MXPA05008922A - Derivados de oxazol como agonistas de proliferador de peroxisoma. - Google Patents
Derivados de oxazol como agonistas de proliferador de peroxisoma.Info
- Publication number
- MXPA05008922A MXPA05008922A MXPA05008922A MXPA05008922A MXPA05008922A MX PA05008922 A MXPA05008922 A MX PA05008922A MX PA05008922 A MXPA05008922 A MX PA05008922A MX PA05008922 A MXPA05008922 A MX PA05008922A MX PA05008922 A MXPA05008922 A MX PA05008922A
- Authority
- MX
- Mexico
- Prior art keywords
- oxazole
- derivatives
- ppar agonists
- dyslipidemia
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Acidos carboxilicos de heteroarilo condensado de formula (I): (ver formula (I)) en la que R1, Ar, A, Y, HET, Q y T son como se han definido en la memoria descriptiva; composiciones farmaceuticas que contienen cantidades eficaces de dichos compuestos o sus sales son utiles para tratar trastornos relativos a PPAR, tales como diabetes, dislipidemia, obesidad y trastornos inflamatorios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44893103P | 2003-02-21 | 2003-02-21 | |
PCT/IB2004/000338 WO2004074284A1 (en) | 2003-02-21 | 2004-02-09 | Oxazole-derivatives as ppar agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05008922A true MXPA05008922A (es) | 2005-10-05 |
Family
ID=32908672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05008922A MXPA05008922A (es) | 2003-02-21 | 2004-02-09 | Derivados de oxazol como agonistas de proliferador de peroxisoma. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20040209929A1 (es) |
EP (1) | EP1597257A1 (es) |
JP (1) | JP2006518366A (es) |
AR (1) | AR044498A1 (es) |
BR (1) | BRPI0407735A (es) |
CA (1) | CA2516475A1 (es) |
GT (1) | GT200400019A (es) |
MX (1) | MXPA05008922A (es) |
NL (1) | NL1025542C2 (es) |
PA (1) | PA8594401A1 (es) |
PE (1) | PE20050223A1 (es) |
TW (1) | TW200424201A (es) |
UY (1) | UY28200A1 (es) |
WO (1) | WO2004074284A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1692506A4 (en) * | 2003-11-17 | 2008-01-09 | Janssen Pharmaceutica Nv | MODELING A SYSTEMIC INFLAMMATORY RESPONSE TO INFECTION |
US20050203151A1 (en) * | 2003-12-19 | 2005-09-15 | Kalypsys, Inc. | Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions |
US7544702B2 (en) * | 2004-08-12 | 2009-06-09 | Amgen Inc. | Bisaryl-sulfonamides |
KR20070053243A (ko) | 2004-09-11 | 2007-05-23 | 사노피-아벤티스 도이칠란트 게엠베하 | 7-아자인돌 및 ppar 작용제로서의 이의 용도 |
WO2006053342A2 (en) * | 2004-11-12 | 2006-05-18 | Osi Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
UY30288A1 (es) * | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
NZ592603A (en) * | 2008-10-21 | 2013-02-22 | Metabolex Inc | Aryl gpr120 receptor agonists and uses thereof |
TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
JP6369951B2 (ja) * | 2015-08-26 | 2018-08-08 | 三井農林株式会社 | ジペプチジルペプチダーゼ−iv阻害剤 |
WO2017121308A1 (en) * | 2016-01-11 | 2017-07-20 | Chongqing Fochon Pharmaceutical Co., Ltd. | Fused pyridine compounds, compositions and methods of use |
WO2018202039A1 (zh) * | 2017-05-03 | 2018-11-08 | 成都海创药业有限公司 | 杂环化合物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
CN1071333C (zh) * | 1994-10-20 | 2001-09-19 | 日本化学医药株式会社 | 喹啉衍生物 |
WO2001040192A1 (fr) * | 1999-12-03 | 2001-06-07 | Kyoto Pharmaceutical Industries, Ltd. | Nouveaux composes heterocycliques et sels de ces derniers, utilisations de ces composes en medecine |
ATE394376T1 (de) * | 2001-06-18 | 2008-05-15 | Ono Pharmaceutical Co | Tetrahydrochinolinderivatverbindung und die verbindung als wirkstoff enthaltendes arzneimittel |
ES2260456T3 (es) * | 2001-08-29 | 2006-11-01 | Warner-Lambert Company Llc | Agentes antidiabeticos orales. |
US20030171377A1 (en) * | 2001-08-29 | 2003-09-11 | Bigge Christopher Franklin | Antidiabetic agents |
-
2004
- 2004-01-22 PA PA20048594401A patent/PA8594401A1/es unknown
- 2004-02-09 BR BRPI0407735-0A patent/BRPI0407735A/pt not_active Application Discontinuation
- 2004-02-09 EP EP04709295A patent/EP1597257A1/en not_active Withdrawn
- 2004-02-09 CA CA002516475A patent/CA2516475A1/en not_active Abandoned
- 2004-02-09 JP JP2006502422A patent/JP2006518366A/ja active Pending
- 2004-02-09 WO PCT/IB2004/000338 patent/WO2004074284A1/en not_active Application Discontinuation
- 2004-02-09 MX MXPA05008922A patent/MXPA05008922A/es unknown
- 2004-02-18 GT GT200400019A patent/GT200400019A/es unknown
- 2004-02-18 PE PE2004000169A patent/PE20050223A1/es not_active Application Discontinuation
- 2004-02-19 UY UY28200A patent/UY28200A1/es not_active Application Discontinuation
- 2004-02-19 US US10/783,654 patent/US20040209929A1/en not_active Abandoned
- 2004-02-20 AR ARP040100541A patent/AR044498A1/es unknown
- 2004-02-20 NL NL1025542A patent/NL1025542C2/nl not_active IP Right Cessation
- 2004-02-20 TW TW093104303A patent/TW200424201A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
UY28200A1 (es) | 2004-09-30 |
US20040209929A1 (en) | 2004-10-21 |
PA8594401A1 (es) | 2004-09-16 |
EP1597257A1 (en) | 2005-11-23 |
WO2004074284A1 (en) | 2004-09-02 |
NL1025542C2 (nl) | 2005-10-11 |
PE20050223A1 (es) | 2005-03-22 |
AR044498A1 (es) | 2005-09-14 |
GT200400019A (es) | 2004-09-21 |
NL1025542A1 (nl) | 2004-08-24 |
JP2006518366A (ja) | 2006-08-10 |
TW200424201A (en) | 2004-11-16 |
BRPI0407735A (pt) | 2006-02-14 |
CA2516475A1 (en) | 2004-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007111864A3 (en) | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use | |
UA96308C2 (ru) | Антагонисты рецептора глюкагона, композиция, которая содержит такие соединения, и их применение | |
NZ594385A (en) | Aminopyrimidines useful as kinase inhibitors | |
WO2007136577A3 (en) | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use | |
WO2008011453A3 (en) | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLβ-HSD-1 | |
IL185275A0 (en) | N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same | |
NO20070731L (no) | Heterocykliske forbindelser. | |
WO2008057856A3 (en) | Modulators of glucocorticoid receptor, ap-1 and/or nf-kappab activity and use thereof | |
MX2009004707A (es) | Piridina carboxamides como inhibidores 11-beta-hsd1. | |
UA97817C2 (ru) | Гетероциклические производные 4-(метилсульфонил)фенила и их применение | |
NO20071549L (no) | Nye benzofuserte heteroalrylsulfamidderivater, anvendelige som anti-krampemidler | |
TW200726739A (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment | |
MX2007005933A (es) | Compuestos de acetamida como fungicidas. | |
WO2007120575A3 (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment | |
TW200745028A (en) | Novel sulphonylpyrroles | |
TW200619218A (en) | Pyrimidines as PLK inhibitors | |
ECSP066886A (es) | Compuestos y métodos para el tratamiento de dislipidemia | |
TW200633698A (en) | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | |
TW200745027A (en) | Novel sulphonylpyrroles | |
WO2006057922A3 (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment | |
WO2007092364A3 (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment | |
RS50807B (sr) | 3,11 b-cis-dihidrotetrabenazin za lečenje šizofrenije i drugih psihoza | |
JO2578B1 (en) | Compounds Theophene benzimidazole | |
WO2008051403A3 (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment | |
TW200726764A (en) | N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |