MXPA03004426A - Proceso quimico y nuevos intermediarios. - Google Patents

Proceso quimico y nuevos intermediarios.

Info

Publication number
MXPA03004426A
MXPA03004426A MXPA03004426A MXPA03004426A MXPA03004426A MX PA03004426 A MXPA03004426 A MX PA03004426A MX PA03004426 A MXPA03004426 A MX PA03004426A MX PA03004426 A MXPA03004426 A MX PA03004426A MX PA03004426 A MXPA03004426 A MX PA03004426A
Authority
MX
Mexico
Prior art keywords
chemical process
new intermediates
general formula
halogen
tioxo
Prior art date
Application number
MXPA03004426A
Other languages
English (en)
Inventor
Istvan Hermecz
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of MXPA03004426A publication Critical patent/MXPA03004426A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Proceso para la preparacion de un compuesto de la formula general (I) y sales y solvatos farmaceuticamente aceptables del mismo, Caracterizandose (I) por reaccionar una N-(amino-tioxo-metil)-1H-indola-2-carboxamida de la formula general (II), con una a-halogeno-cetona de la formula genral (III), donde X significa halogeno.
MXPA03004426A 2000-11-28 2001-11-27 Proceso quimico y nuevos intermediarios. MXPA03004426A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0004741A HUP0004741A2 (hu) 2000-11-28 2000-11-28 Kémiai eljárás tiazolszármazékok előállítására és új intermedier
PCT/HU2001/000121 WO2002044150A1 (en) 2000-11-28 2001-11-27 Chemical process and new intermediates

Publications (1)

Publication Number Publication Date
MXPA03004426A true MXPA03004426A (es) 2004-05-04

Family

ID=89978805

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03004426A MXPA03004426A (es) 2000-11-28 2001-11-27 Proceso quimico y nuevos intermediarios.

Country Status (12)

Country Link
US (1) US20040198793A1 (es)
EP (1) EP1345897A1 (es)
JP (1) JP2004518641A (es)
CN (1) CN1478075A (es)
AU (1) AU2002220932A1 (es)
BR (1) BR0115501A (es)
CA (1) CA2430064A1 (es)
CZ (1) CZ20031813A3 (es)
HU (1) HUP0004741A2 (es)
MX (1) MXPA03004426A (es)
PL (1) PL363702A1 (es)
WO (1) WO2002044150A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10314610A1 (de) 2003-04-01 2004-11-04 Aventis Pharma Deutschland Gmbh Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
MX2009001043A (es) 2006-08-08 2009-02-06 Sanofi Aventis Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso.
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
US8470841B2 (en) 2008-07-09 2013-06-25 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
ES2443016T3 (es) 2009-08-26 2014-02-17 Sanofi Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
WO2012120050A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2159676T3 (es) * 1995-12-22 2001-10-16 Ss Pharmaceutical Co Derivados de triazol con actividad antimicotica e intermediarios.
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant
CO4970713A1 (es) * 1997-09-19 2000-11-07 Sanofi Synthelabo Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
HU0004741D0 (es) 2001-02-28
PL363702A1 (en) 2004-11-29
WO2002044150A1 (en) 2002-06-06
CA2430064A1 (en) 2002-06-06
CN1478075A (zh) 2004-02-25
CZ20031813A3 (cs) 2003-09-17
HUP0004741A2 (hu) 2002-12-28
EP1345897A1 (en) 2003-09-24
US20040198793A1 (en) 2004-10-07
BR0115501A (pt) 2003-10-21
JP2004518641A (ja) 2004-06-24
AU2002220932A1 (en) 2002-06-11

Similar Documents

Publication Publication Date Title
MXPA03004426A (es) Proceso quimico y nuevos intermediarios.
HK1069395A1 (en) Phthalazinone derivatives 2,3
TW200510441A (en) Novel compounds
WO2005105749A3 (en) Process for making montelukast and intermediates therefor
MXPA02003977A (es) Inhibidores de adhesion de celula mediada por al°2.
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
EP1354880A4 (en) HALOGEN COMPOUNDS HAVING AGONISM TOWARDS THROMBOPOIETIN RECEPTOR
GB0111523D0 (en) Chemical compounds
YU73802A (sh) Postupak sinteze perindoprila i njegovih farmaceutski prihvatljivih soli
PH12009500610A1 (en) 4-imidazolin-2-one compounds
WO2007057225A3 (en) Process for making montelukast and intermediates therefor
MXPA05009668A (es) Proceso libre de azida para preparar compuestos de 1,2-diamino.
NO20013684L (no) Substituerte fenetylaminderivater
MY138826A (en) 2,7-substituted indoles
AP2002002466A0 (en) 3-heterocycliylpropanohydroxamic acid PCP INHIBITORS.
TW200621241A (en) Process for the preparation of isothiazole derivatives
NZ513041A (en) N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists; their preparation and medicaments containing them
MY136938A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
AU6220300A (en) Benzofurylpiperazine serotonin agonists
GB0113232D0 (en) Chemical process
MXPA03011401A (es) Procedimiento para la preparacion de derivados de ciclohexanol.
MXPA04004937A (es) Proceso para preparar 3,3??,3,6??,-tetraalquil-2,2??-bifenoles y 3,??,6,??-tetraalquil-5,??-dihalo-2,??-bifenoles.
WO2003093247A3 (en) Antibacterial agents
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
SG149005A1 (en) Process for the preparation of thiazolopyrimidines