MXPA97008434A - Dentifri compositions - Google Patents
Dentifri compositionsInfo
- Publication number
- MXPA97008434A MXPA97008434A MXPA/A/1997/008434A MX9708434A MXPA97008434A MX PA97008434 A MXPA97008434 A MX PA97008434A MX 9708434 A MX9708434 A MX 9708434A MX PA97008434 A MXPA97008434 A MX PA97008434A
- Authority
- MX
- Mexico
- Prior art keywords
- sodium
- abrasive
- composition according
- approximately
- particles
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 89
- 239000002245 particle Substances 0.000 claims abstract description 32
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000000551 dentifrice Substances 0.000 claims abstract description 21
- 238000005296 abrasive Methods 0.000 claims abstract description 20
- 238000005299 abrasion Methods 0.000 claims abstract description 18
- 239000000606 toothpaste Substances 0.000 claims abstract description 18
- 238000004140 cleaning Methods 0.000 claims abstract description 17
- BPQQTUXANYXVAA-UHFFFAOYSA-N silicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000010521 absorption reaction Methods 0.000 claims abstract description 15
- 230000002285 radioactive Effects 0.000 claims abstract description 14
- 210000004268 Dentin Anatomy 0.000 claims abstract description 13
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 13
- 229940034610 Toothpaste Drugs 0.000 claims abstract description 12
- 229920000728 polyester Polymers 0.000 claims abstract description 7
- 229910000906 Bronze Inorganic materials 0.000 claims abstract description 6
- 239000010974 bronze Substances 0.000 claims abstract description 6
- 239000004094 surface-active agent Substances 0.000 claims description 19
- 239000011734 sodium Substances 0.000 claims description 17
- 229910052708 sodium Inorganic materials 0.000 claims description 17
- 239000011780 sodium chloride Substances 0.000 claims description 17
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 16
- 239000002738 chelating agent Substances 0.000 claims description 15
- -1 alkali metal citrates Chemical class 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- KRHYYFGTRYWZRS-UHFFFAOYSA-M fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 11
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- 229910052783 alkali metal Inorganic materials 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 210000000515 Tooth Anatomy 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 229920000591 gum Polymers 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Trimethylglycine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 229960001367 tartaric acid Drugs 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 208000007565 Gingivitis Diseases 0.000 claims description 3
- HELHAJAZNSDZJO-UHFFFAOYSA-L Sodium tartrate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O HELHAJAZNSDZJO-UHFFFAOYSA-L 0.000 claims description 3
- 229960002799 Stannous Fluoride Drugs 0.000 claims description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L Tin(II) fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 3
- 239000000001 dental powder Substances 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- 239000001433 sodium tartrate Substances 0.000 claims description 3
- 229960002167 Sodium tartrate Drugs 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 230000000069 prophylaxis Effects 0.000 claims description 2
- 235000011004 sodium tartrates Nutrition 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 229940041672 Oral Gel Drugs 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M Sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229940104261 taurate Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000000306 component Substances 0.000 description 17
- 239000003921 oil Substances 0.000 description 14
- 235000019198 oils Nutrition 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 229940083542 Sodium Drugs 0.000 description 10
- 229940091252 Sodium supplements Drugs 0.000 description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 6
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- XPPKVPWEQAFLFU-UHFFFAOYSA-J Pyrophosphate Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 150000001340 alkali metals Chemical class 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atoms Chemical group C* 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 235000011180 diphosphates Nutrition 0.000 description 4
- 210000000214 Mouth Anatomy 0.000 description 3
- 229960003975 Potassium Drugs 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N Saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 235000019395 ammonium persulphate Nutrition 0.000 description 3
- 150000008064 anhydrides Chemical class 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M Potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N Potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 229940027983 antiseptics and disinfectants Quaternary ammonium compounds Drugs 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 210000004027 cells Anatomy 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 235000016693 dipotassium tartrate Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000001472 potassium tartrate Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001105 regulatory Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229940071089 sarcosinate Drugs 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-M sarcosinate Chemical compound CNCC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-M 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Inorganic materials [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissues Anatomy 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- NPKLJZUIYWRNMV-UHFFFAOYSA-N 2-[decyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCC[N+](C)(C)CC([O-])=O NPKLJZUIYWRNMV-UHFFFAOYSA-N 0.000 description 1
- ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 2-[diamino(3-formamidopropyl)azaniumyl]acetate Chemical compound [O-]C(=O)C[N+](N)(N)CCCNC=O ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 0.000 description 1
- 229960005164 ACESULFAME Drugs 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 229960003438 Aspartame Drugs 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N Aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 229940113118 Carrageenan Drugs 0.000 description 1
- 210000002421 Cell Wall Anatomy 0.000 description 1
- 229940112822 Chewing Gum Drugs 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 210000003298 Dental Enamel Anatomy 0.000 description 1
- ALKZAGKDWUSJED-UHFFFAOYSA-N Dinuclear Copper Ion Chemical compound [Cu].[Cu] ALKZAGKDWUSJED-UHFFFAOYSA-N 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229960002737 Fructose Drugs 0.000 description 1
- 108060003331 GOT1 Proteins 0.000 description 1
- 241001647328 Gardenia taitensis Species 0.000 description 1
- 229960001031 Glucose Drugs 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241000976924 Inca Species 0.000 description 1
- 241001058354 Inti Species 0.000 description 1
- 229920000126 Latex Polymers 0.000 description 1
- 240000001422 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- NKAAEMMYHLFEFN-UHFFFAOYSA-M Monosodium tartrate Chemical compound [Na+].OC(=O)C(O)C(O)C([O-])=O NKAAEMMYHLFEFN-UHFFFAOYSA-M 0.000 description 1
- 101700022875 PME7 Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K Potassium citrate Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- AVTYONGGKAJVTE-UHFFFAOYSA-L Potassium tartrate Chemical compound [K+].[K+].[O-]C(=O)C(O)C(O)C([O-])=O AVTYONGGKAJVTE-UHFFFAOYSA-L 0.000 description 1
- 229940111695 Potassium tartrate Drugs 0.000 description 1
- 229940081974 Saccharin Drugs 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- BFDWBSRJQZPEEB-UHFFFAOYSA-L Sodium monofluorophosphate Chemical compound [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 241000750042 Vini Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000005042 Zier Kohl Nutrition 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052910 alkali metal silicate Inorganic materials 0.000 description 1
- 125000000217 alkyl group Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000000845 anti-microbial Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002051 biphasic Effects 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- PARMADWNFXEEFC-UHFFFAOYSA-N butyl-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]azanium;sulfate Chemical compound [O-]S([O-])(=O)=O.CCCC[NH2+]CC(O)C1=CC=C(O)C=C1.CCCC[NH2+]CC(O)C1=CC=C(O)C=C1 PARMADWNFXEEFC-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000005824 corn Nutrition 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019524 disodium tartrate Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000001747 exhibiting Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000002070 germicidal Effects 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- VSNHCAURESNICA-UHFFFAOYSA-N hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical group CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000003000 nontoxic Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- NJRWNWYFPOFDFN-UHFFFAOYSA-L phosphonate(2-) Chemical compound [O-][P]([O-])=O NJRWNWYFPOFDFN-UHFFFAOYSA-L 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000000985 reactive dye Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine zwitterion Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 239000010672 sassafras oil Substances 0.000 description 1
- 229910021487 silica fume Inorganic materials 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000011791 tripotassium citrate Substances 0.000 description 1
- 235000015870 tripotassium citrate Nutrition 0.000 description 1
- 239000011778 trisodium citrate Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
Abstract
The present invention relates to oral compositions, such as oral gels and toothpastes containing a novel abrasive, a dentifrice composition comprising: a precipitated silica abrasive composition comprising: a precipitated first silica comprising particles wherein said particles have : an average particle size of 5 to 11 microns (of <9), a hardness of Einlehner of 0.8 to 2.5 for abrasive for bronze screens and 5 to less than 8 for abrasive for polyester screens, an oil absorption from 95 ml / 100 g to 134 ml / 100 g;; and a radioactive dentine abrasion from 25 to less than 80; and a second precipitated silica comprising particles in which said particles have: an average particle size of 5 to 11 microns (from <9), a hardness of Einlihner from 3 to 8 for abrasive for bronze screen and from 8 to 11 for abrasive for polyester screen, an oil absorption of 70 ml / 100 g less than 95 ml / 100g; and an abrasi radioactive dentin from 80 to 200, where at least 70% of all these particles have a diameter below 25 microns and where the film cleaning ratio is 90 to 135 and the abrasion of radioactive dentin is 60 to 100, with a radioactive dentin film / abrasion cleaning ratio ratio of 1.25 to 1.75, and wherein the ratio of the first silica to the second silica is 90:10 to 40:60, respectively; 0.1% to 99% of an orally acceptable toothpaste
Description
DENTÍFRICAS COMPOSITIONS
TECHNICAL FIELD
The invention relates to dentifrice compositions such as toothpastes, which provide improved oral cleansing.
BACKGROUND OF THE INVENTION
The precipitated silicas produced int et-1 cainent e play an important role as an ingre dient in many of the current toothpaste formulations, beyond their cleaning ability, they are also relatively safe, non-toxic, and compatible with other ingredients of toothpaste. toothpaste, including glycerin, sorbitol (ox litol), thickening agents, detergents, coloring materials and fragrances, and optionally, compositions containing fluoride. The synthetic precipitated acids are repaired by mixing diluted solutions of alkali silicate with acids, stirring and then filtering the precipitated silica. Then, the resulting precipitate is washed, dried and crushed to the desired size. When preparing synthetic precipitated silicas, the goal is to obtain silicas that provide maximum cleanliness with no damage to the oral turn. Researchers in the dental area are concerned with the inti ication of precious silicas that meet these objectives.
examples of precipitated silicas include the Patent of I .U.fl. 4,122, Lbl, for Uason, Oct. 24, 1978, U.S. Pat. 4,992,251 and 5,885,879 for Aldcro y o ros, 12 de Pobrero of 1991 and 30 of Julio of 1991 respectively, Patent "Je Los E.U.A. 5,098,695 for Newton et al., March 24, 1992 and Patent of the l-.U.A. 5,279,015 to Wa on et al., January 18, 1994. In addition, various siliceous compounds have also been described in the art. GIÜ desci i on combinations of silica including compositions of different particle sizes and specific surface areas in the patent of fc.U.A. No. 3,577,521 to Karlheinz Scheller et al., May 4, 1971 and the U.S. Patent. No. 4,618,408 par-a Maeyarna et al., Dated October 21, 1986, respectively. Similarly, the Paten e of E.U.A. No. 5,110,574 par-a Rinhar + dy-os, dated May 5, 1992, describes the combination of precipitated thickener silicas and polishers for silica fume co-fractions having oil absorption values of lesser amounts. 200. Additional examples of silica combinations include the US Patent. No. 5,124,143 to Muhleinann, June 23, 1992 and the U.S. Patent. No. 4,632,826 to Ploger et al., December 30, 1986. Despite the many descriptions related to compositions for oral cleansing and anti-lacquer activity, there is still a need for additional compositions that provide improved film cleaning with minimal abrasion. The inventor of the present invention has discovered that abrasive compositions comprising silicas having particles of different hardness values provide improved tooth cleaning with abrasion. Therefore, the object of the present invention is to provide compositions of precipitated silica exhibiting improved film cleaning without a corresponding increase in abrasion dense or enamel, or object of the present invention is to provide an effective method for the prevention or removal of dental stains. The present invention is to provide an effective method for the prevention or removal of plaque These and other objects will become readily apparent from the description that follows.
BRIEF DESCRIPTION OF THE INVENTION
The present invention relates to dental compositions comprising: A) A precipitated silica abrasive composition comprising: a) a precipitated silica comprising particles wherein said particles have: i) an average particle size of about approximately 11 microns (from. < 9); ii) Einlehner hardness - from about 0.8 to about 2.5 for abrasive bronze screen grinder and from about 5 to about 0 for polyester screen abrasive; in) an oil absorption of 95 rnl / lOOg to about 135? nl / 101) g; and iv) an abrasion of radioactive dentin from about 25 to about less than 00; and b) a liquid particle comprising a particle, said particles having: i) an average particle size of approximately 5 to approximately 11 microns (d.e. < 9); ll) an EinLehner hardness of about 3 to about 8 abrasive pair for bronze screen and from 8 to about Ll for polyester screen abrasive; m) an oil absorption of approximately
70 rnL / LOO g at about 95 ml / 100 g; and v) a radioactive dentine abrasion from 00 to r-oxuinly 200; wherein at least about 70% of all these particles have a diameter of about 25 microns, and wherein the film cleaning ratio is from about 90 to about 135 and dent abrasion. The radioactive material is from about 60 to about 100, with a film-to-abrasion ratio of radioactive dentin, from about 1.25 to about 1.75, and wherein the ratio of the silica in a) to the silica on b) is Approximately 90:18 to approximately 40:60, spectacle, and B) from 0.1% to approximately 99% of a toothpaste orally aceμt abLe. All levels and proportions are by weight of the total composition, unless "-e indicate otherwise, the values of NI.P and ADI? they are adimensonal. Additionally, all measurements were made at 25 ° C, unless < e specify from et G? ?? aner \ í. The pH of the compositions described herein ranges from about 4 to about 9.5, with the preferred pH being from about 6.5 to about 9.0, and the highly preferred pH being from 7.0 to about 8.5, measured in a 5% aqueous suspension.
DETAILED DESCRIPTION OF THE INVENTION
By "safe and effective amount", as used herein, is meant an amount sufficient to reduce stains and / or plaque / gingivitis without damaging the tissues and structures of the cavity or-al. By the term "orally acceptable vehicle", as used herein, a suitable vehicle is indicated that can be used to apply the present compositions to the oral cavity in a safe and effective manner. The essential components, as well as the optional components of the compositions of the present invention are described in the following paragraphs.
Abrasive The precipitated solids used to form the compositions of the present invention can be characterized as either lower structure silicas or medium structure in accordance with the definitions indicated in Z). Soc.Oosrnet. Choin. 29., 497-521 (August, 1978) and Pigment Handbook: Volume 1 Proper-t and Economics, Second Edition, Edited by Peter A. Lewis, John Uilwy & Sons, Inc., 1988, pp. 139-159, and are preferably characterized with synthetic hydrated amorphous silicas, also known as silicon dioxides or S? 02. In addition, these silicas can be characterized in that they have a BET surface area in the range of 50 to 250? N2 / g. These compositions are further characterized by having an average particle size ranging from about 5 microns to about 11 microns. with at least 70% of the particle size distribution being less than 20 microns. The average particle size (average and median value or 50%) is measured using a IIícrotrae II, Leeds and Northrup apparatus. Specifically, a beam l is projected through a transparent cell containing a stream of moving particles suspended in a liquid. The light rays hitting the particles are scattered through angles that are inversely proportional to their sizes. The disposition of fotodet ector- mi e 1? amount of light at various predetermined angles. Electrical signals proportional to the measured light flux values are then processed by a microcomputer system to form a histogram of multiple particles of particle size, the precipitated silicas used to form the compositions of The present invention is also distinguished by its hardness values Einlehner r-spectacles, abrasion values of radioactive dentin (ADR) and absorption values of ace 11 o., Einlehner hardness values are measured using a Einlehner At-iüOO Abrader to measure the smoothness of the silicas in the following way: weigh an Eourdrimer wire screen and expose it to the action of a suspension of 10% aqueous silica during a certain period. determines
The amount of abrasion as weight loss in milligrams in l. wire sieve I "ourdi imer por- LOO, 800 revolutions The results of Brass Einlehner (BE) and Polyester Einlehner (PE) are expressed in my igramos.The ADR values were determined according to the method given by- He ff erren, Journal of Dental Research, July-August 1976, pp. 563-573, and described in USPatents 4,340,583, 4,420,312 and 4,421,527, this publication and patent are incorporated herein by reference. the present invention can be characterized in that it has an oil absorption value of less than _M) f) <-c / 100 q "The oil absorption values are using the method of deletion AST D281. The surface area is determined by means of the BET nitrogen adsorption method of Brunaur et al., J "Arn. Chem. Soc ,,, 60,389 (1930) .To measure the brightness, powder materials are compressed into a surface pellet. They are evaluated using a T chnidyne device Bpght unet er S-b / BO. I this instrument has a double beam optical system where the sample is illuminated? An angle of 45 ° and 1? reflected light is observed at 0 ° "Conforms to the TAPPI test methods T452 and T646, and ASTM Standard D985 ,. A series of filters direct the reflected light of desired wavelengths towards a photocell where it is converted into an output voltage. This signal is amplified and then processed by means of an internal computer to be printed and scanned. The precipitation of the silicas from the present invention is achieved according to the general methods described, for example, in the CU Patents. A. No. 3,893,840, issued July 8, 1975 to Uason; 3,988,162, issued October 26, 1976, to Uason, 4,067,746, issued on October 10, 1978 to Uason; and 4,340,583, issued July 29, 1982 to Uason; all of which are incorporated herein by virtue. In an f > As a result of the process, a first precipitated silica suspension is prepared by varying the precipitation reaction parameters in a manner, ordinarily, resulting in precipitate values having BE values on the scale of about 0.8 rng to ap about 2.5 ing. and PE values in the range of about 5 rng to about below 8 mg, an RDA ranging from about 25 to about 80, and an oil absorption of 95 rnl / 100 ng to about 135 nl / L00g. The reaction pairs that affect the characteristics of the resulting silica? include: the speed at which the various reagents are added; the concentration levels of reactive dyes; the pH of the reaction; the reaction temperature or the speed at which the rol rolitos are added. In another step of the precipitation process, a second suspension of precipitated silica is prepared in a similar manner by varying the reaction parameters in a manner, ordinarily, resulting in precipitated silicas having BE values on the scale of about 3 rng to about 8 rng and PE values on the scale from 8 rng to about 11 rng, an RDA that varies from around-from 81 to about 200, and an oil absorption of about-from 70rnl / 100mg to about 95rnl / 100rng. Therefore, the two precipitated silica suspensions can be combined, adjusting the pH to about 5.0. The combination suspension is filtered and then washed with water to remove salts from the filter cake. The filter cake is dried, preferably by conventional spray drying to produce a precipitated silica containing about 3% to 10% moisture, the combination of precipitated silica is milled to a particle size in which 70% of the of particle size is less than 20 microns, Alternatively, the two silicas can be combined before being incorporated into Inca denti compositions. In addition to the essential components described aboveThe tooth compositions of the present invention may contain a variety of optional tooth ingredients, some of which are described below. Optional ingredients include, for example, but not limited to, adhesives, foaming agents, sabotagents, sweetening agents, additional antipylactic agents, abrasives, and color-former agents. These and other optional components are further described. in the US Patent 5,004,597, April 2 of L991 for ajeti; Patent of the U.S.A. 4,885,155, December 5, 1989 for Parran, Jr-. and others; Patent of the U.S.A. 3,959,458, May 25, 1976 par-a Agricola et al. And U.S. Patent No. 3,937,807, February 10, 1976 par-a Haefele, all incorporated herein by reference. The film cleaning ratio (RLP) of the silica composition of the invention, which is a measure of the cleaning characteristics of a dentifrice, ranges from 90 to 135 and preferably from 100 to 130 for the amorphous silica combination of the invention. The Abrasion (Radioactive Dentin (ADR) of the silicas of the invention, which is a measure of the abrasiveness and the combination of precipitated silica, when incorporated in a dentifrice, ranges from 60 to 100, preferably 88. to 90. The RI.P cleaning values (Film Cleaning Ratio) were determined by means of a slightly modified version of the RL P test described in "In Vitro removal of Stam Ui th Toothpaste" G. K, Stookey T A. Bui hai dy 13. R. Schemerhorn, J "Dental Research, 61, 1236-9, 1982. Cleaning was determined m vitro by the use of the modified film cleaning ratio test. Test is identical to that described by- Stookey et al., with the following modifications: i) a thin artificial film was applied clar-a to portions of bovine before application of the stained film, 2) heating of the solution was used instead of heating by radiation during the application of La peUc La, 3) network I count the number of brush strokes at 200 strokes and \) 1 < The concentration of the suspension is 1 ^ + e of toothpaste per 3 parts of water. The precipitated silica compositions of the present invention, when incorporated into a dentifrice composition further provide an improved PCR / RDA ratio. The ratio of PCR / RDA is used to determine the relative ratio of cleaning and abrasion characteristics of a dentifrice formulation. Commercially available dentifrice formulations generally have a CRP / RDA ratio of 0.5 to less than 0.1%. Precipitated silicas used in the compositions of the present invention provide proportions of PCR to RDA for higher dentifrice formulations. -is «1, generally in the scale of 1.25 to 1.r'b, but most preferably in the scale of 1.75 to 1.75. The abrasive in the form of precipitated silica and silica on gel compositions of the present invention, when incorporated into the compositions described hereinabove, is at a level of approximately b% to approximately 70%, preferably from about L5% to about 35% when the toothpaste is a toothpaste. Higher levels can be used, as high as 95%, if the composition is a dental powder.
Pharmaceutically acceptable vehicle Another essential component of the present invention is an orally acceptable dentifrice vehicle. The vehicle for the components of the present compositions can be any dentifrice vehicle suitable for use in the oral cavity. Such vehicles include the usual components of toothpastes, dental powders, prophylaxis pastes, pills, gums, and the like and are described more fully below. Toothpastes are the preferred systems.
OPTIONAL COMPONENTS Surfactants One of the preferred optional agents of the present invention is a surfactant, preferably one selected from the group consisting of sarcosinate surfactants, ethylene terylate and saturated surfactants. It is preferred to use the alkali metal or ammonium salts of these surfactants herein. Most preferred were the sodium and potassium salts of the following: 1 auro-isarcosinate, ip stoilsarcosine, 1-sarcoside, stearoi lsarcosi nato, and oleo 1 sarcosinate. may be present in the compositions of the present invention at from about 0.1% to about 2.5%, preferably from about 0.3% to about 2.5%, and preferably preferably from about
0. 5% to about 2.0% by weight of the total composition. Other suitable compatible surfactants may optionally be used together with the sarcosmate surfactant in the compositions of the present invention. Suitable optional surfactants are described in more detail in U.S. Pat. 3,959,458, May 25, 1976 for Agrícola et al .; Patent of the U.S.A. 3,937,807, February 10, 1976 for Haefele; and U.S. Pat. 4,051,234, September 27, 1988 for Gieske et al. These Patents are incorporated herein by reference. Useful ammonium surfactants preferred l / l
in the present and include water-soluble salts of alkyl ultras which have from 10 to 18 carbon atoms in the alkyl radical and the water-soluble salts of nitrogen-containing sulphonated fatty acid salts ranging from 10 to 18. carbon atoms. Sodium lauryl sulfate and cocomonous sodium ponsulphates are examples of ammonia-based products of this type. Mixtures of ammonium surfactants can also be used. The preferred catholic practices are useful in the
The present invention can be defined in general terms as derivatives of aliphatic quaternary ammonium compounds having a long alkylic chain containing from about 8 to 18 carbon atoms, such as laurel chloride, or priatelarylonium chloride; ceti lpi ridini chloride; 5 ceti bromide Ipipdi o; bromide (Je ceti lth rirnetilarnonio; di-Lso-butii chloride phenoxyethyl il-dirnetiibencilamomo; cocoal nitrite unet prnet 11 ammonium; acetyl lpip di fluoride, etc. Preferred compounds are the quaternary ammonium fluorides disclosed in The Patent of the US 3,535,421, October 20
of 1970 for Hrmer et al., Incorporated herein by reference, wherein said quaternary ammonium fluorides have detergent properties. Certain cationic surfactants may also act as germicides in the compositions described herein. The ensioactives
cathexes such as chlorhexadine, although they are suitable for use in the present invention, are not peopled due to their < , apandad to stain - the hard tissues of the oral cavity. Experts in the matopa are aware of this possibility and should only incorporate their catholic measures taking into account this principle. The non-ionic professed substances that can be used in the compositions of the present invention can be defined in term *: general as compounds produced polya condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrocarbon compound which may be aliphatic or alkyl aromatic in nature. Examples of suitable nonionic surfactants include Pluro cs, condensates of polyethylene oxide of quilphenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylendia, condensates of oxide of the full of aliphatic alcohols, tertiary amine oxides of long chain, long chain tertiary phosphine oxides, dialkylsulfoxides (long chain) and mixtures of these materials The preterm zwi + erionic synthetic surfactants useful in the present invention can be described in general terms as derivatives of alkylated quaternary ammonium compounds, phospho- and sulfone, in which the aliphatic radicals can be straight chain or branched, and where one of the aliphatic substrates contains from about 8 to 18 carbon atoms and one contains an ammonium group solubilizer in water, example carboxyl, sulfonate, sulfate, phosphate or phosphonate The preferred betaine surfactants are described in US Pat. .A. 5,180,577 for Polefl-a et al., Issued January 9, 1993. Typical alkyldimethoxys include decylbetaine or 2-N-dec? LN acetate, N-dirneti ammonium, cocobetaine or sodium acetate. ~ N ~ coc - N, N-dirneti lamonium, rnirist i ibet ama, palmitiibet a, lauri 1 betama, cet ilbet aína, esteanlbetaina, etc. The arninobeta as are exemplified by cocoamidoet i bet ai na, cocoamidopropylbetaine, lauplamidopropylbetaine and the like. The beta-acetes of choice are preferably the cocoamidopropyl beta and, preferably, the amidopropyl beta + aine.
Chelating Agents Another optional preferred agent is a chelating agent selected from the group consisting of tartaric acid and pharmaceutically acceptable salts thereof, citric acid and alkali metal and mixtures of the same. Chelating agents are able to complex with the calcium found in the cell walls of bacteria. Chelating agents can also break the plate by removing calcium from the calcium bridges that help sustain this intact biomass. However, it is possible to use a chelating agent that has an affinity for calcium that is too high. This leads to the denineralization of the teeth and is contrary to the objects and intentions of the present invention. Sodium and potassium citrate are the preferred alkali metal citrates, citra + or sodium being preferred. In a preferred embodiment a combination of citopic acid / alkali metal citrate is preferred. Preferred herein are the alkali metal salts of tartaric acid. Most preferred for use herein are disodium tartrate, dipotassium tartrate, sodium and potassium tartrate, sodium acid tartrate and acid tarmate (eg, potassium) The amounts of chelating agent suitable for use in the present invention they are about 0.1% to about 2.5%, preferably from about 0.5% to about 2.5%, and most preferably from about 1.0% to about 2.5% The tartar rich acid salt chelating agent can be used alone or in combination with other agents optional chelators, Other optional chelating agents can be used Preferably, these chelating agents have a calcium binding constant of about 101 to 105 provide improved cleaning with reduced plaque formation and calculations Another group of agents suitable for use as chelating agents in The present invention is the soluble pyro osophosa The sapphires of pyrophosphate used in the present compositions ions can be any of the salts of pi ofosfat or alkali metal. Specific salts include alkali metal tetrachloride, alkaline dimetal diacid pyrophosphate, alkali metal monoacid pyrophosphate and mixtures thereof, wherein the alkaline metals are preferably sodium or potassium. In their hydrated as well as unhydrated forms, an effective amount of useful salt in the present composition is generally sufficient to provide at least 0.0% of the phosphate content. 1.5% to about 6%, preferably about 3.5% to about 6% of these ions It is to be noted that the level of pyro ions that can be supplied to the composition (ie, the theoretical amount at a pH appropriate) and that forms of pyrophosphate other than P2? 7 ~ 4 (v.gr », HP2O7" "3) may be present when a final pH of the product is established. more detaile in Kirl »- R Othmer, E ncyciopedia of Chemical Technology, Second Edition, Volume 15, Ln + erscience Publishers (1968), incorporated herein by reference. Other possible chelating agents suitable for use in the present invention are polyalkylene ammonium polycarboxylates. These materials are well known in the art; they are used in the form of their free acids or co-salts of ammonium or alkaline metal (e.g., potassium and preferably sodium) soluble in water and partially or of L
pre foroncia, completely neutr-alized. Preferred eopoli are 1 •: 4 to 4: 1 (E anhydride or maleic acid with another monomer polunerizabLe sa + ured e + iienicament e, preferi lement ether met? I vini li co (full ethoxyet) which has a weight Molecular (MW,.) from about 30,000 to about 1,000,000., These copolymers are available for example as Gant rez AN 139 (MW 500,000), AM 119 (MW 250, 000) and preferably S-97 Pharmaceutical Grade (P.M. 70,000), from GAF Chemicals Corporation. Other pol icarboxi lat operative polimepcos include those such as the codend! US Pat. No. 3,990,055, US Pat. No. 4,430,433, which is available, for example, as Monsanto EM No. 1103, P.M., of rnaleic anhydride with ethyl acrylate, hydroxyethyl meta-plate, N-vini 1-2 -pyrrole, or ethylene. 10,000 and EM Grade 61, and limeros 1: 1 Acrylic Acid with methyl methane or hydroxyl urea, methyl or ethyl acrylate, isobutyl ether vinyl or N-vini 1 -2 - pi rro! idona The polycarboxylanes of the additional operational polymers are described in US Pat. 4,138,477, February 06, 1979 for Gaffar and Patent of E.U.A.
4,183,914, January 15, 1980 to Gaffar et al., Both patents are incorporated herein by reference and include copolymers of aleic anhydride with styrene, isobutylene or ether-i-v? nor lico, pol lacplico, polutaconico and polirnaleico acids, and oligoceros sulfoacrilicos de
P.M. as low as 1,000, available as Umroyal ND-2.
In addition, flavor-i agents can be added to the dental compositions beforehand. Suitable flavoring agents include pyrolian oil, peppermint oil, yerbayene oil, sassafras oil, and oily oil The sweetening agents that may be used include aspartame, acesulfame, saccharin, dextrose, levulose and sodium cyclate. Saponifying agents and sweeteners are generally used in dentphenols at levels of approximately 0.085% to approximately 2% in pe. .. It is common to have present an additional water-soluble fluoride compound in dentp and other organic compositions. in a sufficient amount to provide a fluoride ion concentration in the composition at 25 ° C, and / or when used, from about 0.0025% to about 5.0% by weight, preferably from about 0.005% to about 2.0% by weight. weight, to provide additional anti-gallic effectiveness, A wide variety of fluoride ion producing materials may be employed as the sources of soluble fluoride in the present compositions. Suitable fluoride ion producers are found in the US Pat. No. 3,535,421, October 20, 1970 for Bpner et al., And U.S. Pat. No. 3,678,154, July 18, 1972 to Uidder et al., Both are incorporated herein by reference. Representative fluoride ion sources include: stannous fluoride, sodium fluoride, potassium fluoride, sodium fluorophosphate, and many others.
Particularly preferred are stannous fluoride and sodium fluoride, as well as mixtures of the same. Water is also present in the toothpastes of this invention. The water used in the preparation of suitable dental pastes b) should preferably be dosed and free of organic impurities. The water generally comprises from about 10% to 50%, preferably from about 20% to 48%, by weight of the toothpaste compositions in the present. These amounts of water include
The free water that is added more than what is produced with other materials such as sorbitol. When preparing toothpastes, it is necessary to add some thickening material to provide the desired consistency. The preferred thickening agents are polymers of
L5 earboxivim Lo, carrageenan, hi droxiet ilceiulose and water-soluble salts of cellulose ethers such as car-box nnetii cabbage of sodium and sodium carboxylate droxietii sodium cell. Natural gums such as aza-gum, xanthan gum, gum arabic and gum tragacanth can also be used.
Thickening agents can be used in an amount of 0.5% to 5.0% by weight of the total composition. It is also convenient to include some moisturizing material in a toothpaste to preserve it from hardening. Suitable humectants include gl icen na,
Sorbitol and other edible polyhydric alcohols at a level of about 15% to about 70%.
' } ')
[amblen is convenient? the inclusion in the com ponents of the present invention are salts or other salts such as pyro os ato estanoso v gluconate estanoso and ant i microbianos such as quaternary ammonium salts, such as chloride (Je cet ilpip di ruó and cLururo t et radeei 1 ethyl p p dim, salts of bi-buraua da, copper copper batch, non-limean antimicrobial salts and flavor oils. These agents are described in the patent of BUA No. 2 , 9 b ,, '25, July 26, 1960, for Morris et al and U.S. Patent No. 4,051,234, September 27, 1977 for Gies ey otr-os, incorporated herein by reference.Other optional components include pH regulating agents, bicarbonates, peroxides, nitrate salts such as sodium and potassium nitrate. These agents, which are present, are included at levels of approximately 0.01% to approximately 30%. Other useful vehicles include biphasic dentifrice formulations such as those described in Patents of the US, A.A. 5,213.70, issued May 23, 1993, 5,145,666, issued September 8, 1992, and 5,281,410 issued January 25, 1994, all for Lul-acovic and others, and in US Patents. 4,849,213 and 4,528.1 0 for Schaeffer, the descriptions of which are incorporated herein by reference. Suitable chewing gum and tablet components are disclosed in U.S. Pat. No. 4,083,955, Apr. 11, 1978, Grabens + ett rer y or tr-os, incorporated in the document as a ref erenc a.
EXAMPLES
The following examples described in and further demonstrate the preferred embodiments within the scope of the present invention. The examples are given for illustration only and are not intended as limitation of this invention, since many variations of it are possible without departing from its spirit and scope.
EXAMPLE I
A dentifrice composition of the present invention contains the following components as described below.
Component% by weight Sorbitol solution 70% 24.200 Water RO 24.757 Glycerin 7.000 Carboxirneti Ice! ulosai 0.500 PEG 6 4.000 Sodium Fluoride 0.243 Sodium Saccharin 0.130 > h
Phosphate of moh'isodio l) "415 Fos io de tr L hate () ,. 395 Tart ral de sodi ol .000 T1O2 () .. 500 Silica2 Ib, .000 Lauro 11 sai cosí nato de sodio (95% ac 1 vo) 1.üfaO Sabor Ü .800
1 Supplied by Aqualon Oompany. 2 The amorphous silica ingredient possesses the following characteristics average value APS - 8.5 microns; oil absorption - 103 ee / iOOg, DE - L.b; PE-7; PCR-106; RT) A = 67.
The jacket temperature of a mixing tank was fixed at about 55 ° C to about 7 ° C. The humectants and water were added to the mixing tank and stirring was started. When the temperature reached approximately 80 ° C, fluoride, educational agents, pH regulating agents, chelator, coloring agents and titanium dioxide were added. Thickening agents were added to the abrasive and the resulting mixture was added to the mixing tank with high agitation. The surfactant was added to the combination and continued to mix. The tank was cooled to 58 ° C and flavoring agents were added. Mixing was continued for approximately 5 minutes. The resulting composition has a pH (Je approximately 7.
EXAMPLE II
A dentifrice composition of the present invention contains the following components as described above.
Component% by weight Sorbitol solution 70% 29,810 Water RO 24.757 Gilcerina 7.000 Carbox i got 1 cellulose! 0.750 PEG 6 4.000 Sodium fluoride 0.243 Sodium saccharine 0.130 Rnonosodium phosphate 0.415 Trisodium phosphate 0.395 T? 02 0.500 Silica2 30,000 Sodium laurilsui 1,200 Taste 0.800
1 Supplied by Aqualon Cornpany 2 The amorphous silica ingredient has the following characteristics: average value APS = 8.5 microns; oil absorption = 103 cc / lOOg; BE - 1.6; PE = 7; PCR = 106; RDA r 67.
2 b
EXAMPLE III
A gum composition of the present invention contains the following components as described below.
Component% by weight liase (Je gum 30,000 30 parts (Je gum (Je ester 45 resin parts Ooumorono 15 parts dry latex Silica1 18,000 Sugar- 40,000 Corn syrup 18,175 Lauroi Sodium isarcosmate 0.075 Tai-sodium treatment 0.250 Taste 1. 00
1 The amorphous silica ingredient has the following characteristics: average value APS - 8.5 microns; oil absorption - 101 cc / lOOg; BE - 1.9; PE = 7.2.
Claims (10)
1. - A dentifrice composition comprising: A) a precipitated silica abrasive composition comprising a) a precipitated silica comprising particulates, and these particles have: i) an average particle size of about 5 to about 11 microns (( Le, < 9); n) a Finlehner hardness of from about 0.8 to about 2.5 for bronze screen abrasive and from about 5 to about 8 for abrasive polyester screen; m) an oil absorption of about 95 in.l / 100g to about 135 ml / 100 g; and iv) a radioactive dentine abrasion of from about 25 to about less than 80; and b) a precipitated silica comprising particles, said particles having: i) an average particle size of from about 5 to about 11 microns (d.e. < 9); n) an Einlehner hardness of from about 3 to about 8 for bronze screen abrasive and from about 8 to about 11 for polyester screen abrasive; iii) an oil absorption of about 70 μl / 100 g at approximately less than 95 rnl / 100 g; and? v) a radioactive dentine abrasion of from 80 to about 200; wherein at least about 70% of all these particles have a diameter of about 25 microns, and wherein the film cleaning ratio is approximately 90 to about 135 and the abrasion of radioac- tive dentin is approximately 60 to about LOO, with a ratio of Cleaning of skin / abrasion of radioactive dentin, from about 1.25 to about 1.75, and wherein the ratio of silica in a) to The silica in b) is approximately e 90:10 to approximately 40:60, respectively; and D) (Approximately 0.1% to approximately 99% of an orally acceptable dentifrice vehicle.,
2. A dentifrice composition according to claim 1, further characterized in that said composition comprises a source of fluoride ion wherein the source The fluoride ion is selected from the group consisting of sodium fluoride, stannous fluoride, sodium onof luoro phosphate, po + asium fluoride and mixtures of the same ..
3. A dentifrice composition according to claim 2, further characterized in that it comprises a surfactant selected from the group consisting of surfactants of taut sarcos, isethionic surfactants and taurate surfactants.
4. A dentifrice composition according to claim 3, further characterized in that it comprises from about 0.1% to about 2.5% of a chelating agent selected from the group consisting of tartaric acid and pharmaceutically acceptable salts of the same, citric acid and alkali metal citrates and mixtures thereof.
5. - A dentifrice composition according to claim 4, further characterized in that said composition has a pH of more than about 7, and wherein the surfactant is selected from the group consisting of lauroyl sarcosm or sodium, deci sodium tablets , my r'is i isarcos ato de sodio, esteaplsarcosinato of sodium, pal itoilsarcosmate sodium, oleoilsarcos ato sodium and mixtures thereof.
6. A denticidal composition according to claim 5, character! Further it comprises from about 15% to about 70% of a humectant selected from the group consisting of glycerol, sorbitol, propylene glycol and mixtures thereof.
7. A dentifrice composition according to claim 6, further characterized in that the surfactant is a combination of sodium lauroyl sarcosinate and cocoarnid dopropil betaine, and the chelating agent is a combination of tartaric acid and sodium tartrate.
8. A dentifrice composition according to claim 1, in the form of a toothpaste, dental powder, prophylaxis paste, lozenge, gum or oral gel.
9. A method for reducing spots and / or plaque and gingivitis that involves the application of a safe and effective amount of a composition according to claim 2, to teeth and other oral surfaces.
10. A method for reducing spots and / or plaque and gingivitis comprising the application of a safe and effective amount of a composition according to claim 5, to the teeth and other oral surfaces.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/434,149 US5589160A (en) | 1995-05-02 | 1995-05-02 | Dentifrice compositions |
US08434149 | 1995-05-02 | ||
PCT/US1996/005499 WO1996034594A1 (en) | 1995-05-02 | 1996-04-19 | Dentifrice compositions |
Publications (2)
Publication Number | Publication Date |
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MXPA97008434A true MXPA97008434A (en) | 1998-02-01 |
MX9708434A MX9708434A (en) | 1998-02-28 |
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Application Number | Title | Priority Date | Filing Date |
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MX9708434A MX9708434A (en) | 1995-05-02 | 1996-04-19 | Dentifrice compositions. |
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US (1) | US5589160A (en) |
EP (1) | EP0824340B1 (en) |
JP (1) | JPH11504920A (en) |
CN (1) | CN1183037A (en) |
AT (1) | ATE198143T1 (en) |
AU (1) | AU5488096A (en) |
CA (1) | CA2220061C (en) |
CO (1) | CO4750637A1 (en) |
CZ (1) | CZ345097A3 (en) |
DE (1) | DE69611294T2 (en) |
ES (1) | ES2152521T3 (en) |
GR (1) | GR3035122T3 (en) |
HU (1) | HUP9801942A3 (en) |
MX (1) | MX9708434A (en) |
PE (1) | PE48997A1 (en) |
PT (1) | PT824340E (en) |
WO (1) | WO1996034594A1 (en) |
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US4122160A (en) * | 1974-10-31 | 1978-10-24 | J. M. Huber Corporation | Toothpaste compositions containing improved amorphous precipitated silicas |
US4040858A (en) * | 1974-10-31 | 1977-08-09 | J. M. Huber Corporation | Preparation of precipitated silicas having controlled refractive index |
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US4060599A (en) * | 1975-03-25 | 1977-11-29 | Colgate-Palmolive Company | Dentifrices |
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US4412983A (en) * | 1977-02-22 | 1983-11-01 | Colgate-Palmolive Company | Dentifrices containing amorphous silica |
US4421527A (en) * | 1977-12-20 | 1983-12-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
US4272509A (en) * | 1978-09-19 | 1981-06-09 | J. M. Huber Corporation | Precipitated silicon dioxide cleaning agent and dentifrice composition |
US4420312A (en) * | 1979-05-23 | 1983-12-13 | J. M. Huber Corporation | Method for production of high fluoride compatibility dentifrice abrasives and compositions |
US4340583A (en) * | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
DE3114492A1 (en) * | 1981-04-10 | 1982-10-28 | Degussa Ag, 6000 Frankfurt | DENTAL CARE |
US4376763A (en) * | 1981-09-30 | 1983-03-15 | Colgate-Palmolive Company | Functional agglomerated speckles, method for manufacture thereof and dentifrices containing such speckles |
US4376762A (en) * | 1981-09-30 | 1983-03-15 | Colgate-Palmolive Company | Functional agglomerated speckles, dentifrices containing such speckles and methods for manufacturing such speckles and dentifrices containing them |
DE3425152A1 (en) * | 1984-07-07 | 1986-01-16 | Henkel KGaA, 4000 Düsseldorf | TOOTHPASTE |
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DE3639845A1 (en) * | 1986-11-21 | 1988-06-01 | Degussa | FELLING SILICS, METHOD FOR THE PRODUCTION AND USE THEREOF |
GB8718987D0 (en) * | 1987-08-11 | 1987-09-16 | Unilever Plc | Agglomerated abrasive material |
GB8721644D0 (en) * | 1987-09-15 | 1987-10-21 | Unilever Plc | Silicas |
GB8804817D0 (en) * | 1988-03-01 | 1988-03-30 | Unilever Plc | Anticalculas oral compositions |
AU4645089A (en) * | 1988-11-09 | 1990-05-28 | J.M. Huber Corporation | Precipitated silicon dioxide abrasive compositions having superior compatibility with anti-plaque and therapeutic fluoride agents for dentifrice applications; dentifrice thereof; and method of making the same |
US5225177A (en) * | 1990-01-19 | 1993-07-06 | J. M. Huber Corporation | Dentifrice abrasives and compositions |
ATE159232T1 (en) * | 1990-08-06 | 1997-11-15 | Crosfield Joseph & Sons | SILICIC ACIDS |
KR960010781B1 (en) * | 1991-10-02 | 1996-08-08 | 유니레버 엔브이 | Silicas |
DE4237500A1 (en) * | 1992-11-06 | 1994-05-11 | Henkel Kgaa | Remineralizing dentifrice |
US5320831A (en) * | 1992-12-30 | 1994-06-14 | The Procter & Gamble Company | Oral compositions |
US5320830A (en) * | 1992-12-30 | 1994-06-14 | The Procter & Gamble Company | Oral compositions |
US5389360A (en) * | 1993-05-13 | 1995-02-14 | The Procter & Gamble Company | Oral compositions |
US5603920A (en) * | 1994-09-26 | 1997-02-18 | The Proctor & Gamble Company | Dentifrice compositions |
-
1995
- 1995-05-02 US US08/434,149 patent/US5589160A/en not_active Expired - Lifetime
-
1996
- 1996-04-19 JP JP8533337A patent/JPH11504920A/en active Pending
- 1996-04-19 DE DE69611294T patent/DE69611294T2/en not_active Revoked
- 1996-04-19 MX MX9708434A patent/MX9708434A/en unknown
- 1996-04-19 ES ES96911815T patent/ES2152521T3/en not_active Expired - Lifetime
- 1996-04-19 EP EP96911815A patent/EP0824340B1/en not_active Revoked
- 1996-04-19 AT AT96911815T patent/ATE198143T1/en not_active IP Right Cessation
- 1996-04-19 WO PCT/US1996/005499 patent/WO1996034594A1/en not_active Application Discontinuation
- 1996-04-19 AU AU54880/96A patent/AU5488096A/en not_active Abandoned
- 1996-04-19 HU HU9801942A patent/HUP9801942A3/en unknown
- 1996-04-19 CN CN96193671A patent/CN1183037A/en active Pending
- 1996-04-19 CA CA002220061A patent/CA2220061C/en not_active Expired - Fee Related
- 1996-04-19 PT PT96911815T patent/PT824340E/en unknown
- 1996-04-19 CZ CZ973450A patent/CZ345097A3/en unknown
- 1996-04-30 CO CO96021333A patent/CO4750637A1/en unknown
- 1996-05-02 PE PE1996000303A patent/PE48997A1/en not_active Application Discontinuation
-
2000
- 2000-12-21 GR GR20000402590T patent/GR3035122T3/en not_active IP Right Cessation
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