ES2128960A1 - Fluorophenyl-triazine and pyrimidine derivatives as compounds acting on the central nervous system - Google Patents

Fluorophenyl-triazine and pyrimidine derivatives as compounds acting on the central nervous system

Info

Publication number
ES2128960A1
ES2128960A1 ES09602667A ES9602667A ES2128960A1 ES 2128960 A1 ES2128960 A1 ES 2128960A1 ES 09602667 A ES09602667 A ES 09602667A ES 9602667 A ES9602667 A ES 9602667A ES 2128960 A1 ES2128960 A1 ES 2128960A1
Authority
ES
Spain
Prior art keywords
fluorophenyl
triazine
group
pyrimidine derivatives
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09602667A
Other languages
Spanish (es)
Other versions
ES2128960B1 (en
Inventor
Jover Antoni Torrens
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2128960A1 publication Critical patent/ES2128960A1/en
Application granted granted Critical
Publication of ES2128960B1 publication Critical patent/ES2128960B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel fluorophenyl-triazine and pyrimidine derivatives of general formula (I), wherein R1 is an amino group, a 1-piperazinyl group or a 4-alkylpiperazin-1-yl group, where the alkyl group is a C1-4 chain, preferably methyl each of R2, R3 and R4, which are the same or different, is a halogen atom, preferably a fluorine or chlorine atom R5 is a hydrogen atom or a halogen atom, preferably a fluorine or chlorine atom and Y is a nitrogen atom or a CH group, are disclosed. A method for preparing the compounds of formula (I) or physiologically acceptable salts thereof is also disclosed. Furthermore, pharmaceutical compositions containing a pharmaceutically acceptable carrier and at least one compound of general formula (I) or a physiologically acceptable salt thereof, are disclosed.
ES9602667A 1995-12-05 1996-12-05 PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM. Expired - Lifetime ES2128960B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9514354A FR2741879A1 (en) 1995-12-05 1995-12-05 FLUOROPHENYL-TRIAZINE AND PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
ES2128960A1 true ES2128960A1 (en) 1999-05-16
ES2128960B1 ES2128960B1 (en) 2000-01-16

Family

ID=9485150

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9602667A Expired - Lifetime ES2128960B1 (en) 1995-12-05 1996-12-05 PHARMACOLOGICALLY ACTIVE COMPOUNDS OF FLUOROPHENYL-TRIAZINS AND PYRIMIDINES DERIVATIVES IN THE CENTRAL NERVOUS SYSTEM.

Country Status (4)

Country Link
AU (1) AU1194397A (en)
ES (1) ES2128960B1 (en)
FR (1) FR2741879A1 (en)
WO (1) WO1997020827A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625795D0 (en) * 1996-12-12 1997-01-29 Smithkline Beecham Plc Novel treatment
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
CZ20011949A3 (en) * 1998-12-14 2001-09-12 Torrent Pharmacauticals Ltd Enhanced process for preparing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
AU2007204825B2 (en) * 2006-01-13 2011-07-14 Corteva Agriscience Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021121A1 (en) * 1979-06-01 1981-01-07 The Wellcome Foundation Limited 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
EP0459830A1 (en) * 1990-06-01 1991-12-04 The Wellcome Foundation Limited Pharmacologically active CNS compounds
EP0679645A1 (en) * 1990-06-01 1995-11-02 The Wellcome Foundation Limited Pharmacologically active CNS pyridmidin compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021121A1 (en) * 1979-06-01 1981-01-07 The Wellcome Foundation Limited 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
EP0459830A1 (en) * 1990-06-01 1991-12-04 The Wellcome Foundation Limited Pharmacologically active CNS compounds
EP0679645A1 (en) * 1990-06-01 1995-11-02 The Wellcome Foundation Limited Pharmacologically active CNS pyridmidin compounds

Also Published As

Publication number Publication date
ES2128960B1 (en) 2000-01-16
FR2741879A1 (en) 1997-06-06
WO1997020827A1 (en) 1997-06-12
AU1194397A (en) 1997-06-27

Similar Documents

Publication Publication Date Title
EP0269574A3 (en) Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
TW341565B (en) Indole derivatives processes and intermediates for their preparation and pharmaceutical compositions containing them
HK1018208A1 (en) Naphthyl-substituted benzimidazole derivatives as anticoagulants
AU8794291A (en) New oxazolopyridine derivatives, processes for preparing these and pharmaceutical compositions containing them
HUT59081A (en) Process for producing aryl- and heteroaryl-ethylene derivatives and pharmaceutical compositions containing them
DK1023308T3 (en) Inhibitors of nucleoside metabolism
ATE250622T1 (en) 4'-C-ETHYNYL-PYRIMIDINES NUCLEOSIDES
HUP0401575A2 (en) Novel vinyl carboxylic acid derivatives and their use as antidiabetics and pharmaceutical compositions containing them
MY131193A (en) 7-(2-aminoethyl)-benzothiazolones
TW360652B (en) Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
IL106387A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
ES8601934A1 (en) Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same.
HUT50164A (en) Process for production of derivatives of 6-phenil /piperazinil-alkyl/-1h, 3h-pirimidin-2,4-dion and medical compositions containing them
ES2128960A1 (en) Fluorophenyl-triazine and pyrimidine derivatives as compounds acting on the central nervous system
MX9804828A (en) Biologically active benzothiazolone ethanamines.
UA72883C2 (en) Bicyclic compounds, a method for preparing thereof and pharmaceutical compositions containing them
MY103696A (en) Piperazin-l-yl-ergoline derivatives, process for preparing them and pharmaceutical compositions containing them
ATE261441T1 (en) ANALOGUES OF DISTAMYCIN CINNAMIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTI-TUMOR AGENTS
MX9806341A (en) Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands.
HU896551D0 (en) Process for the preparation of aryloxy-, arylthio-, heteroaryloxy- and heteroarylthio-alkenylene derivatives of amines and pharmaceutical compositions containing them
AU3017397A (en) New bisimide compounds, process for preparing them and pharmaceutical compositions containing them
WO2001081315A3 (en) Amino-imidazole derivatives for treating cancer
ES2056025A1 (en) New indole derivatives
JO1720B1 (en) Hetrocyclic derivatives

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19990516

Kind code of ref document: A1

Effective date: 19990516