AU2005222937B2 - Method for treating aortic stenosis with non-antibacterial tetracycline formulations - Google Patents

Method for treating aortic stenosis with non-antibacterial tetracycline formulations Download PDF

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Publication number
AU2005222937B2
AU2005222937B2 AU2005222937A AU2005222937A AU2005222937B2 AU 2005222937 B2 AU2005222937 B2 AU 2005222937B2 AU 2005222937 A AU2005222937 A AU 2005222937A AU 2005222937 A AU2005222937 A AU 2005222937A AU 2005222937 B2 AU2005222937 B2 AU 2005222937B2
Authority
AU
Australia
Prior art keywords
hydrogen
cmt
tetracycline
antibacterial
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005222937A
Other languages
English (en)
Other versions
AU2005222937A1 (en
Inventor
Fausto Biancari
Tatu Juvonen
Antti Nissinen
Jani Oiva
Tuula A. Salo
Jari Satta
Ylermi Soini
Kari Ylitalo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Collagenex Pharmaceuticals Inc
Original Assignee
Collagenex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collagenex Pharmaceuticals Inc filed Critical Collagenex Pharmaceuticals Inc
Publication of AU2005222937A1 publication Critical patent/AU2005222937A1/en
Application granted granted Critical
Publication of AU2005222937B2 publication Critical patent/AU2005222937B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2005222937A 2004-03-12 2005-03-11 Method for treating aortic stenosis with non-antibacterial tetracycline formulations Ceased AU2005222937B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55277904P 2004-03-12 2004-03-12
US60/552,779 2004-03-12
PCT/US2005/008387 WO2005089259A2 (en) 2004-03-12 2005-03-11 Method for treating aortic stenosis with non-antibacterial tetracycline formulations

Publications (2)

Publication Number Publication Date
AU2005222937A1 AU2005222937A1 (en) 2005-09-29
AU2005222937B2 true AU2005222937B2 (en) 2010-06-17

Family

ID=34994224

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005222937A Ceased AU2005222937B2 (en) 2004-03-12 2005-03-11 Method for treating aortic stenosis with non-antibacterial tetracycline formulations

Country Status (10)

Country Link
US (1) US20100137261A1 (https=)
EP (1) EP1729752A4 (https=)
JP (1) JP2007535502A (https=)
KR (1) KR20060130205A (https=)
CN (1) CN101420960A (https=)
AU (1) AU2005222937B2 (https=)
CA (1) CA2558015A1 (https=)
MX (1) MXPA06010404A (https=)
NZ (1) NZ549678A (https=)
WO (1) WO2005089259A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
GB201610400D0 (en) 2016-06-15 2016-07-27 Cambridge Entpr Ltd And Kings College London Vascular calcification

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1494681A4 (en) * 2002-04-16 2008-08-06 Collagenex Pharm Inc PROCESS FOR THE SIMULTANEOUS TREATMENT OF OCULAR ROSACEA AND ACNE ROSACEA
JP2005526114A (ja) * 2002-05-06 2005-09-02 コッラジェネックス ファーマシューチカルス インコーポレイテッド 粘膜炎及び真菌感染症の同時治療方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Curci, J.A. et al, "Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines." J Vasc Surg. 1998, 28(6)1082-93. *
Edep, M.E. et al, "Matrix metalloproteinase expression in nonrheumatic aortic stenosis." Cardiovasc. Pathol. 2000, 9(5):281-6. *
Kaden, J.J. et al, "Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis." Z. Kardiol. 2004 (February) 93(2):124-30. *
Petrinec, D. et al, "Suppression of experimental aneurysmal degeneration with chemically modified tetracycline derivatives." Ann N Y Acad Sci. 1996, 800:263-5. *
Satta, J. et al, "Evidence for an altered balance between matrix metalloproteinase-9 and its inhibitors in calcific aortic stenosis." Ann Thorac Surg. 2003, 76(3):681-8. *
Thompson, R.W. et al, "MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial." Ann N Y Acad Sci. 1999. 30;878:159-78. *

Also Published As

Publication number Publication date
CN101420960A (zh) 2009-04-29
NZ549678A (en) 2009-11-27
WO2005089259A3 (en) 2009-04-02
EP1729752A4 (en) 2012-02-01
WO2005089259A2 (en) 2005-09-29
AU2005222937A1 (en) 2005-09-29
KR20060130205A (ko) 2006-12-18
EP1729752A2 (en) 2006-12-13
US20100137261A1 (en) 2010-06-03
CA2558015A1 (en) 2005-09-29
MXPA06010404A (es) 2007-01-19
JP2007535502A (ja) 2007-12-06

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired