MXPA06010404A - Metodo para tratar la estenosis aortica con formulaciones de tetraciclina no anti-bacterianas. - Google Patents
Metodo para tratar la estenosis aortica con formulaciones de tetraciclina no anti-bacterianas.Info
- Publication number
- MXPA06010404A MXPA06010404A MXPA06010404A MXPA06010404A MXPA06010404A MX PA06010404 A MXPA06010404 A MX PA06010404A MX PA06010404 A MXPA06010404 A MX PA06010404A MX PA06010404 A MXPA06010404 A MX PA06010404A MX PA06010404 A MXPA06010404 A MX PA06010404A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- tetracycline
- cmt
- amino
- antibacterial
- Prior art date
Links
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- 235000019364 tetracycline Nutrition 0.000 title claims abstract description 85
- 229960002180 tetracycline Drugs 0.000 title claims abstract description 70
- 229930101283 tetracycline Natural products 0.000 title claims abstract description 69
- 150000003522 tetracyclines Chemical class 0.000 title claims abstract description 56
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims abstract description 25
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- 238000009472 formulation Methods 0.000 title claims abstract description 16
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- 150000003839 salts Chemical class 0.000 claims description 15
- NBRQRXRBIHVLGI-OWXODZSWSA-N (4as,5ar,12ar)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=CC=CC(O)=C2C(O)=C(C2=O)[C@@H]1C[C@@H]1[C@@]2(O)C(O)=C(C(=O)N)C(=O)C1 NBRQRXRBIHVLGI-OWXODZSWSA-N 0.000 claims description 9
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 9
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- XCCHQGIGHCRZOS-KBKZQPOHSA-N (4as,5as,6s,12ar)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@@](C)(O)[C@@H](C[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)C3)(O)C3=O)C3=C(O)C2=C1O XCCHQGIGHCRZOS-KBKZQPOHSA-N 0.000 claims description 8
- BVFDLIAWTKFZQD-JXVDNWKRSA-N cmt-8 Chemical group O=C1C2=C(O)C=CC=C2C(C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)C[C@@H]1C2O BVFDLIAWTKFZQD-JXVDNWKRSA-N 0.000 claims description 7
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 5
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 5
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- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 4
- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 claims description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55277904P | 2004-03-12 | 2004-03-12 | |
| PCT/US2005/008387 WO2005089259A2 (en) | 2004-03-12 | 2005-03-11 | Method for treating aortic stenosis with non-antibacterial tetracycline formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06010404A true MXPA06010404A (es) | 2007-01-19 |
Family
ID=34994224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA06010404A MXPA06010404A (es) | 2004-03-12 | 2005-03-11 | Metodo para tratar la estenosis aortica con formulaciones de tetraciclina no anti-bacterianas. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100137261A1 (https=) |
| EP (1) | EP1729752A4 (https=) |
| JP (1) | JP2007535502A (https=) |
| KR (1) | KR20060130205A (https=) |
| CN (1) | CN101420960A (https=) |
| AU (1) | AU2005222937B2 (https=) |
| CA (1) | CA2558015A1 (https=) |
| MX (1) | MXPA06010404A (https=) |
| NZ (1) | NZ549678A (https=) |
| WO (1) | WO2005089259A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
| GB201610400D0 (en) | 2016-06-15 | 2016-07-27 | Cambridge Entpr Ltd And Kings College London | Vascular calcification |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1494681A4 (en) * | 2002-04-16 | 2008-08-06 | Collagenex Pharm Inc | PROCESS FOR THE SIMULTANEOUS TREATMENT OF OCULAR ROSACEA AND ACNE ROSACEA |
| JP2005526114A (ja) * | 2002-05-06 | 2005-09-02 | コッラジェネックス ファーマシューチカルス インコーポレイテッド | 粘膜炎及び真菌感染症の同時治療方法 |
-
2005
- 2005-03-11 AU AU2005222937A patent/AU2005222937B2/en not_active Ceased
- 2005-03-11 CA CA002558015A patent/CA2558015A1/en not_active Abandoned
- 2005-03-11 JP JP2007503102A patent/JP2007535502A/ja active Pending
- 2005-03-11 CN CNA2005800080556A patent/CN101420960A/zh active Pending
- 2005-03-11 NZ NZ549678A patent/NZ549678A/en unknown
- 2005-03-11 KR KR1020067018175A patent/KR20060130205A/ko not_active Ceased
- 2005-03-11 EP EP05731432A patent/EP1729752A4/en not_active Withdrawn
- 2005-03-11 WO PCT/US2005/008387 patent/WO2005089259A2/en not_active Ceased
- 2005-03-11 MX MXPA06010404A patent/MXPA06010404A/es not_active Application Discontinuation
- 2005-03-11 US US10/592,206 patent/US20100137261A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101420960A (zh) | 2009-04-29 |
| NZ549678A (en) | 2009-11-27 |
| WO2005089259A3 (en) | 2009-04-02 |
| EP1729752A4 (en) | 2012-02-01 |
| WO2005089259A2 (en) | 2005-09-29 |
| AU2005222937A1 (en) | 2005-09-29 |
| KR20060130205A (ko) | 2006-12-18 |
| EP1729752A2 (en) | 2006-12-13 |
| US20100137261A1 (en) | 2010-06-03 |
| AU2005222937B2 (en) | 2010-06-17 |
| CA2558015A1 (en) | 2005-09-29 |
| JP2007535502A (ja) | 2007-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |