MXPA05001293A - Compuestos aril aminoalquilo-sustituidos y su uso como bloqueadores del canal de sodio. - Google Patents

Compuestos aril aminoalquilo-sustituidos y su uso como bloqueadores del canal de sodio.

Info

Publication number
MXPA05001293A
MXPA05001293A MXPA05001293A MXPA05001293A MXPA05001293A MX PA05001293 A MXPA05001293 A MX PA05001293A MX PA05001293 A MXPA05001293 A MX PA05001293A MX PA05001293 A MXPA05001293 A MX PA05001293A MX PA05001293 A MXPA05001293 A MX PA05001293A
Authority
MX
Mexico
Prior art keywords
treatment
prevention
substituted aryl
aminoalkyl
aryl compounds
Prior art date
Application number
MXPA05001293A
Other languages
English (en)
Inventor
Donald J Kyle
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of MXPA05001293A publication Critical patent/MXPA05001293A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esta invencion se refiere a un metodo para tratar las enfermedades responsables del bloqueo de los canales de ion de calcio usando compuestos aril aminoalquilo sustituidos novedosos de Formula (1), o una sal farmaceuticamente aceptable o solvato del mismo, en donde n, X, R1, R2 y R3 son como se definen en la descripcion. La invencion tambien se dirige al uso de los compuestos de 1 a Formula (1) para el tratamiento del dano neuronal seguido de la isquemia focal o global, para el tratamiento o prevencion de las condiciones neurodegenerativas tales como esclerosis lateral amiotrofica (ALS) y para el tratamiento, prevencion o disminucion del dolor agudo o cronico, dolor neuropatico o dolor quirurgico, como agentes anti-zumbidos de oidos, como anticonvulsionantes y como depresores anti-maniacos, como anestesicos locales, como antiarritmicos y para el tratamiento o prevencion de la neuropatia diabetica.
MXPA05001293A 2002-08-01 2003-08-01 Compuestos aril aminoalquilo-sustituidos y su uso como bloqueadores del canal de sodio. MXPA05001293A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39969702P 2002-08-01 2002-08-01
PCT/US2003/023971 WO2004013114A1 (en) 2002-08-01 2003-08-01 Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers

Publications (1)

Publication Number Publication Date
MXPA05001293A true MXPA05001293A (es) 2005-09-08

Family

ID=31495752

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05001293A MXPA05001293A (es) 2002-08-01 2003-08-01 Compuestos aril aminoalquilo-sustituidos y su uso como bloqueadores del canal de sodio.

Country Status (7)

Country Link
US (1) US20050227974A9 (es)
EP (1) EP1525194A1 (es)
JP (1) JP2005534701A (es)
AU (1) AU2003268039A1 (es)
CA (1) CA2493551A1 (es)
MX (1) MXPA05001293A (es)
WO (1) WO2004013114A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
EP2257296B1 (en) * 2008-02-26 2014-05-07 Parion Sciences, Inc. Poly aromatic sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
WO2013131018A1 (en) * 2012-03-02 2013-09-06 Zalicus Pharmaceuticals Ltd. Biaryl inhibitors of the sodium channel
GEP20186903B (en) 2012-12-17 2018-10-25 Saiensis Ink Perion Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522205A (en) * 1968-04-09 1970-07-28 Thiokol Chemical Corp Ethylene sulfide polymers stabilized with polyamine additives
US3876701A (en) * 1970-04-17 1975-04-08 Sterling Drug Inc N,n'-bisnitrophenoxybenzal-bridged-diamines
DE69429524T2 (de) * 1993-09-24 2002-08-08 Univ British Columbia Aminocyclohexylester und ihre anwendung
AU749214C (en) * 1997-11-21 2006-03-30 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
DE19955476A1 (de) * 1999-11-18 2001-05-23 Boehringer Ingelheim Pharma Bis-basische Verbindungen als Tryptase-Inhibitoren, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
ES2330552T3 (es) * 2000-02-16 2009-12-11 Smithkline Beecham Plc Derivados de pirimidin-5-ona como inhibidores de ldl-pla2.
AR029489A1 (es) * 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
MXPA02009279A (es) * 2000-03-24 2004-09-10 Euro Celtique Sa Pirazoles, triazoles y tetrazoles sustituidos con arilo como bloqueadores del canal de sodio.
KR20020084278A (ko) * 2000-03-31 2002-11-04 코센시스 인크 항경련제 및 나트륨 통로 차단제로서의 아미노피리딘과이의 용도
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
CN1479872A (zh) * 2000-10-12 2004-03-03 艾科斯有限公司 调节含有变构调节位点的α/β蛋白的配体结合/酶活性的物质和方法
WO2002038534A2 (en) * 2000-11-10 2002-05-16 Actelion Pharmaceuticals Ltd Substituted alkyldiamines as inhibitors of plasmepsin or related proteases
JP2004538285A (ja) * 2001-07-16 2004-12-24 ユーロ−セルティック エス． ア． アリール置換チアゾリジノンおよびその使用
AR036873A1 (es) * 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
AR037233A1 (es) * 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
SE0103325D0 (sv) * 2001-10-04 2001-10-04 Astrazeneca Ab Novel compounds
DK1483247T3 (da) * 2002-03-13 2009-08-17 Euro Celtique Sa Arylsubstituerede pyrimidiner og anvendelsen deraf

Also Published As

Publication number Publication date
AU2003268039A1 (en) 2004-02-23
CA2493551A1 (en) 2004-02-12
JP2005534701A (ja) 2005-11-17
WO2004013114A1 (en) 2004-02-12
EP1525194A1 (en) 2005-04-27
US20040116415A1 (en) 2004-06-17
US20050227974A9 (en) 2005-10-13

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