MXPA99007158A - Composition for the extermination of arthropods damage - Google Patents

Abstract

The present invention relates to a composition for the extermination of harmful arthropods, which contains at least one compound selected from 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguani dine and 3 - [(2-chloro -5-thiazolyl) methyl] -5-methyl-4-nitroimino tetrahydro-1,3,5-oxadiazine, and pyriproxyfen, remarkable and therefore has excellent extermination effects against various harmful arthropods, by its application in small amounts

Description

COMPOSITION FOR THE EXTERMINATION OF HARMFUL ARTHROPODS FIELD OF THE INVENTION The present invention relates to a composition for killing harmful arthropods.

BACKGROUND OF THE INVENTION Various types of agents for the extermination of harmful arthropods have been used to date. In some cases of application, however, it can not be said that these show satisfactory effects BRIEF DESCRIPTION OF THE INVENTION Under these circumstances, the present inventors have extensively studied many compositions for the extermination of harmful arthropods. As a result, they have found that the combined use of at least one compound selected from 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine and 3- [(2-chloro-5-thiazoyl) ethyl] -5-methyl-4-nitroiminotetrahydro-l, 3, 5-oxadiazina with REF .: 30852 piriproxifeno makes it possible to show synergism or remarkable and therefore gives excellent effects of extermination against various harmful arthropods by its application in small quantities, with which completes the present invention. Thus, the present invention provides a composition for the extermination of harmful arthropods (hereinafter referred to as the present composition), characterized in that it comprises at least one compound (hereinafter referred to as the nitroimino compound) selected from 1 - (tetrahydrofuran-3-yl) ethyl-3-methyl-2-nitroguanidine and 3- [(2-chloro-5-thiazolyl) methyl] -5-methyl-4-nitroiminotetrahydro-l, 3,5-oxadiazine, and pyriproxyfen as active ingredients.

DETAILED DESCRIPTION OF THE INVENTION The nitroimino compound used in the present invention is known as having control activity against various pests in the field of agriculture and described in US Pat. Nos. 5,532,365 and 5,852,012. On the other hand, pyriproxyfen is a commercially available compound as the active ingredient of pesticides for the domestic prevention of pests and for agriculture. The ratio of the mixture of the nitroimino compound to the pyriproxyfen used in the present composition as expressed by the (weight ratio) of the nitroimino / pyriproxyfen compound is usually not greater than 1000/1, preferably not greater than 100/1, and more preferably not greater than 10/1, but usually not less than 1/10, preferably not less than 1/5, and more preferably not less than 1/1, that is, the mixing ratio of the nitroimino compound to pyriproxyfen is generally in the range of 100: 1 to 1:10, preferably 100: 1 to 1:10.The harmful arthropods that can be killed by the present composition may include, for example, those of the following orders, families and genera: Isopoda: Oniscus asellus, Armadillidium vulgare, Porcellio scaber, etc. Diplopoda: Blanilus guttulatus etc. Chilopoda: Geophilus carpophagus, Scutigera spp., Scolopendra subspinipes, Thereunema spp., etc. Symphyla: Scutigerella immaculata etc.

Thysanura: Ctenolepisma villosa f Lepisma saccharina, etc. Psocoptera: Trogium pulsatorium, etc. Collembola: Onychiurus armatus, etc. Jpostera: Mastotermitidae; Termopsidae such as Zootermopsis, Archotermopsis, Hodotermopsis (for example Hodotermopsis japonica) and Porotetmes, Kalotermitidae such as Kaloter is r Neotermes (for example Neotermes koshuensis), Cryptotermes (for example, Cryptotermes domesticus), Incisitermes (for example, Incisitermes minor) and Glyptotermes (for example Glyptotermes satsumaensis, Glyptotermes nakakimai, Glyptotermes fuscus); Hodotermitidae such as Hodotermes, Microhodotermes and Anacanthotermes; Rhinotermitidae such as Retitulitermes (for example Retituli termes speratus, Retitulitermes kanmonensis, Retitulitermes flaviceps, Retitulitermes miyatakei), Heterotermes, Coptotermes (for example Coptotermes formosanus) and Schedolinotermes; Serritermitidae; Termitidae such as Amitermes, Drepanotermes Hopitalitermes, Trinervitermes, Macrotermes, Odontotermes (for example Odontotermes formosanus); Microtermes, Nasutitermes (for example takasagoensis), Pericapritermes (for example Pericapritermes nitobei) and Anoplotermes, etc. Dityoptera: Blatta orientalisr Periplaneta americana, Periplanetá fuliginosa, Leucophaea maderae, Blattella germanica, etc. Orthoptera: Gryllotalpa spp. Acheta domesticus, Teleogryllus emma, Locusta migratoria, Melanoplus differentialis, Schistocerca gregaria, etc. Dermaptera: Riparian Labidura, Forfícula auricularia, etc. Mallophaga: Trichodectes spp., Tromenopon spp., Bovicola spp., Felicola spp., Etc. Thysanoptera: Frankliniella intonsa, Thrips tabaci, Thrips palmi, etc. Heteroptera: Nezara spp., Eurygaster spp., Dysdercus intermedius, Nezara antennata, Cletus punetiger, etc. Homoptera: Aleurocanthus spiniferus, Bemisia tabaci, Bemisia argentifolii, Thialeurodes vaporariorum, Aphis gossypii, Brevocoryne brassicae, Cryptomyzus ribis, Aphis fabae, Macrosiphum euphorbiae, Myzus persicae, Phorodon humuli, Empoasca spp., Nephotettix cincticeps, Lecanium corni, Saissetia oleae, Laodelphax striatellus , Nilaparvata lugens, Aonidiella, aurantii, Aspidoitus inheritae, Pseudococcus spp., Psylla spp., Phylloxera vastatrix, etc. Lepiodoptera: Pectxnophora gossypiella, Lithocolletis blancardella, Plutella xylostella, Malacosoma neustria, Euproctis subflava, Lymantria dispar, Bucculatrix pyrivorella, Phyllocnistis citrella, Agrotis spp., Euxoa spp., Earias insulana, Heliothx spp., Spodoptera exigua, Spodoptera litura, Spodoptera spp. , Mamestra brassicae, Trxchoplusxa ni, Carpocapsa pomonella, Pieris spp., Chilo spp., Pyrausta nubilalis, Ephestia kuehniella, Galleria mellonella, Tineola Bisselliella, Tinea translucens, Homona magnanimous, Tortrix viridana, etc. Coleoptera: Anobium punctatum, Rhixopertha dominica, Acanthoscelides obtectus, Agelastica alni, Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp. , Psylliodes angusticollis, Phyllotreta striolata, Epilachna spp., Atomaria spp., Oryzaephilus Surinamensis, Anthonomus spp., Sitophilus spp., Otiorhynchus sulcatus, Cosmopolites sordidus, Ceuthorhyncidius albosuturalis, Hypera postica, Dermestes spp., Trogoderma spp., Attagenus unicolor, Lyctridae (for example, Lyctus dentatum, Lyctus planicollis, Lyctus sinensis, Lyctus linearis, Lyctus brunneus, Lyctus africanus) , Meligethes aeneus, Ptinus spp., Gibbium psylloides, Tribolium spp., Tenebrio molitor, Agriotes spp., Melolontha mololontha; Scolytidae such as Xyleborus and Scolytoplatypus; Cerambycidae such as Monochamus, Hylotrupes, Hesperophanus, Chlorophorus, Palaeocallidium, Semanotus, Purpuricenus and Stromatium; Platypodidae such as Crossotarsus and Platypus; Bostrychidae such as Dinoderus, Bostrychus and Sinoderus; Anobiidae such as Ernobius, Anobium, Xyletinus, Xestobium, Ptilinus, Nicobium and Ptilineurus, Buprestidae, etc. Hymenoptera: Diprion spp., Hoplocapma spp., Lasius spp. Japonica formica, Vespa spp., Siricidae such as Urocerus and Sirex, etc. Diptera: Aedes spp., Anopheles spp., Culex spp., Drosophila melanogaster, Musca domestica, Fannia spp., Calliphora spp., Lucilia spp., Chrysomya spp., Cuterebra spp., Gastrophilus spp., Stomoxys spp., Oestrus spp. ., Hypoderma spp., Tajanus spp., Bibio hortulanus, Pegomyia hyoscyami, Ceratitis capitata, Dacus dorsalis, Typula paludosa, Simulium spp., Eusimulium spp., Phlebotomus spp., Culicoides spp., Chrysops spp., Haematopota spp., Braula spp., Morellia spp., Wohlafahrtia spp., Sarcophaga spp., Lipoptena spp., Melophagus spp., Muscina spp., etc. Arachnida: Scorpio maurus, Latrodectus mactans, Chiracanthium spp., Etc. Acariña: Acarus siró, Eriophyes spp., Chelacaropsis moorei, Dermatophagoides spp., Tarsonemus spp., Bryobia praetiosa, Panonychus spp., Tetranychus spp., Acarapis spp., Cheyletiella spp., Myobia spp., Listrophorus spp., Tyrophagus spp., Cytodides spp., Lamínosioptes spp., etc. The present composition, although it may be composed merely of the nitroimino compound and pyriproxyfen, is usually used for practical applications such as formulations that contain suitably solid carriers, liquid carriers, auxiliary agents and other additives. The formulations may be in the form of emulsifiable concentrates, oil sprays, flowable preparations, solutions, powders, wettable powders, granules, paste preparations, foams, aerosol preparations, carbon dioxide gas preparations, tablets, shaped preparations. of foil, or resin preparations. At the time of application, a preferred form is suitably selected for the formulation.

The content of nitroimino compound and pyriproxyfen, although may vary with the form of the formulation, is usually from 0.005% to 50% by weight in total. These formulations can be obtained by any of the ordinary methods, for example, by mixing the nitroimino compound and pyriproxyfen with solid or liquid carriers, and adding, if necessary, other auxiliary agents such as emulsifiers and fixing agents, followed by the additional mixture, and subsequently the formation of the mixture in a desired form for some particular formulations. The carriers and auxiliary agents that can be used in the formulation can include, for example, the following materials: The solid carrier can include, for example, natural or synthetic minerals such as clay, kaolin, talc, bentonite, sericite, quartz, sulfur, activated carbon, calcium carbonate, diatomaceous earth, pumicite, calcite, sepiolite, dolomite, silica, alumina, vermiculite and perlite; fine sawdust granules, corn cobs, coconut husks and tobacco stems; gelatin, ethylcellulose petrolatum, lanolin, lard, and liquid petrolatum. The liquid carrier may include, for example, aromatic or aliphatic hydrocarbons such as xylene, toluene, alkylnaphthalenes, phenylxylylethane, kerosene, light oil, hexane and cyclohexane; halogenated hydrocarbons such as chlorobenzene, dichloromethane, dichloroethane and trichloroethane, alcohols such as methanol, ethanol, isopropyl alcohol, butanol and hexanol; ethers such as diethyl ether, dimethyl ether and ethylene glycol, tetrahydrofuran and dioxane; esters such as ethyl acetate and butyl acetate; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone; nitriles such as acetonitrile and isobutyronitrile; sulfoxides such as dimethyl sulfoxide; acidic amides such as N, N-dimethylformamide and N, N-dimethylacetamide; vegetable oils such as soybean oil and cottonseed oil; essential oils such as orange oil, hyssop oil and lemon oil; and water. The propellant that can be used in the foam, aerosol preparation or preparation of carbon dioxide gas can include, for example, propane gas, butane gas, freon gas, LPG (liquefied petroleum gas), dimethyl ether, and dioxide gas of carbon. The base material that can be used in the preparation of resins can include, for example, polymers of vinyl chloride and polyurethane. These base materials may contain, if necessary, plasticizers such as esters of italic acid (for example dimethyl phthalate, dioctyl phthalate), esters of adipic acid and stearic acid. The resin preparation can be obtained by kneading the active ingredients in the base material with a conventional kneader, and then forming the mixture in a desired form using injection, extrusion, pressing or other molding techniques. If necessary, the additional steps of molding, cutting and other additional steps can be used to make a resin preparation in the form of plate, film, ribbon, net, cord or other forms. For example, the resin preparation can also be made into animal collars, animal ear tags, sheets, attractive lanyards, wrapping films, or garden poles.

Auxiliary agents may include, for example, nonionic emulsifiers such as polyoxyethylene fatty acid esters and polyoxyethylene fatty acid alcohol ethers; ionic emulsifiers such as alkyl sulfonates, alkyl sulfates and aryl sulfonates; dispersing agents such as ligninsulphonates and methylcellulose; fixing agents such as carboxymethylcellulose, gum arabic, polyvinyl alcohol and polyvinyl acetate; and coloring agents such as iron oxide, titanium oxide, Prussian blue, alizarin dyes, azo dyes and phthalocyanine dyes. The present composition may further contain synergistic agents such as PBO, S421, MGK264, IBTA and Synepirin 500. The present composition is usually used by its application directly to harmful arthropods or indirectly to their habitats. The amount of application when the present composition is used for domestic pest prevention is, for example, from about 0.001 to 10 mg / m3 as the amount of active ingredients for the control of flies and mosquitoes in the house, or about 0.001 to 100. mg / m2 as the quantity of active ingredients for the control of cockroaches and ants. The "* amount of active ingredients" as used herein refers to the total amount of the nitroimino compound and pyriproxyfen, unless otherwise indicated. For the control of pests that infest the wood, the present composition can be applied directly to these pests, but it is usually applied to their habitats, for example, wood materials and soil. The amount of application, although it may vary with the types of harmful arthropods that are to be controlled, the forms of the formulations, the application sites, the methods of application and other factors, is generally from about 0.1 to 10,000 mg / m2 as the amount of active ingredients. The present composition when used for agriculture is usually applied in a proportion of about 1 to 1,000 g / ha, preferably about 10 to 300 g / ha, as the amount of the active ingredients. If the present composition is formulated into emulsifiable concentrates, wettable powders, flowable forms or the like, the application concentration is usually from 1 to 1,000 ppm, preferably from 10 to 200 ppm, for the active ingredients. In the case of granules, powders or similar forms, the present composition is usually applied as such. These formulations and their aqueous dilutions can be used either for foliar application on plants such as crop plants that are going to be protected against harmful arthropods or for application in the soil, to control the harmful arthropods that inhabit the soil of the land. of culture. The present composition can also be applied in the form of sheets of strings or other processed resin preparations, for example, by winding them directly around the harvest plants, placing them in the vicinity of the harvest plants, or placing them on top of the crop. Soil surface at the base of the harvest plants.

Eg emplos The present invention will be further illustrated by the following examples; however, it is understood that the present invention is not limited to these examples.

Formulation example 1 Five parts by weight of 3- [(2-chloro-5-thiazolyl) methyl] -5-methyl-4-nitroiminotetrahydro-l, 3, 5-oxadiazine, 10 parts by weight of pyriproxyfen, 8 parts by weight of alkyl ether The polyoxyethylene liquette, 2 parts by weight of sodium alkylarylsulfonate, and 75 parts by weight of xylene were mixed to give an emulsifiable concentrate.

Test example 1 For 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine (hereinafter referred to as compound A) and pyriproxyfen (hereinafter referred to as compound B), a 0.1 solution % (w / v) in ethanol was prepared each and then diluted with water to give an aqueous solution of 1 ppm of compound A or of compound B.

Both solutions are mixed in the prescribed proportions to give test solutions with a compounding ratio of A / B (in ppm) of 1.0 / 0 (compound A only), 0.99 / 0.01, 0.9 / 0.1, 0.8 / 0.2, 0.7 /0.3, 0.5 / 0.5, and 0 / 1.0 (compound B only) (seven test solutions in total). To 50 g of the fly medium (a mixture of fiber and animal powder) 100 ml of a test solution was added, followed by mixing, which was placed in a 650 ml plastic cup. In a nylon net cage (21 cm wide, 28 cm deep, and 21 cm high) were placed water, food (skimmed milk: granulated sugar = 2: 1) and two cups containing the treated medium with the test solution as described above. Thirty 4-day-old larvae of the housefly (strain CSMA) were placed inside one of the two cups containing the medium. Twenty adults of the housefly (strain CSMA, sex ratio and volume = 1) were also placed free in this cage. The number of domestic flies that survive in the cage was then observed after 1, 2 and 8 days, and the cumulative number was recorded. For reference, the same test was carried out, except that a medium treated with water was used. The proportion of control, the expected proportion of control, and the synergism index were determined by the following equations for the calculation: Control ratio (%) = (C -T) + C x 1 00 where C is the cumulative number of surviving adult flies in the reference cage and T is the cumulative number of surviving adult flies in the treated cage.

Expected proportion of control (%) = P x proportion of mixture of compound A + Q x proportion of mixture of compound B. where P is the control ratio for compound A only (1 ppm) and Q is the control ratio for compound B only (1 ppm). synergy index = control ratio + expected proportion of control x 100 The experiment was carried out in duplicate. The results are shown in Table 1.

TABLE 1 Test example 2 The same experiment was carried out as described in Example 1, except that compound A was changed to 3- [(2-chloro-5-thiazolyl) methyl] -5-methyl-4-nitroiminotetrahydro-1,3, 5-oxadiazine (hereinafter referred to as compound C), five test solutions with a C / B compound concentration ratio (in ppm) of 1.0 / 0 (compound C only), 0.9 / 0.1, 0.7 / 0.3 , 0.5 / 0.5, 0 / 1.0 (compound B only) were used, and the experiment was carried out once. For reference, the same results as obtained in Test Example 1 were used. The results are shown in Table 2. The control ratio and the expected control ratio were determined by the equations for the calculation as defined in Test Example 1, except that the values of compound A were changed to those of compound C.

TABLE 2 Example of Comparative Test 1 The same experiment as described in Test Example 2 was carried out, except that compound B was changed to methoprene (hereinafter referred to as comparative compound 1). For reference, the same results as those obtained in Test Example 1 were used. The results are shown in Table 3. The proportion of the control and the expected proportion of the control were determined by the equations for the calculation as defined in Test Example 1, except that the values of compound B were changed for those of comparative compound 1.

TABLE 3 Test Example 3 Cabbage seedlings planted in plastic containers were placed in a net cage containing many live white flies from the silver leaves for 24 hours, so that many white flies from the silver leaves became parasitic on the cabbage seedlings. An emulsifiable concentrate of compound A (prepared by mixing 5 parts by weight of compound A, 9 parts by weight of Sorpol 3005X (from Tono Chemical Industries, Co., Ltd.), 11 parts by weight of xylene, and 10 parts by weight of DMF), an emulsifiable concentrate of compound B (trade name: Laño EC, of Sumitomo Chemical Company, Limited), or a mixture of these emulsifiable concentrates of compounds A and B were each diluted in their prescribed amounts with water , and then sprayed on the cabbage seedlings with spray guns. The number of white flies from the silver leaves (for example, in a total number of adults and larvae) surviving in the cabbage seedlings was examined just before and after 10 days from the treatment. For reference, the same test was carried out, except that a cabbage seedling treated with water was used. The proportion of control and the expected proportion of control were determined by the following equations for the calculation: Control ratio (%) = 100 x. { 1 - (T + T0) + (C + C0)} where T is the number of surviving white flies in the treated cage after 10 days from the treatment, T0 is the number of surviving white flies in the treated cage just before the treatment, C is the number of surviving white flies in the case of "reference after 10 days from the treatment, and C0 is the number of surviving white flies in the reference cage, just before treatment.

Expected control ratio (%) = P + (100-P) x Q -r 100 where P is the control ratio for compound A only (in 50 ppm) and Q is the control ratio for compound B only ( in 50 ppm). The experiment was carried out once. The results are shown in Table 4.

TABLE 4 Test Example 4 The same experiment as described in Test Example 3 was carried out except that compound A was changed to compound C. For compound B only and for reference, the same results as obtained in Test Example 3 were used. The results are shown in Table 6. The control ratio and the expected proportion of the control were determined by the equations for the calculation as defined in Test Example 3, except that the values of compound A were changed to those of the C.

TABLE 5 It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is that which is clear from the present description of the invention.

Claims (5)

CLAIMS Having described the invention as above, the content of the following claims is claimed as property:

1. A composition for the extermination of harmful arthropods, characterized in that it comprises at least one compound selected from 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine and 3 - [(2-chloro-5-thiazolyl) methyl) ] -5-methyl-4-nitroiminotetrahydro-1,3,5-oxadiazine, and pyriproxyfen, as active ingredients.

2. The composition according to claim 1, characterized in that the weight ratio of at least one compound selected from 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine and 3 - [(2-chloro-5 -thiazolyl) ethyl] -5-methyl-4-nitroiminotetrahydro-1,3,5-oxadiazine to pyriproxyfen is in the range of 100: 1 to 1:10.

3. The composition according to claim 1, characterized in that 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine and pyriproxyfen are contained as active ingredients.

4. A method for the control of harmful arthropods, characterized in that it comprises the treatment of the harmful arthropods or their habitats with effective amounts of at least one compound selected from 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine and 3- [(2-Chloro-5-thiazolyl) methyl] -5-methyl-4-nitroiminotetrahydro-l, 3, 5-oxadiazine, and pyriproxyfen.

5. The method according to claim 4, characterized in that the weight ratio of at least one compound selected from 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine and 3 - [(2-chloro-5 -thiazolyl) methyl] -5-methyl-4-nitroiminotetrahydro-1,3,5-oxadiazine to pyriproxyfen is in the range of 100: 1 to 1:10