MX9709396A - Derivados de fenoxipiperazina para el tratamiento de transtornos del sistema dopamina. - Google Patents
Derivados de fenoxipiperazina para el tratamiento de transtornos del sistema dopamina.Info
- Publication number
- MX9709396A MX9709396A MX9709396A MX9709396A MX9709396A MX 9709396 A MX9709396 A MX 9709396A MX 9709396 A MX9709396 A MX 9709396A MX 9709396 A MX9709396 A MX 9709396A MX 9709396 A MX9709396 A MX 9709396A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- carbonyl
- amino
- halogen
- alkoxy
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003638 dopamine Drugs 0.000 title abstract 2
- IFKOXBOKMDXHAH-UHFFFAOYSA-N 1-phenoxypiperazine Chemical class C1CNCCN1OC1=CC=CC=C1 IFKOXBOKMDXHAH-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- -1 furan-2-yl-carbonyl-amino Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
La presente invencion se refiere a compuestos de la Formula general (I) en donde R1 y R3 son cada uno independientemente un átomo de hidrogeno, un radical arilo, carbamoilo, alquilo inferior carbonilo, alquilo inferior, halogeno, alquilo inferior-carbonilamino, alquenilo inferior-carbonilamino,amino, arilamino, ariloxi, nitro, arilacetilo, alcanoilo inferior-alquilo inferior, alquilsulfonilamino, ureido o furan-2-il-carbonilamino y R2 es un átomo de hidrogeno, un radical alquilo inferior, trifluorometilo, halogeno, alcoxi inferior, alquilo inferior-carbonilo o aquilo inferior-carbonilamino, o R1 y R2 juntos pueden ser un radical -OCH2O-, -O(CH2)2O- o -(CH2)3- R4 es un átomo de hidrogeno, un radical halogeno, hidroxi, alquilo inferior, alcoxi inferior o nitro, R5 es un átomo de hidrogeno, un radical halogeno o alcoxi inferior, R6 es un átomo de hidrogeno, un radical alquilo inferior, halogeno, hidroxi, amino, alcoxi inferior, trifluorometilo, nitro o alquilo inferior-carbonilamino, y R7 es un átomo de hidrogeno o un radical alquilo inferior-carbonilo, así como sales farmacéuticamente aceptables de los compuestos de la Formula (I), para el tratamiento o prevencion de infermedades que son causadas por trastornos del sistema dopamina y, respectivamente, para la produccion de los correspondientes medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1703/95-4 | 1995-06-09 | ||
| CH170395 | 1995-06-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9709396A true MX9709396A (es) | 1998-07-31 |
| MXPA97009396A MXPA97009396A (es) | 1998-11-09 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| CN1090480C (zh) | 2002-09-11 |
| BR9608938A (pt) | 1999-06-29 |
| EP0833639A1 (en) | 1998-04-08 |
| JPH10507777A (ja) | 1998-07-28 |
| WO1996041630A1 (en) | 1996-12-27 |
| JP3076065B2 (ja) | 2000-08-14 |
| AU6222096A (en) | 1997-01-09 |
| CA2222225A1 (en) | 1996-12-27 |
| CN1187128A (zh) | 1998-07-08 |
| US5614526A (en) | 1997-03-25 |
| TR199701580T1 (xx) | 1998-03-21 |
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