MXPA01002798A - Antagonistas del receptor acoplado a la proteina g. - Google Patents

Antagonistas del receptor acoplado a la proteina g.

Info

Publication number
MXPA01002798A
MXPA01002798A MXPA01002798A MXPA01002798A MXPA01002798A MX PA01002798 A MXPA01002798 A MX PA01002798A MX PA01002798 A MXPA01002798 A MX PA01002798A MX PA01002798 A MXPA01002798 A MX PA01002798A MX PA01002798 A MXPA01002798 A MX PA01002798A
Authority
MX
Mexico
Prior art keywords
protein
coupled receptor
antagonists
receptor agonists
receptor
Prior art date
Application number
MXPA01002798A
Other languages
English (en)
Inventor
Sylvain Chemtob
Original Assignee
Chu Sainte Justine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chu Sainte Justine filed Critical Chu Sainte Justine
Publication of MXPA01002798A publication Critical patent/MXPA01002798A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invencion se relaciona con una clase nueva de agonista o antagonista del receptor acoplado a la proteina G, el cual se fija de manera especifica a los elementos estructurales de la proteina del receptor, alterando de esta manera la transmision de señal y los efectos fisiologicos subsecuentes. En la presente se describen las secuencias del peptido que se derivan a partir de la proteina del receptor acoplado a la proteina G, que se produce mediante metodos quimicos como inhibidores selectivos de la transduccion de señal que se asocia con la estimulacion del receptor mediante su ligando. Estos peptidos o moleculas que se derivan a partir de sus estructuras primarias, secundarias o terciarias, se pueden usar como tocoliticos efectivos para la prevencion del trabajo de parto prematuro o se pueden usar para el tratamiento de la dismenorrea.
MXPA01002798A 1998-09-17 1999-09-15 Antagonistas del receptor acoplado a la proteina g. MXPA01002798A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15462798A 1998-09-17 1998-09-17
PCT/CA1999/000844 WO2000017348A1 (en) 1998-09-17 1999-09-15 G protein-coupled receptor agonists or antagonists

Publications (1)

Publication Number Publication Date
MXPA01002798A true MXPA01002798A (es) 2003-06-06

Family

ID=22552099

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01002798A MXPA01002798A (es) 1998-09-17 1999-09-15 Antagonistas del receptor acoplado a la proteina g.

Country Status (8)

Country Link
EP (1) EP1114151B1 (es)
JP (1) JP4431280B2 (es)
AT (1) ATE514778T1 (es)
AU (1) AU5722499A (es)
CA (2) CA2342960C (es)
ES (1) ES2369470T3 (es)
MX (1) MXPA01002798A (es)
WO (1) WO2000017348A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1138692A1 (en) 2000-03-29 2001-10-04 Erasmus Universiteit Rotterdam Fragments of human chorionic gonadotropin (hcg) as immunoregulator
US7358330B2 (en) 2001-03-29 2008-04-15 Biotempt B.V. Immunoregulatory compositions
EP1300418A1 (en) * 2001-10-04 2003-04-09 Erasmus Universiteit Rotterdam Gene regulation by oligopeptides
USRE43279E1 (en) 2000-03-29 2012-03-27 Biotemp B.V. Compositions capable of reducing elevated blood urea concentration
EP1429648A4 (en) * 2001-01-24 2005-03-30 Univ Arizona SCREENING METHODS FOR SUBSTANCES THAT INHIBIT THE INTERACTION OF A PROSTANOID FP RECEPTOR WITH A PGF 2 $ G (A) - ACTIVATED COMPOUND, AND METHODS OF TREATING CANCER
EP1425029A4 (en) * 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
WO2003089002A1 (en) * 2002-04-17 2003-10-30 Medical Research Council Fp receptor antagonists or pgf2 alpha antagonists for treating menorrhagia
GB0208785D0 (en) * 2002-04-17 2002-05-29 Medical Res Council Treatment methtods
US7521530B2 (en) 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688938A (en) 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
JPH07501054A (ja) 1991-11-05 1995-02-02 ジー．ディー．サール　アンド　カンパニー プロスタグランジンアンタゴニストとして有用な１０−アシル−ジベンゾ（ｂ，ｆ）（１，４）−オキサゼピンおよびそれらのチアゼピン類縁体
US5869281A (en) 1993-06-25 1999-02-09 Merck Frosst Canada Inc. DNA encoding prostaglandin receptor FP
JPH11514207A (ja) 1995-01-25 1999-12-07 シーオーアール・セラピューティックス・インコーポレーテッド 組換えｃ１４０リセプター、そのアゴニストおよびアンタゴニスト、並びに該リセプターをコードする核酸

Also Published As

Publication number Publication date
AU5722499A (en) 2000-04-10
ATE514778T1 (de) 2011-07-15
WO2000017348A1 (en) 2000-03-30
EP1114151A1 (en) 2001-07-11
JP2002526509A (ja) 2002-08-20
CA2689373A1 (en) 2000-03-30
CA2342960C (en) 2010-03-09
EP1114151B1 (en) 2011-06-29
CA2342960A1 (en) 2000-03-30
JP4431280B2 (ja) 2010-03-10
ES2369470T3 (es) 2011-12-01

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