NI201000182A - DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS. - Google Patents

DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS.

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Publication number
NI201000182A
NI201000182A NI201000182A NI201000182A NI201000182A NI 201000182 A NI201000182 A NI 201000182A NI 201000182 A NI201000182 A NI 201000182A NI 201000182 A NI201000182 A NI 201000182A NI 201000182 A NI201000182 A NI 201000182A
Authority
NI
Nicaragua
Prior art keywords
acilamine
condensed
derivatives
pharmaceutical products
acid replaced
Prior art date
Application number
NI201000182A
Other languages
Spanish (es)
Inventor
Schaefer Matthias
Pernerstorfer Josef
Kadereit Dieter
Strobel Hartmut
Czechtizky Werngard
Charlie Chen L
Safarova Alena
Weichsel Aleksandra
Patek Marcel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NI201000182A publication Critical patent/NI201000182A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula I, en la que A, Y, Z, R3 a R6, R20 a R22 y R50 tienen los significados que se indican en las reivindicaciones, que son valiosos compuestos activos farmacéuticos. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 (Edg-2, EDG2), que es activado por ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.The present invention relates to compounds of formula I, in which A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the receptor for endothelial differentiation gene 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also called LPA1 receptor, and they are useful for the treatment of diseases such as atherosclerosis, infarction of myocardium and heart failure, for example. The invention further relates to processes for preparing the compounds of formula I, to their use and to pharmaceutical compositions comprising them.

NI201000182A 2008-05-05 2010-10-27 DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS. NI201000182A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290427 2008-05-05
US11733608P 2008-11-24 2008-11-24

Publications (1)

Publication Number Publication Date
NI201000182A true NI201000182A (en) 2011-09-29

Family

ID=70471668

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201000182A NI201000182A (en) 2008-05-05 2010-10-27 DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS.

Country Status (2)

Country Link
BR (1) BRPI0912224B1 (en)
NI (1) NI201000182A (en)

Also Published As

Publication number Publication date
BRPI0912224A2 (en) 2020-06-30
BRPI0912224B1 (en) 2021-11-30

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