MY204767A - Polymerases, compositions, and methods of use - Google Patents
Polymerases, compositions, and methods of useInfo
- Publication number
- MY204767A MY204767A MYPI2020006925A MYPI2020006925A MY204767A MY 204767 A MY204767 A MY 204767A MY PI2020006925 A MYPI2020006925 A MY PI2020006925A MY PI2020006925 A MYPI2020006925 A MY PI2020006925A MY 204767 A MY204767 A MY 204767A
- Authority
- MY
- Malaysia
- Prior art keywords
- methods
- polymerases
- compositions
- incorporation
- altered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862775662P | 2018-12-05 | 2018-12-05 | |
| PCT/US2019/064524 WO2020117968A2 (en) | 2018-12-05 | 2019-12-04 | Polymerases, compositions, and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY204767A true MY204767A (en) | 2024-09-12 |
Family
ID=69137980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2020006925A MY204767A (en) | 2018-12-05 | 2019-12-04 | Polymerases, compositions, and methods of use |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US11001816B2 (https=) |
| EP (1) | EP3891275A2 (https=) |
| JP (1) | JP7527208B2 (https=) |
| KR (1) | KR20210098844A (https=) |
| CN (1) | CN112639090A (https=) |
| AU (1) | AU2019391093B2 (https=) |
| BR (1) | BR112020026655A2 (https=) |
| CA (1) | CA3103739A1 (https=) |
| IL (2) | IL279423B (https=) |
| MX (1) | MX2020013357A (https=) |
| MY (1) | MY204767A (https=) |
| SG (1) | SG11202012559SA (https=) |
| WO (1) | WO2020117968A2 (https=) |
| ZA (1) | ZA202007839B (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11104888B2 (en) | 2018-10-31 | 2021-08-31 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| EP3891275A2 (en) | 2018-12-05 | 2021-10-13 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| CN114829369A (zh) | 2019-11-27 | 2022-07-29 | 伊鲁米纳剑桥有限公司 | 含环辛四烯的染料和组合物 |
| CA3165571C (en) | 2019-12-23 | 2023-02-07 | Singular Genomics Systems, Inc. | Methods for long read sequencing |
| IL294459A (en) | 2019-12-31 | 2022-09-01 | Singular Genomics Systems Inc | Polynucleotide barcodes for long read sequencing |
| EP4117682B1 (en) | 2020-04-24 | 2025-06-04 | Singular Genomics Systems, Inc. | Modified nucleotides and uses thereof |
| IL316161A (en) | 2020-06-22 | 2024-12-01 | Illumina Cambridge Ltd | Nucleotides and nucleosides with a 3' masking group |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| US12054506B2 (en) | 2021-03-19 | 2024-08-06 | Singular Genomics Systems, Inc. | Reducing agents and uses thereof |
| JP2024516191A (ja) | 2021-05-05 | 2024-04-12 | イルミナ ケンブリッジ リミテッド | ビス－ホウ素縮合複素環を含有する蛍光色素及び配列決定における使用 |
| US20220403351A1 (en) | 2021-06-18 | 2022-12-22 | Element Biosciences, Inc. | Engineered polymerases |
| US12077789B2 (en) * | 2021-08-14 | 2024-09-03 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| CA3222937A1 (en) | 2021-12-29 | 2023-07-06 | Jonathan Mark Boutell | Methods of nucleic acid sequencing using surface-bound primers |
| US12006518B2 (en) | 2022-02-18 | 2024-06-11 | Element Biosciences, Inc. | Engineered polymerases with reduced sequence-specific errors |
| US20230304086A1 (en) | 2022-03-28 | 2023-09-28 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
| EP4499872B1 (en) | 2022-03-29 | 2026-04-29 | Illumina, Inc. | Systems and methods of sequencing polynucleotides |
| CA3223037A1 (en) | 2022-03-30 | 2023-10-05 | Oliver MILLER | Methods for chemical cleavage of surface-bound polynucleotides |
| AU2023244351A1 (en) | 2022-03-31 | 2024-01-18 | Illumina, Inc. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
| US20230357845A1 (en) | 2022-03-31 | 2023-11-09 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| CA3251383A1 (en) | 2022-05-31 | 2023-12-07 | Illumina, Inc | NUCLEIC ACID COMPOSITIONS AND SEQUENCE METHODS |
| WO2024003087A1 (en) | 2022-06-28 | 2024-01-04 | Illumina, Inc. | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
| WO2024039652A1 (en) | 2022-08-16 | 2024-02-22 | Aldevron, L.L.C. | Cell-free method of producing synthetic circular nucleic acid |
| CA3246518A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Compositions and methods for reducing photolesions during sequencing |
| US20240141427A1 (en) * | 2022-09-30 | 2024-05-02 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| WO2024123866A1 (en) | 2022-12-09 | 2024-06-13 | Illumina, Inc. | Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers |
| CA3246545A1 (en) | 2022-12-22 | 2024-06-27 | Illumina, Inc. | PALLADIUM CATALYST COMPOSITIONS AND SYNTHETIC SEQUENCE PROCESSES |
| EP4638795A1 (en) | 2022-12-22 | 2025-10-29 | Illumina, Inc. | Transition-metal catalyst compositions and methods for sequencing by synthesis |
| CN119095984A (zh) | 2022-12-27 | 2024-12-06 | 伊路米纳有限公司 | 使用3'烯丙基封端的核苷酸的测序方法 |
| CN116286720A (zh) * | 2023-03-29 | 2023-06-23 | 赛纳生物科技(北京)有限公司 | 一种dna聚合酶 |
| WO2024206407A2 (en) | 2023-03-29 | 2024-10-03 | Illumina, Inc. | Naphthalimide dyes and uses in nucleic acid sequencing |
| CN119452101A (zh) | 2023-03-30 | 2025-02-14 | 因美纳公司 | 用于核酸测序的组合物和方法 |
| WO2024249200A1 (en) | 2023-05-26 | 2024-12-05 | Illumina, Inc. | Methods for preserving methylation status during clustering |
| WO2024249591A1 (en) | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Methods for double-stranded sequencing by synthesis |
| WO2024249061A1 (en) | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Detecting a methylated nucleotide using a quencher |
| US20250075269A1 (en) | 2023-08-31 | 2025-03-06 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| US20250137048A1 (en) | 2023-10-26 | 2025-05-01 | Illumina, Inc. | 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing |
| WO2025106715A1 (en) | 2023-11-17 | 2025-05-22 | Illumina, Inc. | Conjugated polymers or polymer dots as fluorescent labels |
| WO2025136890A1 (en) | 2023-12-18 | 2025-06-26 | Illumina, Inc. | Hydrogel nanoparticles as labeling scaffold in sequencing |
| US20250215491A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Sequencing with single-stranded binding proteins |
| US20250215493A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing |
| WO2025144711A1 (en) | 2023-12-29 | 2025-07-03 | Illumina, Inc. | Tricyclic polymethine dyes for nucleic acid sequencing |
| WO2025184226A1 (en) | 2024-02-28 | 2025-09-04 | Illumina, Inc. | Nucleotides with terminal phosphate capping |
| WO2025188906A1 (en) | 2024-03-08 | 2025-09-12 | Illumina, Inc. | Modified adenosine nucleotides |
| WO2025230914A1 (en) | 2024-04-29 | 2025-11-06 | Illumina, Inc. | Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis |
| WO2025264831A1 (en) | 2024-06-18 | 2025-12-26 | Illumina, Inc. | Methods for increasing sequencing quality of gc-rich regions |
| WO2025264836A1 (en) | 2024-06-18 | 2025-12-26 | Illumina, Inc. | Methods for increasing sequencing quality of gc-rich regions |
| WO2026006314A1 (en) | 2024-06-28 | 2026-01-02 | Illumina, Inc. | Tagging target regions prior to nucleotide sequencing |
| WO2026035914A1 (en) | 2024-08-09 | 2026-02-12 | Illumina, Inc. | Nucleotides having 3'-hydroxy blocking groups |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA258147A (en) | 1926-02-16 | W. Pease John | Apple paring machine | |
| CA2044616A1 (en) | 1989-10-26 | 1991-04-27 | Roger Y. Tsien | Dna sequencing |
| US5756334A (en) | 1990-04-26 | 1998-05-26 | New England Biolabs, Inc. | Thermostable DNA polymerase from 9°N-7 and methods for producing the same |
| EP0910664A1 (en) | 1996-04-15 | 1999-04-28 | University Of Southern California | Synthesis of fluorophore-labeled dna |
| EP0822256B1 (en) | 1996-07-29 | 2003-09-24 | Toyo Boseki Kabushiki Kaisha | Modified thermostable DNA polymerase, and DNA polymerase composition for nucleic acid amplification |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6228628B1 (en) | 1997-07-09 | 2001-05-08 | Roche Molecular Systems | Mutant chimeric DNA polymerase |
| US5882904A (en) | 1997-08-04 | 1999-03-16 | Amersham Pharmacia Biotech Inc. | Thermococcus barossii DNA polymerase mutants |
| US5948666A (en) | 1997-08-06 | 1999-09-07 | Diversa Corporation | Isolation and identification of polymerases |
| US20050181440A1 (en) | 1999-04-20 | 2005-08-18 | Illumina, Inc. | Nucleic acid sequencing using microsphere arrays |
| WO2000068422A2 (en) | 1999-05-07 | 2000-11-16 | Roche Diagnostics Gmbh | High density labeling of dna with modified or 'chromophore' carrying nucleotides and dna polymerases used |
| US6492161B1 (en) | 1999-06-02 | 2002-12-10 | Prokaria Ltd. | Bacteriophage RM 378 of a thermophilic host organism |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
| EP1218546A4 (en) | 1999-09-30 | 2005-01-05 | New England Biolabs Inc | INCORPORATION OF MODIFIED NUCLEOTIDES BY ARCHAEON POLYMERASE DNA AND ASSOCIATED METHODS |
| US8268605B2 (en) | 1999-10-29 | 2012-09-18 | Agilent Technologies, Inc. | Compositions and methods utilizing DNA polymerases |
| US20030228616A1 (en) | 1999-10-29 | 2003-12-11 | Stratagene | DNA polymerase mutants with reverse transcriptase activity |
| JP4949585B2 (ja) | 1999-10-29 | 2012-06-13 | アジレント・テクノロジーズ・インク | Ｄｎａポリメラーゼを使用した組成物および方法 |
| WO2001038546A1 (en) | 1999-11-23 | 2001-05-31 | Amersham Biosciences Corp | Improving dideoxynucleotide-triphosphate utilization by the hyper-thermophilic dna polymerase from the archaeon pyrococcus furiosus |
| US6329178B1 (en) | 2000-01-14 | 2001-12-11 | University Of Washington | DNA polymerase mutant having one or more mutations in the active site |
| AU2007201277B2 (en) | 2000-05-24 | 2011-10-13 | Third Wave Technologies, Inc. | Detection of RNA |
| WO2002004680A2 (en) | 2000-07-07 | 2002-01-17 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
| EP1373889A2 (en) | 2000-07-31 | 2004-01-02 | Maxygen, Inc. | Biosensors, reagents and diagnostic applications of directed evolution |
| US7211414B2 (en) | 2000-12-01 | 2007-05-01 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| EP1395805A4 (en) | 2001-06-11 | 2005-03-09 | Illumina Inc | MULTIPLEXED DETECTION TECHNIQUES |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| EP3002289B1 (en) | 2002-08-23 | 2018-02-28 | Illumina Cambridge Limited | Modified nucleotides for polynucleotide sequencing |
| US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
| US8283148B2 (en) | 2002-10-25 | 2012-10-09 | Agilent Technologies, Inc. | DNA polymerase compositions for quantitative PCR and methods thereof |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| US7315019B2 (en) | 2004-09-17 | 2008-01-01 | Pacific Biosciences Of California, Inc. | Arrays of optical confinements and uses thereof |
| US20070048748A1 (en) * | 2004-09-24 | 2007-03-01 | Li-Cor, Inc. | Mutant polymerases for sequencing and genotyping |
| GB0509508D0 (en) * | 2005-05-10 | 2005-06-15 | Solexa Ltd | Improved polymerases |
| WO2006120433A1 (en) | 2005-05-10 | 2006-11-16 | Solexa Limited | Improved polymerases |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| US8921086B2 (en) | 2005-12-22 | 2014-12-30 | Pacific Biosciences Of California, Inc. | Polymerases for nucleotide analogue incorporation |
| EP3722409A1 (en) | 2006-03-31 | 2020-10-14 | Illumina, Inc. | Systems and devices for sequence by synthesis analysis |
| DK2044188T3 (en) | 2006-07-14 | 2015-12-14 | Novozymes As | Polypeptides with lipase activity and polynucleotides encoding them |
| WO2008029085A2 (en) | 2006-09-06 | 2008-03-13 | Medical Research Council | Polymerase |
| GB0617575D0 (en) | 2006-09-06 | 2006-10-18 | Syngenta Ltd | Herbicidal compounds and compositions |
| US8343746B2 (en) | 2006-10-23 | 2013-01-01 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US7948015B2 (en) | 2006-12-14 | 2011-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| JP5386367B2 (ja) | 2006-12-29 | 2014-01-15 | アジレント・テクノロジーズ・インク | 分断ポリメラーゼを使用する組成物および方法 |
| JP5357893B2 (ja) | 2007-12-27 | 2013-12-04 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 迅速超長鎖ｐｃｒのための単一酵素系 |
| WO2009131919A2 (en) | 2008-04-22 | 2009-10-29 | New England Biolabs, Inc. | Polymerases for incorporating modified nucleotides |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US8481685B2 (en) | 2008-11-03 | 2013-07-09 | Kapa Biosystems | Modified DNA polymerases |
| WO2010062776A2 (en) | 2008-11-03 | 2010-06-03 | Kapabiosystems | Chimeric dna polymerases |
| AU2010205133B2 (en) | 2009-01-15 | 2015-01-22 | Hokkaido Mitsui Chemicals Inc. | Enzyme preparation containing thermostable dna polymerase, method for producing same, and method for detecting subject organism to be detected |
| WO2011026194A1 (en) | 2009-09-07 | 2011-03-10 | Reproductive Health Science Pty Ltd | Nucleic acid extraction |
| US8965076B2 (en) | 2010-01-13 | 2015-02-24 | Illumina, Inc. | Data processing system and methods |
| US20110301041A1 (en) | 2010-02-26 | 2011-12-08 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
| GB201007384D0 (en) | 2010-04-30 | 2010-06-16 | Medical Res Council | Enzymes |
| EP2632593B1 (en) | 2010-10-27 | 2021-09-29 | Illumina, Inc. | Flow cells for biological or chemical analysis |
| WO2012154934A1 (en) | 2011-05-11 | 2012-11-15 | New England Biolabs, Inc. | Dna polymerase variants with reduced exonuclease activity and uses thereof |
| US8921044B2 (en) | 2011-05-11 | 2014-12-30 | New England Biolabs, Inc. | DNA polymerase variants with reduced exonuclease activity and uses thereof |
| JP6478444B2 (ja) * | 2012-09-28 | 2019-03-06 | 東洋紡株式会社 | 改変された耐熱性ｄｎａポリメラーゼ |
| US10421996B2 (en) | 2013-03-14 | 2019-09-24 | Illumina, Inc. | Modified polymerases for improved incorporation of nucleotide analogues |
| BR112015022448B1 (pt) | 2013-03-15 | 2020-12-08 | Illumina Cambridge Limited | molécula de nucleotídeo ou nucleosídeo modificado, métodos para preparar o crescimento de polinucleotídeo complementar a polinucleotídeo alvo de fita simples em reação de sequenciação e para determinar a sequência de polinucleotídeo alvo de fita simples e kit |
| GB2526261B (en) | 2014-04-28 | 2017-08-02 | Gelliner Ltd | Encoded cells and cell arrays |
| EP3702471B1 (en) * | 2014-06-27 | 2025-12-24 | Illumina, Inc. | Modified polymerases for improved incorporation of nucleotide analogues |
| JP6594955B2 (ja) * | 2014-08-27 | 2019-10-23 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | シントン形成 |
| WO2016054096A1 (en) | 2014-09-30 | 2016-04-07 | Illumina, Inc. | Modified polymerases for improved incorporation of nucleotide analogues |
| CN107922929A (zh) | 2015-09-09 | 2018-04-17 | 凯杰有限公司 | 聚合酶 |
| TWI658139B (zh) * | 2016-11-01 | 2019-05-01 | 體學生物科技股份有限公司 | 用以提升核苷酸類似物併入之重組dna聚合酶 |
| WO2018126470A1 (zh) | 2017-01-09 | 2018-07-12 | 深圳华大智造科技有限公司 | 重组dna聚合酶 |
| US20200002689A1 (en) | 2017-02-13 | 2020-01-02 | Qiagen Sciences, Llc | Polymerase enzyme from 9°n |
| WO2018148727A1 (en) | 2017-02-13 | 2018-08-16 | Qiagen Waltham Inc. | Polymerase enzyme from 9°n |
| WO2018148723A1 (en) | 2017-02-13 | 2018-08-16 | Qiagen Waltham Inc. | Polymerase enzyme from pyrococcus abyssi |
| WO2018148724A1 (en) | 2017-02-13 | 2018-08-16 | Qiagen Waltham Inc. | Polymerase enzyme from pyrococcus furiosus |
| WO2018148726A1 (en) | 2017-02-13 | 2018-08-16 | Qiagen Waltham Inc. | Polymerase enzyme from phage t4 |
| GB201711219D0 (en) | 2017-07-12 | 2017-08-23 | Illumina Cambridge Ltd | Short pendant arm linkers for nucleotides in sequencing applications |
| CN117802065A (zh) | 2018-09-03 | 2024-04-02 | 深圳华大生命科学研究院 | 聚合活性提高的重组型kod聚合酶 |
| WO2020056044A1 (en) | 2018-09-11 | 2020-03-19 | Singular Genomics Systems, Inc. | Modified archaeal family b polymerases |
| EP3853358A1 (en) | 2018-09-17 | 2021-07-28 | Omniome, Inc. | Engineered polymerases for improved sequencing |
| US11104888B2 (en) | 2018-10-31 | 2021-08-31 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| EP3891275A2 (en) | 2018-12-05 | 2021-10-13 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
-
2019
- 2019-12-04 EP EP19832480.8A patent/EP3891275A2/en active Pending
- 2019-12-04 MY MYPI2020006925A patent/MY204767A/en unknown
- 2019-12-04 BR BR112020026655-8A patent/BR112020026655A2/pt unknown
- 2019-12-04 JP JP2020572440A patent/JP7527208B2/ja active Active
- 2019-12-04 CA CA3103739A patent/CA3103739A1/en active Pending
- 2019-12-04 AU AU2019391093A patent/AU2019391093B2/en active Active
- 2019-12-04 CN CN201980043088.6A patent/CN112639090A/zh active Pending
- 2019-12-04 IL IL279423A patent/IL279423B/en unknown
- 2019-12-04 SG SG11202012559SA patent/SG11202012559SA/en unknown
- 2019-12-04 US US16/703,569 patent/US11001816B2/en active Active
- 2019-12-04 MX MX2020013357A patent/MX2020013357A/es unknown
- 2019-12-04 IL IL297994A patent/IL297994A/en unknown
- 2019-12-04 WO PCT/US2019/064524 patent/WO2020117968A2/en not_active Ceased
- 2019-12-04 KR KR1020207037468A patent/KR20210098844A/ko active Pending
-
2020
- 2020-12-15 ZA ZA2020/07839A patent/ZA202007839B/en unknown
-
2021
- 2021-04-09 US US17/226,393 patent/US11634697B2/en active Active
-
2023
- 2023-03-13 US US18/120,639 patent/US12104182B2/en active Active
-
2024
- 2024-09-04 US US18/824,208 patent/US20250059521A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019391093A1 (en) | 2021-01-07 |
| BR112020026655A2 (pt) | 2021-04-06 |
| CN112639090A (zh) | 2021-04-09 |
| JP2022511206A (ja) | 2022-01-31 |
| AU2019391093B2 (en) | 2025-11-27 |
| US20200181587A1 (en) | 2020-06-11 |
| WO2020117968A2 (en) | 2020-06-11 |
| SG11202012559SA (en) | 2021-01-28 |
| US20210348141A1 (en) | 2021-11-11 |
| US11634697B2 (en) | 2023-04-25 |
| US11001816B2 (en) | 2021-05-11 |
| IL279423A (en) | 2021-01-31 |
| WO2020117968A3 (en) | 2020-08-13 |
| KR20210098844A (ko) | 2021-08-11 |
| MX2020013357A (es) | 2021-04-28 |
| IL297994A (en) | 2025-01-01 |
| ZA202007839B (en) | 2022-04-28 |
| EP3891275A2 (en) | 2021-10-13 |
| IL279423B (en) | 2022-08-01 |
| US12104182B2 (en) | 2024-10-01 |
| CA3103739A1 (en) | 2020-06-11 |
| US20250059521A1 (en) | 2025-02-20 |
| JP7527208B2 (ja) | 2024-08-02 |
| US20230357731A1 (en) | 2023-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY204767A (en) | Polymerases, compositions, and methods of use | |
| MY203805A (en) | Polymerases, compositions, and methods of use | |
| CA3197311A1 (en) | Oligonucleotide compositions and methods thereof | |
| PH12021550686A1 (en) | Compositions and methods for lactate dehydrogenase (ldha) gene editing | |
| EP4328303A3 (en) | Novel use | |
| PH12021550805A1 (en) | Methods and Compositions for Editing RNAs | |
| MX2024006956A (es) | Inserciones de adn no virales orientadas. | |
| PH12022550059A1 (en) | Targeted rna editing by leveraging endogenous adar using engineered rnas | |
| EP4524247A3 (en) | Crispr/cas9-mediated exon-skipping approach for ush2a-associated usher syndrome | |
| WO2020003006A3 (en) | Compositions and methods for genomic editing by insertion of donor polynucleotides | |
| MX2024011205A (es) | Polimerasas, composiciones y metodos de uso. | |
| CR20200192A (es) | Métodos y composiciones para la producción de nucleósido trifosfatos y ácidos ribonucleicos | |
| EP3882343A3 (en) | Thermostable variants of t7 rna polymerase | |
| MX2018014890A (es) | Composiciones de limpieza que comprenden enzimas. | |
| EP4431607A3 (en) | High-throughput precision genome editing | |
| MX2022002462A (es) | Composiciones y métodos para la modificación de cll1. | |
| MX2021006674A (es) | Composiciones para estabilizar bacterias y usos de las mismas. | |
| SG11201907899TA (en) | Method for replicating or amplifying circular dna | |
| MX2025007036A (es) | Metodos y composiciones para generar alelos dominantes usando edicion del genoma | |
| WO2018146557A3 (en) | Long double-stranded rna for rna interference | |
| EP4461821A3 (en) | Polymerase compositions and methods of making and using same | |
| PH12020550654A1 (en) | Asymmetric pcr methods | |
| WO2020198174A8 (en) | Simultaneous multiplex genome editing in yeast | |
| MX2024000277A (es) | Microarns modificados con 5-halouracilo y su uso en el tratamiento del cancer. | |
| WO2020005667A8 (en) | Compositions and methods for editing an endogenous nac gene in plants |