MX9709314A - Proceso para la produccion de clorhidrato de dexfenfluramina. - Google Patents

Proceso para la produccion de clorhidrato de dexfenfluramina.

Info

Publication number
MX9709314A
MX9709314A MX9709314A MX9709314A MX9709314A MX 9709314 A MX9709314 A MX 9709314A MX 9709314 A MX9709314 A MX 9709314A MX 9709314 A MX9709314 A MX 9709314A MX 9709314 A MX9709314 A MX 9709314A
Authority
MX
Mexico
Prior art keywords
production
salt
dexfenfluramine hydrochloride
benzeneethanamine
phenylethyl
Prior art date
Application number
MX9709314A
Other languages
English (en)
Other versions
MXPA97009314A (es
Inventor
Vincenzo Cannata
Stefano Bianchi
Angelo Spreafico
Barbara Maspes
Original Assignee
Alfa Chemicals Italina S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Chemicals Italina S R L filed Critical Alfa Chemicals Italina S R L
Publication of MX9709314A publication Critical patent/MX9709314A/es
Publication of MXPA97009314A publication Critical patent/MXPA97009314A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Proceso para la produccion de un medicamento anoréxico clorhidrato de dexfenfluramina (INN) el cual comprende la etilacion de la (S),(S)-N-(1-feniletil)-alfa-metil-3-(trifluoromet il)bencenoetamina o de una sal de ella con un ácido orgánico o inorgánico, la debenzilacion del intermediario resultante (S),(S)-N-etil-N-(1-feniletil)-alfa-metil-3-(trifl uorometil)bencenoetamina o de una sal de ella con un ácido orgánico o inorgánico por hidrogenacion catalítica y, opcionalmente, la formacion de sales con ácido clorhídrico.
MXPA/A/1997/009314A 1997-06-03 1997-12-01 Proceso para la produccion de clorhidrato de dexfenfluramina MXPA97009314A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97BO000331A IT1292595B1 (it) 1997-06-03 1997-06-03 Processo per la produzione della dexfenfluramina cloridrato.
BOBO97A000331 1997-06-03

Publications (2)

Publication Number Publication Date
MX9709314A true MX9709314A (es) 1998-12-31
MXPA97009314A MXPA97009314A (es) 1999-02-01

Family

ID=

Also Published As

Publication number Publication date
EP0882700A2 (en) 1998-12-09
HUP9701476A2 (hu) 1999-10-28
TR199700899A2 (xx) 1998-12-21
AR008701A1 (es) 2000-02-09
ITBO970331A0 (it) 1997-06-03
HU9701476D0 (en) 1997-10-28
TW367317B (en) 1999-08-21
PL322543A1 (en) 1998-12-07
AU3920597A (en) 1998-12-10
ZA978200B (en) 1998-06-03
CA2215001A1 (en) 1998-12-03
ITBO970331A1 (it) 1998-12-03
JPH10330331A (ja) 1998-12-15
IT1292595B1 (it) 1999-02-08
EP0882700A3 (en) 1999-12-15

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