MX9707191A - Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases. - Google Patents

Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases.

Info

Publication number
MX9707191A
MX9707191A MX9707191A MX9707191A MX9707191A MX 9707191 A MX9707191 A MX 9707191A MX 9707191 A MX9707191 A MX 9707191A MX 9707191 A MX9707191 A MX 9707191A MX 9707191 A MX9707191 A MX 9707191A
Authority
MX
Mexico
Prior art keywords
inhibition
treatment
alkyl
compounds useful
proliferative diseases
Prior art date
Application number
MX9707191A
Other languages
Spanish (es)
Other versions
MXPA97007191A (en
Inventor
Adriano Afonso
Joseph M Kelly
Ronald L Wolin
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9707191A publication Critical patent/MX9707191A/en
Publication of MXPA97007191A publication Critical patent/MXPA97007191A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a novel compound of formula (Ia), (Ib) or (Ic) wherein: R and R1 are H, alkyl, halogeno, OH, alkoxy, NH2, alkylamino, dialkylamino, CF3, SO3H, CO2R3, NO2, SO2NH2, or CONHR4; n is 0 or 1; R2 is a group of the formula R5C(O)-, R5CH2C(O)-, R5C(R6)2C(O)-, R5SO2-, R5CH2SO2-, R5SCH2C(O)-, R5OC(O)-, R5NHC(O)-, R5C(O)C(O)- or R5SC(O)-; R5 is alkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl or heterocycloalkyl; and R6 is alkyl or C(R6)2 is a carboxyclic ring; or pharmaceutically acceptable salts thereof.
MXPA/A/1997/007191A 1995-03-24 1997-09-22 Compound useful trikicicles to inhibit the function of protein g and for treatment of proliferati diseases MXPA97007191A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08410442 1995-03-24
US08/410,442 US5684013A (en) 1995-03-24 1995-03-24 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
PCT/US1996/003306 WO1996030017A1 (en) 1995-03-24 1996-03-20 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
MX9707191A true MX9707191A (en) 1997-11-29
MXPA97007191A MXPA97007191A (en) 1998-07-03

Family

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Also Published As

Publication number Publication date
JP3001982B2 (en) 2000-01-24
EP0814807A1 (en) 1998-01-07
AU708244B2 (en) 1999-07-29
HUP9801396A3 (en) 2000-03-28
US5703090A (en) 1997-12-30
US5958939A (en) 1999-09-28
DE69627993T2 (en) 2004-02-26
IL117603A (en) 2001-01-28
TW473477B (en) 2002-01-21
HUP9801396A2 (en) 1999-05-28
ATE239472T1 (en) 2003-05-15
KR19980703257A (en) 1998-10-15
CA2216291C (en) 2001-06-05
ES2198481T3 (en) 2004-02-01
NZ305133A (en) 1999-11-29
AR003936A1 (en) 1998-09-30
DE69627993D1 (en) 2003-06-12
US5684013A (en) 1997-11-04
AU5307296A (en) 1996-10-16
CA2216291A1 (en) 1996-10-03
EP0814807B1 (en) 2003-05-07
IL117603A0 (en) 1996-07-23
WO1996030017A1 (en) 1996-10-03
JPH10505102A (en) 1998-05-19

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