MXPA98007745A - Dentifri compositions - Google Patents
Dentifri compositionsInfo
- Publication number
- MXPA98007745A MXPA98007745A MXPA/A/1998/007745A MX9807745A MXPA98007745A MX PA98007745 A MXPA98007745 A MX PA98007745A MX 9807745 A MX9807745 A MX 9807745A MX PA98007745 A MXPA98007745 A MX PA98007745A
- Authority
- MX
- Mexico
- Prior art keywords
- composition according
- sodium
- sarcosinate
- dentifrice
- present
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- 238000005296 abrasive Methods 0.000 claims abstract description 13
- 239000000606 toothpaste Substances 0.000 claims abstract description 12
- BPQQTUXANYXVAA-UHFFFAOYSA-N silicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000551 dentifrice Substances 0.000 claims description 21
- 239000004094 surface-active agent Substances 0.000 claims description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 17
- -1 alkali metal citrates Chemical class 0.000 claims description 15
- 239000002738 chelating agent Substances 0.000 claims description 15
- 210000000515 Tooth Anatomy 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 12
- KWIUHFFTVRNATP-UHFFFAOYSA-N Trimethylglycine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- 229910052783 alkali metal Inorganic materials 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-M fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 229940071089 sarcosinate Drugs 0.000 claims description 9
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 9
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- 238000005299 abrasion Methods 0.000 claims description 7
- FSYKKLYZXJSNPZ-UHFFFAOYSA-M sarcosinate Chemical compound CNCC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-M 0.000 claims description 7
- 229910001369 Brass Inorganic materials 0.000 claims description 6
- 208000007565 Gingivitis Diseases 0.000 claims description 6
- 239000010951 brass Substances 0.000 claims description 6
- 239000000969 carrier Substances 0.000 claims description 6
- 229940034610 Toothpaste Drugs 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M Potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 4
- KSAVQLQVUXSOCR-UHFFFAOYSA-M Sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 4
- 229960003237 betaine Drugs 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 229960001367 tartaric acid Drugs 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- HELHAJAZNSDZJO-UHFFFAOYSA-L Sodium tartrate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O HELHAJAZNSDZJO-UHFFFAOYSA-L 0.000 claims description 3
- 229960002799 Stannous Fluoride Drugs 0.000 claims description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L Tin(II) fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 3
- 239000000001 dental powder Substances 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 3
- 239000001433 sodium tartrate Substances 0.000 claims description 3
- 229960002167 Sodium tartrate Drugs 0.000 claims description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 2
- 235000013736 caramel Nutrition 0.000 claims description 2
- 229920000591 gum Polymers 0.000 claims description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-M isethionate Chemical compound OCCS([O-])(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-M 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 239000011698 potassium fluoride Substances 0.000 claims description 2
- 235000003270 potassium fluoride Nutrition 0.000 claims description 2
- 235000011004 sodium tartrates Nutrition 0.000 claims description 2
- 229940104261 taurate Drugs 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 229940041672 Oral Gel Drugs 0.000 claims 1
- 229940048098 Sodium Sarcosinate Drugs 0.000 claims 1
- 235000009470 Theobroma cacao Nutrition 0.000 claims 1
- 240000000280 Theobroma cacao Species 0.000 claims 1
- XZLSZLWWIGFGNE-UHFFFAOYSA-M [Na+].CCCCCCCCCCCCCCCCCCN(C)CC([O-])=O Chemical compound [Na+].CCCCCCCCCCCCCCCCCCN(C)CC([O-])=O XZLSZLWWIGFGNE-UHFFFAOYSA-M 0.000 claims 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000000069 prophylaxis Effects 0.000 claims 1
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 12
- 235000008170 thiamine pyrophosphate Nutrition 0.000 description 12
- 239000000725 suspension Substances 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- 238000004140 cleaning Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- XPPKVPWEQAFLFU-UHFFFAOYSA-J Pyrophosphate Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 8
- 239000011148 porous material Substances 0.000 description 8
- 210000000214 Mouth Anatomy 0.000 description 7
- 235000011180 diphosphates Nutrition 0.000 description 6
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 125000004432 carbon atoms Chemical group C* 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 5
- 229910052753 mercury Inorganic materials 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 229940091249 Fluoride supplements Drugs 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 239000003093 cationic surfactant Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 229960000414 sodium fluoride Drugs 0.000 description 4
- 239000001488 sodium phosphate Substances 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 210000001519 tissues Anatomy 0.000 description 4
- FPYJFEHAWHCUMM-UHFFFAOYSA-N Maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 230000002882 anti-plaque Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000005755 formation reaction Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229920005646 polycarboxylate Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 2-[diamino(3-formamidopropyl)azaniumyl]acetate Chemical compound [O-]C(=O)C[N+](N)(N)CCCNC=O ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 0.000 description 2
- 229910000906 Bronze Inorganic materials 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 229960001927 Cetylpyridinium Chloride Drugs 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M Cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N Coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 210000003298 Dental Enamel Anatomy 0.000 description 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinylpyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 229960003975 Potassium Drugs 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N Potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N Saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 239000010974 bronze Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 235000016693 dipotassium tartrate Nutrition 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000001804 emulsifying Effects 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 239000001472 potassium tartrate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001105 regulatory Effects 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Inorganic materials [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 230000003381 solubilizing Effects 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 235000012976 tarts Nutrition 0.000 description 2
- 235000010215 titanium dioxide Nutrition 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 239000011778 trisodium citrate Substances 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 2
- 235000019801 trisodium phosphate Nutrition 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- CJSBVQVTGSIUAN-UHFFFAOYSA-M (2,6-dimethyl-4-phenylheptan-4-yl)-dimethyl-(2-phenoxyethyl)azanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1OCC[N+](C)(C)C(CC(C)C)(CC(C)C)C1=CC=CC=C1 CJSBVQVTGSIUAN-UHFFFAOYSA-M 0.000 description 1
- CKUJRAYMVVJDMG-IYEMJOQQSA-L (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate;tin(2+) Chemical compound [Sn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O CKUJRAYMVVJDMG-IYEMJOQQSA-L 0.000 description 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- OZCMOJQQLBXBKI-UHFFFAOYSA-N 1-ethenoxy-2-methylpropane Chemical compound CC(C)COC=C OZCMOJQQLBXBKI-UHFFFAOYSA-N 0.000 description 1
- IYSIFQMHXXJRHX-UHFFFAOYSA-M 1-ethyl-2-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC1=CC=CC=[N+]1CC IYSIFQMHXXJRHX-UHFFFAOYSA-M 0.000 description 1
- BMVLUGUCGASAAK-UHFFFAOYSA-M 1-hexadecylpyridin-1-ium;fluoride Chemical compound [F-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 BMVLUGUCGASAAK-UHFFFAOYSA-M 0.000 description 1
- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 description 1
- NPKLJZUIYWRNMV-UHFFFAOYSA-N 2-[decyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCC[N+](C)(C)CC([O-])=O NPKLJZUIYWRNMV-UHFFFAOYSA-N 0.000 description 1
- HVYJSOSGTDINLW-UHFFFAOYSA-N 2-[dimethyl(octadecyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O HVYJSOSGTDINLW-UHFFFAOYSA-N 0.000 description 1
- BACYUWVYYTXETD-UHFFFAOYSA-N 2-[dodecanoyl(methyl)amino]acetic acid Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
- TYIOVYZMKITKRO-UHFFFAOYSA-N 2-[hexadecyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O TYIOVYZMKITKRO-UHFFFAOYSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N 2-hydroxyethyl 2-methylacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical group OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N 2-methyl-2-propenoic acid methyl ester Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 description 1
- 229960005164 ACESULFAME Drugs 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N Aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 Aspartame Drugs 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- RRNIZKPFKNDSRS-UHFFFAOYSA-N Bensulide Chemical compound CC(C)OP(=S)(OC(C)C)SCCNS(=O)(=O)C1=CC=CC=C1 RRNIZKPFKNDSRS-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 229940112822 Chewing Gum Drugs 0.000 description 1
- 241001340526 Chrysoclista linneella Species 0.000 description 1
- 208000002925 Dental Caries Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 210000004268 Dentin Anatomy 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 210000000416 Exudates and Transudates Anatomy 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229960002737 Fructose Drugs 0.000 description 1
- 206010018280 Gingival disease Diseases 0.000 description 1
- 229960001031 Glucose Drugs 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229940039371 Karaya Gum Drugs 0.000 description 1
- 229940075468 LAURAMIDOPROPYL BETAINE Drugs 0.000 description 1
- 229940094506 LAURYL BETAINE Drugs 0.000 description 1
- 229920000126 Latex Polymers 0.000 description 1
- 210000000265 Leukocytes Anatomy 0.000 description 1
- 210000002540 Macrophages Anatomy 0.000 description 1
- NKAAEMMYHLFEFN-UHFFFAOYSA-M Monosodium tartrate Chemical compound [Na+].OC(=O)C(O)C(O)C([O-])=O NKAAEMMYHLFEFN-UHFFFAOYSA-M 0.000 description 1
- DVEKCXOJTLDBFE-UHFFFAOYSA-N N-DODECYL-N,N-DIMETHYLGLYCINATE Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229940081543 Potassium bitartrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K Potassium citrate Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- AVTYONGGKAJVTE-UHFFFAOYSA-L Potassium tartrate Chemical compound [K+].[K+].[O-]C(=O)C(O)C(O)C([O-])=O AVTYONGGKAJVTE-UHFFFAOYSA-L 0.000 description 1
- 229940111695 Potassium tartrate Drugs 0.000 description 1
- 229940081974 Saccharin Drugs 0.000 description 1
- 229940085605 Saccharin Sodium Drugs 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 229960001462 Sodium Cyclamate Drugs 0.000 description 1
- 229940119126 Sodium bitartrate Drugs 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Sodium cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- BFDWBSRJQZPEEB-UHFFFAOYSA-L Sodium monofluorophosphate Chemical compound [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 231100000765 Toxin Toxicity 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
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- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- RNZYXUVYGPJCHL-UHFFFAOYSA-N acetic acid;N,N-dimethyldecan-1-amine Chemical compound CC(O)=O.CCCCCCCCCCN(C)C RNZYXUVYGPJCHL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000000845 anti-microbial Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940027983 antiseptics and disinfectants Quaternary ammonium compounds Drugs 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000002051 biphasic Effects 0.000 description 1
- 150000004287 bisbiguanides Chemical class 0.000 description 1
- 230000001680 brushing Effects 0.000 description 1
- KAKZBPTYRLMSJV-UHFFFAOYSA-N butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
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- VVYPIVJZLVJPGU-UHFFFAOYSA-L copper;2-aminoacetate Chemical class [Cu+2].NCC([O-])=O.NCC([O-])=O VVYPIVJZLVJPGU-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000005824 corn Nutrition 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 230000001186 cumulative Effects 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 235000019524 disodium tartrate Nutrition 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000002919 epithelial cells Anatomy 0.000 description 1
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 230000002070 germicidal Effects 0.000 description 1
- 235000010985 glycerol esters of wood rosin Nutrition 0.000 description 1
- 230000002209 hydrophobic Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002757 inflammatory Effects 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- AWLNSWJVBZROPZ-UHFFFAOYSA-N lauramidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](N)(N)CC([O-])=O AWLNSWJVBZROPZ-UHFFFAOYSA-N 0.000 description 1
- 229940071145 lauroyl sarcosinate Drugs 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical group CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- BSDKWFAJZDUHKQ-UHFFFAOYSA-N methoxyethene Chemical compound COC=C.COC=C BSDKWFAJZDUHKQ-UHFFFAOYSA-N 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000016337 monopotassium tartrate Nutrition 0.000 description 1
- 235000019321 monosodium tartrate Nutrition 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 201000008838 periodontal disease Diseases 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- NJRWNWYFPOFDFN-UHFFFAOYSA-L phosphonate(2-) Chemical compound [O-][P]([O-])=O NJRWNWYFPOFDFN-UHFFFAOYSA-L 0.000 description 1
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- 229920001444 polymaleic acid Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- KYKNRZGSIGMXFH-UHFFFAOYSA-M potassium;2,3-dihydroxybutanedioate;hydron Chemical compound [K+].OC(=O)C(O)C(O)C([O-])=O KYKNRZGSIGMXFH-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting Effects 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine zwitterion Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 239000010672 sassafras oil Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-M sulfoformate Chemical compound OC(=O)S([O-])(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-M 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 108020003112 toxins Proteins 0.000 description 1
- 239000011791 tripotassium citrate Substances 0.000 description 1
- 235000015870 tripotassium citrate Nutrition 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
Abstract
Oral compositions such as oral gels and toothpastes, which contain a precipitated silica as an abrasive, are described.
Description
DENTÍFRICAS COMPOSITIONS
TECHNICAL CAMPQ
The present invention relates to dentifrice compositions, such as toothpastes, which provide improved oral cleansing.
ANTECEDENTS PE THE TNVENCTON
A satisfactory dentifrice composition should have a cosmetic effect on the teeth, that is, keep them light in color. It should also clean and eliminate waste, thereby helping to prevent the deterioration of teeth and promoting the health of the gums. The abrasives help to eliminate the film that is strongly adhered. This film usually comprises a thin, acellular glycoprotein-mucoprotein coating, which adheres to the enamel within minutes after cleaning the teeth. The presence of various food pigments housed inside the film, in most cases account for the discoloration of the teeth. Ideally, an abrasive should provide satisfactory removal (cleaning) of the film with minimal damage (abrasion) to the oral tissue, ie dentin and enamel.
Beyond the cleanliness aspect of the film, the addition of one or more antiplaque agents gives additional benefits. The formation of dental plaque is the primary source of dental caries, gingival and periodontal diseases and the loss of parts. The plaque is a mixed matrix of bacteria, epithelial cells, leukocytes, macrophages and other oral exudate. Bacteria associated with plaque can secrete enzymes and endotoxins that can irritate the gums and cause inflammatory gingivitis. When the gums are irritated more and more by this procedure, they tend to bleed, lose their firmness and elasticity, and separate from the teeth. This separation results in periodontal pockets which, in turn, lead to greater accumulation of waste, secretions and more bacteria / toxins. This process eventually leads to the destruction of both the hard tissue and the soft tissue of the oral cavity. The use of a variety of agents to clean the oral cavity and reduce plaque and odor in the mouth has been recognized for some time. Examples include: U.S. Patent 3,696,191, October 3, 1972, issued to Weeks; U.S. Patent 3,991,177, of November 9, 1976, issued to Vidra and co-inventors; U.S. Patent 4,058,595, November 15, 1977, issued to Colodney; U.S. Patent 4,115,546, to Vidra and co-inventors; U.S. Patent 4,138,476, February 6, 1979, issued to Si onson and co-inventors; U.S. Patent 4,140,758, February 20, 1979, issued to Vidra and co-inventors; U.S. Patent 4,154,815, May 15, 1979, issued to Pader; U.S. Patent 4,737,359, of April 12, 1988, issued to Eigen and co-inventors; U.S. Patent 4,986,981, of January 22, 1991, issued to Glace and co-inventors; U.S. Patent 4,992,420, February 12, 1991, issued to Nesser; US Patent 5,000,939, March 19, 1991, issued to Dring and co-inventors; Kokai 02 / 105,898, published on April 18, 1990, by Kao Corporation; Kokai 03 / 128,313, published May 31, 1991, by Nippon Kotai Kenkyu and Kokai 03 / 223,209, published on October 2, 1991, by Lion Corporation; U.S. Patent No. 4,652,444, March 24, 1987, issued to Maurer; U.S. Patent 4,725,428, of February 16, 1988, issued to Miyahara and co-inventors; U.S. Patent 4,355,022, October 19, 1982, issued to Rabussay; and the application of TCP WO 86/02831, published May 22, 1986 to Zetachron, Inc. Abrasives are disclosed in: Patent 4,340,583,
July 20, 1982, granted to Wason; U.S. Patent 3,574,823, April 13, 1971, issued to Roberts and co-inventors; EPO patent 535,943A1 of April 7, 1993, McKeown and co-inventors, and TCP patent WO 92/02454, February 20, 1992 to McKeown and co-inventors.
Despite the many descriptions that refer to compositions for film cleaning and antiplaque activity, there remains a need for improved products. The inventor of the present has developed oral compositions that provide improved film cleaning. The inventor of the present has developed oral compositions that provide improved film cleaning. Specifically, the inventor of the present has developed oral compositions incorporating a novel silica abrasive and an improved plate reducing system. Accordingly, it is an object of the present invention to provide a product for oral care and methods for using it directly as a film cleaner. It is a further object of the present invention to provide compositions and methods that are effective in arresting plaque buildup and preventing gingival diseases. Another additional objective of the present invention is to provide compositions that also abate the subsequent formation of stones. These objectives and other additional objectives will become readily apparent from the following detailed description.
BRIEF DESCRIPTION OF THE INVENTION
The present invention relates to dentifrice compositions comprising: a) a precipitated silica, in which the silica has a viscosity in suspension at 40%, constituted of less than 20,000 centipoises and a 10% abrasion of Brass Einlehner, of approximately 2.5 at 20.0 mg loss / 100,000 revolutions; and b) about 0.1% to 99% of an orally acceptable dentifrice carrier. All percentages and proportions herein are by weight, unless otherwise specified. The RLP and the RDA are without units. Additionally, all measurements are made at 25 ° C, unless otherwise specified.
DETAILED DESCRIPTION OF THE INVENTION
By "safe and effective amount", as used herein, is meant an amount sufficient to reduce spots and / or plaque / gingivitis, without damaging the tissues and structures of the oral cavity. By the term "orally acceptable carrier, as used herein, it means a suitable vehicle, which can be used to apply the compositions herein to the oral cavity in a safe and effective manner." The pH of the compositions described herein it varies from about 6.5 to about 9.5, with the preferred pH being about 6.5 to 9.0, and the pH that is most preferred is about 7.0 to about 9. The essential components, as well as the optional components of the compositions herein invention are described in the following paragraphs.
THE ABRASIVE
The present invention utilizes novel, amorphous, precipitated silica compositions which are useful for imparting improved cleaning and abrasive characteristics to dentifrice formulations. The silicas of the present invention are preferably characterized as synthetic, hydrated, amorphous silicas, also known as silicon dioxides, Si 2 - In particular, the silicas of the present invention have average particle sizes (TPP) in the reactor slurry. The silicas of the present invention also have a significantly lower viscosity than the known silicas of comparable abrasive capacity. Consequently, the silicas of the present invention can be loaded into the dentifrice compositions in higher concentrations than the known silicas, which results in dentifrice compositions with improved properties and without undue abrasive capability. The TPP of the reactor suspension is defined as the TPP of the precipitated silica compositions, when measured after processing in the washed reactor or suspension, but before drying, grinding and / or using. The TPP of the reactor suspension is measured using a Microtrac II particle analyzer manufactured by Leeds and Northrup. The silicas of the present invention preferably have a TPP of the reactor suspension of about 10 to 50 μm and, more preferably, around 10 to 20 μm. All TPP reactor suspension values, given herein, are the average values ("50%"), unless otherwise indicated. Without being limited to any particular theory, it is believed that the relatively low TPP of the reactor suspension results in the preparation of silicas with low average functional particle size, where the functional particle size is defined as the particle size. of silica while in use (for example, during the brushing process). In other words, the inventor believes that the silicas of the present invention are softer than the silicas with higher TPP of reactor suspension. As a result, the inventor believes that, in use, the silicas of the present invention (ie, with relatively low TPP in the reactor slurry) decompose to smaller and, therefore, less abrasive particles, more easily than the silicas with TPP greater than reactor suspension. The silicas of the present invention, therefore, are less abrasive than the known silicas with the same ground TPP. Additionally, the silicas of the present invention have improved grinding properties, because they are initially smaller and require less grinding and, because they are milder and, consequently, tend to crumble more easily to smaller particles. As a result, the silicas of the present invention are less likely to suffer from graying caused by excessive grinding. The silicas used in the present invention are also relatively less abrasive than the known silicas, about the same ground TPP and the same viscosity buildup. Several tests are used to measure the abrasiveness of the silicas. The most direct measurement is the abrasion test of Brass Einlehner. In the Brass Einlehner abrasion test, an Einlehner AT-1000 eroder is used, as follows: (1) A Fourdrinier bronze wire cloth is weighed and exposed to the action of a 10% aqueous silica suspension. for a fixed time; (2) the amount of abrasion is then determined as milligrams of bronze lost from the Fourdrinier wire sieve per 100,000 revolutions. The results of Brass Einlehner at 10% (BE at 10%) are expressed in milligrams of loss / 100,000 revolutions. The silicas according to the present invention have 10% BE values of about 3.5 to 5.0 mg of loss / 100,000 revolutions and, more preferably, about 3.5 to 4.5 mg of loss / 100,000 revolutions. The silicas used in the present invention also tend to have relatively little impact on the viscosity of the dentifrice compositions, compared to the known silicas. The tendency of a silica to increase the viscosity of a fluid is called "viscosity accumulation". The viscosity can be measured by a viscometer and can be expressed in centipoises. In a 40% suspension test, the silicas according to the present invention, which have a moisture content of 5 to 7% and where moisture is measured by weight loss at 105 ° C for two hours, have an approximate viscosity of 5,000 to 12,000 centipoises. The silicas used in the present invention are preferably low structure silicas, according to the definitions given in J. So. Cosmet. Chem., 29, 49-521 (August 1978) and in Pigment Handbook: Volume 1, Properties and Economics, 23. edition, edited by Peter A. Lewis, John Wiley & Sons, Inc., 1988, pages 139-159. The silicas used in the present invention preferably have an oil absorption on the scale of about 60 to 120 cc / 100 g, and more preferably, about 80 to 100 cc / 100 g; and very preferable, about 80 to 90 cc / 100 g. In the present description, oil absorption is measured using the rub method D281 of the ASTM.
The silicas used in the present invention preferably have a BET surface area in the approximate range of 50 to 250 m / g. The surface area is determined by the BET nitrogen adsorption method of Brunaur and coauthors, J. Am. Chem. Soc., 60, 309 (1938). The silicas used in the present invention also preferably exhibit fluoride availability and compatibility values in the approximate range of 90-100%, as defined in U.S. Patent 4,340,583, which is incorporated herein by this reference. The silicas used in the present invention preferably have hollow volume values per mercury intrusion in the range of 1.0 to 4.0 cc / g and, better still, 1.2 to 2.0 cc / g. Pore volumes (pore volume per mercury) are determined using an Autopore II 9220 porosimeter (Micrometics Corporation). This instrument measures the void volume and the pore size distribution of various materials. Mercury is forced into the gaps as a function of the pressure and the volume of mercury introduced per gram of sample is calculated at each pressure setting. The total pore volume expressed here represents the cumulative volume of mercury introduced at vacuum pressures up to 4.218 kg / cm2. Increases in volume (cc / g each pressure adjustment are plotted against the pore radius corresponding to the pressure adjustment increments) The peak in the volume entered against the pore radius curve corresponds to the mode in the size distribution of pore and identifies the most common pore size in the sample.The silicas used in the present invention preferably have a pH of about 4.0 to 8.5 and, more preferably, of 6.5 to 8.5, when measured in a 5% aqueous suspension. The silicas used in the present invention preferably have a film cleaning ratio (RLP) of about 70 to 140, and preferably about 100 to 130. The silicas used in the present invention preferably have a melt density from about 256.32 g / liter to 400.25 g / liter, and an approximate packing density of 400.25 g / liter to 560.35 g / liter The overall density is measured by measuring the volume in occupied liters for a weight or of silica, and is reported in g / liter. The silicas used in the present invention preferably have a brightness value of about 90 to 100. To measure the brightness, fine powder materials are pressed into a smooth surface pellet, and evaluated using a Technidyne S-5 Brilliance Meter / BC. The Technidyne S-5 / BS brightness meter has a double beam optical system, where the sample is illuminated at an angle of 45 ° and the light reflected at 0o is observed. This method is based on the TAPPI test methods T452 and T646, and on the ASTM D985 standard.
Preferred precipitated silica materials include those obtainable from J. M. Huber Corporation under the trademark "Zeodent", in particular the silica bearing the designation "Zeodent 128" and "Zeodent 118". The abrasive in the compositions described herein is present at a level of about 6% to 70%, preferably about 15% to 35%, when the toothpaste is a toothpaste. Higher levels, up to 95%, can be used if the composition is a dental powder. In addition to the essential components described above, the embodiments of this invention may contain a variety of optional tooth ingredients, some of which are described below. Optional ingredients include, but are not limited to: adhesive, foaming agents, flavoring agents, sweetening agents, additional antiplaque agents, abrasives and coloring agents. These and other optional components are further described in U.S. Patent 5,004,597, of April 2, 1991, issued to Majeti; in U.S. Patent No. 4,885,155, December 5, 1989, issued to Parran, Jr., and co-inventors; in U.S. Patent No. 3,959,458, May 25, 1976, issued to Agricola and co-inventors, and in U.S. Patent No. 3,937,807, of February 10, 1976, issued to Haefele; all of which are incorporated here by this reference.
THE PHARMACEUTICALLY ACCEPTABLE PQRTAPQR
The carrier for the components of the compositions herein can be any dentifrice vehicle suitable for use in the oral cavity. Such carriers include the usual components of toothpastes, dental powders, prophylactic pastes, candies, rubbers and the like, and are described more fully below. The toothpastes are the preferred systems.
The surfactants
One of the preferred optional agents of the present invention is a surfactant, preferably one selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants. Preferred for use herein are the alkali metal or ammonium salts of these surfactants. Sodium and potassium salts of the following are more preferred here: lauroyl sarcosinate, iristoyl sarcosinate, pallocyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate. This surfactant may be present in the compositions of the present invention from about 0.1% to 2.5%, preferably from about 0.3% to about 2.5% and, most preferably, from about 0.5% to 2.0% by weight of the total composition. Other suitable compatible surfactants can optionally be used together with the surfactant sarcosinate in the compositions of the present invention. Suitable optional surfactants are more fully described in U.S. Patent 3,959,458, May 5, 1976, issued to Agricola and co-inventors; in U.S. Patent 3,937,807, of February 10, 1976, issued to Haefele; and in US Patent 4,051,234, of September 27, 1988, issued to Gieske and co-inventors. These patents are incorporated herein by this reference. Preferred anionic surfactants useful herein include the water soluble salts of alkyl sulpates having from 10 to 18 carbon atoms in the alkyl radical, and the water soluble salts of sulfonated monoglycerides of fatty acids having 10 to 18 carbon atoms. Sodium lauryl sulfate and sodium co-onoglyceride sulfonate are examples of anionic surfactants of this type. Mixtures of anionic surfactants can also be used. The cationic surfactants preferred in the present invention can be broadly defined as derivatives of aliphatic quaternary ammonium compounds having a long alkyl chain containing about 8 to 18 carbon atoms, such as lauryltrimethylammonium chloride, cetylpyridinium chloride , cetyltrimethyl ammonium bromide, diisobutylphenoxyethyldimethylbenzylammonium chloride, cocoalkyltrimethylammonium nitrite, cetyl pyridinium fluoride, etc. Preferred compounds are the quaternary ammonium fluorides described in U.S. Patent 3,535,421, October 20, 1970, issued to Briner and co-inventors, incorporated herein by reference; wherein the quaternary ammonium fluorides have detergent properties. Also certain cationic surfactants can act as germicides in the compositions described herein. Cationic surfactants, such as chlorhexadine, while being suitable for use in the present invention, are not preferred because of their ability to stain hard tissues of the oral cavity. Those skilled in the art are aware of this possibility and should incorporate the cationic surfactants only with this limitation in mind. The preferred nonionic surfactants that can be used in the compositions of the present invention can be broadly defined as compounds produced by the condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound which can be aliphatic or alkylated in nature. Attica. Examples of suitable nonionic surfactants include the Pluronics, the condensates with polyethylene oxide of alkylphenols, the products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, the condensates with ethylene oxide of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides, and mixtures of those materials. The preferred hybrid ionic surfactants useful in the present invention as derivatives of quaternary ammonium, phosphonium and sulfonium aliphatic compounds in which the aliphatic radicals can be straight or branched can be broadly described.; and wherein one of the aliphatic substituents contains about 8 to 18 carbon atoms and one contains an anionic water solubilizing group of about 8 to 18 carbon atoms, and one contains a solubilizing group in cationic water, example, carboxy, sulfonate, sulfate, phosphate or phosphonate. Preferred betaine surfactants are described in US Pat. No. 5,180,577 to Polefka and co-inventors, issued January 19, 1993. Typical alkyldimethylbetaines include: decylbetaine or 2 - () N-decyl-N, N-dimethylammonium acetate), cocobetaine or 2- (N-coco-N, N-dimethylammonium) acetate, iristylbetaine, pal itylbetaine, laurylbetaine, cetylbetaine, stearylbetaine, etc. The amidobetaines are exemplified by cocoamidoethyl betaine, cocoamidopropyl betaine, laura idopropyl betaine and the like.
The selection betaines are preferably cocoamidopropylbetaine and, better yet, lauramidopropylbetaine.
Chelating agents
Another preferred optional agent is a chelating agent, selected from the group consisting of tartaric acid and its pharmaceutically acceptable salts; citric acid and alkali metal citrates, and mixtures thereof. The chelating agents are able to form complexes with the calcium found in the walls of the cells of the bacteria. Chelating agents can also alter the plaque by removing calcium from calcium bridges, which help keep this biomass intact. However, it is possible to use a chelating agent that has an affy for calcium, which is too high. This results in the demineralization of the teeth and is contrary to the aims and intentions of the present invention. Sodium citrate and potassium citrate are the preferred alkali metal citrates, sodium citrate being most preferred. A combination of citric acid / alkali metal citrate is also preferred. The alkali metal salts of tartaric acid are preferred herein. It is especially preferred for use herein: disodium tartrate, dipotassium tartrate, sodium and potassium tartrate, sodium bitartrate and potassium bitartrate. The amounts of chelating agent suitable for use in the present invention are about 0.1% to 2.5%, preferably about 0.5% to 2.5% and, most preferably, about 1.0% to 2.5%. The tartaric acid salt chelating agent can be used alone or in combination with other optional chelating agents. Other optional chelating agents can be used. These chelating agents preferably have a calcium binding constant of from about 101 to about 105, and provide improved cleaning with reduced plate and stone formation. Another group of agents suitable for use as chelating agents in the present invention are soluble pyrophosphates. The pyrophosphate salts used in the compositions herein may be any of the alkali metal pyrophosphate salts. Specific salts include alkali tetra-tetraal pyrophosphate, diacid alkaline dimetal pyrophosphate, mono-trimetalkaline pyrophosphate, and mixtures thereof; wherein the alkali metals are preferably sodium or potassium. The salts are useful both in their hydrated form and in their non-hydrated form. An effective amount of pyrophosphate salt useful in the present composition will generally be sufficient to give at least 1.0% pyrophosphate ion, preferably about 1.5% to 6%, better still, about 3.5% to 6% of said ions. It will be appreciated that the level of pyrophosphate ions is that which is capable of being provided to the composition (i.e., the theoretical amount, at an appropriate pH) and that other forms of pyrophosphate other than P2O7- (eg, ( HP2O7"" 3)), when a pH of the final product is established. The pyrophosphate salts are described in more detail in Kirk & Othmer, Encvclopedia of Chemical Technoloav. 2-3 edition, volume 15, Interscience Publishers (1968), incorporated herein by reference. Another possible group of chelating agents suitable for use in the present invention are the polymeric anionic polycarboxylates. These materials are well known in the art, being used in the form of their free acids or their alkali metal salts (eg, potassium and, preferably, sodium) or ammonium salts, water soluble, partial or, preferably, totally neutralized. Preferred are 1: 4 to 4: 1 copolymers of maleic anhydride or maleic acid with another polymerizable ethylenically unsaturated monomer, preferably methylvinyl ether (methoxyethylene) having a molecular weight (MW) of about 30,000 to 1,000,000. These copolymers can be obtained, for example, as Gantrez AN 139 (P.M. 500,000), AN 119 (M.M. 250,000) and, preferably, S-97 Pharmaceutical Grade (P.F.70,000), from GAF Chemicals Corporation. Other functional polymeric polycarboxylates include others such as the 1: 1 copolymers of maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrrolidone or ethylene; the latter being available, for example, as Monsanto EMA No. 1103, MW 10,000 and EMA Grade 61, and the 1: 1 copolymers of acrylic acid with methyl methacrylate or hydroxyethyl, methyl or ethyl acrylate, isobutylvinyl ether or N-vinyl -2-pyrrolidone. The additional operative polymeric polycarboxylates are described in US Pat4,138,477, of February 6, 1979, issued to Gaffar and in US Pat4,183,914, of January 15, 1980 to Gaffar and co-invrs, both pat being incorporated herein by reference; and include copolymers of maleic anhydride with styrene, isobutylene or ethyl vinyl ether, polyacrylic, polyitaconic and polymaleic acids, and sulfoacrylic oligomers of molecular weight as low as 1,000, obtainable as Uni royal ND-2. Flavoring ag may also be added to the dfrice compositions. Suitable flavoring ag include pyrole oil, peppermint oil, peppermint oil, sassafras oil and clove oil. Sweetening ag that can be used include: aspartame, acesulfame, saccharin, dextrose, levulose, and sodium cyclamate. Flavoring and sweetening ag are generally used in dfrices at approximate levels of 0.005% to 2% by weight. The dfrice compositions may also contain emulsifying ag. Suitable emulsifying ag are those that are reasonably stable and foam throughout a wide range of pH, including organic, non-soap, anionic, non-ionic, cationic, zwitterionic and amphoteric deterg. Many of these suitable surfactants are described by Gieske and co-invrs in U.S. PatNo. 4,051,234, September 27, 1977, which is incorporated herein by reference. It is common to have presan additional water-soluble fluoride compound in dfrices and other oral compositions in an amount sufficito give a fluoride ion concation in the composition at 25 ° C and / or when used around 0.0025% to about 5.0% by weight, preferably around 0.005% to 2.0% by weight, to give additional anticaries effectiveness. A wide variety of materials that produce fluoride ion can be used as sources of soluble fluoride in the compositions herein. Examples of suitable materials that produce fluoride ion are found in US Pat3,535,421, October 20, 1970 to Briner and co-invrs; and in U.S. PatNo. 3,678,154, July 18, 1972 to Widder and co-invrs, both incorporated herein by this reference. Represtive sources of fluoride ion include: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate and many others. Especially preferred are stannous fluoride and sodium fluoride, as well as mixtures thereof.
Water is also present in the toothpastes of this invention. The water used in the preparation of commercially suitable toothpastes should preferably be deionized and free of impurities. The water generally comprises about 10% to 50%, preferably about 20% to 40%, by weight of the toothpaste compositions herein. These amounts of water include the free water that is added, plus the water that is introduced with other materials, such as sorbitol. When preparing the toothpastes it is necessary to add some thickener material to give a desirable consistency. Preferred thickeners are the polymers of carboxyvinyl, caragenan, hydroxyethylcellulose and the water soluble salts of cellulose ethers, such as sodium carboxymethylcellulose and sodium carboxymethylhydroxyethylcellulose. You can also use natural gums, such as karaya gum, xanthan gum, gum arabic and tragacanth gum. Thickening agents can be used in an amount of 0.5% to 5.0% by weight of the total composition. It is also convenient to include some moisturizing material in a toothpaste to prevent it from hardening. Suitable humectants include glycerin, sorbitol and other edible polyhydric alcohols, at a level of about 5% to 70%. Also suitable is the inclusion in the compositions of the present invention of other salts such as stannous pyrophosphate and stannous gluconate and of antimicrobial agents, such as the quaternary ammonium salts, such as cetylpyridinium chloride and tetradecylethylpyridinium chloride, the salts of bis -biguanide, copper bisglycinate, non-ionic antimicrobial salts and flavor oils. Such agents are described in U.S. Patent No. 2,946,725, July 26, 1960, of Ñorris and co-inventors, and in U.S. Patent 4,051,234, September 27, 1977 to Gieske and co-inventors, incorporated herein by reference. Other optional components include pH regulating agents, bicarbonates, peroxides, nitrate salts, such as sodium and potassium nitrate. These agents, if present, are included at approximate levels of 0.01% to 30%. Other useful carriers include biphasic dentifrice formulations, such as those described in U.S. Patents 5,213,790, issued May 23, 1993; 5,145,666, issued on September 8, 1992 and 5,281,410, issued on January 25, 1994, all of Lukacovic and co-inventors; and in US Patents 4,849,213 and 4,528,180 to Shaeffer, the disclosure of which is incorporated herein by reference. Suitable caramel and chewing gum components are described in U.S. Patent No. 4,083,955, April 11, 1978, which is incorporated herein by reference.
The following examples further describe and demonstrate the preferred embodiments within the scope of the present invention. The examples are given only for illustration and should not be considered as limitations of this invention, since many variations are possible without departing from the spirit or the scope thereof.
EXAMPLE I
A dentifrice composition of the present invention contains the following components which are described below. Component% by weight Sobitol, 70% solution 24,200 water RO 24,757 glycerine 7,000 carboxymethyl cellulose 0.500 PEG 6 4,000 Sodium fluoride 0.243 sodium saccharin 0.130 monosodium phosphate 0.415 trisodium phosphate 0.395 sodium tart 1.000 1,000 Ti02 0.500 Silica2 35,000 Sodium lauroyl sarcosinate (95% active) 1,060 Sabo r 0.800 1 Supplied by Aqualon Company 2 Obtainable as Zeodent 118 from J. M. Huber Corpo ration The jacket temperature is set in a tank mixed with the red of 65 ° C up to the rededo of 71 * C. The humectants and water are added to the mixed tank r and stirring is started. When the temperature reaches approximately 50 ° C, fluoride, sweetening agents, regulating agents, chelator, coloring agents and titanium dioxide are added. Thickening agents are added to the abrasive and the resulting mixture is added to the mixing tank with high agitation. The surfactant is added to the combination and mixing is continued. The tank is cooled to around 50 ° C and the flavoring agents are added. Continue mixing for about 5 minutes. The resulting composition will have a pH of about 7.
EXAMPLE II
A dentifrice composition of the present invention contains the following components, as described below: Component% by weight Sorbitol, 70% solution 29,810 Water RO 24,757 glycerine 7,000 carboxymethylcellulose 1 0.750 PEG 6 4,000 Sodium fluoride 0.243 Saccharin sodium 0.130 Monosodium phosphate 0.415 Trisodium phosphate 0.395 TiO2 0.500 Silica2 30,000 Sodium lauryl sulfate 1,200 Sabo r 0.800 * Supplied by Aqualon Company 2 Obtainable as Zeodent 128 from J. M. Huber Corporation.
EXAMPLE III
A gum composition of the present invention contains the following components, as described below: Component% by weight Rubber base: 30,000 30 parts of ester gum 45 pats of coumarin resin 15 parts of dry latex Silica1 10.00 Sugar 40,000 ja arabic corn 18,175 sodium lauroyl sarcosinate 0.075 tart sodium time 0.250 flavor 1,500 1 Zeodent 118.
Claims (14)
1. - A dentifrice composition characterized in that it comprises: (a) a precipitated silica, wherein the silica has an accumulated 40% slurry viscosity of about 5,000 to 12,000 centipoises and an abrasion of Brass Einlehner at 10% of about 3.5 to 5.0 mg of loss / 100,000 revolutions; and (b) about 0.1% to 99% of an orally acceptable dentifrice carrier.
2. A dentifrice composition according to claim 1, further characterized in that said abrasive has a Brass Einlehner abrasion value at 10% from 3.5 to 4.5 mg loss / 100,000 revolutions, approximately.
3. A tooth composition according to claim 2, further characterized in that the mean average particle size of said particles varies between about 7 and 11 microns.
4. A dentifrice composition according to claim 3, further characterized in that the composition further comprises a source of fluoride ion, wherein the source of fluoride ion is selected from the group consisting of sodium fluoride, stannous fluoride, sodium onofluorophosphate , potassium fluoride and its mixtures.
5. - A dentifrice composition according to claim 4, further comprising a surfactant selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants.
6. A dentifrice composition according to claim 5, further characterized in that it additionally comprises about 0.1% to 2.5% of a chelating agent selected from the group consisting of tartaric acid and its pharmaceutically acceptable salts, citric acid and alkali metal citrates. , and its mixtures.
7. A dentifrice composition according to claim 6, further characterized in that the composition has a pH greater than about 7, and wherein the surfactant is selected from the group consisting of sodium lauroyl sarcosinate, sodium decinosalinate, myristyl sarcosinate sodium, sodium stearylsarcosinate, palloyl sodium sarcosinate, sodium oleoyl sarcosinate, and mixtures thereof.
8. - A dentifrice composition according to claim 7, further characterized by additionally comprising about 15% to 70% of a humectant selected from the group consisting of glycerin, sorbitol, propylene glycol and mixtures thereof.
9. - A dentifrice composition according to claim 8, further characterized in that the surfactant is a combination of sodium lauroyl sarcosinate and cocoa idopropyl betaine, and the chelating agent is a combination of tartaric acid and sodium tartrate.
10. A tooth composition according to claim 1, in the form of a toothpaste, dental powder, prophylaxis paste, caramel, gum or oral gel.
11. A method for reducing stains and / or plaque and gingivitis, characterized in that it comprises the application of a safe and effective amount of a composition according to claim 1, to the teeth and other oral surfaces.
12. A method for reducing stains and / or plaque and gingivitis, characterized in that it comprises the application of a safe and effective amount of a composition according to claim 4 to the teeth and other oral surfaces.
13. A method for reducing stains and / or plaque and gingivitis, characterized in that it comprises the application of a safe and effective amount of a composition according to claim 7 to the teeth and other oral surfaces.
14. A method for reducing stains and / or plaque and gingivitis, characterized in that it comprises the application of a safe and effective amount of a composition according to claim 10 to the teeth and other oral surfaces.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US08620766 | 1996-03-22 |
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MXPA98007745A true MXPA98007745A (en) | 1999-02-24 |
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