MXPA01008352A - Alcoxidos de metal en c-7 de bacatina iii. - Google Patents
Alcoxidos de metal en c-7 de bacatina iii.Info
- Publication number
- MXPA01008352A MXPA01008352A MXPA01008352A MXPA01008352A MXPA01008352A MX PA01008352 A MXPA01008352 A MX PA01008352A MX PA01008352 A MXPA01008352 A MX PA01008352A MX PA01008352 A MXPA01008352 A MX PA01008352A MX PA01008352 A MXPA01008352 A MX PA01008352A
- Authority
- MX
- Mexico
- Prior art keywords
- baccatin iii
- metal alkoxides
- baccatin
- iii
- making
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Silicon Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Ceramic Products (AREA)
Abstract
La presente invencion proporciona un compuesto quimico que tiene la formula:(ver formula) en donde R es un grupo alquilo y el ion anfoterico o contraion M+ es un ion anfoterico de metal alcalino. La presente invencion tambien proporciona un metodo de produccion de un compuesto que tiene la formula anterior, a partir de la bacatina III o 10-desacetilbacatina III, que comprende las etapas de disolver el compuesto de partida en un primer solvente para formar una primera solucion, enfriar la primera solucion, agregar a la primera solucion una base alcalina para formar un compuesto intermediario que tiene un alcoxido de metal en la posicion C-7 del mismo, y acilar selectivamente en la posicion C-10 cualquiera del compuesto intermediario presente en la primera solucion que ya no tiene un grupo acetilo en la posicion C-10.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/252,739 US5973170A (en) | 1996-09-25 | 1999-02-19 | C-7 metal alkoxides of baccatin III |
| PCT/US2000/004271 WO2000049006A1 (en) | 1999-02-19 | 2000-02-18 | C-7 metal alkoxides of baccatin iii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01008352A true MXPA01008352A (es) | 2003-06-06 |
Family
ID=22957328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01008352A MXPA01008352A (es) | 1999-02-19 | 2000-02-18 | Alcoxidos de metal en c-7 de bacatina iii. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5973170A (es) |
| EP (1) | EP1155008A4 (es) |
| JP (1) | JP2003518004A (es) |
| KR (1) | KR20010102234A (es) |
| CN (1) | CN1148363C (es) |
| AU (1) | AU3701600A (es) |
| BR (1) | BR0008352A (es) |
| CA (1) | CA2361922A1 (es) |
| CZ (1) | CZ20012786A3 (es) |
| IL (1) | IL144591A0 (es) |
| MX (1) | MXPA01008352A (es) |
| NO (1) | NO20013935L (es) |
| RU (1) | RU2001125669A (es) |
| WO (1) | WO2000049006A1 (es) |
| ZA (1) | ZA200106383B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358996B1 (en) | 2000-06-09 | 2002-03-19 | Napro Biotherapeutics, Inc. | Stable isotope labeling of paclitaxel |
| JP2004528309A (ja) * | 2001-03-23 | 2004-09-16 | ナプロ バイオセラピューティクス，インコーポレイテッド | 癌治療用分子複合体 |
| US6452025B1 (en) | 2001-04-25 | 2002-09-17 | Napro Biotherapeutics, Inc. | Three-step conversion of protected taxane ester to paclitaxel |
| US6479679B1 (en) | 2001-04-25 | 2002-11-12 | Napro Biotherapeutics, Inc. | Two-step conversion of protected taxane ester to paclitaxel |
| US6653501B2 (en) | 2001-06-27 | 2003-11-25 | Napro Biotherapeutics, Inc. | Chiral resolution method for producing compounds useful in the synthesis of taxanes |
| CN1303077C (zh) | 2004-01-16 | 2007-03-07 | 桂林晖昂生化药业有限责任公司 | 合成紫杉烷的制备工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
| US5684175A (en) * | 1993-02-05 | 1997-11-04 | Napro Biotherapeutics, Inc. | C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor |
| US5688977A (en) * | 1996-02-29 | 1997-11-18 | Napro Biotherapeutics, Inc. | Method for docetaxel synthesis |
| US5750737A (en) * | 1996-09-25 | 1998-05-12 | Sisti; Nicholas J. | Method for paclitaxel synthesis |
-
1999
- 1999-02-19 US US09/252,739 patent/US5973170A/en not_active Expired - Fee Related
-
2000
- 2000-02-18 MX MXPA01008352A patent/MXPA01008352A/es not_active Application Discontinuation
- 2000-02-18 IL IL14459100A patent/IL144591A0/xx unknown
- 2000-02-18 BR BR0008352-6A patent/BR0008352A/pt not_active Application Discontinuation
- 2000-02-18 AU AU37016/00A patent/AU3701600A/en not_active Abandoned
- 2000-02-18 RU RU2001125669/04A patent/RU2001125669A/ru unknown
- 2000-02-18 WO PCT/US2000/004271 patent/WO2000049006A1/en not_active Application Discontinuation
- 2000-02-18 EP EP00915802A patent/EP1155008A4/en not_active Withdrawn
- 2000-02-18 CZ CZ20012786A patent/CZ20012786A3/cs unknown
- 2000-02-18 CA CA002361922A patent/CA2361922A1/en not_active Abandoned
- 2000-02-18 CN CNB008038716A patent/CN1148363C/zh not_active Expired - Fee Related
- 2000-02-18 JP JP2000599746A patent/JP2003518004A/ja active Pending
- 2000-02-18 KR KR1020017010480A patent/KR20010102234A/ko not_active Application Discontinuation
-
2001
- 2001-08-03 ZA ZA200106383A patent/ZA200106383B/xx unknown
- 2001-08-14 NO NO20013935A patent/NO20013935L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1148363C (zh) | 2004-05-05 |
| US5973170A (en) | 1999-10-26 |
| AU3701600A (en) | 2000-09-04 |
| EP1155008A1 (en) | 2001-11-21 |
| JP2003518004A (ja) | 2003-06-03 |
| BR0008352A (pt) | 2002-01-29 |
| EP1155008A4 (en) | 2002-05-08 |
| NO20013935D0 (no) | 2001-08-14 |
| CN1340047A (zh) | 2002-03-13 |
| CZ20012786A3 (cs) | 2002-01-16 |
| NO20013935L (no) | 2001-10-16 |
| IL144591A0 (en) | 2002-05-23 |
| KR20010102234A (ko) | 2001-11-15 |
| WO2000049006A1 (en) | 2000-08-24 |
| CA2361922A1 (en) | 2000-08-24 |
| ZA200106383B (en) | 2002-03-06 |
| RU2001125669A (ru) | 2004-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |