NI201000182A - DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS. - Google Patents
DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS.Info
- Publication number
- NI201000182A NI201000182A NI201000182A NI201000182A NI201000182A NI 201000182 A NI201000182 A NI 201000182A NI 201000182 A NI201000182 A NI 201000182A NI 201000182 A NI201000182 A NI 201000182A NI 201000182 A NI201000182 A NI 201000182A
- Authority
- NI
- Nicaragua
- Prior art keywords
- acilamine
- condensed
- derivatives
- pharmaceutical products
- acid replaced
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula I, en la que A, Y, Z, R3 a R6, R20 a R22 y R50 tienen los significados que se indican en las reivindicaciones, que son valiosos compuestos activos farmacéuticos. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 (Edg-2, EDG2), que es activado por ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.The present invention relates to compounds of formula I, in which A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the receptor for endothelial differentiation gene 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also called LPA1 receptor, and they are useful for the treatment of diseases such as atherosclerosis, infarction of myocardium and heart failure, for example. The invention further relates to processes for preparing the compounds of formula I, to their use and to pharmaceutical compositions comprising them.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290427 | 2008-05-05 | ||
US11733608P | 2008-11-24 | 2008-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201000182A true NI201000182A (en) | 2011-09-29 |
Family
ID=70471668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201000182A NI201000182A (en) | 2008-05-05 | 2010-10-27 | DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS. |
Country Status (2)
Country | Link |
---|---|
BR (1) | BRPI0912224B1 (en) |
NI (1) | NI201000182A (en) |
-
2009
- 2009-04-22 BR BRPI0912224-9A patent/BRPI0912224B1/en active IP Right Grant
-
2010
- 2010-10-27 NI NI201000182A patent/NI201000182A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0912224A2 (en) | 2020-06-30 |
BRPI0912224B1 (en) | 2021-11-30 |
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