MXPA04011560A - Formulacion anti-cancer. - Google Patents

Formulacion anti-cancer.

Info

Publication number
MXPA04011560A
MXPA04011560A MXPA04011560A MXPA04011560A MXPA04011560A MX PA04011560 A MXPA04011560 A MX PA04011560A MX PA04011560 A MXPA04011560 A MX PA04011560A MX PA04011560 A MXPA04011560 A MX PA04011560A MX PA04011560 A MXPA04011560 A MX PA04011560A
Authority
MX
Mexico
Prior art keywords
rubidium
ursolate
ursolic acid
composition
mmp
Prior art date
Application number
MXPA04011560A
Other languages
English (en)
Inventor
Monroe Stephen
Original Assignee
Greystone Medical Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greystone Medical Group Inc filed Critical Greystone Medical Group Inc
Publication of MXPA04011560A publication Critical patent/MXPA04011560A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

Composicion para detener la metastasis de celulas de cancer que comprende rubidio ursolato. El rubidio ursolato se forma de una mezcla de rubidio y acido ursolico obtenido de la corteza de la planta Virburnum.

Description

FORMULACION ANTI-CANCER Esta invención se relaciona a formulaciones para la prevención o para detener la metástasis de células de cáncer.
DESCRIPCION DE LA INVENCION El ácido ursólico derivado de la corteza de la planta Viburnum ha sido reportado que tiene actividad antiinvasiva con células de fibrosarcoma humanas. El mecanismo de actividad fue reportado para ser ideado en envolver la regulación a la baja de MMP-9, una metaloprotexnasa de matriz que degrada gelatina. Ha sido además reportado que no hubo efecto sobre MMP-2, la segunda de dos MMP's que degradan gelatina.
De acuerdo con la presente invención, el Rubidio es combinado con ácido ursólico para hacer una sal del ácido, Rubidio Ursolato, que cuando se administra a un paciente, regula a la baja MMP-2 y MMP-9. Esta combinación de los dos inhibidores de MMP proporciona un tratamiento para de-tener el esparcimiento o metástasis de las células de cáncer, en general .

Claims (7)

REIVINDICACIONES
1. Una composición para detener la metástasis de células de cáncer que comprende cantidades farmacéuticamente eficaces de rubidio ursolato.
2. La composición de conformidad con la reivindicación 1, en donde la composición, cuando se administra a un paciente, regula a la baja el MMP-2 y MMP-9.
3. La composición de conformidad con la reivindicación 1, en donde el rubidio ursolato se forma de una mezcla de rubidio y ácido ursólico.
4. La composición de conformidad con la reivindicación 3, en donde el ácido ursólico se obtiene -de la corteza de la planta Virburnum.
5. Un método para detener la metástasis de células de cáncer que comprende administrar a un paciente en necesidad de la misma, una cantidad farmacéuticamente eficaz de rubidio ursolato.
6. El método de conformidad con la reivindicación 5, en donde el rubidio ursolato se forma de una mezcla de ácido ursólico y rubidio.
7. El método de conformidad con la reivindicación 5, en donde el ácido ursólico se deriva de la corteza de la planta Virburnum.
MXPA04011560A 2002-05-24 2003-05-22 Formulacion anti-cancer. MXPA04011560A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38246002P 2002-05-24 2002-05-24
PCT/US2003/016188 WO2003099218A2 (en) 2002-05-24 2003-05-22 Anti-cancer formulation

Publications (1)

Publication Number Publication Date
MXPA04011560A true MXPA04011560A (es) 2005-06-08

Family

ID=29584412

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04011560A MXPA04011560A (es) 2002-05-24 2003-05-22 Formulacion anti-cancer.

Country Status (7)

Country Link
US (1) US20040023937A1 (es)
EP (1) EP1507542A4 (es)
JP (1) JP2005527613A (es)
AU (1) AU2003248555A1 (es)
CA (1) CA2486704A1 (es)
MX (1) MXPA04011560A (es)
WO (1) WO2003099218A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050175715A1 (en) * 2003-08-25 2005-08-11 Monroe Stephen H. Cellular depolarization and regulation of matrix metalloproteinases
MX2010006300A (es) * 2007-12-11 2011-08-17 Stephen H Monroe Composicion de solucion acuosa reguladora para el tratamiento del ambiente celular y canales ionicos y metodos para uso de la misma.
DE102009012561B4 (de) * 2009-03-11 2015-01-22 Rohde & Schwarz Gmbh & Co. Kg Verfahren und Mobilfunktester zur Erzeugung einer global gültigen Adresse für ein Mobilfunkgerät für eine Mobilfunk-Testprozedur
CN103923159B (zh) * 2014-04-24 2016-04-27 长沙麓园生物科技有限公司 一种从枇杷叶中提取精制熊果酸的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE191850T1 (de) * 1992-11-06 2000-05-15 Greystone Medical Group Inc Eichenrindenextraktverwandte synthetische zubereitungen und verfahren zur verwendung
JP3041232B2 (ja) * 1995-11-16 2000-05-15 日本ケミカルリサーチ株式会社 癌転移抑制剤
US5932617A (en) * 1998-02-06 1999-08-03 Woundfast Pharmaceuticals Inc. Wound-treating composition and method
WO2001015745A1 (en) * 1999-08-31 2001-03-08 Giles Brian C Method and formula for tumor remission and suppression of cancer
WO2002009719A1 (fr) * 2000-07-31 2002-02-07 The Nisshin Oillio, Ltd. Agents antitumoraux
NZ533252A (en) * 2001-11-29 2006-03-31 Greystone Medical Group Inc Treatment of wounds and compositions employed

Also Published As

Publication number Publication date
CA2486704A1 (en) 2003-12-04
AU2003248555A1 (en) 2003-12-12
EP1507542A4 (en) 2008-01-23
EP1507542A2 (en) 2005-02-23
US20040023937A1 (en) 2004-02-05
WO2003099218A2 (en) 2003-12-04
WO2003099218A3 (en) 2004-04-08
JP2005527613A (ja) 2005-09-15

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Legal Events

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FA Abandonment or withdrawal