MXPA03011898A - Ensayo de seleccion in vitro para ?- secretasa. - Google Patents

Ensayo de seleccion in vitro para ?- secretasa.

Info

Publication number
MXPA03011898A
MXPA03011898A MXPA03011898A MXPA03011898A MXPA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A
Authority
MX
Mexico
Prior art keywords
gamma
secretase
vitro
substrate
secretase activity
Prior art date
Application number
MXPA03011898A
Other languages
English (en)
Spanish (es)
Inventor
Fuchs Klaus
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03011898A publication Critical patent/MXPA03011898A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MXPA03011898A 2001-07-04 2002-06-27 Ensayo de seleccion in vitro para ?- secretasa. MXPA03011898A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131899A DE10131899A1 (de) 2001-07-04 2001-07-04 In vitro-Screening-Assay für gamma-Secretase
PCT/EP2002/007095 WO2003008635A2 (fr) 2001-07-04 2002-06-27 Essai de criblage in vitro de $g(g)-secretase

Publications (1)

Publication Number Publication Date
MXPA03011898A true MXPA03011898A (es) 2004-03-26

Family

ID=7690254

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011898A MXPA03011898A (es) 2001-07-04 2002-06-27 Ensayo de seleccion in vitro para ?- secretasa.

Country Status (6)

Country Link
EP (1) EP1407043A2 (fr)
JP (1) JP2004535206A (fr)
CA (1) CA2452832A1 (fr)
DE (1) DE10131899A1 (fr)
MX (1) MXPA03011898A (fr)
WO (1) WO2003008635A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0229582D0 (en) * 2002-12-19 2003-01-22 Merck Sharp & Dohme Novel assay
DK1849762T3 (da) 2006-04-21 2009-10-12 Cellzome Ltd Substituerede biphenylcarboxylsyrer og derivater deraf
EA200970838A1 (ru) 2007-03-07 2010-02-26 Янссен Фармацевтика Н.В. ЗАМЕЩЕННЫЕ ФЕНОКСИПРОИЗВОДНЫЕ N-АЛКИЛИРОВАННЫЕ ТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ ЭСТРОГЕН-РОДСТВЕННЫХ РЕЦЕПТОРОВ α
EP2134698A1 (fr) 2007-03-07 2009-12-23 Janssen Pharmaceutica, N.V. Phénoxy aminothiazolones substituées comme modulateurs de récepteur alpha d' strogène
US20090023158A1 (en) * 2007-07-13 2009-01-22 Elan Pharmaceuticals, Inc. Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase
ES2395083T3 (es) 2007-10-17 2013-02-08 Janssen Pharmaceutica, N.V. Ácidos bifenilcarboxílicos y sus derivados
BRPI0817433A2 (pt) 2007-10-19 2015-06-16 Janssen Pharmaceutica Nv Moduladores de gama-secretase piperidinila e piperazinila
EA017907B1 (ru) 2007-10-19 2013-04-30 Янссен Фармацевтика Н.В. МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ
JP5417334B2 (ja) 2007-10-19 2014-02-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 炭素結合したγ−セクレターゼの調節物質
WO2009052350A1 (fr) 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Modulateurs de la g-secrétase liés à une amine
US7968725B2 (en) 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
US9023767B2 (en) 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
CN103502466A (zh) * 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
WO2014062771A1 (fr) * 2012-10-16 2014-04-24 The Johns Hopkins University Reconstitution inductible et système cinétique quantitatif en temps réel pour l'étude d'enzymes intramembranaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4589297A (en) * 1996-10-07 1998-05-05 Scios Inc. Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase
DE19941039A1 (de) * 1999-08-28 2001-03-01 Boehringer Ingelheim Pharma gamma-Sekretase in vitro Testsystem

Also Published As

Publication number Publication date
CA2452832A1 (fr) 2003-01-30
DE10131899A1 (de) 2003-02-27
WO2003008635A3 (fr) 2004-01-29
WO2003008635A2 (fr) 2003-01-30
EP1407043A2 (fr) 2004-04-14
JP2004535206A (ja) 2004-11-25
WO2003008635A8 (fr) 2003-10-30

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