CA982591A - Racemic and (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno-(3,4-d)imidazole-2,4-dione - Google Patents

Racemic and (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno-(3,4-d)imidazole-2,4-dione

Info

Publication number
CA982591A
CA982591A CA098,432A CA98432A CA982591A CA 982591 A CA982591 A CA 982591A CA 98432 A CA98432 A CA 98432A CA 982591 A CA982591 A CA 982591A
Authority
CA
Canada
Prior art keywords
thieno
dibenzyl
hexahydro
dione
racemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA098,432A
Inventor
Max Gerecke
Jean P. Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA982591A publication Critical patent/CA982591A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
CA098,432A 1969-11-29 1970-11-18 Racemic and (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno-(3,4-d)imidazole-2,4-dione Expired CA982591A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1777369A CH556867A (en) 1969-11-29 1969-11-29 PROCESS FOR MANUFACTURING A RACEMIC OR OPTICALLY ACTIVE THIOLACTONE.

Publications (1)

Publication Number Publication Date
CA982591A true CA982591A (en) 1976-01-27

Family

ID=4428001

Family Applications (1)

Application Number Title Priority Date Filing Date
CA098,432A Expired CA982591A (en) 1969-11-29 1970-11-18 Racemic and (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno-(3,4-d)imidazole-2,4-dione

Country Status (10)

Country Link
US (1) US3740416A (en)
JP (1) JPS5327279B1 (en)
BE (1) BE759513A (en)
CA (1) CA982591A (en)
CH (1) CH556867A (en)
DK (1) DK154563C (en)
FR (1) FR2077540B1 (en)
GB (2) GB1320798A (en)
NL (1) NL156140B (en)
SE (1) SE391928B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054740A (en) * 1974-12-24 1977-10-18 Hoffmann-La Roche Inc. Hydroxybiotin
US4228295A (en) * 1977-02-23 1980-10-14 Hoffmann-La Roche Inc. Novel cycloheptathiophene intermediates for the synthesis of biotin
US4337345A (en) * 1977-08-05 1982-06-29 Hoffmann-La Roche Inc. Preparation of biotin via thieno [3,2c] isoxazoles
US4130713A (en) * 1977-08-05 1978-12-19 Hoffmann-La Roche Inc. Biotin intermediates
US4189586A (en) * 1977-08-05 1980-02-19 Hoffmann-La Roche Inc. Preparation of biotin
US4245104A (en) * 1978-12-01 1981-01-13 Hoffmann-La Roche Inc. Isoxazolines and isoxazolidines
US4284557A (en) * 1979-05-29 1981-08-18 Hoffmann-La Roche Inc. Intermediate racemates for the preparation of biotin and a process for their preparation
US4247704A (en) * 1979-05-29 1981-01-27 Hoffmann-La Roche Inc. Hexahydro thieno imadazole intermediates for the synthesis of biotin
US4537973A (en) * 1980-03-12 1985-08-27 Sumitomo Chemical Company, Limited Process for preparing biotin
EP0036030B1 (en) * 1980-03-14 1984-06-13 Sumitomo Chemical Company, Limited Process for preparing biotin
US4320056A (en) * 1980-05-15 1982-03-16 Hoffmann-La Roche Inc. Certain thia-diazatricyclo[3,3,3,08,11 ]tridecanes, and their preparation
US4382031A (en) * 1981-03-12 1983-05-03 Hoffmann-La Roche Inc. Intermediates for the preparation of biotin
DK43985A (en) * 1984-03-09 1985-09-10 Hoffmann La Roche PROCEDURE FOR PREPARING HETEROCYCLIC COMPOUNDS
DE4107121C1 (en) * 1991-03-06 1992-06-11 Merck Patent Gmbh, 6100 Darmstadt, De
CA2193774C (en) * 1995-12-26 2005-02-01 Norihiko Hirata Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid
DE10001317A1 (en) * 2000-01-14 2001-07-19 Merck Patent Gmbh Reaction of carbonyl compound with organometallic reagent, e.g. preparation of biotin intermediate or 4-(4-(trans-4-pentylcyclohexyl) -1-cyclohexen-1-yl)-1-trifluoromethoxybenzene, uses mini- or microreactor
TW200300676A (en) 2001-12-04 2003-06-16 Tanabe Seiyaku Co Biotin intermediate and its production
CN101096372B (en) * 2007-01-24 2010-09-29 绍兴文理学院 Process for synthesizing thiolactone
CN102268007B (en) * 2010-02-09 2015-11-25 浙江新和成股份有限公司 The preparation method of dibenzyl biotin derivative
CN103788112B (en) * 2012-11-02 2016-03-09 菏泽市方明制药有限公司 A kind of benzyl vitamin H takes off the method that benzyl prepares vitamin H
CN103554129B (en) * 2013-10-09 2016-03-23 安徽泰格维生素实业有限公司 A kind of preparation method of biotin intermediate thioketone
CN107973806A (en) * 2016-10-21 2018-05-01 大丰海嘉诺药业有限公司 A kind of method for preparing D-Biotin bromide intermediate
JPWO2020110831A1 (en) * 2018-11-28 2021-10-21 株式会社トクヤマ Method for producing thiolactone derivative
WO2021224295A1 (en) 2020-05-07 2021-11-11 Dsm Ip Assets B.V. A process for producing d-biotin intermediates
JP7229434B1 (en) * 2021-06-11 2023-02-27 株式会社トクヤマ Method for producing hydroxy thienoimidazole derivative, vinyl sulfide derivative, n-butylidene sulfide derivative, and saturated linear hydrocarbon-substituted thienoimidazole derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK71723C (en) * 1946-05-31 1950-11-20 Hoffmann La Roche Process for the preparation of d, 1-biotin.
DK73837C (en) * 1947-07-24 1952-03-03 Hoffmann La Roche Process for the preparation of biotin or homologous biotin compounds.
DK81470C (en) * 1947-07-24 1956-07-30 Hoffmann La Roche Process for the preparation of d- and 1-biotin.

Also Published As

Publication number Publication date
DE2058234A1 (en) 1971-06-09
DK154563C (en) 1989-04-17
FR2077540B1 (en) 1975-12-12
NL156140B (en) 1978-03-15
BE759513A (en) 1971-05-27
DE2058234B2 (en) 1977-02-17
GB1320799A (en) 1973-06-20
FR2077540A1 (en) 1971-10-29
JPS5327279B1 (en) 1978-08-07
GB1320798A (en) 1973-06-20
DK154563B (en) 1988-11-28
US3740416A (en) 1973-06-19
SE391928B (en) 1977-03-07
NL7015567A (en) 1971-06-02
CH556867A (en) 1974-12-13

Similar Documents

Publication Publication Date Title
CA982591A (en) Racemic and (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno-(3,4-d)imidazole-2,4-dione
CA954522A (en) Amidine derivatives
CA983938A (en) (+)-cis-1,3-dibenzyl-hexahydro-1h-furo (3,4-d) imidazole-2,4-dione
CA931568A (en) Pyrazolo(3,4-d)pyrimidines
CA934371A (en) 6-amino-4-oxo-4,5-dihydro-isothiazolo (5,4-d) pyrimidines and process for their manufacture
CA961040A (en) 6-substituted-indolo (1,2-c)quinazolines
AU4875672A (en) Thiazolo %5,4-d<pyrimidines
AU1108070A (en) Pyrimidine derivatives
AU2315570A (en) Pyrimidine derivatives
AU2314970A (en) Pyrimidine derivatives
AU429206B2 (en) 1, 5 benzodiazepine 2, 4-dione derivatives
AU445475B2 (en) 6 substituted indolo(1, 2 c)quinazolines
CA814451A (en) Pyrazolo(3,4-d)pyrimidine derivatives
CA932736A (en) Pyrimidine derivatives
CA936160A (en) Pyrimidine fungicide
CA817888A (en) 6,7-dihydro-5h-pyrrolo(3,4-d) pyrimidines
CA780436A (en) 6-phenyl-2,3,6,7-tetrahydro-4h-pyrimido(1,2-c)quinazoline
AU5795469A (en) 1, 5 benzodiazepine 2, 4-dione derivatives
AU2107270A (en) 6 substituted indolo(1, 2 c)quinazolines
AU1107970A (en) Pyrimidine derivatives
CA831002A (en) Quinazolone derivatives
AU445476B2 (en) Heterocyclic azaspirodecanediones
CA820369A (en) Heterocyclic tert-phosphines
CA805675A (en) Aryl and heteroarylpyrazino (2,3-b) pyrazines
CA952526A (en) Pyrimidine compounds and production thereof