MXPA04008517A - Compuestos terapeuticos. - Google Patents
Compuestos terapeuticos.Info
- Publication number
- MXPA04008517A MXPA04008517A MXPA04008517A MXPA04008517A MXPA04008517A MX PA04008517 A MXPA04008517 A MX PA04008517A MX PA04008517 A MXPA04008517 A MX PA04008517A MX PA04008517 A MXPA04008517 A MX PA04008517A MX PA04008517 A MXPA04008517 A MX PA04008517A
- Authority
- MX
- Mexico
- Prior art keywords
- alkylene
- substituted
- aryl
- compound according
- compound
- Prior art date
Links
- -1 Pyridinyloxy Chemical class 0.000 title claims description 56
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title claims description 22
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 title claims 3
- 239000003446 ligand Substances 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 124
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 46
- 125000002947 alkylene group Chemical group 0.000 claims description 41
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 35
- 125000000623 heterocyclic group Chemical group 0.000 claims description 33
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 125000001072 heteroaryl group Chemical group 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- 208000035475 disorder Diseases 0.000 claims description 21
- 241000124008 Mammalia Species 0.000 claims description 20
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 238000002600 positron emission tomography Methods 0.000 claims description 14
- 125000003107 substituted aryl group Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 210000003169 central nervous system Anatomy 0.000 claims description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
- ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 238000003325 tomography Methods 0.000 claims description 6
- 238000005481 NMR spectroscopy Methods 0.000 claims description 5
- 125000004562 2,3-dihydroindol-1-yl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
- 150000007942 carboxylates Chemical class 0.000 claims description 4
- YQWBUIHLQWTMSR-UHFFFAOYSA-N 2H-indole-3-carboxamide Chemical compound N=1CC(=C2C=CC=CC12)C(=O)N YQWBUIHLQWTMSR-UHFFFAOYSA-N 0.000 claims description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical compound [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims description 3
- CWEAMWYRLFYZNJ-UHFFFAOYSA-N n-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]azepane-1-carboxamide Chemical compound CC1=NC=CC=C1OC(N=C1)=CC=C1NC(=O)N1CCCCCC1 CWEAMWYRLFYZNJ-UHFFFAOYSA-N 0.000 claims description 2
- KRHYYFGTRYWZRS-BJUDXGSMSA-N ac1l2y5h Chemical compound [18FH] KRHYYFGTRYWZRS-BJUDXGSMSA-N 0.000 claims 1
- XMBWDFGMSWQBCA-YPZZEJLDSA-N iodane Chemical group [125IH] XMBWDFGMSWQBCA-YPZZEJLDSA-N 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 6
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 22
- 239000000203 mixture Substances 0.000 description 19
- 239000000243 solution Substances 0.000 description 15
- 208000019901 Anxiety disease Diseases 0.000 description 13
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 11
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- 238000002603 single-photon emission computed tomography Methods 0.000 description 9
- 208000008589 Obesity Diseases 0.000 description 8
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 8
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- 150000003254 radicals Chemical class 0.000 description 6
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- VNTXBOJIESFBJS-UHFFFAOYSA-N 6-(2-methylpyridin-3-yl)oxypyridin-3-amine Chemical compound CC1=NC=CC=C1OC1=CC=C(N)C=N1 VNTXBOJIESFBJS-UHFFFAOYSA-N 0.000 description 5
- 208000028017 Psychotic disease Diseases 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 125000001589 carboacyl group Chemical group 0.000 description 5
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 4
- 125000004423 acyloxy group Chemical group 0.000 description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
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- 125000005843 halogen group Chemical group 0.000 description 4
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
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- 108010010803 Gelatin Proteins 0.000 description 3
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
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- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36146602P | 2002-03-04 | 2002-03-04 | |
| PCT/US2003/006167 WO2003076426A2 (en) | 2002-03-04 | 2003-02-27 | Pyridinyloxy derivatives as 5-ht receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04008517A true MXPA04008517A (es) | 2005-08-19 |
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|---|---|---|---|
| MXPA04008517A MXPA04008517A (es) | 2002-03-04 | 2003-02-27 | Compuestos terapeuticos. |
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| Country | Link |
|---|---|
| US (1) | US7291738B2 (enExample) |
| EP (1) | EP1485386A2 (enExample) |
| JP (1) | JP2006506319A (enExample) |
| AU (1) | AU2003217817A1 (enExample) |
| BR (1) | BR0308223A (enExample) |
| CA (1) | CA2475254A1 (enExample) |
| MX (1) | MXPA04008517A (enExample) |
| WO (1) | WO2003076426A2 (enExample) |
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| WO2004089296A2 (en) | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| CA2559665A1 (en) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids |
| NZ554555A (en) | 2004-10-20 | 2011-09-30 | Univ California | Cyclohexyl-urea derivatives as improved inhibitors for the soluble epoxide hydrolase |
| AR059356A1 (es) * | 2006-02-14 | 2008-03-26 | Astrazeneca Ab | Nuevos radioligandos |
| AR059826A1 (es) | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| KR101062376B1 (ko) * | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| WO2012054093A2 (en) | 2010-01-29 | 2012-04-26 | The Regents Of The University Of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| WO2014046544A1 (en) | 2012-09-21 | 2014-03-27 | Aapa B.V. | Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators |
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| US5689606A (en) | 1996-06-03 | 1997-11-18 | Scientific-Atlanta, Inc. | Fiber routing and retention assembly with modular fiber connector support |
| GB9612883D0 (en) * | 1996-06-20 | 1996-08-21 | Smithkline Beecham Plc | Novel compounds |
| GB9612885D0 (en) | 1996-06-20 | 1996-08-21 | Smithkline Beecham Plc | Novel compounds |
| CA2468010A1 (en) * | 2001-11-28 | 2003-06-05 | Pharmacia & Upjohn Company | Benzazepine derivatives and their use as 5-ht ligands |
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2003
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- 2003-02-27 JP JP2003574643A patent/JP2006506319A/ja not_active Withdrawn
- 2003-02-27 US US10/375,687 patent/US7291738B2/en not_active Expired - Fee Related
- 2003-02-27 MX MXPA04008517A patent/MXPA04008517A/es not_active Application Discontinuation
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- 2003-02-27 BR BR0308223-7A patent/BR0308223A/pt not_active IP Right Cessation
- 2003-02-27 CA CA002475254A patent/CA2475254A1/en not_active Abandoned
- 2003-02-27 EP EP03713783A patent/EP1485386A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US7291738B2 (en) | 2007-11-06 |
| WO2003076426A3 (en) | 2004-07-22 |
| AU2003217817A1 (en) | 2003-09-22 |
| JP2006506319A (ja) | 2006-02-23 |
| AU2003217817A8 (en) | 2003-09-22 |
| CA2475254A1 (en) | 2003-09-18 |
| WO2003076426A2 (en) | 2003-09-18 |
| BR0308223A (pt) | 2005-06-28 |
| EP1485386A2 (en) | 2004-12-15 |
| US20030181485A1 (en) | 2003-09-25 |
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