NL139179B - Werkwijze voor de bereiding van preparaten met choleretische en/of hypotensieve eigenschappen, alsmede voor de bereiding van hiervoor geschikte benzothiazepine en benzothiazocine verbindingen. - Google Patents

Werkwijze voor de bereiding van preparaten met choleretische en/of hypotensieve eigenschappen, alsmede voor de bereiding van hiervoor geschikte benzothiazepine en benzothiazocine verbindingen.

Info

Publication number
NL139179B
NL139179B NL646402756A NL6402756A NL139179B NL 139179 B NL139179 B NL 139179B NL 646402756 A NL646402756 A NL 646402756A NL 6402756 A NL6402756 A NL 6402756A NL 139179 B NL139179 B NL 139179B
Authority
NL
Netherlands
Prior art keywords
preparation
benzothiazocine
choleretic
benzothiazepine
preparations
Prior art date
Application number
NL646402756A
Other languages
English (en)
Dutch (nl)
Other versions
NL6402756A (de
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL6402756A publication Critical patent/NL6402756A/xx
Priority claimed from US445248A external-priority patent/US3346638A/en
Publication of NL139179B publication Critical patent/NL139179B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18Eight-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/181,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
NL646402756A 1963-03-18 1964-03-16 Werkwijze voor de bereiding van preparaten met choleretische en/of hypotensieve eigenschappen, alsmede voor de bereiding van hiervoor geschikte benzothiazepine en benzothiazocine verbindingen. NL139179B (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26603063A 1963-03-18 1963-03-18
US44526465A 1965-04-02 1965-04-02
US445248A US3346638A (en) 1965-04-02 1965-04-02 Alpha-phenyl-2-amino-benzylmercaptanes
US535722A US3400119A (en) 1963-03-18 1966-03-21 Novel 4, 1-benzothiazepin-2(1h)-ones and 4, 1-benzothiazepines

Publications (2)

Publication Number Publication Date
NL6402756A NL6402756A (de) 1964-09-21
NL139179B true NL139179B (nl) 1973-06-15

Family

ID=27500875

Family Applications (3)

Application Number Title Priority Date Filing Date
NL646402756A NL139179B (nl) 1963-03-18 1964-03-16 Werkwijze voor de bereiding van preparaten met choleretische en/of hypotensieve eigenschappen, alsmede voor de bereiding van hiervoor geschikte benzothiazepine en benzothiazocine verbindingen.
NL6604383A NL6604383A (de) 1963-03-18 1966-04-01
NL6604470A NL6604470A (de) 1963-03-18 1966-04-04

Family Applications After (2)

Application Number Title Priority Date Filing Date
NL6604383A NL6604383A (de) 1963-03-18 1966-04-01
NL6604470A NL6604470A (de) 1963-03-18 1966-04-04

Country Status (13)

Country Link
US (1) US3400119A (de)
BE (3) BE645242A (de)
BR (3) BR6457097D0 (de)
CH (7) CH441324A (de)
DE (3) DE1445889A1 (de)
DK (2) DK116362B (de)
FR (3) FR3681M (de)
GB (8) GB1043481A (de)
IL (4) IL25425A (de)
MY (2) MY6800086A (de)
NL (3) NL139179B (de)
NO (1) NO121211B (de)
SE (2) SE345670B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3463774A (en) * 1963-03-18 1969-08-26 Hoffmann La Roche Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines
US3485824A (en) * 1963-03-18 1969-12-23 Hoffmann La Roche 1-substituted 4,1-benzothiazepin-2(1h)-ones and 4,1-benzothiazepines
DE1620642A1 (de) * 1965-09-15 1970-08-20 Ucb Sa Heterocyclische Derivate und Verfahren zu ihrer Herstellung
US3542767A (en) * 1968-02-29 1970-11-24 American Home Prod Substituted 1,3,4-benzotriazepin-5h-5-ones
US3539555A (en) * 1968-12-12 1970-11-10 Squibb & Sons Inc Dibenzo(b,f)(1,4)oxazocines,dibenzo(b,f)(1,4)oxazonines and thio analogs
US3682962A (en) * 1970-03-17 1972-08-08 Sterling Drug Inc 1-substituted-1,2,3,5-tetrahydro-4,1-benzothiozepines
US3697516A (en) * 1970-10-19 1972-10-10 Phillips Petroleum Co Certain thiazine-2-thione compounds and method of preparing same
DE3320746A1 (de) * 1982-06-17 1983-12-22 Sandoz-Patent-GmbH, 7850 Lörrach Benzolderivate, ihre herstellung und pharmazeutische praeparate welche sie enthalten
US5246791A (en) * 1988-07-06 1993-09-21 Johnson Matthey Public Limited Company Fuel cell containing a reforming catalyst
CA2016517C (en) * 1989-05-11 1999-01-12 Dale R. Shackle Solid state electrochemical cell having microroughened current collector
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
DE19924668A1 (de) 1999-05-28 2000-11-30 Bayer Ag Substituierte alpha-Phenyl-beta-Ketosulfone
WO2015120059A1 (en) * 2014-02-04 2015-08-13 Yates Charles Ryan Inhibitors of paxillin function and related compositions and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144439A (en) * 1964-08-11 Process for production of benzo-
US3155649A (en) * 1962-07-11 1964-11-03 Olin Mathieson Benzothiazocinones, related compounds and their preparation

Also Published As

Publication number Publication date
BR6678152D0 (pt) 1973-09-06
NL6604470A (de) 1966-10-03
CH442313A (de) 1967-08-31
CH441326A (de) 1967-08-15
GB1098806A (en) 1968-01-10
MY6800086A (en) 1968-12-31
SE345670B (de) 1972-06-05
CH441324A (de) 1967-08-15
US3400119A (en) 1968-09-03
BE678771A (de) 1966-09-30
DE1695134A1 (de) 1970-12-10
GB1098807A (en) 1968-01-10
CH448096A (de) 1967-12-15
IL25447A (en) 1970-06-17
NO121211B (de) 1971-02-01
IL33557A (en) 1970-07-19
FR5314M (de) 1967-08-21
GB1043481A (en) 1966-09-21
MY6800087A (en) 1968-12-31
BR6678325D0 (pt) 1973-09-18
IL25425A (en) 1970-07-19
IL33556A (en) 1970-07-19
CH441327A (de) 1967-08-15
GB1077272A (en) 1967-07-26
FR5746M (de) 1968-01-29
BE678772A (de) 1966-09-30
GB1098805A (en) 1968-01-10
NL6402756A (de) 1964-09-21
GB1098804A (en) 1968-01-10
DK116362B (da) 1970-01-05
BR6457097D0 (pt) 1973-08-09
DE1695132A1 (de) 1970-12-10
DK126383B (da) 1973-07-09
GB1098803A (en) 1968-01-10
GB1077276A (en) 1967-07-26
NL6604383A (de) 1966-10-03
FR3681M (fr) 1965-11-15
SE356983B (de) 1973-06-12
CH481131A (de) 1969-11-15
BE645242A (de) 1964-09-16
CH471809A (de) 1969-04-30
DE1445889A1 (de) 1969-04-10

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