MXPA05012413A - Cepas bacterianas disenadas metabolicamente que tienen transportadores de gluconato endogenos no funcionales. - Google Patents
Cepas bacterianas disenadas metabolicamente que tienen transportadores de gluconato endogenos no funcionales.Info
- Publication number
- MXPA05012413A MXPA05012413A MXPA05012413A MXPA05012413A MXPA05012413A MX PA05012413 A MXPA05012413 A MX PA05012413A MX PA05012413 A MXPA05012413 A MX PA05012413A MX PA05012413 A MXPA05012413 A MX PA05012413A MX PA05012413 A MXPA05012413 A MX PA05012413A
- Authority
- MX
- Mexico
- Prior art keywords
- bacterial strains
- functional endogenous
- metabolically engineered
- engineered bacterial
- endogenous gluconate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se relaciona con el diseno de rutas metabolicas en las celulas huesped bacterianas, que resulta en el flujo de carbono mejorado para la produccion de intermediarios del acido ascorbico (ASA). En particular, la invencion se relaciona con el aumento en la produccion de los intermediarios de ASA en las celulas bacterianas mediante el mejoramiento de la disponibilidad del gluconato, que resulta de la inactivacion de los genes transportadores de gluconato endogeno.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47331003P | 2003-05-22 | 2003-05-22 | |
US47805603P | 2003-06-11 | 2003-06-11 | |
PCT/US2004/014590 WO2005017099A2 (en) | 2003-05-22 | 2004-05-10 | Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05012413A true MXPA05012413A (es) | 2006-02-13 |
Family
ID=34197774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05012413A MXPA05012413A (es) | 2003-05-22 | 2004-05-10 | Cepas bacterianas disenadas metabolicamente que tienen transportadores de gluconato endogenos no funcionales. |
Country Status (7)
Country | Link |
---|---|
US (3) | US7419795B2 (es) |
EP (1) | EP1625211B1 (es) |
JP (1) | JP2007525186A (es) |
CA (2) | CA2852159A1 (es) |
DK (1) | DK1625211T3 (es) |
MX (1) | MXPA05012413A (es) |
WO (1) | WO2005017099A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7419795B2 (en) * | 2003-05-22 | 2008-09-02 | Danisco A/S, Genencor Division | Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters |
KR101269810B1 (ko) * | 2010-07-15 | 2013-05-30 | 씨제이제일제당 (주) | L-라이신 생산능이 향상된 미생물 및 이를 이용한 l-라이신 생산방법 |
EP2430152B1 (en) * | 2010-07-15 | 2016-08-24 | CJ CheilJedang Corporation | Microorganism with enhanced l-lysine productivity and method for producing l-lysine using the same |
EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
CN109055292B (zh) * | 2018-08-20 | 2020-08-04 | 上海凌凯医药科技有限公司 | 一种生产l-木糖的重组变形假单胞菌及其应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4760025A (en) * | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
US4757012A (en) * | 1983-06-28 | 1988-07-12 | Genentech, Inc. | Ascorbic acid intermediates and process enzymes |
US5004690A (en) * | 1983-06-28 | 1991-04-02 | Genetech, Inc. | Ascorbic acid intermediates and process enzymes |
US4758514A (en) * | 1983-06-28 | 1988-07-19 | Genentech, Inc. | Ascorbic acid intermediates and process enzymes |
US5008193A (en) * | 1984-06-14 | 1991-04-16 | Genentech, Inc. | Ascorbic acid intermediates and process enzymes |
US5032514A (en) * | 1988-08-08 | 1991-07-16 | Genentech, Inc. | Metabolic pathway engineering to increase production of ascorbic acid intermediates |
JPH0426860A (ja) | 1990-05-23 | 1992-01-30 | Canon Inc | 静電荷像現像用現像剤 |
US5376544A (en) * | 1992-09-08 | 1994-12-27 | Rutgers The State University Of New Jersey | Enzymes for the production of 2-keto-L-gulonic acid |
US5795761A (en) * | 1996-01-11 | 1998-08-18 | Rutgers, The State University Of New Jersey | Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A |
US6599722B2 (en) * | 1998-12-22 | 2003-07-29 | Genencor International, Inc. | Method for producing ascorbic acid intermediates |
US7256027B1 (en) * | 1999-06-15 | 2007-08-14 | Rutgers, The State University Of New Jersey | Enzymes for the production of 2-keto-L-gulonic acid |
CA2417970C (en) | 2000-08-04 | 2013-09-24 | Genencor International, Inc. | 2,5-dkg permeases |
KR20080113283A (ko) | 2001-04-04 | 2008-12-29 | 제넨코 인터내셔날 인코포레이티드 | 숙주 세포에서의 생산물의 생산 방법 |
JP4267860B2 (ja) | 2002-03-28 | 2009-05-27 | 学校法人早稲田大学 | 窒素・リン同時除去型排水処理方法 |
US7419795B2 (en) * | 2003-05-22 | 2008-09-02 | Danisco A/S, Genencor Division | Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters |
MXPA06000949A (es) * | 2003-07-30 | 2006-05-04 | Genecor Int Inc | Cepas bacterianas manipuladas metabolicamente que tienen acumulacion de 2-ceto-d-gluconato incrementada. |
-
2004
- 2004-05-10 US US10/842,929 patent/US7419795B2/en not_active Expired - Fee Related
- 2004-05-10 DK DK04785902.0T patent/DK1625211T3/en active
- 2004-05-10 WO PCT/US2004/014590 patent/WO2005017099A2/en active Application Filing
- 2004-05-10 CA CA2852159A patent/CA2852159A1/en not_active Abandoned
- 2004-05-10 EP EP04785902.0A patent/EP1625211B1/en not_active Expired - Lifetime
- 2004-05-10 CA CA2526595A patent/CA2526595C/en not_active Expired - Fee Related
- 2004-05-10 JP JP2006514337A patent/JP2007525186A/ja active Pending
- 2004-05-10 MX MXPA05012413A patent/MXPA05012413A/es active IP Right Grant
-
2008
- 2008-06-18 US US12/141,522 patent/US8034583B2/en not_active Expired - Fee Related
-
2011
- 2011-09-09 US US13/228,833 patent/US20120009635A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005017099A3 (en) | 2009-06-04 |
US20080299614A1 (en) | 2008-12-04 |
US7419795B2 (en) | 2008-09-02 |
EP1625211B1 (en) | 2014-11-19 |
JP2007525186A (ja) | 2007-09-06 |
US20050112734A1 (en) | 2005-05-26 |
US20120009635A1 (en) | 2012-01-12 |
CA2852159A1 (en) | 2005-02-24 |
DK1625211T3 (en) | 2015-02-23 |
EP1625211A2 (en) | 2006-02-15 |
US8034583B2 (en) | 2011-10-11 |
WO2005017099A2 (en) | 2005-02-24 |
EP1625211A4 (en) | 2010-03-10 |
CA2526595A1 (en) | 2005-02-24 |
CA2526595C (en) | 2014-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
HH | Correction or change in general |