MXPA96001651A - New liqui formulations - Google Patents

Abstract

The present invention relates to a liquid formulation emulsifiable in water, characterized in that it comprises: a) 2.5 to 30% by weight of the liquid formulation of 2-isopropoxy-phenyl-4-methyl-carbamate; b = 5 to 77.5% by weight of the liquid formulation of a solvent mixture consisting of benzyl acetate and benzyl alcohol, wherein the benzyl acetate represents 25 to 50% by weight of the solvent mixture and the benzyl alcohol represents 50 to 75% by weight of the mixture of solvent, and c) 2.5 to 20% by weight of the liquid formulation of a pharmaceutical formulation.

Description

NEW LIQUID FORMULATIONS DESCRIPTION OF THE INVENTION The present invention refers to new liquid formulations of insecticidal active substances, emulsifiable in agdua. In the application of insecticidal active substances, partly difficult to dissolve in water, in the form of fungicides diluted in water, it is necessary to obtain emulsifiable formulations with water for these active substances. For this, most of the time the active substances are dissolved in organic solvents and mixed with emulsifiers and, if necessary, other additives. The preparation of such formulations is described, for example, in DE-OS 3 027 767. As solvents, dimethylformamide and di-ethylacetamide are used inter alia. It is very desirable to replace these solvents with those that have a good tolerance and are toxicologically harmless. The present invention relates to 1: Liquid formulations of insecticidal active substances, emulsifiable in water, characterized in that they contain a) 2.5 to 30% active substance, b) 5 to 77.5% of a mixture of benzyl acetate and an alcohol, in the proportion of 25-95% to 5-75%, c) 2.5 to 20% of the formulation aid. (The data in% are percentages by weight). The formulations according to the invention are excellently suitable for the production of spray liquors for professional use in the fight against harmful animals in the care of the house, factories, stables, etc. They are distinguished by outstanding storage stability as well as very good emulsifiability in water. They are also obtained at cheap prices. The solvents chosen are not problematic for the user. As active substances, mention should preferably be made of the insecticides used in the field of hygiene and professional control against harmful animals, such as carbamates, pyrethroids, phosphoric acid esters, as well as mixtures of these active substances with synergists. As carbamates, substituted phenyl and naphthyl carbamates are to be mentioned. Mention may preferably be made of: 2-isobutylphenyl-N-methylcarbamate, 4-dimethylamino-3-methyl-phenyl-N-methylcarbamate, 2-isopropoxy-phenyl-N-methylcarbamate, 1-naphthyl-N-methylcarbamate, m-tolyl-N-methylcarbamate, -3, 4-xylyl-N-methylcarbamate, -3,5-xylyl-N-methylcarbamate, -2- (l, 3-dioxolan-2-yl) -phenyl-N-methylcarbamate . As pyrethroids, it is preferable to mention the compounds with the common names permethrin, cypermethrin, detamethrin, cyfluthrin. As esters of phosphoric acid, it is preferable to mention compounds with the common names fenitrothion, dichlorvos, trichlorfon. As the synergistic agent for these compounds, it is preferable to mention piperonyl butoxide. The active substances are present from 2.5 to 30% by weight, preferably from 5 to 25%, very particularly preferably from 15 to 20%. A mixture of benzyl acetate and an alcohol is used as the solvent according to the invention. Preferred alcohols are C 1, aliphatic alcohols which, if appropriate, are also substituted by benzyl alcohol or tetrahydrofurfuryl alcohol. Especially preferred are ethanol, isopropanol, n-butanol as well as benzyl alcohol. In the formulation according to the invention, the solvent mass is present from 5 to 77.5% by weight, preferably from 25 to 75%, very particularly preferably from 50 to 75%. In the formulation according to the invention, the benzyl acetate is present from 25 to 95% by weight, preferably from 20 to 70% by weight, particularly preferably from 25 to 50%. The alcohols (based on the total solvent mass) are present from 5 to 75% by weight, preferably from 50 to 75% by weight, particularly preferably from 30 to 50%. Additionally, the formulations according to the invention may contain customary adjuvants, such as emulsifiers, stabilizers, antioxidants or odor masking agents. Emulsifiers which may be mentioned are: non-ionogenic surfactants, for example polyoxyethylated castor oil, polyoxyethylated sorbitan onooleate, sorbitan onarabide, glycerol monostearate, poly (oxyethyl stearate), alkylphenyl polyglycol ether; ampholytic surfactants such as disodium N-lauryl-β-iminodipropionate or lecithin; surfactants with anionic activity, such as sodium lauryl sulfate, fatty alcohol ethersulfates, ono / dialkyl-polyglycol ether orthophosphoric salt monoethanolamine salt; surfactants with onic activity such as cetyltrimethylammonium chloride. As stabilizers and antioxidants are mentioned sulfites or metabisulfites such as potassium metabisulfite; organic acids such as citric acid; ascorbic acid, phenols, butylhydroxytoluene, butylhydroxyanisole, tocopherol. The emulsifiers are contained in the formulations according to the invention in 2.5 to 17.5% by weight, particularly preferably 5 to 15%. The stabilizers and antioxidants are contained in 0.1 to 0.5% by weight, particularly preferably 0.1 to 0.25%. Odor masking agents are, for example, mixtures of esters of organic fatty acids. They are contained in the formulations according to the invention, preferably in 0.1 to 2% by weight. The following examples should clarify the invention: Example 1 Propoxur (Cas. Ns 114-26-1) 20 g Emulsifier PS 16"'12 g Emulsifier 1371 A' - '1 2 g Tetrahydrofurfuryl alcohol 7.5 g Benzyl acetate 61 , 78 g (up to 100 ml) Citric acid 0.1 g BHT (butylated hydroxytoluene) 0.1 g (l> The emulsifier PS 16 is an alkylaryl polyglycol ether from Bayer AG. () The emulsifier 1371 A is an alkylarylsulphonate (al 67% in n-butanol) of the Bayer AG Firm.

Example 2 Propoxur 11 g Benzyl acetate 60%, benzyl alcohol 40% 77.9 g (up to 100 ml) Emulsifier 1371 A (2) 5 g Emulsogen EL <; i > 8 g Citric acid 0.1 g BHT 0.1 g 0) Emulsogen El is an ethoxylated vegetable oil from the firm Hoechst AG Example 3 Propoxur 20 g Emulsogen EL1'1 8 g Emulsifier 1371 A, 3) 5 g Citric acid 0, 1 g BHT 0.1 g Malodur Courteract14 '2.0 g Benzyl acetate 35%, benzyl alcohol 65% 69.1 g (up to 100 ml) (4' Malodur Couteract is an odor masking agent based on acid esters fatty acids, from the Haar ann und Reimer company.

Test of residual biological activity Test method To determine the activity of the formulation indicated in Example 3, broths for pulverization were obtained. With these spraying bricks, various plinths of PVC floor coverings, lacquered wood, varnished and unvarnished tiles were sprayed, with varying amounts of application (g a.i./m2). One week after the treatment until 4 weeks later, weekly, then after another 6, 8 and 12 weeks, 5 cockroaches were placed on the respective bases. The animals were kept on the treated surface by means of an entangled glass ring (diameter: 9.5 cm, 5.5 cm) and remained there for 24 hours. The valuation of the percentage death was made from the moment of laying and was counted after 15 minutes and 30 minutes, as well as every hour, after an hour to 6 hours. Other assessments were made after 8 and 24 hours (see table 1). As can be seen from table 1, the spray liquors based on the liquid formulation according to the invention exhibit outstanding biological activity on various bases. The storage stability of the liquid formulations indicated in Examples 1-3 or of their spray liquors is outstanding.

Table 1: Residual activity on various bases I 00 I It is noted that, in relation to this date, the best method known to the applicant to carry out the aforementioned invention is that which is clear from the present description of the invention. Having described the invention as above, property is claimed as contained in the following:

Claims (5)

1. CLAIMS 1. Liquid formulations of insecticidal active substances, emulsifiable in water, characterized in that they contain a) 2.5 to 30% active substance, b) 5 to 77.5% of a mixture of benzyl acetate and an alcohol, in the proportion of 25-95% to 5-75%, c) 2.5 to 20% of formulation aid.
2. 2. Liquid formulations emulsifiable in water according to claim 1, characterized. because as an insecticide active substance they contain carbamates.
3. 3. Water-soluble and water-soluble formulations according to claim 1-2, characterized in that they contain stabilizers and antioxidants in 0.1 to 0.5% by weight as formulation aids.
4. 4. Liquid formulations emulsifiable in water according to claim 3, characterized in that they contain stabilizers based on organic acids.
5. 5. Liquid formulations emulsifiable in water according to claim 3, characterized in that they contain antioxidants based on phenols.