NL156140B - PREPARATION OF RACEMIC OR OPTICALLY ACTIVE (+) - CIS-1,3-DIBENZYL-HEXAHYDRO-1H-THIENO (3,4-D) IMIDAZOLE-2,4-DIONE AND / OR OF (+) - BIOTIN. - Google Patents

PREPARATION OF RACEMIC OR OPTICALLY ACTIVE (+) - CIS-1,3-DIBENZYL-HEXAHYDRO-1H-THIENO (3,4-D) IMIDAZOLE-2,4-DIONE AND / OR OF (+) - BIOTIN.

Info

Publication number
NL156140B
NL156140B NL7015567.A NL7015567A NL156140B NL 156140 B NL156140 B NL 156140B NL 7015567 A NL7015567 A NL 7015567A NL 156140 B NL156140 B NL 156140B
Authority
NL
Netherlands
Prior art keywords
thieno
dibenzyl
hexahydro
dione
racemic
Prior art date
Application number
NL7015567.A
Other languages
Dutch (nl)
Other versions
NL7015567A (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7015567A publication Critical patent/NL7015567A/xx
Publication of NL156140B publication Critical patent/NL156140B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NL7015567.A 1969-11-29 1970-10-23 PREPARATION OF RACEMIC OR OPTICALLY ACTIVE (+) - CIS-1,3-DIBENZYL-HEXAHYDRO-1H-THIENO (3,4-D) IMIDAZOLE-2,4-DIONE AND / OR OF (+) - BIOTIN. NL156140B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1777369A CH556867A (en) 1969-11-29 1969-11-29 PROCESS FOR MANUFACTURING A RACEMIC OR OPTICALLY ACTIVE THIOLACTONE.

Publications (2)

Publication Number Publication Date
NL7015567A NL7015567A (en) 1971-06-02
NL156140B true NL156140B (en) 1978-03-15

Family

ID=4428001

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7015567.A NL156140B (en) 1969-11-29 1970-10-23 PREPARATION OF RACEMIC OR OPTICALLY ACTIVE (+) - CIS-1,3-DIBENZYL-HEXAHYDRO-1H-THIENO (3,4-D) IMIDAZOLE-2,4-DIONE AND / OR OF (+) - BIOTIN.

Country Status (10)

Country Link
US (1) US3740416A (en)
JP (1) JPS5327279B1 (en)
BE (1) BE759513A (en)
CA (1) CA982591A (en)
CH (1) CH556867A (en)
DK (1) DK154563C (en)
FR (1) FR2077540B1 (en)
GB (2) GB1320799A (en)
NL (1) NL156140B (en)
SE (1) SE391928B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054740A (en) * 1974-12-24 1977-10-18 Hoffmann-La Roche Inc. Hydroxybiotin
US4228295A (en) * 1977-02-23 1980-10-14 Hoffmann-La Roche Inc. Novel cycloheptathiophene intermediates for the synthesis of biotin
US4337345A (en) * 1977-08-05 1982-06-29 Hoffmann-La Roche Inc. Preparation of biotin via thieno [3,2c] isoxazoles
US4189586A (en) * 1977-08-05 1980-02-19 Hoffmann-La Roche Inc. Preparation of biotin
US4130713A (en) * 1977-08-05 1978-12-19 Hoffmann-La Roche Inc. Biotin intermediates
US4245104A (en) * 1978-12-01 1981-01-13 Hoffmann-La Roche Inc. Isoxazolines and isoxazolidines
US4247704A (en) * 1979-05-29 1981-01-27 Hoffmann-La Roche Inc. Hexahydro thieno imadazole intermediates for the synthesis of biotin
US4284557A (en) * 1979-05-29 1981-08-18 Hoffmann-La Roche Inc. Intermediate racemates for the preparation of biotin and a process for their preparation
US4537973A (en) * 1980-03-12 1985-08-27 Sumitomo Chemical Company, Limited Process for preparing biotin
DE3068160D1 (en) * 1980-03-14 1984-07-19 Sumitomo Chemical Co Process for preparing biotin
US4320056A (en) * 1980-05-15 1982-03-16 Hoffmann-La Roche Inc. Certain thia-diazatricyclo[3,3,3,08,11 ]tridecanes, and their preparation
US4382031A (en) * 1981-03-12 1983-05-03 Hoffmann-La Roche Inc. Intermediates for the preparation of biotin
DK43985A (en) * 1984-03-09 1985-09-10 Hoffmann La Roche PROCEDURE FOR PREPARING HETEROCYCLIC COMPOUNDS
DE4107121C1 (en) * 1991-03-06 1992-06-11 Merck Patent Gmbh, 6100 Darmstadt, De
CA2193774C (en) * 1995-12-26 2005-02-01 Norihiko Hirata Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid
DE10001317A1 (en) * 2000-01-14 2001-07-19 Merck Patent Gmbh Reaction of carbonyl compound with organometallic reagent, e.g. preparation of biotin intermediate or 4-(4-(trans-4-pentylcyclohexyl) -1-cyclohexen-1-yl)-1-trifluoromethoxybenzene, uses mini- or microreactor
TW200300676A (en) 2001-12-04 2003-06-16 Tanabe Seiyaku Co Biotin intermediate and its production
CN101096372B (en) * 2007-01-24 2010-09-29 绍兴文理学院 Process for synthesizing thiolactone
CN102268007B (en) * 2010-02-09 2015-11-25 浙江新和成股份有限公司 The preparation method of dibenzyl biotin derivative
CN103788112B (en) * 2012-11-02 2016-03-09 菏泽市方明制药有限公司 A kind of benzyl vitamin H takes off the method that benzyl prepares vitamin H
CN103554129B (en) * 2013-10-09 2016-03-23 安徽泰格维生素实业有限公司 A kind of preparation method of biotin intermediate thioketone
CN107973806A (en) * 2016-10-21 2018-05-01 大丰海嘉诺药业有限公司 A kind of method for preparing D-Biotin bromide intermediate
WO2020110831A1 (en) * 2018-11-28 2020-06-04 株式会社トクヤマ Method for producing thiolactone derivative
WO2021224295A1 (en) 2020-05-07 2021-11-11 Dsm Ip Assets B.V. A process for producing d-biotin intermediates
EP4353728A1 (en) * 2021-06-11 2024-04-17 Tokuyama Corporation Hydroxy thienoimidazole derivative, vinyl sulfide derivative, n-butylidene sulfide derivative, and production method for saturated straight-chain hydrocarbon-substituted thienoimidazole derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK71723C (en) * 1946-05-31 1950-11-20 Hoffmann La Roche Process for the preparation of d, 1-biotin.
DK73837C (en) * 1947-07-24 1952-03-03 Hoffmann La Roche Process for the preparation of biotin or homologous biotin compounds.
DK81470C (en) * 1947-07-24 1956-07-30 Hoffmann La Roche Process for the preparation of d- and 1-biotin.

Also Published As

Publication number Publication date
NL7015567A (en) 1971-06-02
GB1320799A (en) 1973-06-20
GB1320798A (en) 1973-06-20
DE2058234A1 (en) 1971-06-09
CH556867A (en) 1974-12-13
SE391928B (en) 1977-03-07
CA982591A (en) 1976-01-27
US3740416A (en) 1973-06-19
DK154563B (en) 1988-11-28
DK154563C (en) 1989-04-17
DE2058234B2 (en) 1977-02-17
FR2077540A1 (en) 1971-10-29
JPS5327279B1 (en) 1978-08-07
FR2077540B1 (en) 1975-12-12
BE759513A (en) 1971-05-27

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Legal Events

Date Code Title Description
SNR Assignments of patents or rights arising from examined patent applications

Owner name: F. HOFFMANN-LA ROCHE AG

NL80 Information provided on patent owner name for an already discontinued patent

Owner name: HOFFMANN LA

V4 Discontinued because of reaching the maximum lifetime of a patent