FR2744448B1 - NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS - Google Patents

NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS

Info

Publication number
FR2744448B1
FR2744448B1 FR9601275A FR9601275A FR2744448B1 FR 2744448 B1 FR2744448 B1 FR 2744448B1 FR 9601275 A FR9601275 A FR 9601275A FR 9601275 A FR9601275 A FR 9601275A FR 2744448 B1 FR2744448 B1 FR 2744448B1
Authority
FR
France
Prior art keywords
medicaments
preparation
well
pharmaceutical compositions
aryl piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9601275A
Other languages
French (fr)
Other versions
FR2744448A1 (en
Inventor
Serge Halazy
Lebrun Catherine Jorand
Peter Pauwels
Chantal Moret
Marc Marien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9601275A priority Critical patent/FR2744448B1/en
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to AU16070/97A priority patent/AU1607097A/en
Priority to BR9707261A priority patent/BR9707261A/en
Priority to CA002244940A priority patent/CA2244940A1/en
Priority to JP9527373A priority patent/JP2000504004A/en
Priority to NZ331221A priority patent/NZ331221A/en
Priority to CN97192737A priority patent/CN1212690A/en
Priority to PCT/FR1997/000195 priority patent/WO1997028140A1/en
Priority to EP97902419A priority patent/EP0886636A1/en
Publication of FR2744448A1 publication Critical patent/FR2744448A1/en
Application granted granted Critical
Publication of FR2744448B1 publication Critical patent/FR2744448B1/en
Priority to MX9806246A priority patent/MX9806246A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR9601275A 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS Expired - Fee Related FR2744448B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR9601275A FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS
EP97902419A EP0886636A1 (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl(oxy/amino)carbonyl/-4-aryl-piperidine as selective 5-ht-1d.beta. receptor antagonists
CA002244940A CA2244940A1 (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl(oxy/amino)carbonyl/-4-aryl-piperidine as selective 5-ht1db receptor antagonists
JP9527373A JP2000504004A (en) 1996-02-02 1997-01-31 Novel piperidine derived from 1-/ (piperazin-1-yl) aryl- (oxy / amino) carbonyl / 4-aryl-piperidine as a selective 5-HT 1Dβ receptor antagonist
NZ331221A NZ331221A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl-(oxo/amino)carbonyl/-4-aryl-piperidine as selective 5-ht 1dbeta receptor antagonists
CN97192737A CN1212690A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-(piperazin-1-yl) aryl (oxylamino) carbonyl/4-aryl-piperidine as selective 5-HTiD beta receptor antagonist
AU16070/97A AU1607097A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl(oxy/amino)carbonyl/-4-aryl-piperidin e as selective 5-ht1db receptor antagonists
BR9707261A BR9707261A (en) 1996-02-02 1997-01-31 Compound processes for preparing them and pharmaceutical products and compositions
PCT/FR1997/000195 WO1997028140A1 (en) 1996-02-02 1997-01-31 NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDINE AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS
MX9806246A MX9806246A (en) 1996-02-02 1998-08-03 NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDIN E AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9601275A FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
FR2744448A1 FR2744448A1 (en) 1997-08-08
FR2744448B1 true FR2744448B1 (en) 1998-04-24

Family

ID=9488770

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9601275A Expired - Fee Related FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS

Country Status (10)

Country Link
EP (1) EP0886636A1 (en)
JP (1) JP2000504004A (en)
CN (1) CN1212690A (en)
AU (1) AU1607097A (en)
BR (1) BR9707261A (en)
CA (1) CA2244940A1 (en)
FR (1) FR2744448B1 (en)
MX (1) MX9806246A (en)
NZ (1) NZ331221A (en)
WO (1) WO1997028140A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2758327B1 (en) * 1997-01-15 1999-04-02 Pf Medicament NEW ARYLPIPERAZINES DERIVED FROM PIPERIDINE
JPWO2003053927A1 (en) * 2001-12-21 2005-04-28 大正製薬株式会社 Piperazine derivatives
UA77536C2 (en) 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
PL1648878T3 (en) 2003-07-24 2009-10-30 Euro Celtique Sa Piperidine compounds and pharmaceutical compositions containing them
EP1867644B1 (en) 2003-07-24 2009-05-20 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
KR20080092473A (en) 2003-07-24 2008-10-15 유로-셀띠끄 소시에떼 아노님 Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
US20090176796A1 (en) 2007-04-27 2009-07-09 Purdue Pharma L. P. Trpv1 antagonists including amide substituent and uses thereof
AU2008246202B2 (en) 2007-04-27 2011-12-01 Purdue Pharma L.P. Therapeutic agents useful for treating pain
FR2932481B1 (en) * 2008-06-13 2010-10-08 Sanofi Aventis 4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2932482B1 (en) * 2008-06-13 2010-10-08 Sanofi Aventis NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS
US8703962B2 (en) 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
US8759362B2 (en) 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
FR2953836B1 (en) 2009-12-14 2012-03-16 Sanofi Aventis NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75
FR2953839A1 (en) 2009-12-14 2011-06-17 Sanofi Aventis NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75
EP2585446A4 (en) 2010-06-22 2013-12-25 Shionogi & Co Compounds having trpv1 antagonistic activity and uses thereof
PE20141531A1 (en) 2011-06-22 2014-10-23 Purdue Pharma Lp TRPV1 ANTAGONISTS INCLUDING DIHYDROXI SUBSTITUTES AND THEIR USES
AU2012293417A1 (en) 2011-08-10 2013-05-02 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
US9221796B2 (en) 2014-01-09 2015-12-29 Bristol-Myers Squibb Company Selective NR2B antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022820D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
GB9221931D0 (en) * 1992-10-17 1992-12-02 Wyeth John & Brother Ltd Piperazine derivatives
FR2722788B1 (en) * 1994-07-20 1996-10-04 Pf Medicament NOVEL PIPERAZIDES DERIVED FROM ARYL PIPERAZINE, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

Also Published As

Publication number Publication date
AU1607097A (en) 1997-08-22
MX9806246A (en) 1998-11-29
WO1997028140A1 (en) 1997-08-07
JP2000504004A (en) 2000-04-04
NZ331221A (en) 2000-01-28
BR9707261A (en) 1999-07-20
FR2744448A1 (en) 1997-08-08
CN1212690A (en) 1999-03-31
CA2244940A1 (en) 1997-08-07
EP0886636A1 (en) 1998-12-30

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Legal Events

Date Code Title Description
ST Notification of lapse