MXPA06013483A - Modulacion de produccion de inmunoglobulina y trastornos atopicos. - Google Patents
Modulacion de produccion de inmunoglobulina y trastornos atopicos.Info
- Publication number
- MXPA06013483A MXPA06013483A MXPA06013483A MXPA06013483A MXPA06013483A MX PA06013483 A MXPA06013483 A MX PA06013483A MX PA06013483 A MXPA06013483 A MX PA06013483A MX PA06013483 A MXPA06013483 A MX PA06013483A MX PA06013483 A MXPA06013483 A MX PA06013483A
- Authority
- MX
- Mexico
- Prior art keywords
- ige
- pathway
- agonist
- further characterized
- human
- Prior art date
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| ES2428358T3 (es) * | 2003-10-17 | 2013-11-07 | Novo Nordisk A/S | Terapia de combinación |
| KR20070057789A (ko) * | 2004-08-05 | 2007-06-07 | 와이어쓰 | 인터루킨-21 수용체 활성의 상쇄 |
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| US7914574B2 (en) * | 2005-08-02 | 2011-03-29 | Reva Medical, Inc. | Axially nested slide and lock expandable device |
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| WO2007114861A2 (en) * | 2005-11-28 | 2007-10-11 | Zymogenetics, Inc. | Il-21 receptor antagonists |
| CN101553501A (zh) | 2006-10-26 | 2009-10-07 | 诺沃-诺迪斯克有限公司 | Il-21变种 |
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| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| JP6395379B2 (ja) | 2011-01-18 | 2018-09-26 | バイオニズ リミテッド ライアビリティー カンパニー | γｃサイトカイン活性を調節するための組成物および方法 |
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Family Cites Families (47)
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| US4487603A (en) * | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4486194A (en) * | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4968615A (en) * | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| US4737323A (en) * | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5116742A (en) * | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| DE3883899T3 (de) * | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US4941880A (en) * | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) * | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| EP0705614B1 (en) * | 1989-04-28 | 2002-09-25 | Riker Laboratories, Inc. | Dry powder inhalation device |
| US5034413A (en) * | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| US5312335A (en) * | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5383851A (en) * | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| SE9502800D0 (sv) * | 1995-08-10 | 1995-08-10 | Astra Ab | Disposable inhaler |
| US20030143204A1 (en) * | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
| US7198789B2 (en) * | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| US7189400B2 (en) * | 1998-03-17 | 2007-03-13 | Genetics Institute, Llc | Methods of treatment with antagonists of MU-1 |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US20030212022A1 (en) * | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
| CA2420992C (en) * | 2000-04-05 | 2010-07-13 | Zymogenetics, Inc. | Soluble zalpha11 cytokine receptors |
| CA2312142A1 (en) * | 2000-06-22 | 2001-12-22 | An-Go-Gen Inc. | Injection system for gene delivery |
| WO2003040313A2 (en) * | 2001-11-05 | 2003-05-15 | Zymogenetics, Inc | Il-21 antagonists |
| EP1572902B1 (en) * | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| WO2003093430A2 (en) * | 2002-05-03 | 2003-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in preparing sirnas |
| CN1685063B (zh) * | 2002-08-12 | 2011-12-21 | 新英格兰生物实验室公司 | 与基因沉默相关的方法和组合物 |
| PL376118A1 (en) * | 2002-10-11 | 2005-12-12 | Novo Nordisk A/S | Treatment of allergic conditions by use of il 21 |
| US7495085B2 (en) * | 2003-03-14 | 2009-02-24 | Wyeth | Antibodies against human or mouse IL-21 receptor |
| ZA200507235B (en) * | 2003-03-21 | 2007-03-28 | Wyeth Corp | Treating immunological disorders using agonists of interleukin-21/interleukin-21 receptor |
| GT200600148A (es) * | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis |
-
2005
- 2005-05-19 CA CA002566333A patent/CA2566333A1/en not_active Abandoned
- 2005-05-19 KR KR1020067024218A patent/KR20070014181A/ko not_active Withdrawn
- 2005-05-19 RU RU2006138704/14A patent/RU2006138704A/ru not_active Application Discontinuation
- 2005-05-19 JP JP2007527432A patent/JP2008501042A/ja not_active Withdrawn
- 2005-05-19 WO PCT/US2005/017514 patent/WO2005112983A2/en not_active Ceased
- 2005-05-19 EP EP05779552A patent/EP1753458A4/en not_active Withdrawn
- 2005-05-19 BR BRPI0510996-5A patent/BRPI0510996A/pt not_active IP Right Cessation
- 2005-05-19 CN CNA2005800162359A patent/CN1980698A/zh not_active Withdrawn
- 2005-05-19 MX MXPA06013483A patent/MXPA06013483A/es unknown
- 2005-05-19 AU AU2005244942A patent/AU2005244942A1/en not_active Withdrawn
- 2005-05-19 US US11/132,947 patent/US20060024268A1/en not_active Abandoned
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2006
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- 2006-11-17 ZA ZA200609600A patent/ZA200609600B/xx unknown
- 2006-11-17 EC EC2006007014A patent/ECSP067014A/es unknown
- 2006-11-28 NO NO20065487A patent/NO20065487L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1753458A2 (en) | 2007-02-21 |
| CA2566333A1 (en) | 2005-12-01 |
| JP2008501042A (ja) | 2008-01-17 |
| EP1753458A4 (en) | 2009-07-22 |
| AU2005244942A1 (en) | 2005-12-01 |
| WO2005112983A3 (en) | 2006-10-05 |
| CN1980698A (zh) | 2007-06-13 |
| KR20070014181A (ko) | 2007-01-31 |
| WO2005112983A2 (en) | 2005-12-01 |
| US20060024268A1 (en) | 2006-02-02 |
| ECSP067014A (es) | 2006-12-29 |
| RU2006138704A (ru) | 2008-06-27 |
| NO20065487L (no) | 2006-12-18 |
| BRPI0510996A (pt) | 2007-12-04 |
| IL179243A0 (en) | 2007-03-08 |
| ZA200609600B (en) | 2010-04-28 |
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