MXPA99011713A - Cosmetic compositions - Google Patents
Cosmetic compositionsInfo
- Publication number
- MXPA99011713A MXPA99011713A MXPA/A/1999/011713A MX9911713A MXPA99011713A MX PA99011713 A MXPA99011713 A MX PA99011713A MX 9911713 A MX9911713 A MX 9911713A MX PA99011713 A MXPA99011713 A MX PA99011713A
- Authority
- MX
- Mexico
- Prior art keywords
- acid
- oil
- weight
- ppg
- salicylic acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 140
- 239000002537 cosmetic Substances 0.000 title claims abstract description 38
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 61
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 29
- 210000003491 Skin Anatomy 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000003872 salicylic acid derivatives Chemical class 0.000 claims abstract description 15
- 230000000699 topical Effects 0.000 claims abstract description 5
- 239000000049 pigment Substances 0.000 claims description 56
- 239000012071 phase Substances 0.000 claims description 45
- 229920001296 polysiloxane Polymers 0.000 claims description 35
- 239000000839 emulsion Substances 0.000 claims description 18
- 239000008346 aqueous phase Substances 0.000 claims description 12
- ODLHGICHYURWBS-LKONHMLTSA-N Trappsol Cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 3
- 230000003255 anti-acne Effects 0.000 abstract description 11
- 229920000858 Cyclodextrin Polymers 0.000 abstract description 9
- 206010040880 Skin irritation Diseases 0.000 abstract description 7
- 230000036556 skin irritation Effects 0.000 abstract description 7
- 231100000475 skin irritation Toxicity 0.000 abstract description 7
- 230000003110 anti-inflammatory Effects 0.000 abstract description 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- -1 benzoic acid compound Chemical class 0.000 description 63
- 239000002253 acid Substances 0.000 description 54
- 239000003921 oil Substances 0.000 description 34
- 235000014113 dietary fatty acids Nutrition 0.000 description 32
- 239000000194 fatty acid Substances 0.000 description 32
- 235000019198 oils Nutrition 0.000 description 32
- 229920005862 polyol Polymers 0.000 description 30
- 150000001875 compounds Chemical class 0.000 description 23
- 239000000463 material Substances 0.000 description 21
- 150000004665 fatty acids Chemical class 0.000 description 19
- 150000003077 polyols Chemical class 0.000 description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 17
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 15
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 15
- 229960004793 Sucrose Drugs 0.000 description 15
- 125000000217 alkyl group Chemical group 0.000 description 15
- 229920001577 copolymer Polymers 0.000 description 15
- 239000005720 sucrose Substances 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 14
- 239000003906 humectant Substances 0.000 description 14
- 239000000843 powder Substances 0.000 description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 13
- 239000002904 solvent Substances 0.000 description 13
- 125000004432 carbon atoms Chemical group C* 0.000 description 12
- 239000012530 fluid Substances 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 12
- GTABBGRXERZUAH-UHFFFAOYSA-N hexadecan-1-ol;2-methyloxirane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCCCCCCO GTABBGRXERZUAH-UHFFFAOYSA-N 0.000 description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
- 229920001888 polyacrylic acid Polymers 0.000 description 11
- 150000001298 alcohols Chemical class 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 229920000728 polyester Polymers 0.000 description 10
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000003349 gelling agent Substances 0.000 description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 229920002545 silicone oil Polymers 0.000 description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 8
- 150000003254 radicals Chemical class 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- HNJBEVLQSNELDL-UHFFFAOYSA-N 2-Pyrrolidone Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 7
- 239000003974 emollient agent Substances 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 150000001261 hydroxy acids Chemical class 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 235000019388 lanolin Nutrition 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 6
- 239000004166 Lanolin Substances 0.000 description 6
- 229940039717 Lanolin Drugs 0.000 description 6
- 150000002170 ethers Chemical class 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 150000002596 lactones Chemical class 0.000 description 6
- 239000002480 mineral oil Substances 0.000 description 6
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- 239000006096 absorbing agent Substances 0.000 description 5
- 230000002378 acidificating Effects 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 125000004122 cyclic group Chemical group 0.000 description 5
- 229920001600 hydrophobic polymer Polymers 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
- 238000005063 solubilization Methods 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 235000010356 sorbitol Nutrition 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 229960001031 Glucose Drugs 0.000 description 4
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinylpyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 4
- 239000002738 chelating agent Substances 0.000 description 4
- 230000003750 conditioning Effects 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 150000002191 fatty alcohols Chemical class 0.000 description 4
- 150000002194 fatty esters Chemical class 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 229910000460 iron oxide Inorganic materials 0.000 description 4
- 239000004922 lacquer Substances 0.000 description 4
- 150000002772 monosaccharides Chemical class 0.000 description 4
- 235000021313 oleic acid Nutrition 0.000 description 4
- 235000019271 petrolatum Nutrition 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 230000002335 preservative Effects 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- BLRPTPMANUNPDV-UHFFFAOYSA-N silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 4
- 229910000077 silane Inorganic materials 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- PXWCUJRVSZCPHE-UHFFFAOYSA-N α-Butyl-ω-hydroxypoly(oxyethylene) poly(oxypropylene) Chemical compound CCCCOCCOCC(C)OCCCOC PXWCUJRVSZCPHE-UHFFFAOYSA-N 0.000 description 4
- GZCGUPFRVQAUEE-KCDKBNATSA-N D-(+)-Galactose Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-KCDKBNATSA-N 0.000 description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 3
- 239000005642 Oleic acid Substances 0.000 description 3
- 239000004264 Petrolatum Substances 0.000 description 3
- 229940066842 Petrolatum Drugs 0.000 description 3
- 239000004698 Polyethylene (PE) Substances 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N Xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 229960002675 Xylitol Drugs 0.000 description 3
- SRBFZHDQGSBBOR-SQOUGZDYSA-N Xylose Natural products O[C@@H]1CO[C@@H](O)[C@@H](O)[C@@H]1O SRBFZHDQGSBBOR-SQOUGZDYSA-N 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- 125000004429 atoms Chemical group 0.000 description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 description 3
- 230000002209 hydrophobic Effects 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- 230000003020 moisturizing Effects 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 235000014571 nuts Nutrition 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- 235000020957 pantothenol Nutrition 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000003549 soybean oil Substances 0.000 description 3
- 235000012424 soybean oil Nutrition 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N α-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-Methyl-2,4-pentanediol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- MBIQENSCDNJOIY-UHFFFAOYSA-N 2-hydroxy-2-methylbutyric acid Chemical compound CCC(C)(O)C(O)=O MBIQENSCDNJOIY-UHFFFAOYSA-N 0.000 description 2
- 235000019489 Almond oil Nutrition 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- PZZYQPZGQPZBDN-UHFFFAOYSA-N Aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L Barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- XFTRTWQBIOMVPK-YFKPBYRVSA-N Citramalic acid Natural products OC(=O)[C@](O)(C)CC(O)=O XFTRTWQBIOMVPK-YFKPBYRVSA-N 0.000 description 2
- 229940097362 Cyclodextrins Drugs 0.000 description 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N Dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N Docosanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N Erucic acid Chemical class CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- 229940009714 Erythritol Drugs 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N Erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- YTBSYETUWUMLBZ-IUYQGCFVSA-N Erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 2
- 206010056474 Erythrosis Diseases 0.000 description 2
- BJHIKXHVCXFQLS-UYFOZJQFSA-N Fructose Natural products OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- ODBLHEXUDAPZAU-FONMRSAGSA-N Isocitric acid Natural products OC(=O)[C@@H](O)[C@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-FONMRSAGSA-N 0.000 description 2
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-YOLKTULGSA-N Maltose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@H]1CO)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 GUBGYTABKSRVRQ-YOLKTULGSA-N 0.000 description 2
- NPOAOTPXWNWTSH-UHFFFAOYSA-N Meglutol Chemical compound OC(=O)CC(O)(C)CC(O)=O NPOAOTPXWNWTSH-UHFFFAOYSA-N 0.000 description 2
- 229910018891 PSi Inorganic materials 0.000 description 2
- 229940101267 Panthenol Drugs 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 229920001451 Polypropylene glycol Polymers 0.000 description 2
- DSLZVSRJTYRBFB-LLEIAEIESA-N Saccharic acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-LLEIAEIESA-N 0.000 description 2
- 235000019485 Safflower oil Nutrition 0.000 description 2
- 229940058287 Salicylic acid derivative anticestodals Drugs 0.000 description 2
- 229960004029 Silicic Acid Drugs 0.000 description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N Simethicone Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 2
- JNYAEWCLZODPBN-CTQIIAAMSA-N Sorbitan Chemical class OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N Squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229940057400 TRIHYDROXYSTEARIN Drugs 0.000 description 2
- PBJUNZJWGZTSKL-MRXNPFEDSA-N Tiagabine Chemical compound C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C PBJUNZJWGZTSKL-MRXNPFEDSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Tris Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- JACRWUWPXAESPB-QMMMGPOBSA-N Tropic acid Natural products OC[C@H](C(O)=O)C1=CC=CC=C1 JACRWUWPXAESPB-QMMMGPOBSA-N 0.000 description 2
- 229960003487 Xylose Drugs 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 125000005466 alkylenyl group Chemical group 0.000 description 2
- 239000008168 almond oil Substances 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 239000010775 animal oil Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 150000001479 arabinose derivatives Chemical class 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 235000021302 avocado oil Nutrition 0.000 description 2
- 239000008163 avocado oil Substances 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000008139 complexing agent Substances 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229960000735 docosanol Drugs 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 230000002708 enhancing Effects 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008169 grapeseed oil Substances 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 229940051250 hexylene glycol Drugs 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229940074928 isopropyl myristate Drugs 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 235000020778 linoleic acid Nutrition 0.000 description 2
- 239000000944 linseed oil Substances 0.000 description 2
- 235000021388 linseed oil Nutrition 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229940049920 malate Drugs 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000003472 neutralizing Effects 0.000 description 2
- 239000003883 ointment base Substances 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 125000004430 oxygen atoms Chemical group O* 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- 239000000312 peanut oil Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000010665 pine oil Substances 0.000 description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 2
- 229920002189 poly(glycerol 1-O-monomethacrylate) polymer Polymers 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920000193 polymethacrylate Polymers 0.000 description 2
- 239000010491 poppyseed oil Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- BFZNCPXNOGIELB-UHFFFAOYSA-N propan-2-yl 10-[5,6-dihexyl-2-(8-oxo-8-propan-2-yloxyoctyl)cyclohex-3-en-1-yl]dec-9-enoate Chemical compound CCCCCCC1C=CC(CCCCCCCC(=O)OC(C)C)C(C=CCCCCCCCC(=O)OC(C)C)C1CCCCCC BFZNCPXNOGIELB-UHFFFAOYSA-N 0.000 description 2
- 239000001944 prunus armeniaca kernel oil Substances 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 235000005713 safflower oil Nutrition 0.000 description 2
- 239000003813 safflower oil Substances 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 235000003441 saturated fatty acids Nutrition 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 230000000475 sunscreen Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229960001918 tiagabine Drugs 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 239000010497 wheat germ oil Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2R,3R,4S,5R,6S)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4S,5R,6R)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- SXZYCXMUPBBULW-MEFNJWCVSA-N (3R,5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-one Chemical compound OC[C@H](O)[C@H]1OC(=O)[C@H](O)C1O SXZYCXMUPBBULW-MEFNJWCVSA-N 0.000 description 1
- HXQBZGMVGIDZAJ-UHFFFAOYSA-N (±)-2-Hydroxy-3-(2-hydroxyphenyl)propanoic acid Chemical compound OC(=O)C(O)CC1=CC=CC=C1O HXQBZGMVGIDZAJ-UHFFFAOYSA-N 0.000 description 1
- NJPQAIBZIHNJDO-UHFFFAOYSA-N 1-dodecylpyrrolidin-2-one Chemical compound CCCCCCCCCCCCN1CCCC1=O NJPQAIBZIHNJDO-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- GQXURJDNDYACGE-UHFFFAOYSA-N 1-hydroxycyclopropane-1-carboxylic acid Chemical compound OC(=O)C1(O)CC1 GQXURJDNDYACGE-UHFFFAOYSA-N 0.000 description 1
- YJCJVMMDTBEITC-UHFFFAOYSA-N 10-Hydroxydecanoic acid Chemical compound OCCCCCCCCCC(O)=O YJCJVMMDTBEITC-UHFFFAOYSA-N 0.000 description 1
- ZDHCZVWCTKTBRY-UHFFFAOYSA-N 12-hydroxylauric acid Chemical compound OCCCCCCCCCCCC(O)=O ZDHCZVWCTKTBRY-UHFFFAOYSA-N 0.000 description 1
- XHWHHMNORMIBBB-UHFFFAOYSA-N 2,2,3,3-tetrahydroxybutanedioic acid Chemical compound OC(=O)C(O)(O)C(O)(O)C(O)=O XHWHHMNORMIBBB-UHFFFAOYSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N 2,2-bis(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- KWMLJOLKUYYJFJ-UHFFFAOYSA-N 2,3,4,5,6,7-hexahydroxyheptanoic acid Chemical compound OCC(O)C(O)C(O)C(O)C(O)C(O)=O KWMLJOLKUYYJFJ-UHFFFAOYSA-N 0.000 description 1
- JPIJQSOTBSSVTP-UHFFFAOYSA-N 2,3,4-trihydroxybutanoic acid Chemical compound OCC(O)C(O)C(O)=O JPIJQSOTBSSVTP-UHFFFAOYSA-N 0.000 description 1
- NPTTZSYLTYJCPR-UHFFFAOYSA-N 2,3,4-trihydroxypentanedioic acid Chemical compound OC(=O)C(O)C(O)C(O)C(O)=O NPTTZSYLTYJCPR-UHFFFAOYSA-N 0.000 description 1
- ZKBSDMGDEJPNGS-UHFFFAOYSA-N 2,3-dihydroxypropanoic acid Chemical compound OCC(O)C(O)=O.OCC(O)C(O)=O ZKBSDMGDEJPNGS-UHFFFAOYSA-N 0.000 description 1
- URZHQOCYXDNFGN-UHFFFAOYSA-N 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane Chemical compound FC(F)(F)CC[Si]1(C)O[Si](C)(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O1 URZHQOCYXDNFGN-UHFFFAOYSA-N 0.000 description 1
- AAOFEMJZTYQZRH-UHFFFAOYSA-N 2-(1-butoxypropan-2-yloxy)ethanol Chemical compound CCCCOCC(C)OCCO AAOFEMJZTYQZRH-UHFFFAOYSA-N 0.000 description 1
- BWSFWXSSALIZAU-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-hydroxyacetic acid Chemical compound OC(=O)C(O)C1=CC=C(Cl)C=C1 BWSFWXSSALIZAU-UHFFFAOYSA-N 0.000 description 1
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 description 1
- PXMUSCHKJYFZFD-UHFFFAOYSA-N 2-hydroxy-2-(3-hydroxy-4-methoxyphenyl)acetic acid Chemical compound COC1=CC=C(C(O)C(O)=O)C=C1O PXMUSCHKJYFZFD-UHFFFAOYSA-N 0.000 description 1
- NGEWQZIDQIYUNV-UHFFFAOYSA-N 2-hydroxy-3-methylbutyric acid Chemical compound CC(C)C(O)C(O)=O NGEWQZIDQIYUNV-UHFFFAOYSA-N 0.000 description 1
- NYHNVHGFPZAZGA-UHFFFAOYSA-N 2-hydroxyhexanoic acid Chemical compound CCCCC(O)C(O)=O NYHNVHGFPZAZGA-UHFFFAOYSA-N 0.000 description 1
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 description 1
- HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- QNYWMNCOJRYQJB-UHFFFAOYSA-N 2-methyloxirane;1-octadecoxyoctadecane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC QNYWMNCOJRYQJB-UHFFFAOYSA-N 0.000 description 1
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methylpentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 1
- OORRCVPWRPVJEK-UHFFFAOYSA-N 2-oxidanylethanoic acid Chemical compound OCC(O)=O.OCC(O)=O OORRCVPWRPVJEK-UHFFFAOYSA-N 0.000 description 1
- KVZLHPXEUGJPAH-UHFFFAOYSA-N 2-oxidanylpropanoic acid Chemical compound CC(O)C(O)=O.CC(O)C(O)=O KVZLHPXEUGJPAH-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- KEGHVPSZIWXTPY-UHFFFAOYSA-N 3-hydroxy-3-methylpentanoic acid Chemical compound CCC(C)(O)CC(O)=O KEGHVPSZIWXTPY-UHFFFAOYSA-N 0.000 description 1
- LGVJIYCMHMKTPB-UHFFFAOYSA-N 3-hydroxynorvaline Chemical compound CCC(O)C(N)C(O)=O LGVJIYCMHMKTPB-UHFFFAOYSA-N 0.000 description 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- VOXXWSYKYCBWHO-UHFFFAOYSA-N 3-phenyllactic acid Chemical compound OC(=O)C(O)CC1=CC=CC=C1 VOXXWSYKYCBWHO-UHFFFAOYSA-N 0.000 description 1
- YHXHKYRQLYQUIH-UHFFFAOYSA-N 4-Hydroxymandelic acid Chemical compound OC(=O)C(O)C1=CC=C(O)C=C1 YHXHKYRQLYQUIH-UHFFFAOYSA-N 0.000 description 1
- KZALBFMKMGNMAF-UHFFFAOYSA-N 4-hydroxy-2,2-diphenylbutanoic acid Chemical compound C=1C=CC=CC=1C(C(O)=O)(CCO)C1=CC=CC=C1 KZALBFMKMGNMAF-UHFFFAOYSA-N 0.000 description 1
- QQAVZEYXLCYOKO-UHFFFAOYSA-N 4-hydroxydecanoic acid Chemical compound CCCCCCC(O)CCC(O)=O QQAVZEYXLCYOKO-UHFFFAOYSA-N 0.000 description 1
- FZBYZQPNENFBLV-UHFFFAOYSA-N 4-hydroxypent-3-enoic acid Chemical compound CC(O)=CCC(O)=O FZBYZQPNENFBLV-UHFFFAOYSA-N 0.000 description 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 description 1
- 229940117976 5-hydroxylysine Drugs 0.000 description 1
- MEHUJCGAYMDLEL-LSDHHAIUSA-N Aleuritic acid Chemical compound OCCCCCC[C@@H](O)[C@@H](O)CCCCCCCC(O)=O MEHUJCGAYMDLEL-LSDHHAIUSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- BDJRBEYXGGNYIS-UHFFFAOYSA-N Azelaic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 210000000988 Bone and Bones Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N Boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- HREIECSKSVUDRN-UHFFFAOYSA-N CCCCCCCCCCC(O)C(O)=O.CCCCCCCCCCC(O)C(O)=O Chemical compound CCCCCCCCCCC(O)C(O)=O.CCCCCCCCCCC(O)C(O)=O HREIECSKSVUDRN-UHFFFAOYSA-N 0.000 description 1
- DLQDPUCZIABCES-VZBBZXSKSA-N CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)C=O Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)C=O DLQDPUCZIABCES-VZBBZXSKSA-N 0.000 description 1
- 210000001736 Capillaries Anatomy 0.000 description 1
- 229940075510 Carbopol 981 Drugs 0.000 description 1
- 229940107161 Cholesterol Drugs 0.000 description 1
- VQWFNAGFNGABOH-UHFFFAOYSA-K Chromium(III) hydroxide Chemical compound [OH-].[OH-].[OH-].[Cr+3] VQWFNAGFNGABOH-UHFFFAOYSA-K 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-Galacturonic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- SNPLKNRPJHDVJA-UHFFFAOYSA-N DL-Panthenol Chemical compound OCC(C)(C)C(O)C(=O)NCCCO SNPLKNRPJHDVJA-UHFFFAOYSA-N 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 229960003949 Dexpanthenol Drugs 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N Diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 241001096477 Gazania krebsiana subsp. serrulata Species 0.000 description 1
- 229950002441 Glucurolactone Drugs 0.000 description 1
- 229940097043 Glucuronic Acid Drugs 0.000 description 1
- UYUXSRADSPPKRZ-SKNVOMKLSA-N Glucuronolactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 description 1
- 240000007842 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- RGHNJXZEOKUKBD-KKQCNMDGSA-N Gulonic acid Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-KKQCNMDGSA-N 0.000 description 1
- 235000019487 Hazelnut oil Nutrition 0.000 description 1
- 240000006669 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- HHDDCCUIIUWNGJ-UHFFFAOYSA-N Hydroxypyruvic acid Chemical compound OCC(=O)C(O)=O HHDDCCUIIUWNGJ-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N Iron(III) oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- DSLZVSRJTYRBFB-ZNIBRBMXSA-N L-mannaric acid Chemical compound OC(=O)[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-ZNIBRBMXSA-N 0.000 description 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 1
- 229940067606 Lecithin Drugs 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N Malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N Mandelic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- KUCURORHKGPKIX-UHFFFAOYSA-N OC(=O)C(O)C(O)=O.OC(=O)C(O)C(O)=O Chemical compound OC(=O)C(O)C(O)=O.OC(=O)C(O)C(O)=O KUCURORHKGPKIX-UHFFFAOYSA-N 0.000 description 1
- URSCRKIYUPROKB-PHHCKKAISA-N OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O URSCRKIYUPROKB-PHHCKKAISA-N 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl methoxycinnamate Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 229960002969 Oleic Acid Drugs 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N Oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229940095014 PPG 12 Buteth 16 Drugs 0.000 description 1
- 229940088640 PPG-25-LAURETH-25 Drugs 0.000 description 1
- 229940047663 PPG-26-BUTETH-26 Drugs 0.000 description 1
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 1
- ZQTHOIGMSJMBLM-BUJSFMDZSA-N Pangamic acid Chemical compound CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O ZQTHOIGMSJMBLM-BUJSFMDZSA-N 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940069328 Povidone Drugs 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- AAWZDTNXLSGCEK-WYWMIBKRSA-N Quinic acid Chemical compound O[C@@H]1C[C@](O)(C(O)=O)C[C@@H](O)[C@H]1O AAWZDTNXLSGCEK-WYWMIBKRSA-N 0.000 description 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
- 240000003670 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 241000907903 Shorea Species 0.000 description 1
- 229910018557 Si O Inorganic materials 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M Sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N Stearyl alcohol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- SHGAZHPCJJPHSC-NWVFGJFESA-N Tretinoin Chemical compound OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NWVFGJFESA-N 0.000 description 1
- 229960001727 Tretinoin Drugs 0.000 description 1
- HWKQNAWCHQMZHK-UHFFFAOYSA-N Trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 1
- 229940046001 Vitamin B Complex Drugs 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- WYWZRNAHINYAEF-AWEZNQCLSA-N [(2S)-2-ethylhexyl] 4-(dimethylamino)benzoate Chemical compound CCCC[C@H](CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-AWEZNQCLSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 231100000494 adverse effect Toxicity 0.000 description 1
- 239000005456 alcohol based solvent Substances 0.000 description 1
- 125000003302 alkenyloxy group Chemical group 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 125000005336 allyloxy group Chemical group 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 230000000111 anti-oxidant Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- NWCHELUCVWSRRS-UHFFFAOYSA-N atrolactic acid Chemical compound OC(=O)C(O)(C)C1=CC=CC=C1 NWCHELUCVWSRRS-UHFFFAOYSA-N 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- UHHXUPJJDHEMGX-UHFFFAOYSA-K azanium;manganese(3+);phosphonato phosphate Chemical compound [NH4+].[Mn+3].[O-]P([O-])(=O)OP([O-])([O-])=O UHHXUPJJDHEMGX-UHFFFAOYSA-K 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium(0) Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 230000000536 complexating Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- GMMUMXYUVFRBFV-UHFFFAOYSA-N dodecane;2-methyloxirane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCC GMMUMXYUVFRBFV-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000001804 emulsifying Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N ethanolamine Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 150000002195 fatty ethers Chemical class 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940053049 glucuronolactone Drugs 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000010468 hazelnut oil Substances 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- TZMQHOJDDMFGQX-UHFFFAOYSA-N hexane-1,1,1-triol Chemical compound CCCCCC(O)(O)O TZMQHOJDDMFGQX-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000008633 juniper tar Substances 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- BJHIKXHVCXFQLS-PYWDMBMJSA-N keto-D-sorbose Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)C(=O)CO BJHIKXHVCXFQLS-PYWDMBMJSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-L maleate(2-) Chemical compound [O-]C(=O)\C=C/C([O-])=O VZCYOOQTPOCHFL-UPHRSURJSA-L 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 229960002638 padimate o Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N palmityl palmitate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 229940055705 pangamic acid Drugs 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000020233 pistachio Nutrition 0.000 description 1
- 229920001921 poly-methyl-phenyl-siloxane Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229960002862 pyridoxine Drugs 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 231100000486 side effect Toxicity 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Inorganic materials [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing Effects 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- AEMOLEFTQBMNLQ-QIUUJYRFSA-N β-D-glucuronic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 description 1
- WHBMMWSBFZVSSR-UHFFFAOYSA-N β-Hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N γ-Hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- LMHJFKYQYDSOQO-UHFFFAOYSA-N ξ-5-Hydroxydecanoic acid Chemical compound CCCCCC(O)CCCC(O)=O LMHJFKYQYDSOQO-UHFFFAOYSA-N 0.000 description 1
- LXNOENXQFNYMGT-UHFFFAOYSA-N ξ-5-Hydroxydodecanoic acid Chemical compound CCCCCCCC(O)CCCC(O)=O LXNOENXQFNYMGT-UHFFFAOYSA-N 0.000 description 1
Abstract
Cosmetic composition for topical application to the skin comprising a hydroxyalkyl cyclodextrin, salicylic acid or salicylic acid derivative and water. The compositions herein provide improved anti-acne/anti-inflammatory activity together with reduced skin irritation.
Description
COSMETIC COMPOSITIONS
FIELD OF THE INVENTION
The present invention relates to cosmetic compositions and very particularly to pigmented-based makeup compositions and imperfection concealers.
BACKGROUND OF THE INVENTION • A base composition can be applied to the face and other parts of the body to make the skin tone and texture uniform and to hide pores, imperfections, fine lines and the like. A base composition is also applied to moisten the skin, to balance the oil level of the skin and to
provide protection against the adverse effects of sunlight, wind and the hostile environment. Make-up compositions are generally available in the form of liquid or cream suspensions, emulsions, gels, pressed powders or anhydrous wax and oil compositions. Such cosmetic makeup compositions are described in US-A-3,444,291, US-20 A-4,486,405, US-A-4,804,532, US-A-3,978,207, US-A-4,659,562, US-A-5,143,722 and Nakamura et al., Preprints of the XlVth IFSCC Congress, Barcelona, 1986, Vol. I, 51-63 (1986).
The foundation makeup compositions are well known and provide good coverage and good skin feel, wear and appearance. At the same time, it would be convenient to provide a base composition having topical antiacne activity. It would also be convenient to provide a base composition that is gentle on the skin and causes little skin irritation or no irritation. There are many compounds known to have anti-acne properties when applied topically to the skin. A commonly used keratolytic agent that has anti-acne activity is salicylic acid. Since salicylic acid is virtually insoluble in water, it is difficult to incorporate it into aqueous systems such as aqueous solutions or the aqueous phase of an emulsion composition. Although salicylic acid can be supplied from the oil phase containing pigment of an emulsion base composition, however this can lead to discoloration of the composition due to the interaction between salicylic acid and the pigments, especially the oxide type. iron. Therefore, it would be convenient to supply the salicylic acid in soluble form from an aqueous phase. Attempts have been made to improve the solubility of salicylic acid in aqueous phase. One way to do this involves the use of alcohol solvents such as ethanol. However, such compositions can be hostile and can lead to skin irritation. Another way to help solubilize salicylic acid in aqueous systems involves the use of solubilization aids such as PVP. For example, WO 95/04517 describes a makeup composition in the form of an emulsion comprising an active anti-acne active dissolved in the aqueous phase and a pigment or mixture of pigments dispersed in the oil phase. PVP is described as a complexing agent to aid in the solubilization of salicylic acid. Another way to help solubilize salicylic acid is by using cyclodextrin compounds. Cyclodextrin compounds are known to form inclusion complexes with salicylic acid which can aid solubilization in aqueous systems. Ointment-like compositions comprising cyclodextrin and salicylic acid compounds are known from the following documents "Influence of cyclodextrins and other additives of the release of salicylic acid from various ointment bases", Yakuzaigaku, 50 (4), 341-346 (1990 ) and "Effect of additives on reléase of drugs from ointment bases", Yakuzaigaku, 42 (1), 10-16 (1982). WO 95/31976 describes a transdermal assortment system for anti-epileptic drug assortment containing one or more penetration enhancers and a compound selected from tiagabine, its pharmaceutically acceptable salts, pharmaceutically acceptable alkyl esters of Ca-6 or ion pairs of tiagabine and salicylic acid or oleic acid. The penetration enhancer can be selected from a group of penetration enhancers including hydroxypropyl-beta-cyclodextrin. Despite being able to solubilize salicylic acid in the aqueous phases of cosmetic compositions using methods such as those described above, there is still a need for cosmetic compositions having improved anti-acne / anti-inflammatory activity together with reduced skin softness / skin irritation as well as improved product stability. It has now been surprisingly found that by incorporating salicylic acid or a salicylic acid derivative and a hydroxyalkylcyclodextrin (C 1 -C 4) compound into an aqueous cosmetic composition containing water a composition having improved anti-acne / antibacterial activity is provided together with irritation of the reduced skin Accordingly, a first objective of this invention is to provide a cosmetic composition having improved anti-acne activity. Another object of the invention is also to provide a cosmetic composition having reduced skin irritation. Still another object of the invention is to provide a cosmetic composition in the form of an emulsion having improved product stability.
BRIEF DESCRIPTION OF THE INVENTION
In accordance with the present invention, there is provided a cosmetic composition comprising a hydroxyalkylcyclodextrin (C 1 -C 4), salicylic acid or a derivative of salicylic acid and water. The cosmetic compositions of the present invention provide improved anti-acne / anti-inflammatory activity, mildness and reduced skin irritation.
All levels and relationships are by weight of the total composition, unless otherwise indicated. The long chains and the alkoxylation grades are also specified on an average weight basis.
DETAILED DESCRIPTION OF THE INVENTION
The cosmetic composition according to the present invention comprises a hydroxyalkylcyclodextrin (C 1 -C 4) compound and salicylic acid or a salicylic acid derivative.
Hydroxyalkylcyclodextrin (C1-C4) compound
The first essential ingredient of the cosmetic compositions herein is a hydroxyalkylcyclodextrin compound. As used herein, the term "cyclodextrin" (CD) includes cyclodextrins containing from six to twelve glucose units, especially alpha, beta, gamma-cyclodextrins. Suitable hydroxyalkylcyclodextrin compounds to be used herein are those capable of complexing with salicylic acid or salicylic acid derivatives and / or salicylic acid derivatives. Preferably, the hydroxyalkylcyclodextrin compounds to be used herein are hydroxyalkylcyclodextrin (C 1 -C 4) compounds. Individual hydroxyalkylcyclodextrins can also be linked together, for example, using multifunctional agents to form oligomers, polymers, etc. It is also suitable to use mixtures of hydroxyalkylcyclodextrins to provide a mixture of complexes. The preferred hydroxyalkylcyclodextrin compound for use in the compositions herein is hydroxypropyl-beta-cyclodextrin. A hydroxyalkylcyclodextrin compound is present in the cosmetic compositions of the present invention at a level of from about 0.1 to about 20%, preferably from about 0.8% to about 15%, especially from about 0.8% to about 12%, by weight of the composition. A second essential component of the compositions herein is salicylic acid or a salicylic acid derivative. The term "salicylic acid derivative" as used herein means any substituted 2,3 or 4-OR benzoic acid compound having the formula:
wherein R is selected from C-i.C.sub.β alkyl or C-i-Cβ acyl, preferably wherein R is selected from C2-C3 alkyl or C2-C3 acyl. Especially preferred herein is salicylic acid.
Salicylic acid or a salicylic acid derivative is present in an amount that is safe and effective to provide anti-acne / anti-inflammatory activity and preferably at a level of from about 0.1% to about 10%, most preferably from about 0.1% to about 5%. %, and especially from about 0.5% to about 2% by weight of the composition. As used herein, "safe and effective amount" means a sufficient amount of a compound, composition or other material described by this phrase to significantly induce a positive modification in the condition being treated, but low enough to avoid undesirable side effects. (eg, irritation or significant skin sensitization), within the range of solid judgment of the skilled artisan. The safe and effective amount of the compound, composition or other material may vary with the particular skin being treated, the age and physical condition of the biological subject being treated, the severity of the condition, the duration of the treatment, the nature of the concurrent therapy, the specific compound, composition or other material employed, the particular cosmetically acceptable topical vehicle, and factors within the knowledge and experience of a person skilled in the art. The cosmetic compositions of the present invention can take any form that is suitable as a cosmetic use, for example, emulsion, aqueous gel, cream, lotion, suspension and the like. Preferably, the compositions are in the form of an emulsion having at least one aqueous phase and at least one oil phase. Most preferably, the cosmetic compositions of the present invention are in the form of water-in-oil emulsions. The emulsion compositions of the present invention preferably comprise from about 20% to about 95%, most preferably from about 30% to about 70% by weight oil phase, and from about 5% to about 80%, most preferably from about 30% to about 70% by weight of aqueous phase. The aqueous phase preferably comprises from about 40% to about 90%, most preferably from about 60% to about 80% by weight of the water phase. The total water level in the emulsion compositions herein ranges from about 10% to about 60%, most preferably from about 30% to about 50% by weight of the composition. The oil phase may comprise a mixture of silicone oils and non-silicone organic oils. In preferred embodiments, the oil phase comprises a mixture of volatile silicones and non-volatile silicones. The silicones are useful herein to provide skin conditioning properties. The silicone fluid is present in amounts of about 1% to about 50% by weight. Suitable volatile silicones include cyclic and linear volatile polyorganosiloxanes. The term "non-volatile" as used herein means that the material has a vapor pressure not greater than 0.1 mm Hg at one atmosphere and at 25 ° C. The term "volatile" as used herein means materials that are non-volatile or have a vapor pressure in the same conditions of more than 0.1 mm Hg. A description of several volatile silicones is found in Todd, et al. "Volatile Silicone Fluids for Cosmetics", 91 Cosmetics and Toiletries 27-32 (1976). Preferred cyclic silicones include cyclic dimethylsiloxane chains containing an average of from about 3 to about 9 silicon atoms, preferably from about 4 to about 5 silicon atoms. Preferred linear silicones include polydimethylsiloxanes containing an average of about 3 to about 9 silicon atoms. Linear volatile silicones generally have viscosities less than about 5 centistokes at 25 ° C, while cyclic materials have viscosities of less than about 10 centistokes. Examples of silicone oils useful in the present invention include: Dow Corning 344, Dow Corning 345, and Dow Corning 200 (manufactured by the Dow Corning Corporation): Silicone 7207 and Silicone 7158 (manufactured by the Union Carbide Corporation). SF: 202 (manufactured by General Electric) and SWS-03314 (manufactured by Stauffer Chemical). The non-volatile silicones will have vapor pressures as defined above, and will preferably have an average viscosity of from about 10 to about 100,000 cps at 25 ° C, most preferably from about 100 to about 10,000 cps, most preferably still around 500 at approximately 6000 cps. However, non-volatile low viscosity silicone conditioning agents can also be used. The viscosity can be measured by means of a glass capillary viscometer as disclosed in the Dow Corning Corporate Test Method Method CTM0004, July 20, 1970. Non-volatile silicone fluids suitable for use herein include polyalkylsiloxanes, polyarylsiloxanes, polyalkylarylsiloxanes. , polysiloxanes with amino functional substitutions, polyethersiloxane copolymers and mixtures thereof. The siloxanes useful in the present invention can be replaced and / or blocked at the ends with any number of portions, as long as the material remains suitable for use in a topical cosmetic product, including, for example, methyl, hydroxyl, ethylene oxide, of propylene, amino and carboxyl. However, other silicone fluids having skin conditioning properties can also be used. The non-volatile polyalkylsiloxane fluids that can be used include, for example, polydimethylsiloxanes. These siloxanes are available, for example, from General Electric Company as the Viscasil (RTM) series and from Dow Corning as the Dow Corning 200 series. Preferably, the viscosity ranges from about 10 mm ^ .sl to about 100,000 mm2. s-1 at 25 ° C. Polyalkylaryl siloxane fluids that can also be used include, for example, polymethylphenylsiloxanes. These siloxanes are available, for example, from General Electric Company as SF 1075 methylphenyl fluid or from Dow Corning as cosmetic grade fluid 556. The polyether siloxane copolymer that can be used includes, for example, a dimethylpolysiloxane modified with polypropylene oxide. (e.g., Dow Corning DC-1248) although ethylene oxide or mixtures of ethylene oxide and polypropylene oxide can also be used. References that describe suitable silicone fluids include US-A-2,826,551, Green; US-A-3,964,500, Drakoff, issued June 22, 1976; US-A-4,364,837, Pader; and GB-A-849,433, Woolston. In addition, Silicone Compounds distributed by Petrarch Systems, Inc., 1984 provides an extensive (though not exclusive) list of suitable silicone fluids. Preferred non-volatile silicones for use herein include polydiorganosiloxane-polyoxyalkylene copolymers containing at least one polydiorganosiloxane segments and at least one polyoxyalkylene segment. The polydiorganosiloxane segment has the general formula:
RbS¡O (4_) / 2
The siloxane units wherein b has a value of from about 0 to about 3, inclusive, having an average value of approximately two R radicals per silicon for all the siloxane units in the copolymer, and R denotes a selected radical of methyl , ethyl vinyl, phenyl and a divalent radical linking said polyoxyalkylene segment a with the polydiorganosiloxane segment. The polyoxyalkylene segment has an average molecular weight of at least about 500, preferably at least about 1000 and comprising from about 0 to about 50 mole percent of polyoxypropylene units and from about 50 to about 100 mole percent of units of polyoxyethylene, at least a terminal portion of said polyoxyalkylene segment being grafted to or covalently linked directly or indically to a polydiorganosiloxane segment, any terminal portion of said polyoxyalkylene segment not attached to said polydiorganosiloxane segment being satisfied by a radical of termination; the weight ratio of the polydiorganosiloxane segments to polyoxyalkylene segments in said copolymer preferably having a value of from about 2 to about 8. Such polymers are described in US-A-4,268,499. Preferred for use herein are polydiorganosiloxane-polyoxyalkylene copolymers having the general formula:
(C2H40) a (C3H60) bR
wherein R "! is selected from C1 to C5 alkyl groups, preferably methyl, z is on a scale of 1 to 4, x and y are selected such that the weight ratio of the polydiorganosiloxane segments to polyoxyalkylene segments is about 2 to about 8, the molar ratio of a: (a + b) is from about 0.5 to about 1, and R is a chain termination group, especially selected from hydrogen, hydroxyl, alkyl, such as methyl, ethyl, propyl, butyl, benzyl, aryl, such as phenyl, alkoxy such as methoxy, ethoxy, propoxy, butoxy, benzyloxy, aryloxy, such as phenoxy, alkenyloxy, such as vinyloxy and allyloxy, acyloxy, such as acetoxy, acryloxy and propionoxy and amino, such as dimethylamino Very preferred to be used herein are polydiorganosiloxane-polyoxyalkylene copolymers having the formula:
where x, y and R are as defined above. The number of average molecular weights of the segments in the copolymer are such that the weight ratio of polydiorganosiloxane segments to polyoxyalkylene segments in the copolymer is preferably from about 2.5 to about 4.0. Suitable copolymers are commercially available under the trade names Belsil (RTM) from Wacker-Chemie GmbH, Geschaftsbereich S, Postfach D-8000 Munich 22 and Abil (RTM) from Th. Goldschmidt Ltd., Tego House, Victoria Road, Ruislip, Middlesex, HA4 OYL. Particularly preferred for use herein are Belsil (RTM) 6031, Abil (RTM) B88183, DC3225C, DC5200, Abil We09, Abil EM90, BY22-008 (Dow Corning) and SF1328 (GE Silicones). A preferred silicone herein is known by its CTFA designation as dimethicone copolyol. The compositions of the present invention preferably comprise from about 20% to about 95% by weight of oil phase composition. The oil phase preferably comprises from about 0.01% to about 25%, most preferably from about 0.05% to about 10% by weight of the oil phase of non-volatile silicones. The oil phase preferably comprises from about 75% to about 99.99%, most preferably from about 90% to about 99.95% by weight of the oil phase of volatile silicones. The oil phase in the emulsions of the present invention may also comprise one or more non-silicone organic oils, such as natural or synthetic oil selected from mineral, vegetable and animal oils, fats and waxes, fatty acid esters, fatty alcohols, fatty acids and mixtures thereof, said ingredients being useful for achieving emollient cosmetic properties. It will be understood that the oil phase may contain, for example, up to about 25%, preferably up to only about 10% of emulsifying ingredients soluble in oil phase. Said ingredients should not be considered as oil phase components from the point of view of the determination of the oil phase level. Organic oils suitable for use herein include, for example, optionally hydroxy-substituted C 1 -C 50 unsaturated fatty acids and esters thereof, C 1 -C 24 esters of C 8 -C 30 saturated fatty acids such as isopropyl myristate, palmitate isopropyl, cetyl palmitate and octyldodecyl myristate (Wickenol 142), beeswax, saturated and unsaturated fatty alcohols such as behenyl alcohol and cetyl alcohol, hydrocarbons such as mineral oils, petrolatum and esquanalo, fatty sorbitan esters (see US-A -3988255, Seiden, issued October 26, 1976), lanolin and lanolin derivatives, triglycerides of animal and vegetable origin such as almond oil, peanut oil, wheat germ oil, linseed oil, jojoba oil, apricot kernel oil, poppy seed oil, pine oil, castor oil, soybean oil, avocado oil, safflower oil, coconut oil, av oil ellana, olive oil, grape seed oil, Butyrospermun parkii butter, shorea butter and sunflower seed oil and C1-C24 esters of dimeric and trimeric acids such as diisopropyl dimerate, diisostearyl malate, diisostearyl dimerate and triisostearyl trimetaro. Of the above, highly preferred are mineral oils, petrolatums, unsaturated fatty acids and esters thereof and mixtures thereof.
Optional ingredients A wide variety of optional ingredients can be incorporated into the compositions. The following are non-limiting examples of numerous ingredients that can be used.
Acidic active ingredients for skin care The compositions of the present invention comprise an acid active for skin care, in addition to salicylic acid or salicylic acid derivative. Acidic active agents suitable for skin care can be selected from hydroxycarboxylic acids. As used herein, the term "active acid for skin care" means any active for skin care that contains an acid functional group (eg, carboxy, sulfonic). Suitable hydroxycarboxylic acids can be selected from hydroxymonocarboxylic acids having the following chemical structure: R 1 (CR 2 OH) m (CH 2) nCOOH wherein Ri, R 2 = H, alkyl, aralkyl or aryl group in straight or branched chain or saturated cyclic form or unsaturated having 1 to 25 carbon atoms; m = 1, 2,3,4,5,6, 7,8, or 9; n = 0 or a number up to 23. The hydroxymonocarboxylic acid may be present as a free acid, lactone or salt form. The lactone form can be inter- or intramolecular lactone, however, the most common are the intramolecular lactones with a ring structure formed by elimination of one or more water molecules between a hydroxy group and the carboxylic group. Since the hydroxymonocarboxylic acids are organic in nature, they can form a salt or a complex with an inorganic or organic base such as ammonium hydroxide, sodium or potassium hydroxide or triethanolamine. Hydroxymonocarboxylic acids and their related compounds can exist as stereoisomers such as D, L and DL forms. Typical alkyl, aralkyl and aryl groups for R-j and R2 include methyl, ethyl, propyl, isopropyl, benzyl and phenyl. The hydrogen atoms of R < | and R2 and (CH2) n can be substituted by a non-functional element such as F, Cl, Br, I, S or a radical such as an alkyl or lower alkoxy, saturated or unsaturated, having 1 to 9 carbon atoms. Representative hydroxymonocarboxylic acids are 2-hydroxyacetic acid (glycolic acid), 2-hydroxypropanoic acid (lactic acid), 2-methyl-2-hydroxypropanoic acid (methylactic acid), 2-hydrobutanoic acid, phenyl-2-hydroacetic acid (mandelic acid) , phenyl-2-methyl-2-hydroxyacetic acid, 3-phenyl-2-hydroxypropanoic acid (phenylactic acid), 2,3-dihydroxypropanoic acid (glyceric acid), 2,3,4-trihydroxybutanoic acid, acid 2,3, 4,5-tetrahydroxypentanoic, 2,3,4,5,6-pentahydroxyhexanoic acid, 2-hydroxydodecanoic acid (alpha-hydroxylauric acid), 2,3,4,5,6,7-hexahydroxyheptanoic acid, diphenyl-2- acid hydroxyacetic acid (benzyl acid), 4-hydroxymandelic acid, 4-chloromandelic acid, 3-hydroxybutanoic acid, 4-hydroxybutanoic acid, 2-hydroxyhexanoic acid, 5-hydroxydodecanoic acid, 12-hydroxydodecanoic acid, 10-hydroxydecanoic acid, 16- hydroxyhexadecanoic, 2-hydroxy-3-methylbutanoic acid, 2-hid acid Roxy-4-methylpentanoic acid, 3-hydroxy-4-methoxymandelic acid, 4-hydroxy-3-methoxymelanic acid, 2-hydroxy-2-methylbutanoic acid, 3- (2-hydroxyphenyl) -lactic acid, 3- (4 -hydroxyphenyl), lactic acid, hexahydromanddelic acid, 3-hydroxy-3-methylpentanoic acid, 4-hydroxydecanoic acid, 5-hydroxydecanoic acid and aleuritic acid. Another type of hydroxy acid suitable for use herein is a hydroxydicarboxylic acid having the following formula:
HOOC (CHOH) m (CH2) nCOOH
wherein m = 1, 2,3,4,5,6,7,8 or 9; n = 0 or an integer of up to 23. The hydroxydicarboxylic acid may also be present as a free acid, lactone or salt form. The hydroxydicarboxylic acid and its related compounds may also exist as stereoisomers such as D, L DL and meso forms.
The hydrogen bonded to the carbon atom can be replaced by a non-functional element such as F, Cl, Br, I, S, or a radical such as a lower saturated or unsaturated alkyl or alkoxy having from 1 to 9 carbon atoms. Representative hydroxydicarboxylic acids are 2-hydroxypropanedioic acid (tartronic acid), 2-hydroxybutanedioic acid (melicic acid), erythranic acid and trearic acid (tartaric acid), arabiraric acid, ribaric acid, xylarylic acid and liaric acid, glucaric acid (saccharic acid) , galactárico acid (mucic acid), manárico acid, guiaric acid, alárico acid, alárrico acid, idárico acid and talárico acid. A third type of hydroxy acid suitable for use herein is a diverse group of compounds that is not readily represented by the above generic structure of either the first type or the second type described above. Included in the third type of hydroxy acids are the following: Hydroxycarboxylic acids of the formula:
R (OH) m (COOH) n
where m, n = 1, 2,3,4,5,6,7,8 or 9, R = H, alkyl, aralkyl or aryl group in straight or branched chain or cyclic, saturated or unsaturated form, having from 1 to 25 carbon atoms; citric acid, isocitric acid, citramalic acid, agaricic acid (n-hexadecyclic acid) quinic acid, uranic acids including glucuronic acid, glucuronolactone, galacturonic acid, galacturonolactone, hydroxypyruvic acid, hydroxypyrubic acid phosphate, ascorbic acid, dihydroascorbic acid, dihydroxytartaric acid, 2-hydroxy-2-methylbutanoic acid, 1-hydroxy-1-cyclopropanecarboxylic acid, 2-hydroxyhexanodial, 5-hydroxylysine, 3-hydroxy-2-aminopentanoic acid, tropic acid, 4-hydroxy-2,2-diphenylbutanoic acid, acid 3-hydroxy-3-methylglutaric acid and 4-hydroxy-3-pentenoic acid. The third type of hydroxy acid may be present as a free acid, lactone or salt form and may also exist as stereoisomers such as D, L, DL and meso forms. The hydrogen atom attached to the carbon atom can be replaced by a non-functional element such as F, Cl, Br, I, S or a radical such as an alkyl or saturated or unsaturated lower alkoxy having from 1 to 9 carbon atoms . Mixtures of hydroxy acids can also be used in the compositions herein. The hydroxy acids are useful herein from the point of view of reducing wrinkles and improving the skin feel and appearance of the skin. Other hydroxy acids suitable for use herein include retinoic acid and azelaic acid. The acid active for skin care may be present at a level of from about 0.1% to about 10%, preferably from about 0.1% to about 5%, most preferably from about 0.5% to about 3% by weight of the composition.
The acid active for skin care can be solubilized in water or a hydroalcoholic solution, for example, solutions based on C2-C5 alcohols, diols and polyols, preferred alcohols being selected from ethanol, dipropylene glycol, butylene glycol, hexylene glycol and mixtures thereof. same. The compositions of the present invention may also comprise a solubilizing agent, in addition to the cyclodextrin compound, for solubilizing the acid active for skin care and / or salicylic acid or salicylic acid derivative. Any suitable solubilizing agent for use in a cosmetic composition can be used. Preferably the solubilizing agent herein is selected from polyoxyethylene-polyoxypropylene ethers of C4 to C22 alcohols, solubilizers based on pyrrolidone, nonionic surfactants based on polyethylene glycol having an HLB greater than about 15, preferably greater than about 18 and mixtures thereof. Suitable pyrrolidone-based solubilizing agents for use herein include polyvinylpyrrolidone or C 1 -C 4 alkylpolyvinylpyrrolidone having a molecular weight (average viscosity) on the scale of from about 1500 to about 1,500,000, preferably from about 3,000 to about 700,000, most preferably from about 5,000 to about 100,000. Suitable examples of solubilizers based on pyrrolidone are polyvinylpyrrolidone (PVP) (or povidone) and butylated polyvinylpyrrolidone. The most preferred pyrrolidone-based solubilizing agent herein is polyvinylpyrrolidone. PVP is commercially available under the trade name Luviskol (RTM) of BASF. A preferred PVP solubilizing agent herein is Luviskol K17 having a viscosity average molecular weight of about 9,000. Other solubilizers based on pyrrolidone for use herein include Ci-Ci s alkyl or hydroxyalkylpyrrolidones such as laurylpyrrolidone. The pyrrolidone-based solubilizing agent is preferably present in the composition herein at a level of about
0. 1% to about 10%, most preferably from about 0.1% to about 5%, especially from about 0.5% to about 2% by weight of the composition. Preferred embodiments of the invention further comprise from about 0.01% to about 5% by weight of an additional acid or a salt thereof which is soluble in water at pH values of less than or equal to the pKa of the corresponding acid, for example , an acid selected from citric acid, boric acid, and salts, and mixtures thereof. These materials are valuable herein in combination with the pyrrolidone-based complexing agent from the viewpoint of aiding the solubilization of the acidic acid for the care of the pile / salicylic acid or salicylic acid derivative. Particularly preferred herein from this point of view is a sodium salt of citric acid. In preferred embodiments, the acid or salt thereof is soluble at a level of at least 5% w / w at 25 ° C. A particularly preferred solubilizing agent in the compositions of the present invention is a nonionic surfactant selected from polyoxyethylene-polyoxypropylene ethers of C4-C22 alcohols, and mixtures thereof. The nonionic surfactant is valuable herein as a solubilizing agent for the acid active for skin care in the discontinuous aqueous phase. Suitable polyoxyethylene-polyoxypropylene ethers of C4-C22 alcohols for use herein include those having the general formula:
R (OCHCH2)? (OCH2CH2) yOH CH3
wherein x is on the scale of about 1 to about 35, preferably about 1 to about 10, and is on the scale of about 1 to about 45, preferably about 1 to about 30 and R is an alkyl group from C4 to C22 straight chain or branched chain, or a mixture thereof. In preferred embodiments (x + y) it is greater than or equal to 5, preferably greater than or equal to 10, most preferably greater than or equal to 15. The ratio x: y is on the scale of 1: 1 to 1: 10 . Examples of suitable R groups in the above formula include cetyl, butyl, stearyl, cetearyl, decyl, lauryl and myristyl. Examples of suitable polyoxyethylene-polyoxypropylene alcohol ethers include (using CTFA designations) PPG-4-Ceteth-1, PPG-4-Ceteth-5, PPG-4-Ceteth-10, PPG-4-Ceteth-20, PPG-5-Ceteth-20, PPG-8- Ceteth-1, PPG-8-Ceteth-2, PPG-8-Ceteth-5, PPG-8-Ceteth-10, PPG-8-Ceteth-20, PPG- 2-Buteth-3, PPG-2-Buteth-5"PPG-5-Buteth-7, PPG-9-Buteth-12, PPG-28-Buteth-35, PPG-12-Buteth-16, PPG-15- Buteth-20, PPG-20-Buteth-30, PPG-24-Buteth-27, PPG-26-Buteth-26, PPG-33-Buteth-45, PPG-2-Ceteareth-9, PPG-4-Ceteareth- 12, PPG-10-Ceteareth-20, PPG-2-Deceth-10, PPG-4-Deceth-4, PPG-6-Deceth-4, PPG-6-Deceth-9, PPG-8-Deceth-6, PPG-2-lsodeceth-4, PPG-2-lsodeceth-6, PPG-2-lsodeceth-9, PPG-2-lsodeceth-12, PPG-3-lsodeceth-1, PPG-4-Laureth-5, PPG- 4-Laureth-2, PPG-4-Laureth-7, PPG-5-Laureth-5, PPG-25-Laureth-25, PPG-3-Myreth-1 1, PPG-3-Myreth-3 and PPG-9 -Steareth-3 The preferred polyoxyethylene-polyoxypropylene ethers for use herein are ethers of C8 to C16 alcohols having the formula (I) wherein x is from 2 to 12 and y is from 10 to 30 and wherein the ratio of x: is on the scale of about 1: 2 to about 1: 8. Polyoxyethylene-polyoxypropylene ethers of C4 to C22 alcohols particularly preferred for use herein are those having the formula (I) above wherein R is cetyl and wherein x is on the scale of about 4 to about 8, and where y is on the scale of about 15 to about 25, and the ratio of x: y is on the scale of about 1: 3 to about 1: 5. A particularly preferred ether from the viewpoint of improving solubilization of the acidic acid for pile care is PPG-5-Ceteth-20, which is available under the tradename Procetyl AWS.
The solubilizing agent herein is preferably present at a level of from about 0.1% to about 15%, most preferably from about 1% to about 10%, especially from about 2% to about 8% by weight of the composition. Preferred embodiments herein comprise a pigment or mixtures of pigments. The pigment used herein must be compatible with any acidic skin care / salicylic acid / salicylic acid derivative that is present in the composition and has excellent overall color stability. Pigments suitable for use herein may be inorganic and / or organic. Also included within the term pigment are materials that have a low color or gloss such as matte finishing agents, and also light scattering agents. Examples of suitable pigments are iron oxides, rutile-titanium dioxide, anatase-titanium dioxide, ferric oxide, ferrous oxide, chromium oxide, chromium hydroxide, manganese violet, acylglutamate-iron oxides, ultramarine blue, dyes D &; C, carmine and mixtures thereof. Depending on the type of makeup composition, for example, base or blush, a mixture of pigments will normally be used. The base composition may also include at least one matte finishing agent. The function of the matte finish agent is to hide skin defects and reduce shine. Such cosmetically acceptable inorganic agents, ie, those included in the CTFA Cosmetic Ingredient Dictionary, third edition, such as silica, hydrated silica, silica spheres treated with silicone, mica, talc, polyethylene, titanium dioxide, bentonite, hectorite , kaolin, chalk, diatomaceous earth, zinc attapulgite oxide and the like can be used. Of particular utility as a mat finishing agent is a low gloss pigment such as titrated mica (mica coated with titanium dioxide) coated with barium sulfate. Of the inorganic components useful as a mat finishing agent, the low luster pigment, talc, polyethylene, hydrated silica, kaolin, titanium dioxide and mixtures thereof are particularly preferred. Materials suitable for use herein as light scattering agents can generally be described as spherical shaped inorganic materials having a particle size of up to about 100 microns, preferably from about 5 to about 50 microns, for example spherical silica particles . Other examples of pigments include lacquers of organic dyes such as calcium lacquer Red from FD &C No. 7, aluminum lacquer Yellow FD &C No. 5, red barium lacquer from D &C No. 9, and Red from D &; C No. 30. Preferred pigments for use herein from the standpoint of wetting, skin feel, skin appearance and emulsion compatibility are treated pigments. The pigments can be treated with compounds such as amino acids such as lysine, silicones, lauroyl, collagen, polyethylene, lecithin and ester oils. The most preferred pigments are the pigments treated with silicone (polysiloxane).
A highly preferred pigment for use herein is a pigment that has been coated with an organosilicon component selected from a polyorganosiloxane or a silane wherein the coated pigment has a hydrogen potential of less than about 2.0, preferably less than about 1.0. , most preferably less than about 0.5 ml, and especially less than about 0.1 ml H2 / g of coated pigment. The preferred pigment for use herein is a particulate form. The pigment is incorporated into the phase containing continuous silicone oil in the compositions herein. The coatings used can be attached to the surface of the pigment by covalent bond, physical adsorption or adhesion, preferably by covalent bonding to the surface of the pigment. The function of the coatings herein is to hydrophobically modify the pigments so that they are "wettable" in the continuous silicone phase of the water-in-silicone emulsions. The coated pigment is also useful herein from the point of view of reducing the evolution of hydrogen gas and improving the stability of the product. Without being limited by theory, it is believed that although the pigments are present in the phase containing silicone oil from the water emulsion * in oil, the hydrogen ions in the aqueous phase can pass through the interface of the emulsion to the phase containing silicone oil, where they are available to react with the pigment coatings, for example, to release hydrogen gas. However, by using organosilicon-coated pigments having a hydrogen potential of less than about 2 ml of H2 / g of coated pigment, the generation of hydrogen gas is reduced. The hydrogen potential of the coated pigment is measured herein using the following test method. A dispersion of the coated pigment containing 20 g of the coated pigment is produced in a flask on a magnetic stirrer and 100 ml of a 2% ethanolic solution of potassium hydroxide is added with stirring at room temperature. The gaseous hydrogen that is released is collected in a second flask at room temperature and ambient pressure (25 ° C, 1At). The gaseous hydrogen released can therefore be measured volumetrically. A wide variety of organosilicon components can be used to treat the pigments herein. A polyorganosiloxane suitable in the present invention is selected from: (A) material of the formula: (R1) 3S¡O- (YES (R2R3) 0) PSi (R2R3) OA2 wherein p is 1 to 1000, preferably 1 to 100, A2 is hydrogen or a group
alkyl having 1 to 30 carbon atoms, R 1 is a C 1 -C 30 alkyl,
preferably methyl, R and R3 are independently selected from a C 1 -C 30 alkyl and a phenyl, preferably wherein R 2 and R are both
methyl or wherein R2 is methyl and R3 is phenyl; or (B) material of the formula: (R) 3SiO (Si (R2) (H) -O) -Yes (Rl) 3
wherein i is 1 to 1000, preferably 1 to 100, and wherein R1 and R2 are as defined above for formula (A). In preferred embodiments, the organosilicon component is selected from a silane. The silane can be selected from material of the formula: (C) A < | S¡X < X2X3 wherein A is an alkyl or alkenyl group having from 1 to 30 carbon atoms, and X- | , X2 and X3 are independently C 1 -C 4 alkoxy preferably methoxy or ethoxy, or halogen, preferably chloro. When the pigment of the present invention is treated with a silane material having the formula (C) described above, a pigment having the following formula (1) is produced: PO-Si (OH) (A) - [- O- Si (OH) (A) -] 0-i OO-OH wherein P is an atom on the surface of the pigment and each A is an alkyl or alkenyl group having up to 30 carbon atoms. A number of adjacent polysiloxane chains as shown in formula (1) can be entangled through oxygen atoms to form a polysiloxane chain with up to 100 repeating units of -Si (-OP) -O extending to length of the pigment surface, in addition to the polysiloxane chain that extends away from the surface of the pigment. Examples of linear or branched alkyl groups are methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, etc., up to octadecyl. "Alkenyl" includes carbon chains with one or more double bonds; examples of such groups include ethylene, propylene, acrylyl, methacrylyl and unsaturated fatty acid residues such as oleic acid (C17C33-), linoleic (C-17H31-) and linolenic (C-17H29-). When the pigment of the present invention is treated with polyorganosiloxane material having the formula (A) described above, a pigment is produced having the following formula (2): PO- (Si (R2R3) 0) PSi (R1) 3 (2)
wherein p is 1-1000, preferably 1 to 100, R1, R2 and R are as defined above for formula (A) and P is an atom on the surface of the pigment. When the pigment of the present is treated with polyorganosiloxane material having the formula (B) described above, a pigment having the following formula (3) is produced: (R1) 3 SiO- [Si (R2) (-OP) -O -] p-Si (Rl) 3 (3) wherein each P is an atom on the surface of the pigment, p is from 1 to 1000, preferably from 1 to 100, R1 and R2 are as defined above in the formula ( B) and in which each of the 100 repeating units (Si-O) is bonded through an oxygen atom to the surface of the pigment. The pigment (or mixture of two or more pigments) can be coated by placing it in a dry, finely divided form in a mixer, adding the organosilicon component and mixing. The organosilicon coating is preferably present at a level of from about 0.01% to about 5%, most preferably from about 0.1% to about 4% and especially from about 0.5% to about 2% by weight of the organosilicon-coated pigment. The most preferred coated pigment from the viewpoint of reducing the evolution of gaseous hydrogen and improving the stability of the product is Cardre 70429. The total concentration of the coated pigment may be from about 0.1 to about 25% by weight and is preferably about from 1 to about 15%, most preferably from about 8% to about 12% by weight of the total composition, the exact concentration depending to some degree on the specific mixture of pigments selected for use in a base or blush makeup to achieve the desired shadows. Preferred compositions contain from about 2% to about 20% by weight of titanium dioxide and most preferably from about 5% to about 10% by weight of titanium dioxide. A highly preferred component of the compositions of the present invention is a humectant or mixture of humectants. The humectant or mixture of humectants of the present invention is present in an amount of from about 0.1% to about 30%, preferably from about 1% to about 25%, most preferably from about 1% to about 10% by weight of the composition. Suitable humectants are selected from glycerin lubricant and polyglyceryl methacrylate having a viscosity at 25 ° C of 300,000 to 1, 100,000 cps; a specific density at 25 ° C of 1 to 1.2 g / ml, a pH of 5.0 to 5.5, a bound water content of 33 to 58% and a free water content of 5 to 20%. The humectant can be incorporated at least partially into the phase containing silicone oil of a water-in-oil emulsion. The phase containing silicone oil preferably comprises from about 0.1% to about 10%, most preferably from about 0.1 to about 3% by weight of humectant on a composition basis. The humectant can be introduced into the phase containing silicone oil in the form of a mixture with or incorporated into a particulate lipophilic or hydrophobic particulate carrier material. Polyglyceryl methacrylate lubricants having the desired properties are marketed by Guardian Chemical Corporation under the tradename "Lubrajel". The "Lubrajels" identified as "Lubrajel DV", "Lubrajel MS", and "Lubrajel CG" are preferred in the present invention. The gelling agents sold under these trade names contain about 1% propylene glycol. Other suitable humectants include sorbitol, panthenols, propylene glycol, dipropylene glycol, butylene glycol, hexylene glycol, alkoxylated glucose derivatives, such as Glucam (RTM) E-20, hexanetriol and glucose ethers, and mixtures thereof. The panthenol humectant can be selected from D-panthenol ([R] -2,4-dihydroxy-N- [3-hydroxypropyl]] - 3,3-dimethylbutamide), DL-panthenol, calcium pantothenate, jelly royal, panthenol, pantothein, panthenylether, pangamic acid, pyridoxine, pantoylactose, and vitamin B complex. The preferred humectant herein is glycerin. Chemically, glycerin is 1, 2,3-propanetriol and is a commercial product. A preferred component of the compositions of the present invention, in addition to the organic amphiphilic surfactant, is a polyol ester skin conditioning agent. The compositions of the present invention preferably comprise from about 0.01% to about 20%, most preferably from about 0.1% to about 15%, and especially from about 1% to about 10% by weight of the polyol ester. The level of polyol ester by weight of the oil in the composition is from about 1% to about 30%, most preferably from about 5% to about 20%. The preferred polyol ester for use in the present invention is a non-occlusive liquid or liquifiable polyol carboxylic acid ester. These polyol esters are derived from a radical or polyol portion and one or more carboxylic acid radicals or carboxylic acid moieties. In other words, these esters contain a portion derived from a polyol and one or more portions derived from a carboxylic acid. These carboxylic acid esters can also be derived from a carboxylic acid. These carboxylic acid esters can also be described as liquid polyol fatty acid esters, because the terms carboxylic acid and fatty acid are often used interchangeably by those skilled in the art. The preferred liquid polyol polyesters employed in this invention comprise certain polyols, especially sugars or sugar alcohols, esterified with at least four fatty acid groups. Accordingly, the polyol starting material must have at least four esterifiable hydroxyl groups. Examples of preferred polyols are sugars, including monosaccharides and disaccharides, and sugar alcohols. Examples of monosaccharides containing four hydroxyl groups are xylose and arabinose and the sugar alcohol derived from xylose having five hydroxyl groups, i.e., xylitol. The monosaccharide, erythrose, is not suitable in the practice of this invention since it only contains three hydroxyl groups, but the sugar alcohol derived from erythrose, ie erythritol, contains four hydroxyl groups and can therefore be used. The right monosaccharides containing five hydroxyl groups are galactose, fructose and sorbit. Sugar alcohols containing six -OH groups derived from the products of hydrolysis of sucrose, as well as glucose and sorbose, for example sorbitol, are also suitable. Examples of disaccharide polyols that can be used include maltose, lactose and sucrose, all of which contain eight hydroxyl groups. The preferred polyols for preparing the polyesters for use in the present invention are selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose. Sucrose is especially preferred.
The polyol starting material having at least four hydroxyl groups is esterified in at least four of the -OH groups with a fatty acid containing from about 8 to about 22 carbon atoms. Examples of said fatty acids include caprylic, capric, lauric, myristic, myristoleic, palmitic, palmitoleic, stearic, oleic, ricinoleic, linoleic, linolenic, eleostearic, arachidic, arachidonic, behenic and erucic acids. The fatty acids can be derived from natural or synthetic fatty acids; they can be saturated or unsaturated, including positional and geometric isomers. However, in order to provide preferred liquid polyesters for use herein, at least about 50% by weight of the fatty acid incorporated in the polyester molecule must be unsaturated. Oleic and linoleic acids and mixtures thereof are especially preferred. The polyol fatty acid polyesters useful in this invention should contain at least four fatty acid ester groups. It is not necessary that all hydroxyl groups of the polyol be esterified with fatty acid, but it is preferable that the polyester contains no more than two non-esterified hydroxyl groups. Most preferably, substantially all of the hydroxyl groups of the polyol are esterified with fatty acid, ie, the polyol portion is substantially completely esterified. The fatty acids esterified to the polyol molecule can be the same or mixed, but as indicated above, a substantial amount of the unsaturated acid ester groups must be present to provide liquidity.
To illustrate the above points, a sucrose fatty triester to be used herein would not be suitable since it does not contain the four fatty acid ester groups required. An ester of sucrose tetrahydric acid would be suitable, but is not preferred because it has more than two non-esterified hydroxyl groups. An ester of sucrose hexahydric acid would be preferred because it has no more than two unesterified hydroxyl groups. Highly preferred compounds in which all hydroxyl groups are esterified with fatty acids include the liquid sucrose octa-substituted fatty acid esters. The following are non-limiting examples of specific polyol fatty acid polyesters containing at least four fatty acid ester groups suitable for use in the present invention: glucose tetraoleate, glucose tetraesters of soybean oil fatty acids (unsaturated ), tetraesters of mixed fatty acid fatty acid maleate, galactose tetraesters of oleic acid, arabinose tetraesters of linoleic acid, xylose tetralinoleate, galactose pentaoleate, sorbitol tetraoleate, sorbitol hexaesters of oil fatty acids of unsaturated soybean, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate and mixtures thereof. As indicated above, the highly preferred polyol fatty acid esters are those wherein the fatty acids are from about 14 to about 18 carbon atoms.
Preferred liquid polyol polyesters for use in the present invention have complete melting points below about 30 ° C, preferably below about 27.5 ° C, most preferably below about 25 ° C. The full melting points reported in the present invention are measured by Differential Scanning Calorimetry (DSC). The polyol fatty acid polyesters suitable for use in the present invention can be prepared by a variety of methods well known to those skilled in the art. These methods include: transesterification of the polyol with fatty acid esters of methyl, ethyl or glycerol using a variety of catalysts; acylation of the polyol with a fatty acid chloride; acylation of the polyol with a fatty acid anhydride; and acylating the polyol with a fatty acid per se. See Patent of E.U.A. No. 2,831, 854; Patent of E.U.A. No. 4,005,196, to Jandacek, issued on January 25, 1997; Patent of E.U.A. No. 4,005, 196, to Jandacek issued January 25, 1977. The makeup compositions of the present invention may also comprise a hydrophobic acrylate or methacrylate copolymer crosslinked into particles. This copolymer is particularly valuable in reducing the gloss and controlling the oil while helping to provide effective wetting benefits. The hydrophobic interlaced polymer is preferably in the form of a copolymer lattice with at least one active ingredient uniformly dispersed therethrough and trapped within the copolymer network. Alternatively, the hydrophobic polymer can take the form of a porous particle having a surface area (N2-BET) on the scale of
about 50 to 500, preferably 100 to 300 m2 / g and having the active ingredient absorbed therein. The crosslinked hydrophobic polymer when used in the present invention is in an amount of from about 0.1% to about 10% by weight and is preferably incorporated in the silicone oil containing phase containing external silicone. The active ingredient may be one or more or a mixture of skin-compatible oils, skin-compatible humectants, emollients, wetting agents and sunscreens. The polymer material is in the form of a powder, the powder being a combined system of particles. The powder particle system forms a grid including unitary particles of less than about one average diameter, agglomerates of merged unit particles of sizes on the scale of about 20 to 100 microns in average diameter and aggregates of groups of fused agglomerates. of sizes that oscillate in the scale of around 200 to 1, 200 microns of average diameter. The powder material of the present invention that can be employed as the carrier for the active ingredient can be broadly described as an interlaced "post-absorbed" hydrophobic polymer lattice. The powder preferably has entrapped and dispersed therein an active which may be in the form of a solid, liquid or gas. The grid is in the form of particles and constitutes discrete solid particles of free flow when loaded with the active material. The grid may contain a predetermined amount of the active material. The polymer has the structural form:
where the ratio of x to y is 80:20, R 'is -CH2CH2- and R "is - (CH2)? - | CH_
A hydrophobic polymer suitable for use in the present invention is a highly entangled polymer, most particularly a highly entangled polymethacrylate copolymer such as that manufactured by Dow Corning Corporation, Midland. Michigan, USA, and sold under the trade name POLYTRAP (RTM). It is an ultralight free-flowing white powder and the particles are capable of absorbing high levels of lipophilic liquids and some hydrophilic liquids while at the same time maintaining a free-flowing powder character. The powder structure consists of a network of unitary smaller particles of one ore that are fused into agglomerates of 20 to 100 microns and the agglomerates are loosely grouped into macroparticles or aggregates of about 200 to about 1, 200 microns in size. The polymer powder is able to contain as many as four times its weight of molten fluids, emulsions, dispersions or solids. The adsorption of active ingredients on the polymer powder can be achieved using a stainless steel mixing bowl and a ladle, where the active is added to the powder and the ladle is used to gently mix the active in the polymer powder. The low viscosity fluids can be absorbed by adding the fluids to a sealable container containing the polymer and then stirring the materials until a consistency is achieved. More elaborate mixing equipment such as batten mixers or double cones can also be employed. The active ingredient for use herein is glycerin. Preferably, the weight ratio of humectant: vehicle is from about 1: 4 to about 3: 1. Also suitable as a highly entangled polymethacrylate copolymer is Microsponges 5640. It takes the form of generally spherical particles of interlaced hydrophobic polymer having a pore size of about 0.01 to about 0.005μ and a surface area of 200-300m2 / g. . Again, it is preferably loaded with humectant at the levels described above. The compositions of the invention may also contain a gelling agent at a level preferably of from about 0.01% to about 10%, most preferably from about 0.02% to about 2%, and especially from around 0.02% to approximately 0.5%. The gelling agent preferably has a viscosity (1% aqueous solution, 20 ° C, Brookfield RVT) of at least about 4000 mPa.s, most preferably at least about 10,000 mPa.s, and especially at least 50,000 mPa.s .s. Suitable hydrophilic gelling agents can generally be described as water soluble or colloidally water soluble polymers, and include cellulose ethers (e.g., hydroxyethylcellulose, methylcellulose, hydroxypropylmethylcellulose), polyvinyl alcohol, polyquaternium-10, guar gum, hydroxypropyl guar gum and xanthan gum. Among the suitable hydrophilic gelling agents are the copolymers of acrylic acid / alkyl acrylate and the carboxyvinyl polymers sold by B.F. Goodrich Company under the trade name of Carbopol resins. These resins consist essentially of interlaced polyalkenyl polyester polymer, water-soluble, of interlaced acrylic acid with an amount of 0.75% to 2.00% of an interlacing agent such as for example polyallylsucrose or polyallyl pentaerythritol. Examples of these include Carbopol 934, Carbopol 940, Carbopol 950, Carbopol 980, Carbopol 951 and Carbopol 981. Carbopol 934 is a water soluble polymer of acrylic acid crosslinked with about 1% of a polyallyl ether of sucrose having an average of about 5.8 allyl groups for each molecule of sucrose. Also suitable for use herein are hydrophobically modified entangled polymers of acrylic acid having amphiphatic properties available under the tradename Carbopol 1382, Carbopol 1342, and Pemulen TR-1 (CTFA Designation: Acrylates / interlaced polymer of ethyl acrylate 10-30). A combination of polyether polyalkenyl crosslinked acrylic acid polymer and the hydrophobically modified crosslinked acrylic acid polymer is also suitable for use in the present invention. Other gelling agents suitable for use herein are oleogels such as trihydroxystearin and aluminum magnesium hydroxystearate. The gelling agents of the present invention are particularly valuable in providing excellent stability characteristics at normal and elevated temperatures. Preferably the acid group containing hydrophilic gelling agents is neutralized. Neutralizing agents suitable for use in the hydrophilic gelling agents containing neutralizing acid group in the present invention include sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine and triethanolamine. The makeup compositions of the present invention may further comprise an emollient. Suitable emollients for the compositions of the present invention include natural and synthetic oils selected from mineral, vegetable and animal oils, fats and waxes, fatty acid esters, fatty alcohols, ethers and esters of alkylene glycol and polyalkylene glycol, fatty acids and mixtures thereof. same. Emollients suitable for use herein include, for example, optionally hydroxy-substituted C8-C50 unsaturated fatty acids and esters thereof, C-1-C24 esters of C8-C30 saturated fatty acids such as isopropyl myristate, palmitate cetyl and octyldodecyl meristate (Wickenol 142), beeswax, saturated and unsaturated fatty alcohols such as behenyl alcohol and cetyl alcohol, hydrocarbons such as mineral oils, petrolatum and squalane, fatty sorbitan esters (see US-A-3988255, Seiden, issued October 26, 1976), lanolin and lanolin derivatives, such as ethoxylated lanolin alcohol, hydroxylated and acetylated lanolins, cholesterol and derivatives thereof, triglycerides of animal and vegetable origin such as almond oil, peanut oil, wheat germ oil, flaxseed oil, jojoba oil, apricot kernel oil, nuts, palm nuts, pistachio nuts, sesame seeds, rape seed, cade oil, corn oil, bone oil peach, poppy seed oil, pine oil, castor oil, soybean oil, avocado oil, safflower oil, coconut oil, hazelnut oil, olive oil, grape seed oil, seed oil of sunflower and C1-C24 esters of dimeric and trimeric acids such as diisopropyl dimerate, diisostearyl malate, diisostearyl dimerate and triisostearyl trimerate. Preferred emollients are selected from hydrocarbons such as isohexadecane, mineral oils, petrolatum and squalane, lanolin alcohol and stearyl alcohol. These emollients may be used independently or in mixtures and may be present in the composition of the present invention in an amount of from about 1% to about 30% by weight, and are preferably present in an amount of about 5% to about 15% by weight. % by weight of the total composition. The composition may also contain additional materials such as, for example, fragrances, sunscreens, preservatives, electrolytes such as sodium chloride, proteins, antioxidants, chelating agents and water-in-oil emulsifiers as appropriate. Another optional component of the makeup composition is one or more ultraviolet light absorbing agents. The ultraviolet light absorbing agents, often described as sunscreen agents, may be present in a concentration in the range of between about 1% and about 12% by weight, based on the total weight of the composition. Preferably, ultraviolet light absorbing agents constitute between about 2% and 8% by weight. Most preferably, the ultraviolet light absorbing agents may be present in the composition in a concentration range of about 4% and about 6% by weight. Of the ultraviolet light absorbing agents suitable for use herein, benzophenone-3, octyldimethyl PABA (Padimate O), Parsol MCX and mixtures thereof are particularly preferred. Another optional but preferred component herein is one or more additional chelating agents, preferably in the range of about 0.02% to about 0.10% by weight, based on the total weight of the composition. Preferably, the chelating agent is present at a concentration in the range of between about 0.03% and about 0.07% by weight, based on the total weight of the composition. Among the chelating agents that can be included in the composition is tetrasodium EDTA. Another optional but preferred component of the base composition is one or more preservatives. The concentration of preservative in the base composition, based on the total weight of the composition is on the scale between about 0.05% and about 0.8% by weight, preferably between about 0.1% and about 0.3% by weight. Suitable preservatives for use herein include sodium benzoate and propylparaben and mixtures thereof. Another optional but preferred component is DryFlow provided by Dow Corning LTD, Avco House, Castle Street, Reading RG1 7DZ, United Kingdom. The pH of the cosmetic compositions herein is preferably about 5 or less, most preferably about 4 or less and especially about 3. The cosmetic compositions of the present invention may be in the form of bases, flushes, concealers, compact powders, moisturizing creams and moisturizing lotions, inked moisturizing creams and lotions and the like, preferably as bases and concealers. The following Table shows examples of cosmetic compositions of the present invention.
1. Provided by Procter & Gamble 2. Provided by Dow Corning Ltd, Avco House, Castle Street, Readin RG1 7DZ, R.U. 3. Provided by Cardre Incorporated, 70 Tyler Pl., South Plainfield, NJ07090, E.U.A. 4. Provided by Dow Corning Ltd, Avco House, Castle Street, Readin RG1 7DZ, R.U. 5. Supplied by Astor-Stag Ltd., Tavistock Road, Wets Drayton, Middlesex UB7 7RA, R.U. 6. Supplied by Caschem Inc., 40 Avenue A, Bayonne, NJ07002, E.U.A. 7. Trihydroxystearin, provided by Rheox Ltd, Barons Court, Manchester Road, Wilmslow, SK9 1 BQ, R.U. 8. Provided by BASF, Earl Road, Cheadle Hulme, Cheadle, Cheshire, SK8 6QB 9. Provided by Union Carbide, 39 Old Ridgebury Road, Danbury 10. Provided by Cerestar USA Inc., 1 100 Indianapolis Boulevard, Hammond, Indiana, E.U.A. 46320 1 1. Supplied by Croda Chemicals Ltd., Cowick Hall, Snaith, Goole, North Humberside, DN14 9AA 12. Supplied by Degussa Ltd, Winterton House, Winterton Way, Macclesfield, Cheshire SK1 1 OLP The formulations of examples I to VI You can prepare them in the following way. The various components listed in the Table have been segregated into groups, the constituents of each group being mixed together before being added to the members of the remaining groups according to the procedures set out below. In the first step, the mixture of phase A components is stirred for approximately 15 minutes with shear mixing until homogeneous. With high speed shear mixing, the phase B materials are gradually added to A and the batch is mixed for about 30 minutes. Phase C is added and the resulting mixture is milled for about 15 minutes. The components of phase D are then added and the resulting mixture is milled until completely dispersed. Waxy phase E is then added to each batch and the batch is heated to 85 ° C with mixing until the waxes have melted and then cooled to 50 ° C with stirring. The phase F premix is then added to the batch and homogenized for 10 minutes. The batch is cooled to room temperature with stirring. Phase G is added to the batch and homogenized for 10 minutes.
The water phase is prepared in the following manner. The components of phase I are mixed until dissolved. The components of phase H are mixed together under high speed shear until dissolved. The solution is mixed until it becomes clear. Phase I is added to phase H and mixed, followed by the addition of phase J under mixing. The water phase is finally added to the oil phase slowly while homogenizing at low speed, with stirring. When the entire water phase has been added, high shear stress is applied to the batch for about 5 minutes to increase the viscosity of the final product. The resulting makeup composition is ready to pack. The cosmetic compositions of the examples show improved anti-acne / anti-inflammatory activity and reduce skin irritation.
Claims (9)
1. - A cosmetic composition for topical application to the skin comprising a hydroxyalkylcyclodextrin, a salicylic acid or salicylic acid derivative, and water.
2. The cosmetic composition according to claim 1, comprising salicylic acid.
3. The cosmetic composition according to any of claims 1 or 2, further characterized in that it comprises from about 0.1% to about 10%, preferably from about 0.1% to about 5% by weight of salicylic acid or acid derivative salicylic.
4. The cosmetic composition according to any of claims 1 to 3, comprising from about 0.1% to about 20%, preferably from about 0.8% to about 15% by weight of hydroxyalkylcyclodextrin.
5. The cosmetic composition according to any of claims 1 to 4, further characterized in that the hydroxyalkylcyclodextrin is hydroxyalkylcyclodextrin (C1-C4), preferably hydroxypropyl-beta-cyclodextrin.
6. The cosmetic composition according to any of claims 1 to 5, further characterized in that the composition is in the form of an emulsion comprising at least one aqueous phase and at least one oil phase, preferably a water emulsion in oil.
7. The cosmetic composition according to any of claims 1 to 6, further characterized in that the salicylic acid or salicylic acid derivative is solubilized in the aqueous phase.
8. The cosmetic composition according to any of claims 1 to 7, further comprising from about 0.1% to about 30%, preferably from about 0.1% to about 25%, most preferably from about 1% to about 15% by weight of pigment.
9. The cosmetic composition according to any of claims 1 to 8, further characterized in that the oil phase comprises from about 0.01% to about 25% by weight of oil phase of non-volatile silicones and from about 75% to about 99.99% by weight of the oil phase of volatile silicones.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9712269.1 | 1997-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA99011713A true MXPA99011713A (en) | 2001-05-17 |
Family
ID=
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6267978B1 (en) | Water-in-oil emulsions containing amino acid salts of salicylic acid | |
AU742341B2 (en) | Cosmetic compositions | |
US6143310A (en) | Cosmetic compositions | |
AU742273B2 (en) | Cosmetic compositions | |
US6331305B1 (en) | Water-in-oil cosmetic compositions comprising willow bark extract | |
US20020136743A1 (en) | Cosmetic compositions | |
AU3476897A (en) | Cosmetic compositions | |
US6537537B2 (en) | Water-in-silicone emulsion cosmetic compositions | |
AU742272B2 (en) | Cosmetic compositions | |
GB2319177A (en) | Cosmetic compositions | |
WO1999004753A1 (en) | Cosmetic compositions | |
US6316010B2 (en) | Cosmetic compositions | |
WO1998047470A1 (en) | Cosmetic compositions | |
WO2000010513A1 (en) | Cosmetic compositions containing rutile and anatase titanium oxide and emollients | |
MXPA99011713A (en) | Cosmetic compositions | |
GB2320432A (en) | Cosmetic compositions | |
MXPA99011712A (en) | Cosmetic compositions | |
MXPA99011711A (en) | Cosmetic compositions | |
CZ446899A3 (en) | Cosmetic preparations | |
CZ446999A3 (en) | Cosmetic preparations | |
CZ447099A3 (en) | Cosmetic preparations |