NL151709B - Werkwijze ter bereiding van 6-fenyl-4 h-s-triazolo (4,3-a) (1,4) benzodiazepinen. - Google Patents
Werkwijze ter bereiding van 6-fenyl-4 h-s-triazolo (4,3-a) (1,4) benzodiazepinen.Info
- Publication number
- NL151709B NL151709B NL727201692A NL7201692A NL151709B NL 151709 B NL151709 B NL 151709B NL 727201692 A NL727201692 A NL 727201692A NL 7201692 A NL7201692 A NL 7201692A NL 151709 B NL151709 B NL 151709B
- Authority
- NL
- Netherlands
- Prior art keywords
- benzodiazepines
- triazolo
- phenyl
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2233682A DE2233682A1 (de) | 1971-02-09 | 1972-07-08 | 2- eckige klammer auf 3-(subst. aminomethyl)-4-h-1,2,4-triazol-4-yl eckige klammer zu -benzophenone, ein verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel |
| JP3475673A JPS5710106B2 (da) | 1971-02-09 | 1973-03-28 | |
| FR7311783A FR2182925B2 (da) | 1971-02-09 | 1973-04-02 | |
| BE129585A BE797705R (fr) | 1971-02-09 | 1973-04-03 | Derives de benzodiazepines et leur preparation |
| US00372313A US3856792A (en) | 1971-02-09 | 1973-06-21 | 2-{8 2-(substituted aminomethyl)-4h-1,2,4-triazol-4-yl{9 benzophenones |
| NL7605446.A NL166471C (nl) | 1971-02-09 | 1976-05-21 | Werkwijze ter bereiding van een therapeutisch preparaat alsmede werkwijze ter bereiding van een daarvoor ge- schikt benzofenonderivaat. |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11404971A | 1971-02-09 | 1971-02-09 | |
| US24075672A | 1972-04-03 | 1972-04-03 | |
| US00372313A US3856792A (en) | 1971-02-09 | 1973-06-21 | 2-{8 2-(substituted aminomethyl)-4h-1,2,4-triazol-4-yl{9 benzophenones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL7201692A NL7201692A (da) | 1972-08-11 |
| NL151709B true NL151709B (nl) | 1976-12-15 |
Family
ID=27381433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL727201692A NL151709B (nl) | 1971-02-09 | 1972-02-09 | Werkwijze ter bereiding van 6-fenyl-4 h-s-triazolo (4,3-a) (1,4) benzodiazepinen. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3709898A (da) |
| JP (1) | JPS4966679A (da) |
| BE (1) | BE779144A (da) |
| BR (1) | BR7200590D0 (da) |
| CA (1) | CA966123A (da) |
| CH (2) | CH570404A5 (da) |
| DE (2) | DE2265617C3 (da) |
| DK (1) | DK513578A (da) |
| FR (1) | FR2124559B1 (da) |
| GB (4) | GB1374823A (da) |
| HK (1) | HK2580A (da) |
| NL (1) | NL151709B (da) |
| SE (1) | SE414928B (da) |
| ZA (1) | ZA7251B (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE397831B (sv) * | 1971-06-05 | 1977-11-21 | Takeda Chemical Industries Ltd | Sett att framstella s-triazolo-(4,3-a)(1,4)bensodiazepinderivat |
| US3904641A (en) * | 1971-06-18 | 1975-09-09 | Yoshitomi Pharmaceutical | Triazolothienodiazepine compounds |
| BE790838A (fr) * | 1971-11-02 | 1973-04-30 | Upjohn Co | Nouvelles 1-aminophenyl-6-phenyl-s-triazolo (4,3-a) (1,4)- benzodiazepines, leur procede de preparation et medicament les contenant |
| US3842090A (en) * | 1973-02-14 | 1974-10-15 | Upjohn Co | Certain 1-aminomethyl-6-phenyl 4h-s-triazolo(4,3-a)(1,4)benzodiazepines |
| CA999000A (en) * | 1973-02-14 | 1976-10-26 | Jackson B. Hester (Jr.) | Process for new benzodiazepines and intermediates |
| US3879413A (en) * | 1973-02-14 | 1975-04-22 | Upjohn Co | Process for the production of 6-phenyl-4-H-s-triazolo {8 4,3-a{9 {8 1,4{9 benzodiazepines |
| US4263310A (en) * | 1974-03-02 | 1981-04-21 | Boehringer Ingelheim Gmbh | 8-Bromo-6-(o-chloro-phenyl)-4H-S-triazolo-[3,4,-c]-thieno-[2,3-e]-1,4-diazepines and salts thereof |
| GB1517164A (en) * | 1974-08-20 | 1978-07-12 | Roche Products Ltd | Substituted-phenyl ketones and a process for the manufacture thereof |
| US4000151A (en) * | 1974-09-11 | 1976-12-28 | The Upjohn Company | Triazolyl benzophenone compounds |
| US4000153A (en) * | 1974-09-26 | 1976-12-28 | The Upjohn Company | Triazolobenzodiazepine intermediates |
| NL7512983A (nl) * | 1974-11-06 | 1976-05-10 | Parke Davis & Co | Werkwijze voor het bereiden van diazepineverbin- dingen, werkwijze voor het bereiden van een far- maceutisch preparaat met toepassing daarvan als- mede een zo gevormd preparaat. |
| CH601267A5 (da) * | 1975-12-12 | 1978-06-30 | Ciba Geigy Ag | |
| US4105851A (en) * | 1975-09-08 | 1978-08-08 | Parke, Davis & Company | 1,3,8-Trimethylimidazopyrazolodiazepine compounds |
| US4009175A (en) * | 1976-03-15 | 1977-02-22 | The Upjohn Company | 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines |
| US4405518A (en) * | 1981-07-23 | 1983-09-20 | Hoffmann-La Roche Inc. | Pyrrolo[3,4-d] [2] benzazepines |
| US4409390A (en) * | 1981-07-23 | 1983-10-11 | Hoffmann-La Roche Inc. | Pyrrolo[3,4-D][2]Benzazepines |
| US4375473A (en) * | 1982-01-04 | 1983-03-01 | The Upjohn Company | Method |
| US4501698A (en) * | 1983-03-31 | 1985-02-26 | The Upjohn Company | Preparing 1-(hydroxymethyl)-triazolobenzodiazepines and 1-(aminomethyl)-triazolobenzodiazepines |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| BR122014024883A2 (pt) * | 2010-05-14 | 2019-08-20 | Dana-Farber Cancer Institute, Inc. | Compostos no tratamento de neoplasia |
| AU2015201727B2 (en) * | 2010-05-14 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| WO2015013635A2 (en) | 2013-07-25 | 2015-01-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
| EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| CN106456653A (zh) | 2014-02-28 | 2017-02-22 | 腾沙治疗公司 | 高胰岛素血症相关病症的治疗 |
| US9969747B2 (en) | 2014-06-20 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| CA2955077A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
| BR112017002369A2 (pt) | 2014-08-08 | 2017-12-05 | Dana Farber Cancer Inst Inc | derivados de diazepana e usos dos mesmos |
| EA033325B1 (ru) | 2014-10-27 | 2019-09-30 | Тэнша Терапеутикс, Инк. | Ингибиторы бромодомена |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| WO2017044792A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazoldiazepines and uses thereof |
| BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
| SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3413346A (en) * | 1966-01-19 | 1968-11-26 | Hoffmann La Roche | 2-(2-haloethylamino)-5-halo-benzophenones |
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| DE1955349C2 (de) * | 1969-11-04 | 1982-01-28 | Takeda Chemical Industries, Ltd., Osaka | s-Triazolo [4,3-a] [1,4] benzodiazepine |
| YU34997B (en) * | 1970-03-27 | 1980-06-30 | Hiroyuki Tawada | Process for preparing benzodiazepine derivatives |
-
1971
- 1971-02-09 US US00114049A patent/US3709898A/en not_active Expired - Lifetime
-
1972
- 1972-01-04 ZA ZA720051A patent/ZA7251B/xx unknown
- 1972-01-05 CA CA131,732A patent/CA966123A/en not_active Expired
- 1972-01-07 GB GB82374A patent/GB1374823A/en not_active Expired
- 1972-01-07 GB GB87572A patent/GB1374822A/en not_active Expired
- 1972-01-07 GB GB82474A patent/GB1374824A/en not_active Expired
- 1972-01-07 GB GB82574A patent/GB1374825A/en not_active Expired
- 1972-01-19 CH CH1039775A patent/CH570404A5/xx not_active IP Right Cessation
- 1972-01-19 CH CH78472A patent/CH569736A5/xx not_active IP Right Cessation
- 1972-01-27 DE DE2265617A patent/DE2265617C3/de not_active Expired
- 1972-01-27 DE DE2203782A patent/DE2203782C2/de not_active Expired
- 1972-02-02 BR BR590/72*[A patent/BR7200590D0/pt unknown
- 1972-02-07 SE SE7301375A patent/SE414928B/xx unknown
- 1972-02-08 FR FR7204137A patent/FR2124559B1/fr not_active Expired
- 1972-02-09 NL NL727201692A patent/NL151709B/xx not_active IP Right Cessation
- 1972-02-09 BE BE779144A patent/BE779144A/xx not_active IP Right Cessation
-
1973
- 1973-03-28 JP JP48034757A patent/JPS4966679A/ja active Pending
-
1978
- 1978-11-17 DK DK513578A patent/DK513578A/da not_active Application Discontinuation
-
1980
- 1980-01-17 HK HK25/80A patent/HK2580A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR7200590D0 (pt) | 1973-07-17 |
| DE2203782A1 (de) | 1972-08-24 |
| GB1374822A (en) | 1974-11-20 |
| GB1374823A (en) | 1974-11-20 |
| NL7201692A (da) | 1972-08-11 |
| SE414928B (sv) | 1980-08-25 |
| GB1374825A (en) | 1974-11-20 |
| JPS4966679A (da) | 1974-06-27 |
| FR2124559B1 (da) | 1975-08-01 |
| BE779144A (fr) | 1972-08-09 |
| DE2265617C3 (de) | 1982-05-06 |
| DE2265617B2 (de) | 1981-07-16 |
| CA966123A (en) | 1975-04-15 |
| ZA7251B (en) | 1972-09-27 |
| CH569736A5 (da) | 1975-11-28 |
| DK513578A (da) | 1978-11-17 |
| US3709898A (en) | 1973-01-09 |
| HK2580A (en) | 1980-01-25 |
| FR2124559A1 (da) | 1972-09-22 |
| AU3772572A (en) | 1973-07-12 |
| GB1374824A (en) | 1974-11-20 |
| DE2203782C2 (de) | 1982-05-13 |
| CH570404A5 (da) | 1975-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| V1 | Lapsed because of non-payment of the annual fee | ||
| NL80 | Information provided on patent owner name for an already discontinued patent |
Owner name: UPJOHN |