MX9707433A - Peptidos con propiedades para la estimulacion del desarrollo. - Google Patents

Peptidos con propiedades para la estimulacion del desarrollo.

Info

Publication number
MX9707433A
MX9707433A MX9707433A MX9707433A MX9707433A MX 9707433 A MX9707433 A MX 9707433A MX 9707433 A MX9707433 A MX 9707433A MX 9707433 A MX9707433 A MX 9707433A MX 9707433 A MX9707433 A MX 9707433A
Authority
MX
Mexico
Prior art keywords
xaa
pst
peptides
sequence
leu
Prior art date
Application number
MX9707433A
Other languages
English (en)
Inventor
Brian Lee Buckwalter
Hong-Ming Shieh
Bosco Shang Wang
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of MX9707433A publication Critical patent/MX9707433A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los péptidos que se describen tienen bien definida su estructura secundaria, preferentemente una conformacion helicoidal, la cual simula la region correspondiente de la somatotropina porcina (pST), y la cual incrementa la actividad de la pST y estimula el desarrollo de animales de sangre caliente. Estos péptidos compiten con la pST para la union al anticuerpo monocional PS-7.6. Estos péptidos contienen allí dentro la, secuencia de aminoácidos Xaa-Xaa-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leu-Xaa-Val-Xa a-Xaa (SEC DE ID NO:1), en donde la secuencia diferente de la secuencia nativa de la pST, así como las secuencias en las cuales la localizacion de los aminoácidos esenciales es cambiada por tres aminoácidos, representando casi un grito a lo largo de la hélice, la cual contiene allí dentro la secuencia de aminoáciodos Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Le u-Xaa-Xaa-Xaa-Val (SEC DE ID NO:18), y en donde la secuencia difiere de la secuencia nativa de la pST.
MX9707433A 1995-03-31 1996-03-15 Peptidos con propiedades para la estimulacion del desarrollo. MX9707433A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41523995A 1995-03-31 1995-03-31
PCT/US1996/003490 WO1996030405A1 (en) 1995-03-31 1996-03-15 Peptides with growth promotion properties

Publications (1)

Publication Number Publication Date
MX9707433A true MX9707433A (es) 1997-12-31

Family

ID=23644898

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707433A MX9707433A (es) 1995-03-31 1996-03-15 Peptidos con propiedades para la estimulacion del desarrollo.

Country Status (10)

Country Link
EP (1) EP0819137A1 (es)
JP (1) JPH11502844A (es)
KR (1) KR19980703438A (es)
AU (1) AU5422596A (es)
BG (1) BG101927A (es)
CA (1) CA2216755A1 (es)
HU (1) HUP9801337A2 (es)
MX (1) MX9707433A (es)
PL (1) PL322585A1 (es)
WO (1) WO1996030405A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699466B1 (en) * 1999-08-05 2004-03-02 Research Corporation Technologies, Inc. IL-16 antagonist peptides and DNA encoding the peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338836A (en) * 1992-07-29 1994-08-16 American Cyanamid Company Biologically active porcine somatotropin polypeptides and methods of using the same

Also Published As

Publication number Publication date
PL322585A1 (en) 1998-02-02
AU5422596A (en) 1996-10-16
WO1996030405A1 (en) 1996-10-03
KR19980703438A (ko) 1998-11-05
HUP9801337A2 (hu) 1998-08-28
BG101927A (en) 1998-09-30
JPH11502844A (ja) 1999-03-09
CA2216755A1 (en) 1996-10-03
EP0819137A1 (en) 1998-01-21

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