MX9806246A - NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDIN E AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS. - Google Patents
NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDIN E AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS.Info
- Publication number
- MX9806246A MX9806246A MX9806246A MX9806246A MX9806246A MX 9806246 A MX9806246 A MX 9806246A MX 9806246 A MX9806246 A MX 9806246A MX 9806246 A MX9806246 A MX 9806246A MX 9806246 A MX9806246 A MX 9806246A
- Authority
- MX
- Mexico
- Prior art keywords
- aryl
- ht1db
- piperazin
- piperidin
- oxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compounds of formula (I), wherein Ar1 is an aromatic residue such as optionally substituted phenyl, naphthyl or pyridyl, or an optionally substituted heterocyclic ring, A-B is CH-CH2 or C=CH, X is O, NH, CH2O or CH2-NH, and Ar2 is an aromatic radical such as phenyl or naphthyl to which X and the piperazine are attached on different carbons, and which itself is optionally substituted by a straight or branched C1-6 alkyl radical, alkoxy (OR4) or halogen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9601275A FR2744448B1 (en) | 1996-02-02 | 1996-02-02 | NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9806246A true MX9806246A (en) | 1998-11-29 |
Family
ID=9488770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9806246A MX9806246A (en) | 1996-02-02 | 1998-08-03 | NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDIN E AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0886636A1 (en) |
JP (1) | JP2000504004A (en) |
CN (1) | CN1212690A (en) |
AU (1) | AU1607097A (en) |
BR (1) | BR9707261A (en) |
CA (1) | CA2244940A1 (en) |
FR (1) | FR2744448B1 (en) |
MX (1) | MX9806246A (en) |
NZ (1) | NZ331221A (en) |
WO (1) | WO1997028140A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2758327B1 (en) * | 1997-01-15 | 1999-04-02 | Pf Medicament | NEW ARYLPIPERAZINES DERIVED FROM PIPERIDINE |
CA2470808A1 (en) * | 2001-12-21 | 2003-07-03 | Taisho Pharmaceutical Co., Ltd. | Piperazine derivative |
UA77536C2 (en) | 2002-07-03 | 2006-12-15 | Lundbeck & Co As H | Secondary aminoaniline piperidines as mch1 antagonists and their use |
ES2327684T3 (en) | 2003-07-24 | 2009-11-02 | Euro-Celtique S.A. | HETEROARIL-TETRAHIDROPIRIDILO COMPOUNDS USEFUL FOR THE TREATMENT OR PREVENTION OF PAIN. |
PL1867644T3 (en) | 2003-07-24 | 2009-10-30 | Euro Celtique Sa | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
PL1648878T3 (en) * | 2003-07-24 | 2009-10-30 | Euro Celtique Sa | Piperidine compounds and pharmaceutical compositions containing them |
US8389549B2 (en) | 2007-04-27 | 2013-03-05 | Purdue Pharma L.P. | Substituted pyridines useful for treating pain |
DK2142529T3 (en) | 2007-04-27 | 2014-02-10 | Purdue Pharma Lp | TRPV1 ANTAGONISTS AND APPLICATIONS THEREOF |
FR2932482B1 (en) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS |
FR2932481B1 (en) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | 4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
US8759362B2 (en) | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
US8703962B2 (en) | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
FR2953839A1 (en) | 2009-12-14 | 2011-06-17 | Sanofi Aventis | NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75 |
FR2953836B1 (en) | 2009-12-14 | 2012-03-16 | Sanofi Aventis | NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75 |
JP5876423B2 (en) | 2010-06-22 | 2016-03-02 | 塩野義製薬株式会社 | Compounds having TRPV1 inhibitory activity and uses thereof |
EP2723732B1 (en) | 2011-06-22 | 2017-01-18 | Purdue Pharma LP | Trpv1 antagonists including dihydroxy substituent and uses thereof |
US9394293B2 (en) | 2011-08-10 | 2016-07-19 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
US9221796B2 (en) | 2014-01-09 | 2015-12-29 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9022820D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9221931D0 (en) * | 1992-10-17 | 1992-12-02 | Wyeth John & Brother Ltd | Piperazine derivatives |
FR2722788B1 (en) * | 1994-07-20 | 1996-10-04 | Pf Medicament | NOVEL PIPERAZIDES DERIVED FROM ARYL PIPERAZINE, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
-
1996
- 1996-02-02 FR FR9601275A patent/FR2744448B1/en not_active Expired - Fee Related
-
1997
- 1997-01-31 BR BR9707261A patent/BR9707261A/en not_active Application Discontinuation
- 1997-01-31 WO PCT/FR1997/000195 patent/WO1997028140A1/en not_active Application Discontinuation
- 1997-01-31 NZ NZ331221A patent/NZ331221A/en unknown
- 1997-01-31 EP EP97902419A patent/EP0886636A1/en not_active Withdrawn
- 1997-01-31 AU AU16070/97A patent/AU1607097A/en not_active Abandoned
- 1997-01-31 JP JP9527373A patent/JP2000504004A/en active Pending
- 1997-01-31 CN CN97192737A patent/CN1212690A/en active Pending
- 1997-01-31 CA CA002244940A patent/CA2244940A1/en not_active Abandoned
-
1998
- 1998-08-03 MX MX9806246A patent/MX9806246A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR9707261A (en) | 1999-07-20 |
JP2000504004A (en) | 2000-04-04 |
CN1212690A (en) | 1999-03-31 |
AU1607097A (en) | 1997-08-22 |
CA2244940A1 (en) | 1997-08-07 |
EP0886636A1 (en) | 1998-12-30 |
NZ331221A (en) | 2000-01-28 |
FR2744448A1 (en) | 1997-08-08 |
WO1997028140A1 (en) | 1997-08-07 |
FR2744448B1 (en) | 1998-04-24 |
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