NI201200073A - CYCLIC CARBOXYL ACID DERIVATIVES SUBSTITUTED WITH ACILAMINE AND THEIR USE AS A PHARMACEUTICAL PRODUCT - Google Patents
CYCLIC CARBOXYL ACID DERIVATIVES SUBSTITUTED WITH ACILAMINE AND THEIR USE AS A PHARMACEUTICAL PRODUCTInfo
- Publication number
- NI201200073A NI201200073A NI201200073A NI201200073A NI201200073A NI 201200073 A NI201200073 A NI 201200073A NI 201200073 A NI201200073 A NI 201200073A NI 201200073 A NI201200073 A NI 201200073A NI 201200073 A NI201200073 A NI 201200073A
- Authority
- NI
- Nicaragua
- Prior art keywords
- acilamine
- acid derivatives
- pharmaceutical product
- carboxyl acid
- compounds
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de la fórmula I, en la que A, Y, Z, R20 a R22 y R50 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Específicamente, son inhibidores del receptor del gen de diferenciación endotelial 2 ( Edg-2, EDG2), que se activa por el ácido lisofosfatídico (LPA) y también se denomina receptor LPA1, y son útiles para el tratamiento de enfermedades tales como aterosclerosis, infarto de miocardio e insuficiencia cardiaca, por ejemplo. La invención se refiere además a procedimientos para preparar los compuestos de la fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.The present invention relates to compounds of formula I, in which A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable active pharmaceutical compounds. Specifically, they are inhibitors of the receptor for endothelial differentiation gene 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also called LPA1 receptor, and they are useful for the treatment of diseases such as atherosclerosis, heart attack. of myocardium and heart failure, for example. The invention further relates to processes for preparing the compounds of formula I, their use and pharmaceutical compositions comprising them.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09290831 | 2009-11-02 | ||
| US31961910P | 2010-03-31 | 2010-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201200073A true NI201200073A (en) | 2012-10-29 |
Family
ID=69650461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201200073A NI201200073A (en) | 2009-11-02 | 2012-04-27 | CYCLIC CARBOXYL ACID DERIVATIVES SUBSTITUTED WITH ACILAMINE AND THEIR USE AS A PHARMACEUTICAL PRODUCT |
Country Status (2)
| Country | Link |
|---|---|
| CL (1) | CL2012001142A1 (en) |
| NI (1) | NI201200073A (en) |
-
2012
- 2012-04-27 NI NI201200073A patent/NI201200073A/en unknown
- 2012-04-30 CL CL2012001142A patent/CL2012001142A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2012001142A1 (en) | 2012-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP12011861A (en) | DERIVATIVES OF CYCLIC CARBOXYLIC ACID SUBSTITUTED WITH ACILAMINE AND ITS USE AS PHARMACEUTICAL PRODUCTS | |
| CO6300933A2 (en) | CONDENSED CYCLOPENTANOCARBOXYLIC ACID DERIVATIVES SUBSTITUTED WITH ACILAMINE AND ITS USE AS PHARMACEUTICAL PRODUCTS | |
| BR112012023421A2 (en) | pharmaceutical composition for intraocular pressure increase treatment | |
| EA201171066A1 (en) | NEW SUBSTITUTED DERIVATIVES OF BENZOXIAZOLE, BENZIMIDAZOLE, OXAZOZOLOPIRIDINE AND IMIDAZOPIRIDINE AS GAMMA SECRETIS MODULATORS | |
| CO6351778A2 (en) | NAFTILACETIC ACIDS | |
| CO7310531A2 (en) | 4-methyl-2,3,8,9,9b-pentaaza-cyclopenta [a] naphthalenes | |
| UY35156A (en) | DERIVATIVES OF ACETIC INDANILOXI DIHIDROBENZOFURANIL ACID AS AGONISTS OF THE GPR40 | |
| CO6761373A2 (en) | Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceutical substances | |
| ECSP13012494A (en) | OXADIAZOL INHIBITORS OF LEUCOTRENE PRODUCTION. | |
| BR112013004662B8 (en) | Compound, pharmaceutical composition, uses of a compound, and method of preparing a pharmaceutical composition | |
| UA109867C2 (en) | Substituted pyrazole compounds as antagonists lysophosphatidic acid receptors (lpar) | |
| BR112013030391A2 (en) | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists | |
| NI201200073A (en) | CYCLIC CARBOXYL ACID DERIVATIVES SUBSTITUTED WITH ACILAMINE AND THEIR USE AS A PHARMACEUTICAL PRODUCT | |
| MX2013003736A (en) | Novel gpr 119 agonists. | |
| NI201000182A (en) | DERIVATIVES OF CONDENSED CYCLOPENTANOCARBOXYLIC ACID REPLACED WITH ACILAMINE AND THEIR USE AS PHARMACEUTICAL PRODUCTS. | |
| IN2014MN02433A (en) | ||
| DOP2013000182A (en) | CATEPSIN C INHIBITORS | |
| UY29550A1 (en) | DERIVATIVES OF (SULFAMOIL-ALQUIL) -AMIDE OF HETEROARIL-CARBOXYL ACID AS INHIBITORS OF THE XA FACTOR | |
| PA8825401A1 (en) | SYSTEMS AND METHODS TO SELECT FLOUR | |
| TN2010000466A1 (en) | Acylamino subsitutued fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals | |
| CU20100214A7 (en) | IMIDAZOQUINOLINAS AS LIPID KINASE INHIBITORS | |
| CU20100173A7 (en) | INDAZOL DERIVATIVES |