
prostaglandine
divine
manufacture
Prior art date
Application number
NLAANVRAGE7410487,A
Other languages
English (en)
Other versions
NL181552B (nl
NL7410487A (nl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7410487A publication Critical patent/NL7410487A/nl
Publication of NL181552B publication Critical patent/NL181552B/nl
Application granted granted Critical
Publication of NL181552C publication Critical patent/NL181552C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0058—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a not condensed ring different from a five-membered ring
    • C07C405/0066—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a not condensed ring different from a five-membered ring to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C07C53/21—Acids containing three or more carbon atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/38—Acyl halides
    • C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
    • C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/143—Esters of phosphorous acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
NLAANVRAGE7410487,A 1973-08-06 1974-08-05 Werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten met prostaglandine-achtige eigenschappen, aldus bereid of vervaardigd gevormd preparaat alsmede werkwijze voor de bereiding van hiervoor geschikte hepteenzuurderivaten. NL181552C (nl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38611773A 1973-08-06 1973-08-06
US05/480,458 US4052446A (en) 1973-08-06 1974-06-18 11,16-substituted prostaglandins
US06/026,125 US4226985A (en) 1973-08-06 1979-04-02 11-Substituted prostaglandins

Publications (3)

Publication Number Publication Date
NL7410487A NL7410487A (nl) 1975-02-10
NL181552B NL181552B (nl) 1987-04-16
NL181552C true NL181552C (nl) 1987-09-16

Family

ID=27362698

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7410487,A NL181552C (nl) 1973-08-06 1974-08-05 Werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten met prostaglandine-achtige eigenschappen, aldus bereid of vervaardigd gevormd preparaat alsmede werkwijze voor de bereiding van hiervoor geschikte hepteenzuurderivaten.

Country Status (10)

Country Link
US (2) US4052446A (nl)
JP (1) JPS5817746B2 (nl)
AT (1) AT347609B (nl)
BE (1) BE818487A (nl)
CA (1) CA1060888A (nl)
CH (2) CH602627A5 (nl)
DE (1) DE2437622C2 (nl)
FR (3) FR2239998B1 (nl)
GB (3) GB1485946A (nl)
NL (1) NL181552C (nl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218565A (en) * 1972-07-24 1980-08-19 American Cyanamid Company Novel 11-deoxy-11-substituted prostaglandins of the E and F series
US4187381A (en) * 1973-08-06 1980-02-05 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4237276A (en) * 1974-06-18 1980-12-02 Hoffmann-La Roche Inc. Bicyclic lactone intermediates for 16-substituted prostaglandins
US3950363A (en) * 1975-03-10 1976-04-13 The Upjohn Company Prostaglandin cyclic ethers
US3996263A (en) * 1975-05-05 1976-12-07 Sankyo Company Limited 9-Oxo-11α-methyl-15Ε-hyroxyprost-13(trans)-enoic acid derivatives and process for the preparaion thereof
IN143632B (nl) * 1975-07-30 1978-01-07 Ici Ltd
US4144251A (en) * 1976-03-02 1979-03-13 American Home Products Corporation 5-Unsaturated prostanoic acid derivatives
PT67818A (en) * 1977-03-28 1978-04-01 Union Carbide Corp Process for the synthesis of biocidal 2-aryl-1,3-cycloalkanedionas and their enol esters
US4204074A (en) * 1977-07-05 1980-05-20 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4325970A (en) * 1980-10-09 1982-04-20 Hoffmann-La Roche Inc. 15-Acetyl-prostaglandins
US4310543A (en) * 1980-10-09 1982-01-12 Hoffmann-La Roche Inc. Prostaglandin compositions
US4568762A (en) * 1981-07-01 1986-02-04 Hoffmann-La Roche Inc. 4-Methyl-2-oxo-cyclopentylidene acetic acid and esters thereof
US4477684A (en) * 1982-06-23 1984-10-16 The Upjohn Company 11-Deoxy-11α-alkyl-PGE compounds from PGA compounds by lithium alkylation
US4739078A (en) * 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
US5057621A (en) * 1984-07-31 1991-10-15 Syntex (U.S.A.) Inc. 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4681962A (en) * 1985-06-24 1987-07-21 Hoffmann-La Roche Inc. Novel 7-fluoro-dihydro PGI compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (nl) * 1970-06-10 1975-02-04
US3903131A (en) * 1971-04-12 1975-09-02 Upjohn Co 16 and 16,16-dimethyl PGE{HD 2{B
US3849474A (en) * 1972-03-27 1974-11-19 Ayerst Mckenna & Harrison 11-deoxyprostaglandin derivatives and process therefor
US3816343A (en) * 1972-04-24 1974-06-11 Nl Industries Inc Kaolinite coated with synthesized layer-type silicate minerals
DE2317019A1 (de) * 1972-04-27 1973-11-08 Upjohn Co Neue 4,5-didehydro-prostaglandine
GB1396207A (en) * 1972-04-27 1975-06-04 Upjohn Co Prostaglandin intermediates and the preparation thereof
US4141914A (en) * 1972-07-24 1979-02-27 American Cyanamid Company Novel 11-deoxy-11-substituted prostaglandins of the E and F series
US3873607A (en) * 1972-07-24 1975-03-25 American Cyanamid Co 3-Oxa(and thia) 11-deoxy PGE
US3845042A (en) * 1972-08-21 1974-10-29 American Home Prod 11-substituted-prostaglandin derivatives
CH608012A5 (en) * 1972-10-25 1978-12-15 Hoffmann La Roche Process for the preparation of lactones
DE2317660A1 (de) * 1973-04-07 1974-10-24 Berstorff Gmbh Masch Hermann Fuenf-walzen-kalander

Also Published As

Publication number Publication date
ATA638274A (de) 1978-05-15
DE2437622A1 (de) 1975-02-27
BE818487A (fr) 1975-02-05
GB1485946A (en) 1977-09-14
DE2437622C2 (de) 1984-05-30
FR2239998B1 (nl) 1978-11-10
AT347609B (de) 1979-01-10
FR2296631B1 (nl) 1979-09-28
JPS5070341A (nl) 1975-06-11
JPS5817746B2 (ja) 1983-04-09
US4226985A (en) 1980-10-07
FR2296632B1 (nl) 1979-04-20
GB1485291A (en) 1977-09-08
FR2296632A1 (fr) 1976-07-30
CH614193A5 (nl) 1979-11-15
US4052446A (en) 1977-10-04
FR2296631A1 (fr) 1976-07-30
FR2239998A1 (nl) 1975-03-07
CH602627A5 (nl) 1978-07-31
NL181552B (nl) 1987-04-16
NL7410487A (nl) 1975-02-10
CA1060888A (en) 1979-08-21
GB1485292A (en) 1977-09-08

Similar Documents

Publication Publication Date Title
NL7503696A (nl) Werkwijze ter vervaardiging van farmaceutische preparaten, alsmede de aldus gevormde voort- brengselen.
NL7503754A (nl) Werkwijze voor de bereiding van anilidederiva- ten, alsmede met toepassing hiervan bereide microbicide preparaten.
NL7506675A (nl) Werkwijze ter bereiding van alkanolaminederivaten, werkwijze ter vervaardiging van farmaceutische pre- paraten hiermede, alsmede de aldus vervaardigde voortbrengselen.
NL7508197A (nl) Werkwijze voor het bereiden van n-methylcarba- minezuurderivaten, werkwijze voor het bereiden van een insecticide preparaat alsmede het aldus verkregen gevormde preparaat.
NL154500B (nl) Werkwijze ter bereiding van 2-cyclohexeen-1-on-derivaten en van herbicide preparaten, die deze bevatten.
NL181552C (nl) Werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten met prostaglandine-achtige eigenschappen, aldus bereid of vervaardigd gevormd preparaat alsmede werkwijze voor de bereiding van hiervoor geschikte hepteenzuurderivaten.
NL7415174A (nl) Werkwijze ter bereiding van nieuwe verbindingen, werkwijze ter vervaardiging van farmaceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL158701B (nl) Werkwijze voor de bereiding van nitroglycerol bevattende mengsels, werkwijze voor de bereiding van farmaceutische preparaten die deze mengsels bevatten en de aldus verkregen gevormde farmaceutische preparaten.
NL7415925A (nl) Werkwijze voor de bereiding van bekledingssa- menstellingen en gevormde voortbrengselen, ver- vaardigd onder toepassing van de aldus bereide bekledingssamenstellingen.
NL7505140A (nl) Werkwijze ter bereiding van morfolinederivaten, werkwijze ter vervaardiging van farmaceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL180585C (nl) Werkwijze voor de bereiding van oxim-ethers, alsmede werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten die deze bevatten.
NL7508706A (nl) Werkwijze ter bereiding van pyrazofurinederivaten, alsmede werkwijze ter bereiding van farmaceutische preparaten.
NL185841C (nl) Werkwijze ter bereiding van farmaceutische preparaten en werkwijze ter bereiding van voor toepassing daarbij geschikte 5-mercaptopyridoxinederivaten.
NL172446C (nl) Werkwijze voor de bereiding van 4-aryl-1-(4.4-diarylbutyl)4-hydroxypiperidinen en werkwijze voor de bereiding van farmaceutische preparaten.
NL182224C (nl) Werkwijze ter bereiding van steroiden, alsmede van farmaceutische preparaten, die deze steroiden bevatten en de aldus verkregen gevormde farmaceutische preparaten.
NL166018C (nl) Werkwijze ter bereiding van een farmaceutisch pre- paraat, alsmede onder toepassing van deze werkwijze verkregen gevormde preparaten en werkwijze ter berei- ding van daarvoor geschikte verbindingen.
NL174462C (nl) Werkwijze voor de bereiding van farmaceutische preparaten met werking tegen schimmels en bacterien, en werkwijze voor de bereiding van daarbij toe te passen fenethylimidazolen.
NL7705680A (nl) Werkwijze ter bereiding van gesubstitueerde fenylacetylenen, werkwijze ter vervaardiging van farmaceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL7609266A (nl) Werkwijze ter bereiding van hydroxyzuren, werk- wijze ter vervaardiging van farmaceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL175063C (nl) Werkwijze ter bereiding van 11,11-alkylideensteroiden, werkwijze ter bereiding van farmaceutische preparaten en gevormde farmaceutische preparaten.
NL7412208A (nl) Werkwijze voor de bereiding van van gesubstitu- eerde gamma-hydroxylactonen afgeleide carbama- ten, alsmede de bereiding van geneeskundige pre- paraten met toepassing daarvan en de zo verkre- gen preparaten.
NL187164C (nl) Werkwijze ter bereiding van een farmaceutisch preparaat met anti-fertiliteitswerking, aldus verkregen gevormde preparaten, alsmede werkwijze ter bereiding van daarin toegepaste aroylfenylnaftaleenverbindingen.
NL7601418A (nl) Werkwijze voor de bereiding van geneesmiddelen met maagzweergenezende werking, een dergelijk geneesmiddel en werkwijze voor de bereiding van de werkzame verbindingen.
NL144923B (nl) Werkwijze voor de bereiding van een nalfa-gesubstitueerd 2-0-methyloxytocinederivaat, werkwijze ter bereiding van farmaceutische preparaten en gevormde preparaten.
NL7505202A (nl) Werkwijze voor de bereiding van een farmaceutisch preparaat en aldus verkregen gevormde farmaceu- tische preparaten.

Legal Events

Date Code Title Description
BC A request for examination has been filed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee